Optical bio/chemical sensors for vitamin B₁₂ analysis in food and pharmaceuticals: state of the art, challenges, and future outlooks

• Seyed Mohammad Taghi Gharibzahedi and
• Zeynep Altintas

Beilstein J. Nanotechnol. 2025, 16, 2207–2244, doi:10.3762/bjnano.16.153

• , electrochemical and optical biosensing platforms are one of the best approaches to detect VB12. Various electrochemical methods have been employed for the effective detection of VB12, focusing on its electroactive nature and the redox chemistry of the cobalt atom, primarily utilizing the Co3+/Co2+ and Co2+/Co

Missing links in nanomaterials research impacting productivity and perceptions

• Santosh K. Tiwari and
• Nannan Wang

Beilstein J. Nanotechnol. 2025, 16, 2168–2176, doi:10.3762/bjnano.16.149

• acceleration after the discovery of fullerene by Kroto and co-workers in 1985 and witnessed an even more rapid surge following the discovery of graphene and the award of the Physics Nobel Prize in 2010 [6][7]. Graphene is often referred to as a “wonder material” due to its seemingly infinite potential in

• manufacturable products, supported by co-funded pilot projects and shared IP models. (3) Implement strategic and transparent funding models that prioritize translational potential, incorporating techno-economic analyses, reproducibility metrics, and scalability considerations to accelerate technology readiness

Microplastic pollution in Himalayan lakes: assessment, risks, and sustainable remediation strategies

• Sameeksha Rawat,
• S. M. Tauseef and
• Madhuben Sharma

Beilstein J. Nanotechnol. 2025, 16, 2144–2167, doi:10.3762/bjnano.16.148

Quality by design optimization of microemulsions for topical delivery of Passiflora setacea seed oil

• Daniel T. Pereira,
• Douglas Dourado,
• Danielle T. Freire,
• Dayanne L. Porto,
• Cícero F. S. Aragão,
• Myla L. de Souza,
• Guilherme R. S. de Araujo,
• Ana Maria Costa,
• Wógenes N. Oliveira,
• Anne Sapin-Minet,
• Éverton N. Alencar and
• Eryvaldo Sócrates T. Egito

Beilstein J. Nanotechnol. 2025, 16, 2116–2131, doi:10.3762/bjnano.16.146

• address these challenges, nanotechnology-based delivery systems, particularly microemulsions (MEs), offer a promising solution. Microemulsions are thermodynamically stable, isotropic mixtures typically composed of oil, water, surfactants, and co-surfactants [6]. Their spontaneous formation, high

• surfactant and/or co-surfactant concentrations to sufficiently reduce interfacial tension and promote spontaneous formation of stable nanodroplets [6][28]. However, a previous study from our group (Dourado et al. (2022) [13]) successfully developed stable microemulsion regions using the same surfactant blend

Multifrequency AFM integrating PeakForce tapping and higher eigenmodes for heterogeneous surface characterization

• Yanping Wei,
• Jiafeng Shen,
• Yirong Yao,
• Xuke Li,
• Ming Li and
• Peiling Ke

Beilstein J. Nanotechnol. 2025, 16, 2077–2085, doi:10.3762/bjnano.16.142

• include topographic step-like distortions and sudden phase-contrast inversions arising from bistable transitions between co-existing oscillation states, which complicate data interpretation [13][14][15][16][17]. Additionally, operational complexity escalates in liquid environments, where low-quality

Stereodiscrimination of guests in chiral organosilica aerogels studied by ESR spectroscopy

• Sebastian Polarz,
• Yasar Krysiak,
• Martin Wessig and
• Florian Kuhlmann

Beilstein J. Nanotechnol. 2025, 16, 2034–2054, doi:10.3762/bjnano.16.140

• physisorption measurements. NHxSIL was prepared by co-condensation of tetraalkyloxysilanes (e.g., Si(OMe)4) with a second sol–gel precursor such as aminopropyltriethoxysilane (APTMS, (MeO)3SiPrNH2). One can control the amine content, x, by adjusting the ratio of the two precursors in the precursor sol. A

