Incorporation of doxorubicin in different polymer nanoparticles and their anticancer activity

• Sebastian Pieper,
• Hannah Onafuye,
• Dennis Mulac,
• Jindrich Cinatl Jr.,
• Mark N. Wass,
• Martin Michaelis and
• Klaus Langer

Beilstein J. Nanotechnol. 2019, 10, 2062–2072, doi:10.3762/bjnano.10.201

• easily degraded into their monomers, lactic acid and glycolic acid. Furthermore, a copolymer composed of polyethylene glycol (PEG) and PLGA (PLGA-PEG) was used for nanoparticle preparation. PEGylated (“stealth”) nanoparticles display prolonged systemic circulation time, because they avoid agglomeration

• polyethylene glycol (PEG) and PLGA (PLGA-PEG) and polylactic acid (PLA), respectively, were prepared in the presence of doxorubicin by either emulsion diffusion or solvent displacement technique. The resulting particle diameters are presented in Figure 1. Emulsion diffusion (173.5 ± 5.9 nm) and solvent

Optimization and performance of nitrogen-doped carbon dots as a color conversion layer for white-LED applications

• Tugrul Guner,
• Hurriyet Yuce,
• Didem Tascioglu,
• Eren Simsek,
• Umut Savaci,
• Aziz Genc,
• Servet Turan and
• Mustafa M. Demir

Beilstein J. Nanotechnol. 2019, 10, 2004–2013, doi:10.3762/bjnano.10.197

• using glucose and polyethylene glycol 200. It is reported that the WLED showed a superior performance indicated by Commission Internationale de l'Éclairage (CIE) coordinates of (0.32, 0.37) and a CCT of 5584 K. In another study, Joseph et al. reported the synthesis of CDots by the electrochemical

Correlation of surface-enhanced Raman scattering (SERS) with the surface density of gold nanoparticles: evaluation of the critical number of SERS tags for a detectable signal

• Vincenzo Amendola

Beilstein J. Nanotechnol. 2019, 10, 1016–1023, doi:10.3762/bjnano.10.102

• AuNP solution at a 1:100 volume ratio. After 30 min under mild stirring, an aqueous solution of thiolated polyethylene glycol (PEG, MW 5000, Sigma-Aldrich) was added to the AuNPs with a final concentration of 30 µM. After stirring for 14 h at room temperature, the mixtures were washed with deionized

The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model

• Qura Tul Ain,
• Samina Hyder Haq,
• Abeer Alshammari,
• Moudhi Abdullah Al-Mutlaq and
• Muhammad Naeem Anjum

Beilstein J. Nanotechnol. 2019, 10, 901–911, doi:10.3762/bjnano.10.91

• polyethylene glycol (PEG). PEGylation of nGO was confirmed by Fourier-transform infrared spectroscopy (FTIR), UV spectroscopy and TEM. The average size distribution of nGO and PEG-nGO was determined by using dynamic light scattering (DLS). Subsequently, an in vivo study measuring a marker for oxidative stress

• restricts its use for biomedical applications. Scientists have overcome this challenge through the oxidation of graphene by an improved Hummer’s method [3]. Graphene oxide (GO), due to its hydrophilic nature, can host a large number of biocompatible polymers, such as chitosan [4], polyethylene glycol (PEG

• Zhang and co-workers [29]. Biocompatibility of nGO was achieved by coating with polyethylene glycol (PEG). Then, a single dose (5 mg/kg) of synthesized PEG-nGO was administered to groups of groups of six mice. The dosage was found to be optimum in previous studies [28][29]. The animals were dissected

Polydopamine-coated Au nanorods for targeted fluorescent cell imaging and photothermal therapy

• Boris N. Khlebtsov,
• Andrey M. Burov,
• Timofey E. Pylaev and
• Nikolai G. Khlebtsov

Beilstein J. Nanotechnol. 2019, 10, 794–803, doi:10.3762/bjnano.10.79

• -functionalized nanoparticles in folate-positive HeLa cells in contrast to the folate-negative HEK 293 cells using fluorescent microscopy. The replacement of folic acid with polyethylene glycol (PEG) leads to a decrease in nanoparticle uptake by both folate-positive and folate-negative cells. We performed NIR

