Streptavidin-coated gold nanoparticles: critical role of oligonucleotides on stability and fractal aggregation

• Roberta D'Agata,
• Pasquale Palladino and
• Giuseppe Spoto

Beilstein J. Nanotechnol. 2017, 8, 1–11, doi:10.3762/bjnano.8.1

• thorough understanding of the fundamental properties of bioconjugated AuNPs is of great importance for the design of highly sensitive and reliable functionalized AuNP-based assays. Keywords: biosensors; DNA; gold nanoparticles; nanoparticles aggregation; plasmonics; streptavidin; Introduction Gold

A novel electrochemical nanobiosensor for the ultrasensitive and specific detection of femtomolar-level gastric cancer biomarker miRNA-106a

• Maryam Daneshpour,
• Kobra Omidfar and
• Hossein Ghanbarian

Beilstein J. Nanotechnol. 2016, 7, 2023–2036, doi:10.3762/bjnano.7.193

• method for sensitive, specific and non-invasive miRNA detections in early cancer diagnosis [8]. Biosensors are commonly defined as devices composed of recognition elements interfaced with a transducer, which finally transform a capture process into a detectable output signal. This signal, which is almost

• always the result of a specific bio-interaction, could be received as an evident change in color, pH value, or electrochemical properties of the microenvironment [17][18]. Among all types of biosensors, electrochemical sensors have been of great interest particularly because they are simple, portable

• been recently employed to improve the detection sensitivity and also the stability of the electrochemical biosensors. It has been shown that these approaches can strongly amplify the signal, extend the linear detection range, and lower the detection limit of the assay [19]. Nowadays, electrochemical

Layered composites of PEDOT/PSS/nanoparticles and PEDOT/PSS/phthalocyanines as electron mediators for sensors and biosensors

• Celia García-Hernández,
• Cristina García-Cabezón,
• Fernando Martín-Pedrosa,
• José Antonio De Saja and
• María Luz Rodríguez-Méndez

Beilstein J. Nanotechnol. 2016, 7, 1948–1959, doi:10.3762/bjnano.7.186

• biosensors containing tyrosinase and laccase, and they combine the recognition and biocatalytic properties of biomolecules with the unique catalytic features of composite materials. The observed increase in the intensity of the responses allowed detection limits of 1 × 10−7 mol·L−1 to be attained. Keywords

• character which is an intrinsic semiconductor) [9][16][17][18]. On the other hand, enzymatic electrochemical biosensors based on phenol oxidases are a good alternative to analyze phenols due to their high sensitivity and selectivity. Tyrosinase oxidizes monophenols and o-diphenols to the corresponding

• electron mediators to facilitate the transfer of electrons from the enzyme to the electrode [20]. PEDOT/PSS is becoming popular as an electron mediator in biosensing [21][22]. Gold nanoparticles and phthalocyanines have also been positively demonstrated as electron mediators in tyrosinase biosensors [16

Low temperature co-fired ceramic packaging of CMOS capacitive sensor chip towards cell viability monitoring

• Niina Halonen,
• Joni Kilpijärvi,
• Maciej Sobocinski,
• Timir Datta-Chaudhuri,
• Antti Hassinen,
• Someshekar B. Prakash,
• Peter Möller,
• Pamela Abshire,
• Sakari Kellokumpu and
• Anita Lloyd Spetz

Beilstein J. Nanotechnol. 2016, 7, 1871–1877, doi:10.3762/bjnano.7.179

• Eitel reported a LTCC material as a substrate for biosensors that is regarded as biocompatible [22]. Also, from our experience, cell growth, at least over 24 h, seems to be fully compatible with the LTCC material [23]. We suggest that the previous statement about LTCC material being non-biocompatible

Surface-enhanced infrared absorption studies towards a new optical biosensor

• Lothar Leidner,
• Julia Stäb,
• Jennifer T. Adam and
• Günter Gauglitz

Beilstein J. Nanotechnol. 2016, 7, 1736–1742, doi:10.3762/bjnano.7.166

• -enhanced infrared absorption (SEIRA); Introduction Optical biosensors play an important role in the detection and quantification of analytes. Among others, some applications include point-of-care testing (POCT), the monitoring of blood, urine, sudor and respiratory air, and the search for metabolites and

