Optical bio/chemical sensors for vitamin B₁₂ analysis in food and pharmaceuticals: state of the art, challenges, and future outlooks

• Seyed Mohammad Taghi Gharibzahedi and
• Zeynep Altintas

Beilstein J. Nanotechnol. 2025, 16, 2207–2244, doi:10.3762/bjnano.16.153

• biosensors into cellular bioimaging and the potential for non-invasive in vitro and in vivo analysis demonstrate their versatility and applicability across a broad spectrum of biomedical research, diagnostics, and nutrient analysis. Keywords: carbon dots; cobalamin; energy transfer; fluorescence sensor

• showed potential for bioimaging Escherichia coli cells due to its fluorescence response when exposed to Co2+ [81]. A new fluorescent–colorimetric chemosensor was designed based on 1,8-bis{2-{N-[2′-(8′-hydroxy-9,10-anthraquinon-1-yloxy) ethyl] benzimidazoliumyl} ethoxy}-9′,10′ anthraquinone

• nanoscale, serve as an advanced spectroscopic platform for improved molecular identification. They highlighted graphene’s potential in biosensing owing to its capability to be functionalized with dissimilar biomolecules such as enzymes and DNA. In their study, they presented a quantitative bioassay

Electromagnetic study of a split-ring resonator metamaterial with cold-electron bolometers

• Ekaterina A. Matrozova,
• Alexander V. Chiginev,
• Leonid S. Revin and
• Andrey L. Pankratov

Beilstein J. Nanotechnol. 2025, 16, 2199–2206, doi:10.3762/bjnano.16.152

• constructing ultrabroadband, high-sensitivity receivers essential for next-generation spectroscopic and radioastronomical applications, particularly in demanding space and balloon-borne environments. One more important potential application for such broadband receiving system is the use for axion search

Ultrathin water layers on mannosylated gold nanoparticles

• Maiara A. Iriarte Alonso,
• Jorge H. Melillo,
• Silvina Cerveny,
• Yujin Tong and
• Alexander M. Bittner

Beilstein J. Nanotechnol. 2025, 16, 2183–2198, doi:10.3762/bjnano.16.151

• carbohydrate display, which defines their biological function [10], a small globular core, and chemically well-defined composition. Proof-of-concept studies have demonstrated the vast potential of glyconanoparticles for glyconanotechnology in solution. However, potential changes of “glycoclusters” [2] in dry

• short oligo(ethylene glycol) chains. The particles were first characterized by dynamic light scattering (DLS) and zeta potential (ZP) measurements in solution, and by scanning electron microscopy (SEM) and scanning transmission electron microscopy (STEM) in vacuum. Samples were adsorbed on flat

• scattering and zeta potential measurements DLS was used to determine the hydrodynamic diameter, and ZP was used to estimate the NP surface charge of both particles in solution. We employed Zetasizer Nano ZS (Malvern Panalytical, UK) equipment. For DLS measurements, 70 µL of the sample (1.0 × 1012 particles

Hartree–Fock interaction in superconducting condensate fractals

• Edward G. Nikonov,
• Yajiang Chen,
• Mauro M. Doria and
• Arkady A. Shanenko

Beilstein J. Nanotechnol. 2025, 16, 2177–2182, doi:10.3762/bjnano.16.150

• superconductors as its effect is mainly reduced to a chemical potential shift. Deviations from this behavior can only arise in situations of translational symmetry breaking, for example, caused by the presence of external fields that induce spatial variations of the order parameter and electron density. We

• solve the Bogoliubov–de Gennes equations and show that, beyond the half-filling, the HF potential significantly enhances the self-similar spatial oscillations of the order parameter while simultaneously reducing its average value and altering its critical exponent. Consequently, the critical temperature

• : Fibonacci chain; fractal superconductivity; Hartree–Fock interaction; quasicrystal; Introduction It is well known, dating back to the classical book by de Gennes [1], that, in conventional superconducting materials, the Hartree–Fock (HF) interaction merely reduces to a shift of the chemical potential, as

Missing links in nanomaterials research impacting productivity and perceptions

• Santosh K. Tiwari and
• Nannan Wang

Beilstein J. Nanotechnol. 2025, 16, 2168–2176, doi:10.3762/bjnano.16.149

• productive technologies like generative AI, machine learning, and related progress, nanotechnology has not achieved autonomous societal integration. The author argues that without a unified, transparent, and science-driven global regulatory framework, the transformative potential of nanotechnology will

• acceleration after the discovery of fullerene by Kroto and co-workers in 1985 and witnessed an even more rapid surge following the discovery of graphene and the award of the Physics Nobel Prize in 2010 [6][7]. Graphene is often referred to as a “wonder material” due to its seemingly infinite potential in

• usage remain uncertain As discussed above, during the last three decades, extensive work has been done in various domains of nanoscience and nanotechnology, mainly focusing on large-scale production and potential consumer applications. It is estimated that, globally, investments in nanomaterials and

Microplastic pollution in Himalayan lakes: assessment, risks, and sustainable remediation strategies

