Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

• pathways to prevent cross talk between multiple growth factor receptors have emerged as valid approaches that could be used to tackle cancer resistance and maximize the efficacy of EGFR inhibition. Presently, a combinatorial therapeutic strategy is believed to be a rational approach to combat the

• the adverse effects. Inhibitors of multiple targets within a single pathway exerting synergistic effects Amplification, overexpression, and mutation of MET and HER2 are heavily involved in EGFR TKI resistance development, and the cross talk of these receptors is a way to avoid TK inhibition in many

Numerical modeling of a multi-frequency receiving system based on an array of dipole antennas for LSPE-SWIPE

• Alexander V. Chiginev,
• Anton V. Blagodatkin,
• Dmitrii A. Pimanov,
• Ekaterina A. Matrozova,
• Anna V. Gordeeva,
• Andrey L. Pankratov and
• Leonid S. Kuzmin

Beilstein J. Nanotechnol. 2022, 13, 865–872, doi:10.3762/bjnano.13.77

• a bow-tie dipole antenna was calculated (Figure 5) with the DC bias lines connected to the central parts of the antennas. The frequency response of the receiving matrix with bow-tie antennas is shown in Figure 6. Rather good band separation is visible in spite of a certain cross-talk of the 210 GHz

Protruding hydrogen atoms as markers for the molecular orientation of a metallocene

• Linda Laflör,
• Michael Reichling and
• Philipp Rahe

Beilstein J. Nanotechnol. 2020, 11, 1432–1438, doi:10.3762/bjnano.11.127

• samples, custom-built sensors were fabricated with a separate tunnelling current wire to exclude cross-talk between the NC-AFM and tunnelling current signals [30], while sensors as supplied by the manufacturer were used for measurements on bulk CaF2 samples. Sensors were excited to oscillation amplitudes

Integrated photonics multi-waveguide devices for optical trapping and Raman spectroscopy: design, fabrication and performance demonstration

• Gyllion B. Loozen,
• Arnica Karuna,
• Mohammad M. R. Fanood,
• Erik Schreuder and
• Jacob Caro

Beilstein J. Nanotechnol. 2020, 11, 829–842, doi:10.3762/bjnano.11.68

• process of Si3N4. The 200 nm thick waveguides are multimode. Using a minimum bend radius of 300 μm for low bend loss and minimizing overlap with the excitation waveguides for low cross talk, the waveguides are routed towards a chip edge, where these are merged into a single waveguide with a width of 500

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

• Varsha Sharma and
• Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

Subsurface imaging of flexible circuits via contact resonance atomic force microscopy

• Wenting Wang,
• Chengfu Ma,
• Yuhang Chen,
• Lei Zheng,
• Huarong Liu and
• Jiaru Chu

Beilstein J. Nanotechnol. 2019, 10, 1636–1647, doi:10.3762/bjnano.10.159

• ranging from 1000 to 6000 rpm. The resulting cover thicknesses were 52, 117, 185, 380, and 653 nm as measured by AFM. Furthermore, the top surface was smoothed to eliminate the cross-talk of surface topography in subsurface CR-AFM imaging. Our experiments were performed on an MFP-3D Origin AFM (Asylum

Electromigrated electrical optical antennas for transducing electrons and photons at the nanoscale

• Arindam Dasgupta,
• Mickaël Buret,
• Nicolas Cazier,
• Marie-Maxime Mennemanteuil,
• Reinaldo Chacon,
• Kamal Hammani,
• Jean-Claude Weeber,
• Juan Arocas,
• Laurent Markey,
• Gérard Colas des Francs,
• Alexander Uskov,
• Igor Smetanin and
• Alexandre Bouhelier

Beilstein J. Nanotechnol. 2018, 9, 1964–1976, doi:10.3762/bjnano.9.187

• requirements. Silicon-based photonics for instance is offering a cost-effective strategy to merge microelectronics and photonics [1][2] and address the next generation of interchip and intrachip optical interconnects. Optical and electrical cross talk between vertical interconnect accesses, thermal envelope