• prepare chiral oSILs by co-condensation of Si(OiPr)4 with a sol–gel precursor that already contains the amino acid. An example is an Ala-modified 1,3-bis(triisopropoxysilyl)aniline [45][49] as shown in Scheme 1. The resulting material was characterized by scanning electron microscopy (SEM; Figure 2a); it

• in Supporting Information File 1, Figure S7. The alanine-modified precursor can also be used for co-condensation with the thiol precursor as shown in Scheme 2. The co-condensation of the latter precursor with the aforementioned Fmoc-protected, alanine-modified precursor delivers SH-FmocAlaNHzoSIL

Beyond the shell: exploring polymer–lipid interfaces in core–shell nanofibers to carry hyaluronic acid and β-caryophyllene

• Aline Tavares da Silva Barreto,
• Francisco Alexandrino-Júnior,
• Bráulio Soares Arcanjo,
• Paulo Henrique de Souza Picciani and
• Kattya Gyselle de Holanda e Silva

Beilstein J. Nanotechnol. 2025, 16, 2015–2033, doi:10.3762/bjnano.16.139

• encapsulated within a PLA shell, highlighting substantial potential for biomedical applications by overcoming key material integration hurdles. Keywords: co-axial nanofibers; electrospinning; hybrid nanosystem; nanofibers; nanoemulsion; poly(lactic acid); Introduction Driven by the significant potential of

• critical gap persists in thoroughly understanding the complex polymer–lipid interactions, particularly in systems designed for the simultaneous co-encapsulation of compounds with vastly different physicochemical properties, such as hydrophilic HA and lipophilic βCp. An in-depth understanding of these

• engineered for hyaluronic acid and βCp co-delivery. The insights gained from this investigation are crucial for bridging this specific knowledge gap and may guide the design of optimized hybrid therapeutic platforms. Results and Discussion This study aimed to develop and investigate PLA nanofibers

Laser ablation in liquids for shape-tailored synthesis of nanomaterials: status and challenges

• Natalie Tarasenka

Beilstein J. Nanotechnol. 2025, 16, 1963–1997, doi:10.3762/bjnano.16.137

• ions (Ag+, Fe3+, Co+) and complexes (W(CO)6) [41]. These additives are known to promote growth of nonspherical shapes in colloidal chemical synthesis by preferential adsorption on specific crystalline planes. Another example of the influence of ligand concentration on nanoparticle shape is given in [42

Evaluating metal-organic precursors for focused ion beam-induced deposition through solid-layer decomposition analysis

• Benedykt R. Jany,
• Katarzyna Madajska,
• Aleksandra Butrymowicz-Kubiak,
• Franciszek Krok and
• Iwona B. Szymańska

Beilstein J. Nanotechnol. 2025, 16, 1942–1951, doi:10.3762/bjnano.16.135

• decomposition mechanisms are proposed. Studies have been conducted on ion–molecule interactions in both solid and gas phases. Ultrahigh vacuum experiments on a few monolayers of FIBID precursors, such as [Ru(CO)4I2], [(η5-C5H5)Fe(CO)2Re(CO)5], and [Fe(CO)5], have been used to elucidate decomposition pathways

• . Gas-phase interactions between [Fe(CO)5] molecules and ions of helium, neon, argon, and krypton were carried out. However, the authors noted that these results may not accurately reflect the behavior of the precursor on the surface during actual FIBID processing since the conditions under which the

• . EIMS reveals how ligands respond to electron irradiation; simple molecules such as CO and CO2 detach cleanly, making them “favorable” in FEBID. In contrast, anionic or polyhapto ligands, such as cyclopentadienyl (Cp) or allyl fragments, readily fragment form CxHy matrices, leading to film contamination

Self-assembly and adhesive properties of Pollicipes pollicipes barnacle cement protein cp19k: influence of pH and ionic strength

• Shrutika Sawant,
• Anne Marie Power and
• J. Gerard Wall

Beilstein J. Nanotechnol. 2025, 16, 1863–1872, doi:10.3762/bjnano.16.129

• conformation and adhesion in the protein. Results Protein expression and fibril formation Co-expression of rPolcp19k-his with E. coli GroEL-GroES chaperones to improve folding was performed as described previously [21]. Purified rPolcp19k-his protein yields of 1.8 to 2 mg per litre of E. coli culture were

