Design of a nanostructured mucoadhesive system containing curcumin for buccal application: from physicochemical to biological aspects

• Sabrina Barbosa de Souza Ferreira,
• Gustavo Braga,
• Évelin Lemos Oliveira,
• Jéssica Bassi da Silva,
• Hélen Cássia Rosseto,
• Lidiane Vizioli de Castro Hoshino,
• Mauro Luciano Baesso,
• Wilker Caetano,
• Craig Murdoch,
• Helen Elizabeth Colley and
• Marcos Luciano Bruschi

Beilstein J. Nanotechnol. 2019, 10, 2304–2328, doi:10.3762/bjnano.10.222

• activity, mainly in oral squamous cancer; however, its physicochemical characteristics hinder its application. Therefore, the aim of this study was to develop nanostructured formulations containing curcumin for oral cancer therapy. The photophysical interactions between curcumin and the formulations were

• 8 h and could permeate through the porcine oral mucosa. Cytotoxicity testing revealed that the formulations were selective to cancer cells over healthy cells. Therefore, these systems could improve the physicochemical characteristics of curcumin by providing improved release and permeation, while

• selectivity targeting cancer cells. Keywords: curcumin; mucoadhesion; oral squamous cell carcinoma; permeation; poloxamer 407; Introduction The development of nanostructured systems containing poloxamer 407 (P407) and Carbopol 974P® (C974P) have previously been shown to have rheological and mechanical

Dynamics of superparamagnetic nanoparticles in viscous liquids in rotating magnetic fields

• Nikolai A. Usov,
• Ruslan A. Rytov and
• Vasiliy A. Bautin

Beilstein J. Nanotechnol. 2019, 10, 2294–2303, doi:10.3762/bjnano.10.221

• ][3][19][20], certain thermal effects in combination with radiotherapy or chemotherapy can significantly improve the results of cancer treatment. One of the main technological problems of current magnetic hyperthermia development is the optimal choice of sizes and magnetic parameters of nanoparticles

• and analytical calculations. This topic has recently attracted considerable interest [33][34][35][36][37][38][39][40][41][42][43] in view of the possibility of using magnetic nanoparticles in magnetic hyperthermia for the cancer treatment. Unfortunately, in experiments [41][43] very small SAR values

Targeted therapeutic effect against the breast cancer cell line MCF-7 with a CuFe₂O₄/silica/cisplatin nanocomposite formulation

• B. Rabindran Jermy,
• Vijaya Ravinayagam,
• Widyan A. Alamoudi,
• Dana Almohazey,
• Hatim Dafalla,
• Lina Hussain Allehaibi,
• Abdulhadi Baykal,
• Muhammet S. Toprak and
• Thirunavukkarasu Somanathan

Beilstein J. Nanotechnol. 2019, 10, 2217–2228, doi:10.3762/bjnano.10.214

• /HYPS was applied as the support. An in vitro experiment was conducted to determine the potential of CuFe2O4/HYPS as an anticancer agent against the human breast cancer cell line MCF-7. The results show that the nanoparticle formulation can effectively target cancerous cells and could be an effective

• have been broadened in terms of chronic cancer, diabetic and other metabolic disorders. The global burden of cancer is expected to affect about 24 million people by 2035. The robust technological advancements in utilizing nanoparticles for therapeutic applications are the new hope to circumvent the

• materials have been reported to be effective for cancer therapeutics [3][4]. However, due to the poor crystallinity of SPIONs on silica supports, a low saturation value of magnetization occurs in the silica bound nanocomposites. For instance, the magnetometer (superconducting quantum interference device

Use of data processing for rapid detection of the prostate-specific antigen biomarker using immunomagnetic sandwich-type sensors

• Camila A. Proença,
• Tayane A. Freitas,
• Thaísa A. Baldo,
• Elsa M. Materón,
• Flávio M. Shimizu,
• Gabriella R. Ferreira,
• Frederico L. F. Soares,
• Ronaldo C. Faria and
• Osvaldo N. Oliveira Jr.