Know your full potential: Quantitative Kelvin probe force microscopy on nanoscale electrical devices

• Amelie Axt,
• Ilka M. Hermes,
• Victor W. Bergmann,
• Niklas Tausendpfund and
• Stefan A. L. Weber

Beilstein J. Nanotechnol. 2018, 9, 1809–1819, doi:10.3762/bjnano.9.172

• cross talk [19][21][22] and the choice of frequencies. All in all, an overwhelming number of studies have reported a superior lateral resolution, both laterally and in voltage, for FM-KPFM [18][19][23][24][25][26]. Li et al. [19] also reported a higher sensitivity for the potential detection. Until now

• while keeping the topography variations below ≈50 nm, minimizing the effect of topographic cross talk. To further eliminate the influence of variations in the work function between the electrodes and on the tip, we applied a defined voltage between the electrodes and only considered the potential

• small offset in the voltage source or by electrostatic cross talk (see discussion later in the manuscript). Nevertheless, with values <20 mV, these offsets are on the order of the experimental error. The next measurement was performed close to edge of the model electrode structure at a position, where

Artifacts in time-resolved Kelvin probe force microscopy

• Sascha Sadewasser,
• Nicoleta Nicoara and
• Santiago D. Solares

Beilstein J. Nanotechnol. 2018, 9, 1272–1281, doi:10.3762/bjnano.9.119

• cantilever eigenmodes, namely at 500 Hz and at 1428 Hz. We speculate that these deviations are due to possible capacitive cross talk between the ac voltage and the piezo cables or the photodetector. We can disregard these deviations since they are not related to the cantilever eigenmodes and have a different

• deviations can appear due to a direct cross talk of the modulation signal (bias, light, etc.) with the cantilever oscillation. Our results provide the following guidelines to avoid artifacts in time-resolved KPFM measurements: (i) during the acquisition of CPD spectra, application of the modulation signal at

Involvement of two uptake mechanisms of gold and iron oxide nanoparticles in a co-exposure scenario using mouse macrophages

• Dimitri Vanhecke,
• Dagmar A. Kuhn,
• Dorleta Jimenez de Aberasturi,
• Sandor Balog,
• Ana Milosevic,
• Dominic Urban,
• Diana Peckys,
• Niels de Jonge,
• Wolfgang J. Parak,
• Alke Petri-Fink and
• Barbara Rothen-Rutishauser

Beilstein J. Nanotechnol. 2017, 8, 2396–2409, doi:10.3762/bjnano.8.239

• treated with endocytotic inhibitors recovered after co-exposure, which additionally hinted that two uptake mechanisms are involved. Cross-talk between uptake pathways is relevant for toxicological studies: Co-exposure acts as an uptake accelerant. If the goal is to maximize the cellular uptake, e.g., for

Optimizing qPlus sensor assemblies for simultaneous scanning tunneling and noncontact atomic force microscopy operation based on finite element method analysis

• Omur E. Dagdeviren and
• Udo D. Schwarz

Beilstein J. Nanotechnol. 2017, 8, 657–666, doi:10.3762/bjnano.8.70

• experimentalists to collect the tunneling current by means of a separate electrode [42]. In this case, however, cross-talk may be induced between different data channels due to the finite size of the electrodes. Conclusion In this paper, we have provided a systematic study based on numerical calculations using

Analysis and modification of defective surface aggregates on PCDTBT:PCBM solar cell blends using combined Kelvin probe, conductive and bimodal atomic force microscopy

• Hanaul Noh,
• Alfredo J. Diaz and
• Santiago D. Solares

Beilstein J. Nanotechnol. 2017, 8, 579–589, doi:10.3762/bjnano.8.62

• for fresh and aged samples. For the fresh samples used for the measurements of Figure 2, the images do not typically show any correlation between the measured topography and the features of interest in the phase and potential. If the imaging parameters are properly set, cross-talk artifacts between