• replaced with the thiolated polyethylene glycol (PEG-SH) as the latter molecules interact more strongly with the Au surface. Without this intermediate procedure, the adsorption of dopamine on CTAB-stabilized AuNRs resulted in nanoparticle aggregation. The formation of the PDA coating can be easily induced

• , 25% water solution), L-ascorbic acid (AA, >99.9%), hydrochloric acid (HCl, 37 wt % in water), folic acid (99.9%), thiolated polyethylene glycol (mPEG-SH, 99%), rhodamine 123 (BioReagent, for fluorescence, ≥85%) and sodium borohydride (NaBH4, 99%) were purchased from Sigma-Aldrich. Hydrogen

Targeting strategies for improving the efficacy of nanomedicine in oncology

• Gonzalo Villaverde and
• Alejandro Baeza

Beilstein J. Nanotechnol. 2019, 10, 168–181, doi:10.3762/bjnano.10.16

• strong affinity for NET. The replacement of the iodine by an amino group in MABG did not reduce the ability to bind to NET while it provided a reactive group that allowed for grafting this molecule to the surface of MSN employing a bifunctionalized polyethylene glycol (PEG) molecule as spacer between the

Accurate control of the covalent functionalization of single-walled carbon nanotubes for the electro-enzymatically controlled oxidation of biomolecules

• Naoual Allali,
• Veronika Urbanova,
• Mathieu Etienne,
• Xavier Devaux,
• Martine Mallet,
• Brigitte Vigolo,
• Jean-Joseph Adjizian,
• Chris P. Ewels,
• Sven Oberg,
• Alexander V. Soldatov,
• Edward McRae,
• Yves Fort,
• Manuel Dossot and
• Victor Mamane

Beilstein J. Nanotechnol. 2018, 9, 2750–2762, doi:10.3762/bjnano.9.257

• several linkers, in order to see if the chemical nature of the linker and/or its length might influence the electrochemical response of our final device. An alkyl chain and polyethylene glycol linkers with various chain lengths were used in this study (Figure 4). The corresponding ferrocene derivatives

• functions introduced by the microwave-assisted oxidation process. For the HIPCO-HNO3-FcETG2 sample, additional peaks around 340 and 675 °C are visible for both CO and CO2 fragments. They are due to the fragmentation of the polyethylene glycol linkers, confirming that ferrocene derivatives are covalently

• inset of Figure 10a). The bright dot corresponds to the ferrocene group, the gray line to the polyethylene glycol linker, and the less bright dot at the other extremity to the ester link between the CNT and the linker. The contrast obtained is not sensitive to the focus (in the focus range used). For BF

Size-selected Fe₃O₄–Au hybrid nanoparticles for improved magnetism-based theranostics

• Maria V. Efremova,
• Yulia A. Nalench,
• Eirini Myrovali,
• Anastasiia S. Garanina,
• Ivan S. Grebennikov,
• Polina K. Gifer,
• Maxim A. Abakumov,
• Marina Spasova,
• Makis Angelakeris,
• Alexander G. Savchenko,
• Michael Farle,
• Natalia L. Klyachko,
• Alexander G. Majouga and
• Ulf Wiedwald

Beilstein J. Nanotechnol. 2018, 9, 2684–2699, doi:10.3762/bjnano.9.251

• impact on the NP performance in MRI. For this purpose, the NPs were stabilized in water by modification with a biocompatible derivative of polyethylene glycol and phospholipid (DSPE-PEG-COOH). The NPs with a polymer shell have a hydrodynamic diameter ranging from 95 to 160 nm, according to the dynamic

• -octadecene and 1,2-hexadecanediol were purchased from Sigma-Aldrich. 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-5000] ammonium salt (DSPE-PEG-COOH) was delivered by Avanti Polar Lipids. Isopropanol, hexane and chloroform were purchased from Reachim. Water used in the

• oxidized by stirring for 1 h under ambient air. The NPs were isolated via centrifugation, washed with isopropanol and dispersed in hexane. Oleic-acid-coated Fe3O4–Au NPs were transferred into water by modification with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-5000