Beilstein J. Nanotechnol. 2019, 10, 2171–2181, doi:10.3762/bjnano.10.210

• Carlos 13560-970, São Paulo, Brazil Chemistry Department, Federal University of Paraná, Curitiba, 81531-980, Paraná, Brazil 10.3762/bjnano.10.210 Abstract Diagnosis of cancer using electroanalytical methods can be achieved at low cost and in rapid assays, but this may require the combination with data

• -linked immunosorbent assay. The approaches for immunoassays and data processing are generic, and therefore the strategies described here may provide a simple platform for clinical diagnosis of cancers and other types of diseases. Keywords: cancer biomarkers; magnetite nanoparticles; microfluidic devices

• ; nanoarchitectonics; information visualization; sandwich-type immunosensors; screen-printed electrodes; Introduction The prostate-specific antigen (PSA) used in clinical diagnosis is present in normal prostatic secretions, but its concentration is often elevated in prostate cancer patients. In spite of its lack of

Nitrogen-vacancy centers in diamond for nanoscale magnetic resonance imaging applications

• Alberto Boretti,
• Lorenzo Rosa,
• Jonathan Blackledge and
• Stefania Castelletto

Beilstein J. Nanotechnol. 2019, 10, 2128–2151, doi:10.3762/bjnano.10.207

• the singlet state. Magnetic nanoparticles (MNPs) can act as contrast agents [16] to improve the imaging of tumors in specific cancer MRI. Multimodal imaging has been recently made possible by functionalizing the particle surface with biocompatible chemicals, where surface coverings (such as the

• whose features are used in many technologies, from magnetic information storage to ferrofluids or nanoscale drug-delivery systems and magneto-assisted hyperthermia cancer treatments [65]. Single SPION detection with 10 nm accuracy was shown by bulk diamond NV center magnetometry combining spin

Incorporation of doxorubicin in different polymer nanoparticles and their anticancer activity

• Sebastian Pieper,
• Hannah Onafuye,
• Dennis Mulac,
• Jindrich Cinatl Jr.,
• Mark N. Wass,
• Martin Michaelis and
• Klaus Langer

Beilstein J. Nanotechnol. 2019, 10, 2062–2072, doi:10.3762/bjnano.10.201

• . The expression of efflux transporters such as the ATP-binding cassette (ABC) transporter ABCB1 is an important resistance mechanism in therapy-refractory cancer cells. Drug encapsulation into nanoparticles has been shown to bypass efflux-mediated drug resistance, but there are also conflicting results

• an important step in the development of improved nanoparticle preparations for anticancer therapy. Further research is required to understand under which circumstances nanoparticles can be used to overcome efflux-mediated resistance in cancer cells. Keywords: cancer; doxorubicin; drug release

• ; nanoparticles; poly(lactic-co-glycolic acid) (PLGA); Introduction According to Globocan, there “were 14.1 million new cancer cases, 8.2 million cancer deaths and 32.6 million people living with cancer (within five years of diagnosis) in 2012 worldwide” [1]. Despite substantial improvements over recent decades

Review of advanced sensor devices employing nanoarchitectonics concepts

• Katsuhiko Ariga,
• Tatsuyuki Makita,
• Masato Ito,
• Taizo Mori,
• Shun Watanabe and
• Jun Takeya

Beilstein J. Nanotechnol. 2019, 10, 2014–2030, doi:10.3762/bjnano.10.198

• nanoarchitectonics strategy could be applied for the sensing of various bio-related substances and may become useful for diagnostics of diseases such as cancer. Sensors that are used to detect environmental risks mostly require detection of metal ions and toxic ions. Akamatsu et al. developed an optode-type sensor

• could be applicable for demands requiring the evaluation of small normal pressures even on dynamic surfaces such as natural tissues and is expected to be useful for in situ biomedical digital monitoring, such as palpation for breast cancer. Triboelectric nanogenerators to convert mechanical energy to

• electron mobility transistors were used to dynamically monitor changes in the transmembrane potential, as reported by Lee, Wang, and co-workers [110]. Here, circulating tumor cells of colorectal cancer together with cellular bioelectric signals were investigated. The proposed sensor design would also be

Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells

• Liang Xu,
• Dekang Xu,
• Ziying Li,
• Yu Gao and
• Haijun Chen

Beilstein J. Nanotechnol. 2019, 10, 1933–1942, doi:10.3762/bjnano.10.189

• Liang Xu Dekang Xu Ziying Li Yu Gao Haijun Chen Cancer Metastasis Alert and Prevention Center, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, Fujian 350116

• and synthesized, aiming to discover new steroid-based antitumor agents. In this work, we synthesized several Di derivatives and screened FZU-0021-194-P2 (P2), which showed more potent cytotoxic activities against human non-small-cell lung cancer A549 and PC9 cells. Considering that Di has a unique

• sterol structure similarly to cholesterol, P2 phytosomes (P2Ps) were prepared to further improve the water solubility of P2. The P2Ps exhibited a particle size of 53.6 ± 0.3 nm with oval shape and a zeta potential of −4.0 ± 0.7 mV. P2Ps could inhibit the proliferation of lung cancer cells more

Engineered superparamagnetic iron oxide nanoparticles (SPIONs) for dual-modality imaging of intracranial glioblastoma via EGFRvIII targeting

• Xianping Liu,
• Chengjuan Du,
• Haichun Li,
• Ting Jiang,
• Zimiao Luo,
• Zhiqing Pang,
• Daoying Geng and
• Jun Zhang

Beilstein J. Nanotechnol. 2019, 10, 1860–1872, doi:10.3762/bjnano.10.181

• ) diseases, such as glioblastoma [4]. On one hand, given the lack of sensitivity in conventional MR imaging, the development of molecular MR imaging of tumor biomarkers is highly urgent for noninvasive, visual presentation of cancer aggressiveness and guidance of glioblastoma excision [5]. In addition

• for sensitive characterization and detection of glioblastoma. Compared with single mode imaging, multimodal imaging can facilitate early cancer detection, providing a more comprehensive and multidimensional description of tumor biological behavior [27][28][29]. Optical imaging enables the

Microfluidic manufacturing of different niosomes nanoparticles for curcumin encapsulation: Physical characteristics, encapsulation efficacy, and drug release

• Mohammad A. Obeid,
• Ibrahim Khadra,
• Abdullah Albaloushi,
• Margaret Mullin,
• Hanin Alyamani and
• Valerie A. Ferro

Beilstein J. Nanotechnol. 2019, 10, 1826–1832, doi:10.3762/bjnano.10.177

• cancer such as prostate and cervical cancers [3]. However, the therapeutic application of curcumin is limited by its high hydrophobicity with poor water solubility, photosensitivity, chemical instability, and rapid metabolism rate [4][5]. Therefore, as a result, systemic bioavailability is much reduced

• surfactants prepared by the solvent evaporation method, Xu et al. were able to achieve around 92% loading efficiency of curcumin and measured enhanced cytotoxic activity against ovarian cancer cells compared with freely dispersed curcumin [9]. Microfluidic mixing is a recently developed method for the

Nanoarchitectonics meets cell surface engineering: shape recognition of human cells by halloysite-doped silica cell imprints

• Elvira Rozhina,
• Ilnur Ishmukhametov,
• Svetlana Batasheva,
• Farida Akhatova and
• Rawil Fakhrullin

Beilstein J. Nanotechnol. 2019, 10, 1818–1825, doi:10.3762/bjnano.10.176

• recognition of human cells. Viral and chemical transformation of cells induce changes in the architecture of the membrane [38], and tumor cells have many more microvilli than non-dividing normal cells [39]. These differences in the surfaces characteristics of cancer and normal cells can potentially be used

Toxicity and safety study of silver and gold nanoparticles functionalized with cysteine and glutathione

• Barbara Pem,
• Igor M. Pongrac,
• Lea Ulm,
• Ivan Pavičić,
• Valerije Vrček,
• Darija Domazet Jurašin,
• Marija Ljubojević,
• Adela Krivohlavek and
• Ivana Vinković Vrček

Beilstein J. Nanotechnol. 2019, 10, 1802–1817, doi:10.3762/bjnano.10.175

• nanoparticles (AuNPs) range from molecular imaging, targeted drug delivery, gene therapy, cancer treatment or radio-sensitization and theranostics [1][4][6]. Moreover, AgNPs and AuNPs are among the most investigated engineered nanomaterials for medical use. A search performed in the Web of Science (WoS