• . coli BL21 (DE3) cells as previously described [21] and purified by two step purification, that is, immobilised metal affinity chromatography (IMAC) followed by ion exchange chromatography (IEC). For IMAC, the Co-IDA resin column was washed with 25 mM Tris-HCl buffer (pH 8.0) containing 150 mM NaCl and

• Galway (https://imaging.universityofgalway.ie/imaging/) and the scientific and technical assistance of Dr. Éadaoin Timmins in TEM imaging. Funding This publication was supported by Taighde Éireann – Research Ireland (Science Foundation Ireland) and co-funded under the European Regional Development Fund

Current status of using adsorbent nanomaterials for removing microplastics from water supply systems: a mini review

• Nguyen Thi Nhan and
• Tran Le Luu

Beilstein J. Nanotechnol. 2025, 16, 1837–1850, doi:10.3762/bjnano.16.127

• synthesized Co-MOFs for removing MPs. SEM images of (a) CeO2, (b) CeO2 3D flower-spheres, (c, d) ZIF-67 before and after calcination at 500 °C, (e, f) ZIF-67-90@CeO2, and (g, h) Co–N/C-90@CeO2 composites. TEM images of (i) CeO2 3D flower-spheres, (j) Co–N/C-90@CeO2 composite. (k) Enlarged TEM image of Co–N/C

• -90@CeO2 composite. (l) HRTEM, (m) HAADF, and (n–r) elemental mapping images of Co–N/C-90@CeO2 composites [(n) O, (o) Co, (p) Ce, (q) C, and (r) N]. Figure 3 was reprinted from [67], Chem. Eng. J., Vol. 514, by Wang, H.; Chen, H.; Wan, Q.; Zheng, Y.; Wan, Y.; Liu, X.; Song, X.; Ma, W.; Huo, P

• ., “Catalytic degradation of polyethylene terephthalate microplastics by Co-N/C@CeO2 composite in thermal-assisted activation PMS system: Process mechanism and toxicological analysis”, Article No. 163192, Copyright (2025), with permission from Elsevier. This content is not subject to CC BY 4.0. Illustration of

Phytol-loaded soybean oil nanoemulsion as a promising alternative against Leishmania amazonensis

• Victória Louise Pinto Freire,
• Mariana Farias Alves-Silva,
• Johny W. de Freitas Oliveira,
• Matheus de Freitas Fernandes-Pedrosa,
• Alianda Maira Cornélio,
• Marcelo de Souza-Silva,
• Thayse Silva Medeiros and
• Arnóbio Antônio da Silva Junior

Beilstein J. Nanotechnol. 2025, 16, 1826–1836, doi:10.3762/bjnano.16.126

• agents such as surfactants and co-surfactants, forming a kinetically stable system. With droplet sizes ranging from 20 to 500 nm, NEs can significantly enhance drug permeability and bioavailability [24][25][26][27]. Therefore, the present study aimed to develop a nanoemulsion containing phytol, produced

• fully confirm the long-term stability and therapeutic reliability of the formulation. Additionally, the presence of glycerin as a co-solvent may have contributed to the reduction in interfacial tension and improved droplet uniformity, factors known to enhance long-term stability [41]. Importantly, the

• HS7) at a temperature of 25 ± 2 °C. Following the complete addition of the AP, the mixtures were stirred for an additional 30 min to ensure homogeneity. The AP consisted of purified water and poloxamer 407 (POL), as a stabilizing agent, while the OP was composed of soybean oil (SO), glycerin, as a co

Piezoelectricity of layered double hydroxides: perspectives regarding piezocatalysis and nanogenerators

• Evgeniy S. Seliverstov,
• Evgeniya A. Tarasenko and
• Olga E. Lebedeva

Beilstein J. Nanotechnol. 2025, 16, 1812–1817, doi:10.3762/bjnano.16.124

• dodecylbenzene sulfonate-modified Ni/Co-LDH as a filler promoted the formation of the electroactive β-phase in PVDF-based electrospun nanocomposite fabrics [12]. The enhanced piezoelectric response was attributed to the realignment of PVDF dipoles in combination with their interfacial interactions with the

