Ultrasonic irradiation in the synthesis of nanohydroxyapatite: a chemically friendly technique for improving hemocompatibility and antibiofilm applications

• Juan Mendoza Turmero,
• Cristina Parra Pantoja,
• Marcos Sabino Gutiérrez,
• Milagro Fernández-Delgado,
• Claudia Alvarado-Castillo,
• Damarys Soto Gil,
• María E. Gomes Gomes,
• Yony Gutiérrez Barrios and
• Daniel Suárez Arteaga

Beilstein J. Nanotechnol. 2026, 17, 991–1015, doi:10.3762/bjnano.17.68

• quantitative analysis of particle size was conducted using field-emission scanning electron microscopy (FESEM) and BET surface area measurements. These findings, along with their corresponding statistical evaluations, are presented and extensively discussed in section “Field emission scanning electron

• microscopy and particle size determination via the BET method” (see below Table 6), confirming the nanometric control achieved through the sonochemical process [56][57]. Regarding the reactions in the W/ETOH mixture, rhombohedral calcite formation (space group R3c) was confirmed by a well-defined signal at

• only undergoes transformations leading to its decomposition at temperatures above 1000 to 1300 °C; this promotes the formation of other biocompatible phosphate species, such as tetracalcium phosphate and tricalcium phosphate [77]. Field-emission scanning electron microscopy and particle size

Development of Protium heptaphyllum essential oil-loaded nanocapsules: experimental design and biological activity

• Debora Freitas Silva,
• Kaidy Giselle Orellana,
• Allessya Lara Dantas Formiga,
• Jin Wang,
• Eloisa Helena de Aguiar Andrade,
• Aline Collares Valente Pinheiro,
• Maria Izabel de Jesus,
• Francisco Canindé Ferreira de Luna,
• Wallax Augusto Silva Ferreira,
• Edivaldo Herculano Correa de Oliveira,
• Francisco Humberto Xavier Junior,
• Emmanuel Abraham Ho and
• Marcele Fonseca Passos

Beilstein J. Nanotechnol. 2026, 17, 974–990, doi:10.3762/bjnano.17.67

• Abstract Poly(ε-caprolactone) nanocapsules containing breu branco (Protium heptaphyllum) essential oil were successfully prepared by nanoprecipitation and optimized using a Box–Behnken design. Spherical nanosystems were obtained, with a mean particle size of 172.10 ± 0.90 nm, a polydispersity index of 0.14

• et al. [15], successfully demonstrated oil-loaded nanocapsules using interfacial polymerization, supporting the importance of evaluating critical parameters like particle size, polydispersity index (PDI), and zeta potential. Building on this evidence, the present study aimed to develop and

• behavior when incorporated into nanostructured delivery systems. Therefore, this study aims to develop and optimize polymeric nanocapsules containing P. heptaphyllum essential oil using a Box–Behnken experimental design, focusing on key physicochemical parameters such as particle size, PDI, and zeta

Nanocarrier strategies to overcome P-glycoprotein-mediated drug resistance in cancer therapy

• Andreina Quevedo-Enríquez,
• Katty Yi Zhang,
• Denisse Yajaira Enriquez,
• Byron Raul Inapanta,
• Roxana Noemí Peroni and
• Christian Rafael Quijia

Beilstein J. Nanotechnol. 2026, 17, 882–921, doi:10.3762/bjnano.17.64

Restorative potential of laser-synthesized silver nanoparticles with Salvia officinalis for periodontal disease treatment: an in vitro study

• Jelena Filipović Tričković,
• Sanja Živković,
• Bojana Ilić,
• Miloš Tošić,
• Jelena Marinković,
• Ana Valenta Šobot and
• Miloš Momčilović

Beilstein J. Nanotechnol. 2026, 17, 781–795, doi:10.3762/bjnano.17.55

• sage extract using two different laser pulse energies (2 and 6 mJ) (Table 1). The reported values represent the total silver concentration in the colloidal solution and do not directly reflect nanoparticle number concentration due to differences in particle size distribution. Although the applied pulse

• diameters (dH). The smallest nanoparticles with the highest concentration were produced by applying a laser energy of 6 mJ in the sage solution (SageAgNPs6mJ). The two AgNP types with the higher concentration and the smaller particle size, with and without sage extract, that is SageAgNPs6mJ and dwAgNPs6mJ