Single-molecule mechanics of protein-labelled DNA handles

• Vivek S. Jadhav,
• Dorothea Brüggemann,
• Florian Wruck and
• Martin Hegner

Beilstein J. Nanotechnol. 2016, 7, 138–148, doi:10.3762/bjnano.7.16

• least amount of parasitic cross-talk in measurements at forces above 10 pN using this particular dual-trap OT instrument. Measurements with the dual-trap tweezers using double handles (1000 bp each) yielded stable specific interactions and a representative force curve of such a double-handle construct

Large area scanning probe microscope in ultra-high vacuum demonstrated for electrostatic force measurements on high-voltage devices

• Urs Gysin,
• Thilo Glatzel,
• Thomas Schmölzer,
• Adolf Schöner,
• Sergey Reshanov,
• Holger Bartolf and
• Ernst Meyer

Beilstein J. Nanotechnol. 2015, 6, 2485–2497, doi:10.3762/bjnano.6.258

• mesh to avoid capacitive cross talk between the individual PSD signals, the piezo and electrical excitation, and the scanner signal lines. Several separated electrical UHV feedthroughs are implemented for the sample bias voltage, the piezo excitation, the PSD signals, the scanner, and the coarse motion

A scanning probe microscope for magnetoresistive cantilevers utilizing a nested scanner design for large-area scans

• Tobias Meier,
• Alexander Förste,
• Ali Tavassolizadeh,
• Karsten Rott,
• Dirk Meyners,
• Roland Gröger,
• Günter Reiss,
• Eckhard Quandt,
• Thomas Schimmel and
• Hendrik Hölscher

Beilstein J. Nanotechnol. 2015, 6, 451–461, doi:10.3762/bjnano.6.46

• x–y piezo stage and a dedicated z-piezo for a short response time. Additionally, the x–y stage must only move in the x–y plane without any cross-talk to the z-axis. This is reached by flexure joints. However, as the stiffness of a lever amplified system is reduced quite significantly, the initial

Dynamic force microscopy simulator (dForce): A tool for planning and understanding tapping and bimodal AFM experiments

• Horacio V. Guzman,
• Pablo D. Garcia and
• Ricardo Garcia

Beilstein J. Nanotechnol. 2015, 6, 369–379, doi:10.3762/bjnano.6.36

• the presence of higher harmonic components in the tip motion with the presence of nonlinear interactions [15]. In the process, the cross talk between modes and harmonics has been clarified [16][17][18][19][20]. The complicated cantilever motion in liquid and the differences observed between the

High-frequency multimodal atomic force microscopy

• Adrian P. Nievergelt,
• Jonathan D. Adams,
• Pascal D. Odermatt and
• Georg E. Fantner

Beilstein J. Nanotechnol. 2014, 5, 2459–2467, doi:10.3762/bjnano.5.255

• readout laser sits well within the pass-band of the bandpass filter, measured at 618 nm to 656 nm at 50% transmission. At the drive laser emission wavelength we measured an extinction higher than OD3 from the bandpass filter, effectively reducing cross-talk from the drive laser to below 0.03% at typical

Dynamic nanoindentation by instrumented nanoindentation and force microscopy: a comparative review

• Sidney R. Cohen and
• Estelle Kalfon-Cohen

Beilstein J. Nanotechnol. 2013, 4, 815–833, doi:10.3762/bjnano.4.93

• detected in an optical-lever-based AFM system as normal force. The latter may, or may not, influence the detected normal force signal depending on the extent of cross-talk, but it will certainly influence the overall force balance

Optimal geometry for a quartz multipurpose SPM sensor

• Julian Stirling

Beilstein J. Nanotechnol. 2013, 4, 370–376, doi:10.3762/bjnano.4.43

• Needles [22]. This maintains the symmetry; however, great care needs to be taken to consider the possibility of capacitive cross-talk between the tunnelling and deflection channels [23]. Conclusion We have demonstrated a new geometry of a piezoelectric sensor for use in combined AFM/LFM, which utilises

Towards 4-dimensional atomic force spectroscopy using the spectral inversion method

• Jeffrey C. Williams and
• Santiago D. Solares

Beilstein J. Nanotechnol. 2013, 4, 87–93, doi:10.3762/bjnano.4.10

• and in order to filter out the effect of flexural–torsional cross-talk [8][11][12]. Upon completion of the scan and post-processing of the data [11], the user will have acquired for every (x,y) pixel on the surface (see Figure 1, expanded representation), which is equivalent to the 4D representation