• organically modified Ni/Co-LDH nanosheets. However, some concerns arise regarding whether the synthesized material reported by the authors can indeed be classified as a Ni/Co-LDH. First, the synthesis was carried out using salts of divalent nickel and divalent cobalt at a Ni/Co ratio of 1:2. In the absence of

• evidence to unambiguously confirm the formation of a Ni/Co-LDH phase. Piezocatalysis A large part of the published studies of piezoelectric properties of LDHs and combined materials based on them are focused not so much on the piezoelectric effect itself as on its application in piezocatalysis. This

Exploring the potential of polymers: advancements in oral nanocarrier technology

• Rousilândia de Araujo Silva,
• Igor Eduardo Silva Arruda,
• Luise Lopes Chaves,
• Mônica Felts de La Roca Soares and
• Jose Lamartine Soares Sobrinho

Beilstein J. Nanotechnol. 2025, 16, 1751–1793, doi:10.3762/bjnano.16.122

• polymers are classified based on their chemical composition and include polyesters, polyamides, polyethylene glycol derivatives, and responsive polymers, among others. The most frequently used polymers as oral nanocarriers include poly(lactic-co-glycolic) acid (PLGA), polycaprolactone (PCL), and

• Figure 1. To address this challenge, and given that cysteine promotes both mucoadhesion and the opening of tight junctions, Han et al. [117] developed a trimethyl chitosan–cysteine conjugate (GTC) to formulate PNs for the co-delivery of antitumor shRNA and siRNA via oral administration. These therapeutic

Advances of aptamers in esophageal cancer diagnosis, treatment and drug delivery

• Yang Fei,
• Hui Xu,
• Chunwei Zhang,
• Jingjing Wang and
• Yong Jin

Beilstein J. Nanotechnol. 2025, 16, 1734–1750, doi:10.3762/bjnano.16.121

• . These sensors feature minimal invasiveness and low detection limits, demonstrating unique advantages in the early detection of cancer biomarker proteins. Moreover, an advanced drug delivery platform [28] was engineered by functionalizing nanocarriers with the AS1411 aptamer, enabling the targeted co

• domains, including RGD [94], and participates in cell adhesion, migration, proliferation, and signal transduction [95]. Five subtypes of OPN are co-upregulated in primary EAC, among which OPNc expression was relatively low, inducing cell separation via an integrin-independent binding mode, probably due to

• delivery of gene-silencing therapeutics; (2) direct intercalation of aptamers with small-molecule chemotherapeutic drugs (e.g., DOX), forming stable complexes; (3) co-encapsulation of aptamers and hydrophobic drugs into nanoparticles (e.g., liposomes or polymeric micelles) to improve drug solubility and

Multifunctional anionic nanoemulsion with linseed oil and lecithin: a preliminary approach for dry eye disease

• Niédja Fittipaldi Vasconcelos,
• Almerinda Agrelli,
• Rayane Cristine Santos da Silva,
• Carina Lucena Mendes-Marques,
• Isabel Renata de Souza Arruda,
• Priscilla Stela Santana de Oliveira,
• Mércia Liane de Oliveira and
• Giovanna Machado

Beilstein J. Nanotechnol. 2025, 16, 1711–1733, doi:10.3762/bjnano.16.120

• required to produce nanoemulsions with a uniform particle size and incorporated a co-surfactant to enhance the stability of the nanoformulation. A straightforward method was proposed, involving the dilution of the preformulation in an ophthalmic vehicle, followed by homogenization through ultrasonication

• reagents Linseed oil (code 430021), egg lecithin or egg ʟ-α-phosphatidylcholine (surfactant, ~60% TLC, code 61755), Kolliphor® HS15 (co-surfactant, code 42966), benzalkonium chloride (cationic detergent, code B4136), disodium EDTA (C10H14N2Na2O8, code 114), DPPH (2,2-diphenyl-1-picrylhydrazyl, code D9132