Fabrication of photothermally active poly(vinyl alcohol) films with gold nanostars for antibacterial applications

• Mykola Borzenkov,
• Maria Moros,
• Claudia Tortiglione,
• Serena Bertoldi,
• Nicola Contessi,
• Silvia Faré,
• Angelo Taglietti,
• Agnese D’Agostino,
• Piersandro Pallavicini,
• Maddalena Collini and
• Giuseppe Chirico

Beilstein J. Nanotechnol. 2018, 9, 2040–2048, doi:10.3762/bjnano.9.193

• ) were commercially available from Fluka. Poly(ethylene glycol) thiols ( = 5000 g/mol; SH-PEG5000–OCH3 and SH-PEG5000–COOH), polyethylene glycol tert-octylphenyl ether (Triton X-100), chloroauric acid, ascorbic acid, silver nitrate, and sodium borohydride were purchased from Sigma-Aldrich and used as

Atomic-level characterization and cilostazol affinity of poly(lactic acid) nanoparticles conjugated with differentially charged hydrophilic molecules

• María Francisca Matus,
• Martín Ludueña,
• Cristian Vilos,
• Iván Palomo and
• Marcelo M. Mariscal

Beilstein J. Nanotechnol. 2018, 9, 1328–1338, doi:10.3762/bjnano.9.126

• promising field for numerous diseases and represents the forefront of modern medicine. In the present work, full atomistic computer simulations were applied to study poly(lactic acid) (PLA) nanoparticles conjugated with polyethylene glycol (PEG). The formation of this complex system was simulated using the

Surface characterization of nanoparticles using near-field light scattering

• Eunsoo Yoo,
• Yizhong Liu,
• Chukwuazam A. Nwasike,
• Sebastian R. Freeman,
• Brian C. DiPaolo,
• Bernardo Cordovez and
• Amber L. Doiron

Beilstein J. Nanotechnol. 2018, 9, 1228–1238, doi:10.3762/bjnano.9.114

• , namely uncoated superparamagnetic iron oxide nanoparticles, polyethylene glycol-coated superparamagnetic iron oxide nanoparticles, and interpolymer complex-superparamagnetic iron oxide nanoparticles, were studied for changes in collective size and surface properties using an analysis of particle velocity

BN/Ag hybrid nanomaterials with petal-like surfaces as catalysts and antibacterial agents

• Konstantin L. Firestein,
• Denis V. Leybo,
• Alexander E. Steinman,
• Andrey M. Kovalskii,
• Andrei T. Matveev,
• Anton M. Manakhov,
• Irina V. Sukhorukova,
• Pavel V. Slukin,
• Nadezda K. Fursova,
• Sergey G. Ignatov,
• Dmitri V. Golberg and
• Dmitry V. Shtansky

Beilstein J. Nanotechnol. 2018, 9, 250–261, doi:10.3762/bjnano.9.27

• produce grams of BN/Ag HNMs in a single experimental run (referred to as CVD BN/Ag HNMs). To prepare BN/Ag HNMs via UV decomposition of AgNO3 (abbreviated as UV BN/Ag HNMs), we have dispersed 100 mg of raw BN NPs in 50 mL of polyethylene glycol 400 (PEG-400) using an ultrasonic homogenizer Bandelin HD2200

Refractive index sensing and surface-enhanced Raman spectroscopy using silver–gold layered bimetallic plasmonic crystals

• Somi Kang,
• Sean E. Lehman,
• Matthew V. Schulmerich,
• An-Phong Le,
• Tae-woo Lee,
• Stephen K. Gray,
• Rohit Bhargava and
• Ralph G. Nuzzo

Beilstein J. Nanotechnol. 2017, 8, 2492–2503, doi:10.3762/bjnano.8.249

• % methylhydrosiloxane)-(dimethylsiloxane) (HMS-301), poly(7–8% vinylmethylsiloxane)-(dimethylsiloxane), (VDT-731), platinum divinyltetramethyldisiloxane (SIP6831.1) and (1,3,5,7-tetravinyl-1,3,5,7-tetramethylcyclotetrasiloxane) (7900), were purchased from Gelest. Polyethylene glycol (PEG, MW = 10,000 g/mol) and