• , respectively, underwent TEM analysis. SageAgNPs6mJ were well dispersed, spherical, and in the narrow size range from 2.1 to 16.3 nm, with an average particle size of 7.98 ± 2.90 nm. Minor agglomeration after one month was observed, suggesting high stability of the nanoparticles (Figure 1a,b). dwAgNPs6mJ were

Tailoring Ag–Pt nanoalloys through solid-state dewetting: structural and optical insights

• Marcin Łapiński,
• Piotr Okoczuk,
• Blaž Grobiša,
• Ewa Pawlikowska,
• Amelia Rozwadowska,
• Wojciech Sadowski and
• Barbara Kościelska

Beilstein J. Nanotechnol. 2026, 17, 748–759, doi:10.3762/bjnano.17.52

• . Observations of alloy formation at the nanoscale confirm that the miscibility between different metals can significantly increase as particle size decreases [3][4][5][6][33]. Nevertheless, in the case of nanoalloy formation induced by thermal dewetting of alternately deposited thin metallic layers, it is

Environmental applications of silver nanoparticles: state-of-the-art review and emerging trends

• Soni Prajapati,
• Akash Kumar and
• Ranjana Singh

Beilstein J. Nanotechnol. 2026, 17, 697–736, doi:10.3762/bjnano.17.49

• particle size, surface composition, state stability, and organic matter, which ultimately generate bioavailability and toxicity concerns [34]. The regulatory framework governing AgNP environmental applications remains fragmented across jurisdictions; while OECD, ISO, EU, and US EPA guidelines address

• through various synthetic approaches, including physical, chemical, and biological methods [35]. Each offers distinct advantages and limitations regarding particle size control, morphology, stability, and cost-effectiveness [35]. Chemical methods are commonly employed to synthesise AgNPs due to their

Two-step laser synthesis of Ag@TiO₂ nanomaterials for the photocatalytic degradation of rhodamine B

• Marija Kovačević,
• Miloš Tošić,
• Rafaela Radičić,
• Vladimir Rajić,
• Nikša Krstulović,
• Miloš Momčilović and
• Sanja Živković

Beilstein J. Nanotechnol. 2026, 17, 622–634, doi:10.3762/bjnano.17.43

• capacity of the photocatalyst and the concentration of active site. This is in line with the correlation between particle size and silver content, where smaller particles provide a higher surface-to-volume ratio, making surface effects more dominant. In contrast, Ag@TiO2 2000p NPs followed the pseudo-first

• -order model, which is more typical when the main process is controlled by light absorption and charge carrier transfer rather than surface adsorption. The smaller particle size and higher silver content in the 2000p sample improved electron–hole separation; hence, the reaction was mainly driven by

• species [28]. These combined effects lead to faster degradation of rhodamine B compared to pure TiO2. The different kinetic behavior of the samples reflects differences in particle size and Ag surface modification. The kinetic models are used as empirical descriptions of the overall process rather than

Laser–material interactions in liquids for the synthesis of nanomaterials: current status and perspectives

• Carlos Doñate Buendia,
• Bilal Gökce and
• Leonid V. Zhigilei

Beilstein J. Nanotechnol. 2026, 17, 571–575, doi:10.3762/bjnano.17.38

• photothermal mechanisms [17]. Laser melting in liquids (LML) employs lower pulse intensities to increase particle size [18] and/or modify crystallinity and morphology through melting and resolidification [19]. At moderate laser fluences, close to or even below the melting threshold, irradiation can induce

Synthesis of Cu–Mo/TiO₂ and Co–Mo/TiO₂ photocatalysts for the efficient degradation of organic pollutants in water

• Ilse Acosta,
• Brenda Zermeño,
• Edgar Moctezuma,
• Luis F. Garay-Rodríguez and
• Isaías Juárez-Ramírez

Beilstein J. Nanotechnol. 2026, 17, 559–570, doi:10.3762/bjnano.17.37

• increase in copper concentration (0.5 wt %) resulted in a decrease in particle size and their agglomeration, leading to particles of undefined shape. In contrast, the incorporation of 0.2 wt % of cobalt resulted in smaller particles forming agglomerations. When the cobalt content is increased, particles