• , homogeneity, and stability in colloidal systems are influenced by component proportions (surfactant, oil, and co-surfactant), emulsification methods (low-energy or high-energy techniques) [40][41][42], and intrinsic properties like linseed oil viscosity and lecithin’s molecular structure [43]. These last

Ambient pressure XPS at MAX IV

• Mattia Scardamaglia,
• Ulrike Küst,
• Alexander Klyushin,
• Rosemary Jones,
• Jan Knudsen,
• Robert Temperton,
• Andrey Shavorskiy and
• Esko Kokkonen

Beilstein J. Nanotechnol. 2025, 16, 1677–1694, doi:10.3762/bjnano.16.118

• case studies from MAX IV’s APXPS beamlines. We will not concentrate on the typical reactions (e.g., CO oxidation, ethylene epoxidation, and methanol oxidation) already deeply reviewed elsewhere [5][12][13]. We will instead discuss a few catalysis niche cases dealing with complex catalytic reactions and

• here. Instead, we focus on a study by Vesselli and co-workers that directly addresses catalytic activity in a biomimetic SAC system [20][21]. In their work, a cobalt single-atom biomimetic model catalyst is based on a self-assembled monolayer of Co-porphyrins grown on an almost free-standing graphene

• Physics of the University of Trieste [22], and supported by DFT, the authors demonstrated that the Co-porphyrin SAC stabilizes a hydroperoxyl–water (O2H-H2O) cluster in O2+H2O atmosphere at room temperature [21]. This is considered the fundamental reaction intermediate in the ORR. In particular, the

Prospects of nanotechnology and natural products for cancer and immunotherapy

• Jan Filipe Andrade Santos,
• Marcela Bernardes Brasileiro,
• Pamela Danielle Cavalcante Barreto,
• Ligiane Aranha Rocha and
• José Adão Carvalho Nascimento Júnior

Beilstein J. Nanotechnol. 2025, 16, 1644–1667, doi:10.3762/bjnano.16.116

• , nanotechnology opens up unprecedented opportunities in cancer immunotherapy by facilitating the co-delivery of chemotherapeutic agents, immunomodulators, and gene editing tools [22]. These multifunctional platforms can modulate the tumor microenvironment, enhance antigen presentation, reverse local

• ) describes the formation of metal–organic co-assembly nanoparticles without a carrier. The formulation contains sorafenib, a molecularly targeted anticancer drug, ursolic acid as an API, and iron ions. Ursolic acid, a naturally occurring pentacyclic triterpenoid, exhibits a variety of biological activities

• tumor inhibition rate of 75.9% in 15 days, significantly higher than ursolic acid and sorafenib alone [66]. Patent CN117064865 (2023) claims a nano bionic CRISPR/Cas9 drug co-assembly system to treat liver cancer. The technology is composed of ursolic acid as an API, a Cas9 ribonucleoprotein (RNP

Nanotechnology-based approaches for the removal of microplastics from wastewater: a comprehensive review

• Nayanathara O Sanjeev,
• Manjunath Singanodi Vallabha and
• Rebekah Rubidha Lisha Rabi

Beilstein J. Nanotechnol. 2025, 16, 1607–1632, doi:10.3762/bjnano.16.114

• solution into a gel, enabling precise compositional control and producing homogenous metal oxides suited for photocatalytic applications [74]. Hydrothermal synthesis uses high-temperature, high-pressure aqueous environments to yield well crystalized particles with controlled morphologies, while co

Bioinspired polypropylene-based functionally graded materials and metamaterials modeling the mistletoe–host interface

• Lina M. Rojas González,
• Naeim Ghavidelnia,
• Christoph Eberl and
• Max D. Mylo

Beilstein J. Nanotechnol. 2025, 16, 1592–1606, doi:10.3762/bjnano.16.113

• moduli are manufacturer’s data and were obtained by testing injection molded specimens. The polymer blends were extruded using a co-rotating twin-screw microcompounder (XPlore 15 mL, Sittard, Netherlands) at a screw speed of 120 rpm, a barrel temperature of 200 °C and a processing time of 90 s. Five