• markers for many diseases. Optical biosensors are used in basic research and life science, for example, to study protein–protein interactions [1][2]. A subfield of optical biosensors are those operated through direct optical detection. Direct optical sensing relates to the detection of analyte molecules

• many optical biosensors operating in the visible or near-infrared wavelength regimes with great success. Shifting the detection window to the mid-infrared (MIR) region has some advantages, but also creates many new problems to be solved. In his review article, Mizaikoff [5] asks the rhetorical question

Graphene-enhanced plasmonic nanohole arrays for environmental sensing in aqueous samples

• Christa Genslein,
• Peter Hausler,
• Eva-Maria Kirchner,
• Rudolf Bierl,
• Antje J. Baeumner and
• Thomas Hirsch

Beilstein J. Nanotechnol. 2016, 7, 1564–1573, doi:10.3762/bjnano.7.150

• Christa Genslein Peter Hausler Eva-Maria Kirchner Rudolf Bierl Antje J. Baeumner Thomas Hirsch Institute of Analytical Chemistry, Chemo and Biosensors, University of Regensburg, 93040 Regensburg, Germany Sensorik-ApplikationsZentrum, OTH Regensburg, Franz-Mayer-Str. 1, 93053 Regensburg, Germany

• detection limits in the environmental interesting concentration is important for water safety and direly needed. Surface plasmon resonance spectroscopy (SPR) is a widely-used technique for quantifying and characterizing biomolecular interactions in biosensors for medical diagnostics, food safety and

Nanostructured germanium deposited on heated substrates with enhanced photoelectric properties

• Ionel Stavarache,
• Valentin Adrian Maraloiu,
• Petronela Prepelita and
• Gheorghe Iordache

Beilstein J. Nanotechnol. 2016, 7, 1492–1500, doi:10.3762/bjnano.7.142

• [18] and biosensors [19]. To produce high-quality Ge particles packed into different matrices, various approaches are reported in scientific papers such as pulsed laser deposition [20][21], sol–gel [22], evaporation under vacuum [23], chemical vapor deposition [24], microwave-assisted heating [25

Straightforward and robust synthesis of monodisperse surface-functionalized gold nanoclusters

• Silvia Varela-Aramburu,
• Richard Wirth,
• Chian-Hui Lai,
• Guillermo Orts-Gil and
• Peter H. Seeberger

Beilstein J. Nanotechnol. 2016, 7, 1278–1283, doi:10.3762/bjnano.7.118

• prepared under reflux using 1-thioglucose as reducing and stabilizing agent [24] but the resulting nanoparticles are too unstable to be used as biosensors [25]. In an effort to create monodisperse, stable and surface-functionalized gold nanoclusters, we explored 1-thioglucose as a stabilizing and reducing

Large-scale fabrication of achiral plasmonic metamaterials with giant chiroptical response

• Morten Slyngborg,
• Yao-Chung Tsao and
• Peter Fojan

Beilstein J. Nanotechnol. 2016, 7, 914–925, doi:10.3762/bjnano.7.83

• implementations in various fields such as optics [1], improved photovoltaic devices [2], electronics [3], surface-enhanced infrared spectroscopy [4], Raman spectroscopy [5] and biosensors [6]. Planar chiral metamaterials (PCMs) have also attracted attention because of their negative refractive index [7][8] and

Microwave solvothermal synthesis and characterization of manganese-doped ZnO nanoparticles

• Jacek Wojnarowicz,
• Roman Mukhovskyi,
• Elzbieta Pietrzykowska,
• Sylwia Kusnieruk,
• Jan Mizeracki and
• Witold Lojkowski