• previously reported [17][32]. In contrast, with the addition of 0.5 wt % Mo and 0.2 wt % Co into TiO2, the area increases to 80.9 m2/g. These results are consistent with the morphological characterization, which showed a decrease in particle size in the cobalt-containing materials, which may have influenced

• phase and distorts the TiO2 lattice structure. The introduction of the metallic ions Cu and Co was confirmed. Cu–Mo/TiO2 materials exhibited higher crystallinity, larger particle size, and lower surface area. However, the material 0.2 Cu–0.5 Mo/TiO2 was the most efficient in the photocatalytic oxidation

Probing internal continua and atomic ultrafast charge transfer within size-controlled nanoparticles by post-collision interaction in core-hole clock spectroscopy

• Johannes Lütgert,
• Erika Giangrisostomi,
• Nomi L. A. N. Sorgenfrei and
• Alexander Föhlisch

Beilstein J. Nanotechnol. 2026, 17, 505–514, doi:10.3762/bjnano.17.33

• properties of QDs such as absorption wavelength are collective properties of the entire system and are primarily determined by the particle size [8]. Advances in synthesis techniques have allowed for precise control over QD size, making these properties reliably tunable [9]. Other properties, such as

• ultimately governed by the asymmetry parameter ξ, shown normalized to the asymmetry parameter of the DL15 sample in Figure 4 (top panel) at various photon energies as a function of particle size. It is clear that the asymmetry parameters increase for smaller QDs. The consistency of this trend across

• different photon energies strongly suggests that the observed variations are indeed the result of a size-dependent process. To gain further insight into the PCI effect, we modeled the observed evolution of the asymmetry parameter as a function of the particle size. As previously discussed, the strength of

Upcycling agroindustrial waste into graphene oxide supports for gold nanoparticles: toward sustainable nanomaterials

• Juan Marcos Castro-Tapia,
• Selene Acosta,
• Hiram Joazet Ojeda-Galván,
• Elsie Evelyn Araujo-Palomo,
• Edgar Giovanni Villabona-Leal and
• Mildred Quintana

Beilstein J. Nanotechnol. 2026, 17, 489–504, doi:10.3762/bjnano.17.32

• sites, resulting in the sparse, agglomerated AuNPs observed in Agro-GOC. The final panel of each row shows high-magnification views of spherical AuNPs with diameters ranging from 6.9 to 10.9 nm, consistent with the particle-size distribution analysis. The average particle sizes were 6.9 ± 2.2 nm (AuNP

• -based materials. Each row represents a hybrid: (a–d) AuNPs@GO, (e–h) AuNPs@rGO, (i–l) AuNPs@Agro-GOP, (m–p) AuNPs@Agro-GOX, and (q–t) AuNPs@Agro-GOC. Columns show increasing magnifications of each sample. Particle size distribution histograms of AuNPs deposited on GO platforms. Relative atomic

Nanocarrier-integrated multilayer films produced by 3D printing for improved skin adhesion and curcumin photostability

• Thayse Viana de Oliveira,
• Ana Paula Farias Leão,
• Júlia Leão,
• Cesar Liberato Petzhold and
• Ruy Carlos Ruver Beck

Beilstein J. Nanotechnol. 2026, 17, 440–453, doi:10.3762/bjnano.17.30

• produced by SSE could address these limitations. To overcome its poor solubility and enhance bioadhesion, curcumin was encapsulated in polymeric nanocapsules (C-NCs), yielding a mean particle size of 218 ± 5 nm, a polydispersity index of 0.10 ± 0.02, a zeta potential of −11 ± 4 mV, and 100% encapsulation

• concentrated to 10 mL. The experiment was carried out in a dark environment, protected from light. Blank formulations (B-NC) were prepared under the same conditions, without addition of curcumin in the organic phases. All formulations were prepared and characterised in triplicate. Particle size, pH and zeta

• potential The z-average particle size and the polydispersity index were measured by dynamic light scattering using a Zetasizer® Nano ZS (ZEN 3600, Malvern Instruments, USA). For this analysis, 10 µL of the C-NC formulation was diluted in 5 mL of ultrapure water (previously filtered through a 0.45 µm