• Sameeksha Rawat,
• S. M. Tauseef and
• Madhuben Sharma

Beilstein J. Nanotechnol. 2025, 16, 2144–2167, doi:10.3762/bjnano.16.148

• its behavior in distant, elevated lake systems such as the Himalayas. The most important areas to focus with regard to the ecotoxicological impact of microplastics are the bioaccumulation of microplastics in the Himalayan food web, plasticizer toxicity, and long-term potential health and ecological

• catalysts, are a good example of a new method that has achieved great degrading effectiveness and is under study regarding its potential application to cold environments [46]. However, before being widely used in delicate ecosystems like Himalayan lakes, chemical methods must be carefully optimized since

• Aspergillus spp., have already shown potential in degrading MPs in a controlled settings, with the possibility of further application in larger-scale bioremediation schemes [44]. Table 3 gives a comparative summary of the most recent physical, chemical, and biological technologies for MP remediation. Among

Quality by design optimization of microemulsions for topical delivery of Passiflora setacea seed oil

• Daniel T. Pereira,
• Douglas Dourado,
• Danielle T. Freire,
• Dayanne L. Porto,
• Cícero F. S. Aragão,
• Myla L. de Souza,
• Guilherme R. S. de Araujo,
• Ana Maria Costa,
• Wógenes N. Oliveira,
• Anne Sapin-Minet,
• Éverton N. Alencar and
• Eryvaldo Sócrates T. Egito

Beilstein J. Nanotechnol. 2025, 16, 2116–2131, doi:10.3762/bjnano.16.146

• , Brazil 10.3762/bjnano.16.146 Abstract Passiflora setacea seed oil is a natural source of bioactive unsaturated fatty acids, notably linoleic acid (ω-6) and oleic acid (ω-9), with promising antioxidant and anti-inflammatory potential for dermatological applications. However, its direct use is limited by

• of fixed oils and bioactive compounds, including flavonoids and alkaloids, which exhibit significant therapeutic potential [1]. While Passiflora edulis, P. alata, and P. incarnata have been extensively studied in phytopharmaceutical research, recent investigations have turned attention toward

• linked to diverse biological effects, including anti-inflammatory, antioxidant, and skin-regenerative activities, underscoring its potential for dermatological applications [4]. Despite these promising attributes, the direct use of natural oils in topical applications is often limited by their

Rapid synthesis of highly monodisperse AgSbS₂ nanocrystals: unveiling multifaceted activities in cancer therapy, antibacterial strategies, and antioxidant defense

• Funda Ulusu,
• Adem Sarilmaz,
• Yakup Ulusu,
• Faruk Ozel and
• Mahmut Kus

Beilstein J. Nanotechnol. 2025, 16, 2105–2115, doi:10.3762/bjnano.16.145

• , particularly on cancer cell lines (MCF-7 and HT-29), in a dose-dependent manner over a 24 h period. These findings highlight the potential of the NCs as anticancer agents. Furthermore, the synthesized NCs demonstrated potent antibacterial properties against the tested microorganisms and notable antioxidant

• effects by efficiently eliminating DPPH activity. This research highlights the potential of AgSbS2 NCs as versatile agents with applications in biomedical and environmental domains, including cancer therapy, antimicrobial strategies, and free radical neutralization. Keywords: AgSbS2 nanocrystals

• therapeutic approaches [2]. Currently, the assessment of nanotechnology’s impact on the health of both humans and animals, along with its potential in therapy, has become an imperative scientific consideration. Nanotechnology, which is multidisciplinary, is the synthesis of materials and particles with

Toward clinical translation of carbon nanomaterials in anticancer drug delivery: the need for standardisation

• Michał Bartkowski,
• Francesco Calzaferri and
• Silvia Giordani

Beilstein J. Nanotechnol. 2025, 16, 2092–2104, doi:10.3762/bjnano.16.144

• uncontrolled cell growth and their potential to metastasise, poses a significant global health challenge. Numerous preventable factors contribute to cancer, including tobacco use, exposure to viruses, alcohol consumption, ultraviolet radiation (photocarcinogenesis), ionising radiation, poor diet and nutrition

• , laser ablation, or electrochemical techniques, among others. These CNMs must then be thoroughly characterised to confirm their structural and physicochemical properties, including size, shape, charge, surface functionality, stability, and potential toxicity. Following characterisation, anticancer

• , and the dose and duration of treatment can be tailored to minimise toxicity. The use of nanocarriers for the delivery of anticancer therapeutics is a promising strategy for improving the efficacy of the drug while minimising its toxicity to healthy tissues. This approach has the potential to reduce

Calibration of piezo actuators and systems by dynamic interferometry

• Knarik Khachatryan and
• Michael Reichling

Beilstein J. Nanotechnol. 2025, 16, 2086–2091, doi:10.3762/bjnano.16.143

• long as the respective stabilization loop of interferometer alignment is active [16], this adjustment is maintained even in the presence of drift or piezo creep by the automatic adjustment of the voltage applied between the fiber tube piezo inner electrode and the common potential of the tube piezo