• use of the correct expression describing the time-dependent tip position is mathematically straightforward, but is not trivial in an experiment, where there can be signal cross-talk [8][11] and where calibration and noise limitations are present. For all these reasons, it is recommended to apply the

Nanostructure-directed chemical sensing: The IHSAB principle and the dynamics of acid/base-interface interaction

• James L. Gole and
• William Laminack

Beilstein J. Nanotechnol. 2013, 4, 20–31, doi:10.3762/bjnano.4.3

• nanostructure deposition must be maintained at a sufficiently low level to avoid cross-talk between the nanostructures (Figure 11) that, as it increases, leads to a noisy device and the eventual loss of functionality. The time for exposure of the pore structure to the nanostructure-forming solutions is

Characterization of the mechanical properties of qPlus sensors

• Jan Berger,
• Martin Švec,
• Martin Müller,
• Martin Ledinský,
• Antonín Fejfar,
• Pavel Jelínek and
• Zsolt Majzik

Beilstein J. Nanotechnol. 2013, 4, 1–9, doi:10.3762/bjnano.4.1

• . Keywords: AFM; Cleveland’s method; cross talk; force; qPlus; stiffness; STM; thermal noise; tuning fork; Introduction The invention of scanning tunneling microscopy [1] and atomic force microscopy (AFM) [2] opened new horizons in characterization and modification of surfaces and nanostructures. STM is

Simultaneous current, force and dissipation measurements on the Si(111) 7×7 surface with an optimized qPlus AFM/STM technique

• Zsolt Majzik,
• Martin Setvín,
• Andreas Bettac,
• Albrecht Feltz,
• Vladimír Cháb and
• Pavel Jelínek

Beilstein J. Nanotechnol. 2012, 3, 249–259, doi:10.3762/bjnano.3.28

• measured at the tip, a cross-talk of the tunneling current with the force signal can easily occur. The origin and general features of the capacitive cross-talk will be discussed in detail in this contribution. Furthermore, we describe an experimental setup that improves the level of decoupling between the

• interferometric deflection. Keywords: AFM; cross-talk; current; dissipation; force; qPlus; STM; tuning fork; Introduction The invention of scanning probe techniques, in particular scanning tunneling microscopy (STM) [1] and atomic force microscopy (AFM) [2], had a tremendous impact on our understanding of the

• , the presence of the tunneling current may introduce an undesired interference (cross-talk) between the current and the deflection channel. Therefore special attention has to be paid to minimize the impact of this phenomena to a negligible level. Albers et al. [33] already mentioned a kind of coupling

An NC-AFM and KPFM study of the adsorption of a triphenylene derivative on KBr(001)

• Antoine Hinaut,
• Adeline Pujol,
• Florian Chaumeton,
• David Martrou,
• André Gourdon and
• Sébastien Gauthier

Beilstein J. Nanotechnol. 2012, 3, 221–229, doi:10.3762/bjnano.3.25

• no net surface charges are present, the topographic image becomes a pure van der Waals image. The measured height of the observed structures is then close to that given by the molecular models, facilitating the structural identification. Great care was taken to avoid any cross-talk between the

An MCBJ case study: The influence of π-conjugation on the single-molecule conductance at a solid/liquid interface

• Wenjing Hong,
• Hennie Valkenier,
• Gábor Mészáros,
• David Zsolt Manrique,
• Artem Mishchenko,
• Alexander Putz,
• Pavel Moreno García,
• Colin J. Lambert,
• Jan C. Hummelen and
• Thomas Wandlowski

Beilstein J. Nanotechnol. 2011, 2, 699–713, doi:10.3762/bjnano.2.76

• cross talk between the different functional parts of the setup. The two electrodes of the MCBJ setup are connected to the controller through special low-noise coaxial cables. Operation of the stepper motor introduces considerable noise. As a consequence and to avoid this kind of interference, the