Imidazolium-based ionic liquids used as additives in the nanolubrication of silicon surfaces

• Patrícia M. Amorim,
• Ana M. Ferraria,
• Rogério Colaço,
• Luís C. Branco and
• Benilde Saramago

Beilstein J. Nanotechnol. 2017, 8, 1961–1971, doi:10.3762/bjnano.8.197

• polyethylene glycol (PEG) to lubricate Si surfaces. The friction coefficients were measured in a nanotribometer. The viscosity of the PEG + IL mixtures as well as their contact angles on the Si surface were measured. The topography and chemical composition of the substrates surfaces were determined with atomic

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

• Cem Varan and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1446–1456, doi:10.3762/bjnano.8.144

• reported to be nontoxic, biocompatible and biodegradable and is approved for therapeutic use in humans by the FDA. PCL can be copolymerized with other synthetic polymers such as polyethylene glycol (PEG) and polyethylene oxide (PEO) to obtain new polycaprolactone derivatives with various novel properties

Micro- and nano-surface structures based on vapor-deposited polymers

• Hsien-Yeh Chen

Beilstein J. Nanotechnol. 2017, 8, 1366–1374, doi:10.3762/bjnano.8.138

• for the pattern formation of polyethylene glycol (PEG)-like polymer derivatives to guide fibroblast attachment [21]. A photodefinable polymer of poly(4-benzoyl-p-xylylene-co-p-xylylene) was synthesized by CVD, and a combined soft lithographical and UV light process was performed to create the

Nanoscale isoindigo-carriers: self-assembly and tunable properties

• Tatiana N. Pashirova,
• Andrei V. Bogdanov,
• Lenar I. Musin,
• Julia K. Voronina,
• Irek R. Nizameev,
• Marsil K. Kadirov,
• Vladimir F. Mironov,
• Lucia Ya. Zakharova,
• Shamil K. Latypov and
• Oleg G. Sinyashin

Beilstein J. Nanotechnol. 2017, 8, 313–324, doi:10.3762/bjnano.8.34

• isoindigo scaffold was functionalized with carbohydrate substituents [36][37]. Over the last three decades, extensive research in nanomedicine led to several strategies to improve drug biocompatibility and drug delivery efficacy (e.g., synthesis of polymer–drug conjugates, such as polyethylene glycol

Comparison of four functionalization methods of gold nanoparticles for enhancing the enzyme-linked immunosorbent assay (ELISA)

• Paula Ciaurriz,
• Fátima Fernández,
• Edurne Tellechea,
• Jose F. Moran and
• Aaron C. Asensio

Beilstein J. Nanotechnol. 2017, 8, 244–253, doi:10.3762/bjnano.8.27

• -polyethylene glycol-dithiol, was used to control the orientation of the molecules on the surface of the nanoparticle. Hydrazide is able to react with aldehyde groups that can be generated by oxidizing the carbohydrates of glycosylated proteins, such as antibodies [20]. For this purpose, antibody and HRP

Effective intercalation of zein into Na-montmorillonite: role of the protein components and use of the developed biointerfaces

• Ana C. S. Alcântara,
• Margarita Darder,
• Pilar Aranda and
• Eduardo Ruiz-Hitzky

Beilstein J. Nanotechnol. 2016, 7, 1772–1782, doi:10.3762/bjnano.7.170

• examples, organoclays containing alkylammonium surfactant species [20][22] or polyethylene glycol as plasticizer [21] were required to produce the zein-based materials. Nevertheless, the process of formation of zein–montmorillonite biohybrids making use of sodium-exchanged montmorillonite (Na

Comparison of the interactions of daunorubicin in a free form and attached to single-walled carbon nanotubes with model lipid membranes

• Dorota Matyszewska

Beilstein J. Nanotechnol. 2016, 7, 524–532, doi:10.3762/bjnano.7.46

• conjugated to either polyethylene glycol (PEG) functionalized single-walled carbon nanotubes (SWCNTs) [20] or to aptamer-wrapped SWCNTs via π–π interactions. In both cases the cytotoxicity of the conjugates was verified on the selected cancer cell lines. In this study the influence of both free daunorubicin