Lipid nanostructures for antioxidant delivery: a comparative preformulation study

• Elisabetta Esposito,
• Maddalena Sguizzato,
• Markus Drechsler,
• Paolo Mariani,
• Federica Carducci,
• Claudio Nastruzzi,
• Giuseppe Valacchi and
• Rita Cortesi

Beilstein J. Nanotechnol. 2019, 10, 1789–1801, doi:10.3762/bjnano.10.174

• air quality all over the world. Besides being the primary cause of many respiratory diseases (e.g., chronic obstructive pulmonary disease, asthma and lung cancer), pollution is also responsible for cutaneous pathologies, spanning from skin aging, inflammation and allergy to skin cancer [1]. Cigarette

• smoke (CS) is one of the major toxic pollutants, exerting an important role in the onset of many serious and fatal diseases. Indeed, it is well known that CS can provoke various pathologies especially related to the lungs (e.g., cancer, emphysema, bronchitis) as well as the cardiovascular apparatus [2

• , with respect to non-smokers, as well as oral leukoplakia and oral cancers, such as lip cancer. Indeed, tobacco smoke is constituted of thousands of toxic compounds, including benzene, formaldehyde, hydrogen cyanide, carbon monoxide, arsenic and radioactive components, producing free radicals that cause

Doxorubicin-loaded human serum albumin nanoparticles overcome transporter-mediated drug resistance in drug-adapted cancer cells

• Hannah Onafuye,
• Sebastian Pieper,
• Dennis Mulac,
• Jindrich Cinatl Jr.,
• Mark N. Wass,
• Klaus Langer and
• Martin Michaelis

Beilstein J. Nanotechnol. 2019, 10, 1707–1715, doi:10.3762/bjnano.10.166

• body distribution of its many substrates including drugs, xenobiotics, and other molecules. HSA nanoparticles may provide an alternative, more specific way to overcome transporter-mediated resistance. Keywords: ABCB1; cancer; doxorubicin; drug resistance; human serum albumin; nanoparticles

• ; transporter; Introduction According to Globocan there "were 14.1 million new cancer cases, 8.2 million cancer deaths and 32.6 million people living with cancer (within 5 years of diagnosis) in 2012 worldwide" [1]. Despite substantial improvements over recent decades, the prognosis for many cancer patients

• limited by therapy resistance [2][3][4]. Drug efflux mediated by transporters including adenosine triphosphate (ATP)-binding cassette (ABC) transporters has been shown to play a crucial role in cancer cell drug resistance [2][5]. ABCB1 (also known as P-glycoprotein or MDR1) seems to play a particularly

Materials nanoarchitectonics at two-dimensional liquid interfaces

• Katsuhiko Ariga,
• Michio Matsumoto,
• Taizo Mori and
• Lok Kumar Shrestha

Beilstein J. Nanotechnol. 2019, 10, 1559–1587, doi:10.3762/bjnano.10.153

• sophisticated strategy to realize chemotherapy targeting at cancer cells using the controlled assembly and disassembly of layer-by-layer hybrid structures made of two dimensional MoS2 nanosheets with DNA [87]. The preparation of functional low-dimensional materials requires preservation of nanoscale features in

The effect of magneto-crystalline anisotropy on the properties of hard and soft magnetic ferrite nanoparticles

• Hajar Jalili,
• Bagher Aslibeiki,
• Ali Ghotbi Varzaneh and
• Volodymyr A. Chernenko

Beilstein J. Nanotechnol. 2019, 10, 1348–1359, doi:10.3762/bjnano.10.133

• ) and especially magnetic hyperthermia therapy, which is one of the efficient and new approaches for cancer treatment [4][15]. When magnetic NPs concentrated in tumor tissue are exposed to an ac magnetic field, the electromagnetic energy is converted into thermal energy, and the generated heat is used

• to destroy cancer cells through the elevated temperatures [16][17]. The heating efficiency of the NPs as heat sources under ac magnetic fields is often denominated as specific absorption rate (SAR), which is directly related to the area of the magnetic hysteresis loop of the nanoparticles by the

On the relaxation time of interacting superparamagnetic nanoparticles and implications for magnetic fluid hyperthermia