Beilstein J. Nanotechnol. 2016, 7, 721–732, doi:10.3762/bjnano.7.64

• , varistors, TFT display windows and laser technology [5][6][7]. ZnO displays pyroelectric and piezoelectric properties, thanks to which it is used in electroacoustic devices [8]. It is a biocompatible material used for producing biosensors and in drug delivery applications [9]. Thanks to antibacterial

Gold nanoparticles covalently assembled onto vesicle structures as possible biosensing platform

• M. Fátima Barroso,
• M. Alejandra Luna,
• Juan S. Flores Tabares,
• Cristina Delerue-Matos,
• N. Mariano Correa,
• Fernando Moyano and
• Patricia G. Molina

Beilstein J. Nanotechnol. 2016, 7, 655–663, doi:10.3762/bjnano.7.58

• , biodegradability and biocompatibility, so that they are utilized as versatile carriers in the fields of medical and analytical applications [1][2][3][4]. Several strategies employing vesicles in analytical fields have been reported, namely their use as signal amplifiers in the development of biosensors [3][5] to

• fulfil performance criteria such as high sensitivity and low limit of detection. In this context, vesicles can be used in the construction of biosensors as supporting film to coat Au or Ag electrodes [3]. Self-assembly of nanoparticles onto organised systems combines the advantages of nanomaterials

• inactivation and also in biosensors [12]. There are many properties that depend on the shape of the nanostructures. In this regard, there have been many studies with different ways to synthesize them [13][14][15][16][17]. For example, tips and edges located in the nanoparticles have regions of high electric

Novel roles for well-known players: from tobacco mosaic virus pests to enzymatically active assemblies

• Claudia Koch,
• Fabian J. Eber,
• Carlos Azucena,
• Alexander Förste,
• Stefan Walheim,
• Thomas Schimmel,
• Alexander M. Bittner,
• Holger Jeske,
• Hartmut Gliemann,
• Sabine Eiben,
• Fania C. Geiger and
• Christina Wege

Beilstein J. Nanotechnol. 2016, 7, 613–629, doi:10.3762/bjnano.7.54

• procedure might lead towards tight spatial control over the positions of the enzyme nanocarriers, which could be of high interest also for basic research on prerequisites for efficient enzymatic cooperation. Fast, sensitive and cost-saving biosensors often employ label-free read-out, in which signal

Bacteriorhodopsin–ZnO hybrid as a potential sensing element for low-temperature detection of ethanol vapour

• Saurav Kumar,
• Sudeshna Bagchi,
• Senthil Prasad,
• Anupma Sharma,
• Ritesh Kumar,
• Rishemjit Kaur,
• Jagvir Singh and
• Amol P. Bhondekar

Beilstein J. Nanotechnol. 2016, 7, 501–510, doi:10.3762/bjnano.7.44

• monolayer/multilayer of thin films, biosensors, and protein-based photonic devices [7][8][9]. The application of proteins for enhancement in signal transduction has been demonstrated by a number of researchers [1][10]. In general, the major drawbacks associated with proteins are their low stability, poor

Organized films

• Maurizio Canepa and
• Helmuth Möhwald

Beilstein J. Nanotechnol. 2016, 7, 406–408, doi:10.3762/bjnano.7.35

• applications. This was most notable in the fields of molecular electronics and biosensors, which were emerging in those times and are now undergoing flourishing development. The interdisciplinary character of OFs, at the fortunately ill-defined borders between physical chemistry, chemical physics, biophysics

Characterisation of thin films of graphene–surfactant composites produced through a novel semi-automated method

• Nik J. Walch,
• Alexei Nabok,
• Frank Davis and
• Séamus P. J. Higson

Beilstein J. Nanotechnol. 2016, 7, 209–219, doi:10.3762/bjnano.7.19

• spectral range, the deposition of graphene layers on gold progressively enhances the plasmon resonance in TIRE Ψ spectra and caused an extra phase shift in TIRE Δ spectra. This phenomenon can be explored in the future for enhancing the performance of SPR-based biosensors. A schematic diagram of the

Fabrication and characterization of novel multilayered structures by stereocomplexion of poly(D-lactic acid)/poly(L-lactic acid) and self-assembly of polyelectrolytes