Green and energy-efficient methods for the production of metallic nanoparticles

• Mitra Naghdi,
• Mehrdad Taheran,
• Satinder K. Brar,
• M. Verma,
• R. Y. Surampalli and
• J. R. Valero

Beilstein J. Nanotechnol. 2015, 6, 2354–2376, doi:10.3762/bjnano.6.243

• , they produced spherical Ag NPs with an average diameter of 26 nm, and polydispersity of 2.3%. They also investigated the capability of different ionic and non-ionic surfactants and also polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) in surface modification and stabilization of Ag NPs produced

• their FTIR results, different sugars, amino acids and fatty acids are responsible for the stabilization processes. They also observed that by changing the concentration of precursor, one can obtain NPs with average particle diameter from 7.8 to 4.8 nm [89]. Polyols Shameli et al. used polyethylene

• glycol (PEG) and β-D-glucose as stabilizing and reducing agents, respectively, to produce colloidal Ag NPs from AgNO3 at 60 °C. They studied the properties of Ag NPs at different reaction times and found that the average particle sizes were 10.60, 11.23, 15.30 and 25.31 nm for different mixing times of 3

Nanofibers for drug delivery – incorporation and release of model molecules, influence of molecular weight and polymer structure

• Jakub Hrib,
• Jakub Sirc,
• Radka Hobzova,
• Zuzana Hampejsova,
• Zuzana Bosakova,
• Marcela Munzarova and
• Jiri Michalek

Beilstein J. Nanotechnol. 2015, 6, 1939–1945, doi:10.3762/bjnano.6.198

• amount of released molecules after 72 hours. However, the influence of the chemical composition of nanofibers was even more distinct – the highest amount of polyethylene glycol molecules released from polyvinyl alcohol nanofibers, the lowest amount from polylactide nanofibers. Keywords: nanofibers

• molecular weights of 2,000, 6,000, 10,000 and 20,000 g/mol were selected as model molecules. Polyethylene glycol (PEG) is a hydrophilic polyether commercially available in various molecular weights with narrow distribution. It is widely used in various medical applications, for example as surfactant

• into aqueous media in which the solubility of such drugs are very low. Conclusion The release kinetics of polyethylene glycol molecules of various molecular weights from nanofibers prepared from polycaprolactone, polylactide and polyvinyl alcohol were assessed. The release rate and the total released

From lithium to sodium: cell chemistry of room temperature sodium–air and sodium–sulfur batteries

• Philipp Adelhelm,
• Pascal Hartmann,
• Conrad L. Bender,
• Martin Busche,
• Christine Eufinger and
• Juergen Janek

Beilstein J. Nanotechnol. 2015, 6, 1016–1055, doi:10.3762/bjnano.6.105

Protein corona – from molecular adsorption to physiological complexity

• Lennart Treuel,
• Dominic Docter,
• Michael Maskos and
• Roland H. Stauber

Beilstein J. Nanotechnol. 2015, 6, 857–873, doi:10.3762/bjnano.6.88

• indeed alters the cellular response to NPs. For example, NP opsonization with immunoglobulin reportedly promoted receptor-mediated phagocytosis by macrophages [155]. The presence of polyethylene glycol (PEG) was shown to suppress protein absorption resulting in a decreased uptake by macrophages [142] and

Novel ZnO:Ag nanocomposites induce significant oxidative stress in human fibroblast malignant melanoma (Ht144) cells

• Syeda Arooj,
• Samina Nazir,
• Akhtar Nadhman,
• Nafees Ahmad,
• Bakhtiar Muhammad,
• Ishaq Ahmad,
• Kehkashan Mazhar and
• Rashda Abbasi

Beilstein J. Nanotechnol. 2015, 6, 570–582, doi:10.3762/bjnano.6.59

• potential cytotoxicity, biocompatibility and biosafety of such particles in vitro as well as in vivo. Experimental Reagents Acetic acid, DMSO, ethylenediaminetetraacetic acid disodium salt dihydrate (Na2EDTA·2H2O), FeSO4, L-glutamine, hydrochloric acid (HCl), mannitol, penicillin-G, polyethylene glycol (PEG