• Andrei Kuncser,
• Nicusor Iacob and
• Victor E. Kuncser

Beilstein J. Nanotechnol. 2019, 10, 1280–1289, doi:10.3762/bjnano.10.127

• nanoparticulate contrasting agents on proton relaxivity [7][8][9]) and cancer therapy (through magnetic fluid hyperthermia therapy [10][11]). The efficiency of the magnetic nanoparticles (MNPs) in a colloidal system to convert the energy of AC magnetic fields into temperature increments is of high importance for

• -transfer equation which is of key interest in the optimization of cancer therapy by magnetic hyperthermia therapy [19]. The second option may be effective in exploiting the theoretical models proposed for linking the experimental SAR dependencies to the physical mechanisms. From the theoretical point-of

Scavenging of reactive oxygen species by phenolic compound-modified maghemite nanoparticles

• Małgorzata Świętek,
• Yi-Chin Lu,
• Rafał Konefał,
• Liliana P. Ferreira,
• M. Margarida Cruz,
• Yunn-Hwa Ma and
• Daniel Horák

Beilstein J. Nanotechnol. 2019, 10, 1073–1088, doi:10.3762/bjnano.10.108

• stress, inflammation, aging in general, and the development of fatal diseases, such as cancer, neurodegenerative disorders, atherosclerosis, heart failure, myocardial infarction, and infections. ROS of radical origin (superoxide and hydroxyl) are particularly harmful because they initiate oxidative chain

Enhanced inhibition of influenza virus infection by peptide–noble-metal nanoparticle conjugates

• Zaid K. Alghrair,
• David G. Fernig and
• Bahram Ebrahimi

Beilstein J. Nanotechnol. 2019, 10, 1038–1047, doi:10.3762/bjnano.10.104

• different molar fractions of FluPep ligand. Supporting Information Supporting Information File 94: Additional experimental data. Acknowledgements Zaid K Alghrair was supported by a PhD studentship award from the Iraqi Ministry of Higher Education. DGF is supported by the Cancer and Polio Research Fund

• , and North West Cancer Research. An earlier version of this work was published as a preprint (Alghrair, Z., Fernig, D. G.; Ebrahimi, B. Enhanced inhibition of influenza virus infection by peptide-noble metal nanoparticle conjugates. Biorxiv, 2018; doi:10.1101/324939).

Serum type and concentration both affect the protein-corona composition of PLGA nanoparticles

• Katrin Partikel,
• Robin Korte,
• Dennis Mulac,
• Hans-Ulrich Humpf and
• Klaus Langer

Beilstein J. Nanotechnol. 2019, 10, 1002–1015, doi:10.3762/bjnano.10.101

• assay, zeta potential measurements, and liquid chromatography–mass spectrometry/mass spectrometry (LC–MS/MS). Additionally, the time-dependent cell interaction of PLGA NPs in the absence or presence of a preformed protein corona was assessed by in vitro incubation experiments with the human liver cancer

• proteins was conducted by Bradford assay after alkaline hydrolysis of PLGA–NPs. Finally, the consequences of corona formation on the interaction between NPs and cells were examined by in vitro incubation experiments with the human liver cancer cell line HepG2. Results and Discussion Compositional evolution

• human liver cancer cell line HepG2 was used for in vitro incubation experiments. For an easy tracking of NPs in cell culture experiments, the fluorescent dye Lumogen® Red was incorporated into the hydrophobic particle matrix. Due to the lipophilic properties of the dye molecule an average of 8.14 µg

The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model

• Qura Tul Ain,
• Samina Hyder Haq,
• Abeer Alshammari,
• Moudhi Abdullah Al-Mutlaq and
• Muhammad Naeem Anjum

Beilstein J. Nanotechnol. 2019, 10, 901–911, doi:10.3762/bjnano.10.91

• ) [5], poly(ε-caprolactone) (PCL) [6], hydroxypropyl-β-cyclodextrin (HPCD) [7], and poly(L-lactic acid) (PLLA) [8]. Biocompatible GO has many prospective uses in tissue engineering [9], drug delivery [10], cancer therapy [11][12], and treatment of bacterial infections [13][14]. Dinescu et al. designed