Eco-efficient materials for agricultural crops based on a mineral rich in MOR- and HEU-type zeolites

• Esperanza Yamile de la Nuez-Pantoja,
• Inocente Rodríguez-Iznaga,
• Gerardo Rodríguez-Fuentes,
• Vitalii Petranovskii,
• Ariel Martínez García,
• José Juan Calvino Gámez and
• Daniel Goma Jiménez

Beilstein J. Nanotechnol. 2026, 17, 381–395, doi:10.3762/bjnano.17.26

• zeolitic minerals in agriculture allows one to obtain low-cost, eco-efficient materials for massive application, with rational use of nutrients and agroecological benefits. Experimental Materials and methods In this work, a zeolitic mineral from the San Andrés deposit in Holguín, Cuba, with a particle size

Beam shaping techniques for pulsed laser ablation in liquids: Unlocking tunable control of nanoparticle synthesis in liquids

• Sergio Molina-Prados,
• Nadezhda M. Bulgakova,
• Alexander V. Bulgakov,
• Jesus Lancis,
• Gladys Mínguez Vega and
• Carlos Doñate-Buendia

Beilstein J. Nanotechnol. 2026, 17, 309–342, doi:10.3762/bjnano.17.22

• Al2O3 NPs by nanosecond laser ablation in water [141]. Tilting the target results in smaller particles with a narrower distribution due to the larger spot and lower fluence [141]. Morphology and shape of the ablated NPs remain constant. The produced NPs were spherical with an average particle size

Gold nanoparticle-decorated reduced graphene oxide as a highly effective catalyst for the selective α,β-dehydrogenation of N-alkyl-4-piperidones

• Brenda Flore Kenyim,
• Mihir Tzalis,
• Marilyn Kaul,
• Robert Oestreich,
• Aysenur Limon,
• Chancellin Pecheu Nkepdep and
• Christoph Janiak

Beilstein J. Nanotechnol. 2026, 17, 218–238, doi:10.3762/bjnano.17.15

• tunability, making AuNPs highly versatile in catalytic applications [5][6]. Traditional ligands such as thiols and citrates are commonly used in the synthesis of AuNPs due to their ability to control particle size, prevent aggregation, and enhance stability in solution [7]. Also, polyoxometalates (POMs) have

• scattering (DLS) measurements was 12 nm (Figure 4b). Transmission electron microscopy (TEM) analysis showed spherical and well-dispersed nanoparticles and their particle size distribution (Figure 4c), based on the measurements of approximately 200 nanoparticles, yielded an average diameter of 12 nm with a

• synthesized composites, Au-SiW9/AC (Figure 7a), Au-SiW9/rGO (Figure 7b), and Au-SiW9/CB (Figure 7c), revealed small, spherical, and well-dispersed particles. The particle size was between 2 and 8 nm with an average of 5–6 nm and a standard deviation of ±1 nm, as determined from their corresponding

Safe and sustainable by design with ML/AI: A transformative approach to advancing nanotechnology

• Georgia Melagraki

Beilstein J. Nanotechnol. 2026, 17, 176–185, doi:10.3762/bjnano.17.11

• powerful aspects of materials informatics lies in its ability to integrate machine learning with multiscale simulation tools – ranging from molecular dynamics to density functional theory – which helps researchers correlate nanoscale features such as particle size, shape, and surface functionalization with

• interpolation from limited experimental datasets [57]. Given that protein corona formation [58] can drastically alter the biodistribution and immunological profile of a nanoparticle, digital twins help pinpoint safer design parameters – such as surface coatings or particle size modifications – which improve

Influence of surface characteristics on the in vitro stability and cell uptake of nanoliposomes for brain delivery

• Dushko Shalabalija,
• Ljubica Mihailova,
• Nikola Geskovski,
• Andreas Zimmer,
• Otmar Geiss,
• Sabrina Gioria,
• Diletta Scaccabarozzi and
• Marija Glavas Dodov

Beilstein J. Nanotechnol. 2026, 17, 139–158, doi:10.3762/bjnano.17.9

• qualitatively confirmed by spectrophotometry (e.g., by the absence of fluorescence in the supernatant obtained in the last washing cycle), ensuring that the fluorescence signal in subsequent experiments originates exclusively from liposome-associated dye. Particle size, particle size distribution and z