• Elena Dellacasa,
• Li Zhao,
• Gesheng Yang,
• Laura Pastorino and
• Gleb B. Sukhorukov

Beilstein J. Nanotechnol. 2016, 7, 81–90, doi:10.3762/bjnano.7.10

• structures for biotechnological and biomedical applications, such as biosensors and carriers for drug delivery, led researchers to extend this technique beyond multilayer structure fabrication based on electrostatic interactions [7][8][9][10][11]. Over the years, other interactions such as covalent bonding

Chemiresistive/SERS dual sensor based on densely packed gold nanoparticles

• Sanda Boca,
• Cosmin Leordean,
• Simion Astilean and
• Cosmin Farcau

Beilstein J. Nanotechnol. 2015, 6, 2498–2503, doi:10.3762/bjnano.6.259

• necessary, e.g., by introducing molecular recognition elements, in order to improve the selectivity of the sensor. Knowledge and technology existing on chemiresistive biosensors on one side and SERS detection on the other, can be commonly exploited for developing advanced dual sensors benefiting from the

Orthogonal chemical functionalization of patterned gold on silica surfaces

• Francisco Palazon,
• Didier Léonard,
• Thierry Le Mogne,
• Francesca Zuttion,
• Céline Chevalier,
• Magali Phaner-Goutorbe,
• Éliane Souteyrand,
• Yann Chevolot and
• Jean-Pierre Cloarec

Beilstein J. Nanotechnol. 2015, 6, 2272–2277, doi:10.3762/bjnano.6.233

• immobilize proteins onto gold nanostructures on a silica substrate, as demonstrated by atomic force microscopy (AFM). These results are especially promising in the development of future biosensors where the selective anchoring of target molecules onto nanostructured transducers (e.g., nanoplasmonic

• biosensors) is a major challenge. Keywords: characterization; self-assembled monolayer; surface functionalization; ToF–SIMS; XPS; Introduction The orthogonal self-assembly of different molecules onto a patterned substrate was first demonstrated in 1989 by Whitesides and co-workers [1]. Recently, especially

• with the development of localized surface plasmon resonance (LSPR) biosensors, this topic has become a major focus [2][3][4][5][6][7][8]. Indeed, LSPR transduction is expected to yield enhanced signal as compared to classical SPR transduction. However, the enhancement of the LSPR limit of detection is

Optimized design of a nanostructured SPCE-based multipurpose biosensing platform formed by ferrocene-tethered electrochemically-deposited cauliflower-shaped gold nanoparticles

• Wicem Argoubi,
• Maroua Saadaoui,
• Sami Ben Aoun and
• Noureddine Raouafi

Beilstein J. Nanotechnol. 2015, 6, 1840–1852, doi:10.3762/bjnano.6.187

• peroxidase (HRP) enzyme yields biosensors, which have been applied for the selective electrochemical detection of human IgG (hIgG) or H2O2 as model analytes, respectively. Parameters such as the number of sweeps, amount of charge generated from the oxidation of the electrodeposited gold, time of incubation

• substrates using various types of conductive inks can be considered as one of the most promising routes for the development of cost-effective, disposable biosensors [4]. Electrochemical (bio)sensors are inherently endowed with several attracting features which are useful for various technological

• concentrations of, e.g., biologically active analytes and disease-related biomarkers [9][10]. Many electrochemical biosensors use ferrocene to transduce the biological reactions into readily measurable electrical signals [11][12]. For instance, Chen and Diao developed a glucose biosensor using gold nanoparticles

Nonlinear optical properties of near-infrared region Ag₂S quantum dots pumped by nanosecond laser pulses

• Li-wei Liu,
• Si-yi Hu,
• Yin-ping Dou,
• Tian-hang Liu,
• Jing-quan Lin and
• Yue Wang

Beilstein J. Nanotechnol. 2015, 6, 1781–1787, doi:10.3762/bjnano.6.182

• . In the last ten years, the study and development of QDs has rapidly progressed, and also influenced other research areas, such as nonlinear optics, plasmonics and biosensors. The special optical properties of QDs include good resistance to photo-bleaching, large absorption cross section, long