• a speed of 1 mm/min at room temperature using a RetroLine universal testing machine (ZwickRoell GmbH & Co. KG., Ulm, Germany) equipped with a 10 kN load cell. Samples for which slippage was visible during tensile loading were excluded from further evaluation. Stress (σ = F/A0) and strain (ε = (li

Photocatalytic degradation of ofloxacin in water assisted by TiO₂ nanowires on carbon cloth: contributions of H₂O₂ addition and substrate absorbability

• Iram Hussain,
• Lisha Zhang,
• Zhizhen Ye and
• Jin-Ming Wu

Beilstein J. Nanotechnol. 2025, 16, 1567–1579, doi:10.3762/bjnano.16.111

• . Hydrogen peroxide (30 wt %, AR), HNO3 (65 wt %, AR), and ethyl alcohol (99.7 wt %, AR) were purchased from Sinopharm Chemical Reagent Co., Ltd., China. Melamine (99 wt %, AR) was purchased from Aladdin, China. PHILPS Lighting Investment Company Limited, China, provided the UV lamp. All chemicals were used

Modeling magnetic properties of cobalt nanofilms used as a component of spin hybrid superconductor–ferromagnetic structures

• Aleksey Fedotov,
• Olesya Severyukhina,
• Anastasia Salomatina and
• Anatolie Sidorenko

Beilstein J. Nanotechnol. 2025, 16, 1557–1566, doi:10.3762/bjnano.16.110

• structure and composition of Co–Ni–Fe films were evaluated, and it was found out how the deposition rate affects the conversion of a weak magnetic field into magnetic induction. In addition, thin-film structures based on Fe and Co are among the most promising materials that can be applied in the creation of

• materials for implementation in spintronics, thermoelectricity, and optoelectronics” (samples preparation and investigation of Nb/Co interfaces).

Transient electronics for sustainability: Emerging technologies and future directions

• Jae-Young Bae,
• Myung-Kyun Choi and
• Seung-Kyun Kang

Beilstein J. Nanotechnol. 2025, 16, 1545–1556, doi:10.3762/bjnano.16.109

• mechanical flexibility of bioresorbable polymers have emerged as a representative form of transient electronics [14]. A typical example includes devices that integrate inorganic silicon nanomembranes or metal oxide semiconductors on bioresorbable polymer substrates such as poly(lactic-co-glycolic acid) (PLGA

• Polymers”, Adv. Mater., vol. 26, pages 3905–3911, 2014, with permission from John Wiley and Sons. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This content is not subject to CC BY 4.0. (d) Wafer-scale detachment of ultrathin silicon devices fabricated via foundry processes for transient

• . Funct. Mater., 24, 4427–4434 (2014), with permission from John Wiley and Sons. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This content is not subject to CC BY 4.0. (f) PBTPA films, formed via capillary molding and UV curing, exhibit high flexibility and tunable wettability based on monomer

Dendrimer-modified carbon nanotubes for the removal and recovery of heavy metal ions from water

• Thao Quynh Ngan Tran,
• Huu Trung Nguyen,
• Subodh Kumar and
• Xuan Thang Cao

Beilstein J. Nanotechnol. 2025, 16, 1522–1532, doi:10.3762/bjnano.16.107

• of highly branched dendrimers. CNTs-G5 as adsorbent provide a high number of binding sites in the form of functional groups (–NH2 and –CO–NH–) and have a high surface area, allowing facile accessibility to more metal ions. Moreover, we have investigated the effect of various parameters such as the

Nanomaterials for biomedical applications

• Iqra Zainab,
• Zohra Naseem,
• Syeda Rubab Batool,
• Filippo Pierini,
• Seda Kizilel and
• Muhammad Anwaar Nazeer

Beilstein J. Nanotechnol. 2025, 16, 1499–1503, doi:10.3762/bjnano.16.105

• [9]. Along with liposomes, polymeric nanoparticles have turned out to be an equally dynamic platform. Typically, these particles are composed of biodegradable materials, such as poly(lactic-co-glycolic acid) (PLGA) or chitosan. One of the main advantages of polymers is that they can be designed to