• highlight the dominant independent variables that have a significant effect in the model, the VIP score was used. Results and Discussion Particle size, particle size distribution and z-potential of the nanoliposomes Several studies have reported that despite the composition and the other surface properties

• nanoliposomes in cell culture medium In order to provide a more detailed examination of the influence of serum components present in the cell culture medium on the average NLs size, AF4–MALS/DLS analysis was performed. For this purpose, the particle size of the native formulations (NLb0, NLb1, and NLb2) was

Development and in vitro evaluation of liposomes and immunoliposomes containing 5-fluorouracil and R-phycoerythrin as a potential phototheranostic system for colorectal cancer

• Raissa Rodrigues Camelo,
• Vivianne Cortez Sombra Vandesmet,
• Octavio Vital Baccallini,
• José de Brito Vieira Neto,
• Thais da Silva Moreira,
• Luzia Kalyne Almeida Moreira Leal,
• Claudia Pessoa,
• Daniel Giuliano Cerri,
• Maria Vitória Lopes Badra Bentley,
• Josimar O. Eloy,
• Ivanildo José da Silva Júnior and
• Raquel Petrilli

Beilstein J. Nanotechnol. 2026, 17, 97–121, doi:10.3762/bjnano.17.7

• Sepharose CL-4B column eluted with PBS (pH 7.4) [19]. 2.3 Sample characterization 2.3.1 Particle size, polydispersity and zeta potential The hydrodynamic vesicle size and polydispersity index (PDI) were performed by dynamic light scattering (DLS), and the zeta potential by electrophoretic light scattering

Improving magnetic properties of Mn- and Zn-doped core–shell iron oxide nanoparticles by tuning their size

• Dounia Louaguef,
• Ghouti Medjahdi,
• Sébastien Diliberto,
• Klaus M. Seemann,
• Thomas Gries,
• Joelle Bizeau,
• Damien Mertz,
• Eric Gaffet and
• Halima Alem

Beilstein J. Nanotechnol. 2025, 16, 2285–2295, doi:10.3762/bjnano.16.157

• material to eliminate the cytotoxicity concerns associated with cobalt. Furthermore, we demonstrate size control through synthesis by varying the concentration of oleic acid, a surfactant that influences particle size and morphology. This approach enables the synthesis of NPs with sizes ranging from 5 to

• -capping agents, such as oleic acid, which is commonly used during synthesis to control particle size and prevent aggregation. The broad peak observed at ≈3400 cm−1 is linked to the O–H stretching vibrations of adsorbed water or hydroxy groups on the particle surface, which is a common feature for

• moments [18][19][20]. For instance, Wang et al. observed that ZnFe2O4 NPs with sizes ranging from 5 nm to 50 nm displayed Ms values increasing from 1.5 to 30 A·m2·kg−1, highlighting the critical role of particle size in magnetic properties [21]. The role of the core–shell structure in enhancing the

Optical bio/chemical sensors for vitamin B₁₂ analysis in food and pharmaceuticals: state of the art, challenges, and future outlooks

• Seyed Mohammad Taghi Gharibzahedi and
• Zeynep Altintas

Beilstein J. Nanotechnol. 2025, 16, 2207–2244, doi:10.3762/bjnano.16.153

• AuNP suspensions is substantially influenced by their particle size and dispersion speed. 10–20 nm AuNPs with a narrow size distribution tend to absorb light from the blue-green spectrum and reflect red light. In contrast, their aggregation leads to a light absorption shift to longer wavelengths

Ultrathin water layers on mannosylated gold nanoparticles

• Maiara A. Iriarte Alonso,
• Jorge H. Melillo,
• Silvina Cerveny,
• Yujin Tong and
• Alexander M. Bittner

Beilstein J. Nanotechnol. 2025, 16, 2183–2198, doi:10.3762/bjnano.16.151

• properties on particle size and shape has been demonstrated for particle sizes in the 1–100 nm range and on biological interfaces [7]. Limited biocompatibility and high tendency to aggregate in solution inspired new mechanisms of particle biofunctionalization with proteins, lipids, or carbohydrates. Coupling