Synthesis, characterization and in vitro biocompatibility study of Au/TMC/Fe₃O₄ nanocomposites as a promising, nontoxic system for biomedical applications

• Hanieh Shirazi,
• Maryam Daneshpour,
• Soheila Kashanian and
• Kobra Omidfar

Beilstein J. Nanotechnol. 2015, 6, 1677–1689, doi:10.3762/bjnano.6.170

• various fields of application, especially the biomedical sciences and biosensors. Keywords: Au/polymer/Fe3O4 nanocomposites; Au nanoparticles; cell viability; magnetic nanoparticles; N-trimethyl chitosan; Introduction Nanotechnology is the science of the fabrication of novel materials, devices and

• engineering, as well as the in the design of sensors and biosensors [11][12][13][14][15][16][17]. Although all nanoparticles containing a magnetic core are considered as magnetic nanoparticles, the most commonly used are iron oxide nanoparticles, which are mostly synthesized in the form of magnetite (Fe3O4

• particularly anticipated in the fields of electrochemical sensors and biosensors, where Au nanoparticles play a fundamental role as labels or platforms for immobilization. In this respect, our results suggest that enhanced signal amplification and increased magnetic separation efficiency are likely. In

Scalable, high performance, enzymatic cathodes based on nanoimprint lithography

• Dmitry Pankratov,
• Richard Sundberg,
• Javier Sotres,
• Dmitry B. Suyatin,
• Ivan Maximov,
• Sergey Shleev and
• Lars Montelius

Beilstein J. Nanotechnol. 2015, 6, 1377–1384, doi:10.3762/bjnano.6.142

• commercially available MCO, bilirubin oxidase (BOx), which is one of the main biocatalysts exploited today to design third-generation (i.e., direct electron-transfer-based), O2 reducing biodevices (e.g., O2-sensitive biosensors [18] and biocathodes of enzymatic fuel cells [19]). Contrary to many other MCOs

The convenient preparation of stable aryl-coated zerovalent iron nanoparticles

• Olga A. Guselnikova,
• Andrey I. Galanov,
• Anton K. Gutakovskii and
• Pavel S. Postnikov

Beilstein J. Nanotechnol. 2015, 6, 1192–1198, doi:10.3762/bjnano.6.121

• due to their unique properties and the possibility of widespread applications [1][2]. The modification of magnetic materials may solve a number of high priority problems in medicine and pharmacology [3]. The principal biomedical applications of magnetic NPs include the design of biosensors [4

Effects of swift heavy ion irradiation on structural, optical and photocatalytic properties of ZnO–CuO nanocomposites prepared by carbothermal evaporation method

• Sini Kuriakose,
• D. K. Avasthi and
• Satyabrata Mohapatra

Beilstein J. Nanotechnol. 2015, 6, 928–937, doi:10.3762/bjnano.6.96

• ], biosensors [22] and photocatalysts [23][24][25]. Nanocomposites consisting of nanostructures of ZnO and other metal-oxide semiconductors are being widely studied due to their improved physicochemical properties as compared to the individual counterparts. CuO, a p-type narrow band gap semiconductor, is

Novel ZnO:Ag nanocomposites induce significant oxidative stress in human fibroblast malignant melanoma (Ht144) cells

• Syeda Arooj,
• Samina Nazir,
• Akhtar Nadhman,
• Nafees Ahmad,
• Bakhtiar Muhammad,
• Ishaq Ahmad,
• Kehkashan Mazhar and
• Rashda Abbasi

Beilstein J. Nanotechnol. 2015, 6, 570–582, doi:10.3762/bjnano.6.59

• antibacterial properties [12][13], are used in the cosmetics industry [14][15], and are used as nanoscale biosensors [11] and as drug carriers [16][17]. These NPs are being increasingly recognized due to their differential activity against tumor cells while being non-toxic to normal cells [18][19][20][21][22