• dual-functionalized GO for the photothermal enhancement of gene delivery [23]. Xiong et al. studied the synergistic effects of PEG-functionalized GO for chemo-photothermal therapy [24]. Tian et al. revealed that PEG-GO enhanced the uptake of chlorin e6 by cancer cells [25]. Shen et al. exploited the

• delivery in clinical use remains unclear. Reactive oxygen species (ROS) have the potential to cause tissue destruction [35] and play an important role in the pathology of certain human diseases including atherosclerosis [36], rheumatoid arthritis [37], cancer [38], and neurodegenerative diseases [39

Tungsten disulfide-based nanocomposites for photothermal therapy

• Tzuriel Levin,
• Hagit Sade,
• Rina Ben-Shabbat Binyamini,
• Maayan Pour,
• Iftach Nachman and
• Jean-Paul Lellouche

Beilstein J. Nanotechnol. 2019, 10, 811–822, doi:10.3762/bjnano.10.81

• for the targeted treatment of cancer, in which a light-responsive material is irradiated with a laser in the near-infrared range. In the current article we present WS2 nanotubes functionalized with previously reported ceric ammonium nitrate–maghemite (CAN-mag) nanoparticles, used for PTT

• . Functionalization of the nanotubes with CAN-mag nanoparticles resulted in a magnetic nanocomposite. When tested in vitro with two types of cancer cells, the functionalized nanotubes showed a better PTT activity compared to non-functionalized nanotubes, as well as reduced aggregation and the ability to add a second

• -step functionality. This ability is demonstrated here with two polymers grafted onto the nanocomposite surface, and other functionalities could be additional cancer therapy agents for achieving increased therapeutic activity. Keywords: cerium complex; magnetic nanoparticles; photothermal therapy

Polydopamine-coated Au nanorods for targeted fluorescent cell imaging and photothermal therapy

• Boris N. Khlebtsov,
• Andrey M. Burov,
• Timofey E. Pylaev and
• Nikolai G. Khlebtsov

Beilstein J. Nanotechnol. 2019, 10, 794–803, doi:10.3762/bjnano.10.79

• fluorescent imaging and plasmonic phothothermal abilities have not been reported previously. The multifunctional nanoparticles were stable in cell buffer, nontoxic and suitable for targeted fluorescent imaging and photothermal therapy of cancer cells. We demonstrate the enhanced accumulation of folate

• light-mediated targeted phototherapy using AuNR-PDA-R123-folate and obtained a remarkable cancer cell killing efficiency in vitro in comparison with only weak-efficient nontargeted PEGylated nanoparticles. Our work illustrates that AuNR-PDA could be a promising nanoplatform for multifunctional tumor

• theranostics in the future. Keywords: Au nanorods; cancer theranostics; fluorescent bioimaging; folate; polydopamine; targeted phototherapy; Introduction Multifunctional imaging and combined multimodal therapy strategies are very promising in cancer theranostics [1][2]. Possible way for such purpose is to

Ceria/polymer nanocontainers for high-performance encapsulation of fluorophores

• Kartheek Katta,
• Dmitry Busko,
• Yuri Avlasevich,
• Katharina Landfester,
• Stanislav Baluschev and
• Rafael Muñoz-Espí

Beilstein J. Nanotechnol. 2019, 10, 522–530, doi:10.3762/bjnano.10.53

• free-radical scavengers in biomedical applications as a potent therapeutic option for the treatment of disorders generated by reactive oxygen species, such as neurodegenerative disorders, retinal disorders and cancer [43][44][45]. In this work, we report the process of armoring anionically

Heating ability of magnetic nanoparticles with cubic and combined anisotropy

• Nikolai A. Usov,
• Mikhail S. Nesmeyanov,
• Elizaveta M. Gubanova and
• Natalia B. Epshtein

Beilstein J. Nanotechnol. 2019, 10, 305–314, doi:10.3762/bjnano.10.29

• ; Introduction Magnetic hyperthermia [1][2][3] is a promising therapeutic method that can be used in combination with chemotherapy or radiotherapy for cancer treatment. Iron oxide nanoparticles are among the materials most popular for application in biomedicine due to their biocompatibility, biodegradability [4