• inorganic surfaces, usually modified with organic layers, and probed by Fourier-transform infrared spectroscopy (FTIR), vibrational sum frequency generation (VSFG), and atomic force microscopy (AFM). For VSFG and AFM, we systematically varied the relative air humidity (RH). DLS and ZP yield particle size

• of dimannoside and PEGylated ligands. The PEG AuNPs were functionalized only with the PEGylated component; they can be seen as a precursor, and we used them as negative controls. Particle size and shape Particle size and stability in an aqueous solution were characterized by DLS and ZP measurements

Missing links in nanomaterials research impacting productivity and perceptions

• Santosh K. Tiwari and
• Nannan Wang

Beilstein J. Nanotechnol. 2025, 16, 2168–2176, doi:10.3762/bjnano.16.149

• equipment, especially characterization tools used for nanosystems, are unavoidable challenges. Another critical challenge is the precision required to produce nanomaterials. The unique properties of nanomaterials arise from controlled particle size, but achieving the desired size and uniformity is extremely

• aggregate, agglomerate, and self-assemble according to their morphology. These issues cannot be fully eliminated without external stabilization and suggestively impact their performance in real-world applications. Furthermore, such an instability becomes more pronounced as the particle size decreases. For

Quality by design optimization of microemulsions for topical delivery of Passiflora setacea seed oil

• Daniel T. Pereira,
• Douglas Dourado,
• Danielle T. Freire,
• Dayanne L. Porto,
• Cícero F. S. Aragão,
• Myla L. de Souza,
• Guilherme R. S. de Araujo,
• Ana Maria Costa,
• Wógenes N. Oliveira,
• Anne Sapin-Minet,
• Éverton N. Alencar and
• Eryvaldo Sócrates T. Egito

Beilstein J. Nanotechnol. 2025, 16, 2116–2131, doi:10.3762/bjnano.16.146

• evaluated over a 60 day period (Figure 7A). Throughout this time, no significant changes were detected in particle size, with the hydrodynamic diameter consistently remaining below 100 nm, and the PdI remaining below 0.20, confirming the physical stability of the base microemulsion and its preservation of

Rapid synthesis of highly monodisperse AgSbS₂ nanocrystals: unveiling multifaceted activities in cancer therapy, antibacterial strategies, and antioxidant defense

• Funda Ulusu,
• Adem Sarilmaz,
• Yakup Ulusu,
• Faruk Ozel and
• Mahmut Kus

Beilstein J. Nanotechnol. 2025, 16, 2105–2115, doi:10.3762/bjnano.16.145

• , indicating robust crystallization. Moreover, the presence of prominent peaks aligning with (220), (311), (420), and (511) planes confirmed alignment with XRD results. Furthermore, utilizing particle size distribution analysis, the crystallite size of average particles was estimated, as illustrated in the

• inset in Figure 2c. The particle size distribution graphs in this image unequivocally affirmed the successful attainment of the desired homogeneity. Biological applications Antibacterial activity of AgSbS2 NCs Disc diffusion. The antimicrobial activity of AgSbS2 NCs at a concentration of 10 mg/mL

• infections dominated by this pathogen. However, their relatively weaker activity against E. coli and B. subtilis suggests that optimization may be necessary to broaden their spectrum through surface modification, particle size reduction, or combination with other antibacterial agents. Cytotoxicity of AgSbS2

Toward clinical translation of carbon nanomaterials in anticancer drug delivery: the need for standardisation

• Michał Bartkowski,
• Francesco Calzaferri and
• Silvia Giordani

Beilstein J. Nanotechnol. 2025, 16, 2092–2104, doi:10.3762/bjnano.16.144

• safety. Insights from these studies guide further optimisation of the delivery system, which may involve adjusting particle size, surface chemistry, or drug-loading strategies. Once optimised and evaluated, the system enters regulatory review, requiring preclinical safety and efficacy data to meet

• tend to evade renal filtration due to the formation of a protein corona that effectively increases their hydrodynamic size [38]. Beyond renal clearance, particle size also critically influences toxicity, metabolic fate, tumour targeting, protein interactions, and hepatic processing. Additional