• thickness, respectively. According to the widely used convention, the piezo tube is poled so that a negative potential applied to the inner electrode Vz,f < 0 results in an extension ΔL > 0 that translates into a reduction of the cavity length Δd = derr = −ΔL < 0. From d31 and the geometry parameters of the

Multifrequency AFM integrating PeakForce tapping and higher eigenmodes for heterogeneous surface characterization

• Yanping Wei,
• Jiafeng Shen,
• Yirong Yao,
• Xuke Li,
• Ming Li and
• Peiling Ke

Beilstein J. Nanotechnol. 2025, 16, 2077–2085, doi:10.3762/bjnano.16.142

• montmorillonite (MMT) nanosheets, demonstrating its potential to improve material property contrast and characterization. Experimental Experimental setup Our experiments were conducted using a commercial AFM system (Bruker Dimension Icon) equipped with a cantilever holder that incorporates a piezoelectric

• potential sample damage, we re-imaged the scan areas after the multifrequency measurements. No discernible sample damage or topographic alterations were observed within the specific regions of interest (ROIs) used for contrast quantification after multifrequency testing (see Supporting Information File 1

Molecular and mechanical insights into gecko seta adhesion: multiscale simulations combining molecular dynamics and the finite element method

• Yash Jain,
• Saeed Norouzi,
• Tobias Materzok,
• Stanislav N. Gorb and
• Florian Müller-Plathe

Beilstein J. Nanotechnol. 2025, 16, 2055–2076, doi:10.3762/bjnano.16.141

• parametrization of our coarse-grained potential against united-atom simulations of gecko keratin on nonpolar surfaces [10]. Hydrophilic substrates, roughness, and humidity, which introduce additional mechanisms such as keratin softening and capillary forces, have been addressed in our previous spatula-scale

• ], and the parameter set that reproduced the target adhesion ( = 290 kJ/mol, σ = 4 nm, and rcutoff = 12 nm) was selected. The relatively large σ value reflects the coarse graining, and rcutoff = 3σ retains most of the attractive tail of the LJ potential. Any surface bead deeper than the cutoff (12 nm

• ) does not interact with the spatula beads; therefore, any substrate thicker than the spatula–substrate potential cutoff (rcutoff ≤ thickness ≤ ∞) would result in identical dynamics and forces. Our substrate (1 monolayer + 13 nm amorphous bulk) exceeds the cutoff, fully representing all interactions

Stereodiscrimination of guests in chiral organosilica aerogels studied by ESR spectroscopy

• Sebastian Polarz,
• Yasar Krysiak,
• Martin Wessig and
• Florian Kuhlmann

Beilstein J. Nanotechnol. 2025, 16, 2034–2054, doi:10.3762/bjnano.16.140

Beyond the shell: exploring polymer–lipid interfaces in core–shell nanofibers to carry hyaluronic acid and β-caryophyllene

• Aline Tavares da Silva Barreto,
• Francisco Alexandrino-Júnior,
• Bráulio Soares Arcanjo,
• Paulo Henrique de Souza Picciani and
• Kattya Gyselle de Holanda e Silva

Beilstein J. Nanotechnol. 2025, 16, 2015–2033, doi:10.3762/bjnano.16.139

• -sectional imaging, and attenuated total reflectance with Fourier transform infrared (ATR-FTIR) spectroscopy provided compelling evidence for the successful formation of the intended core–shell structure. The resulting nanofibers exhibited surface hydrophobicity, suggesting potential for anti-adhesive

• encapsulated within a PLA shell, highlighting substantial potential for biomedical applications by overcoming key material integration hurdles. Keywords: co-axial nanofibers; electrospinning; hybrid nanosystem; nanofibers; nanoemulsion; poly(lactic acid); Introduction Driven by the significant potential of

• various biomedical applications [28][29]. Complementing the regenerative and biocompatible profile of HA, β-caryophyllene (βCp) is another critical component of significant pharmaceutical potential. Among the array of attributes exhibited by βCp, it notably possesses potent analgesic, antioxidant

The cement of the tube-dwelling polychaete Sabellaria alveolata: a complex composite adhesive material

• Emilie Duthoo,
• Aurélie Lambert,
• Pierre Becker,
• Carla Pugliese,
• Jean-Marc Baele,
• Arnaud Delfairière,
• Matthew J. Harrington and
• Patrick Flammang

Beilstein J. Nanotechnol. 2025, 16, 1998–2014, doi:10.3762/bjnano.16.138

• several studies. However, some aspects of cement formation are still poorly understood and several differences have been pointed out between the two main model species. This study aims to investigate the adhesive system of Sabellaria alveolata by identifying new potential adhesive proteins, as well as

• , and other putative adhesive proteins (Pc-6 to Pc-26) have been reported [12][16]. By comparing all putative P. californica adhesive proteins with the transcriptome of the honeycomb worm, a potential Sa-5 and a new Sa-3 adhesive proteins were identified. However, no other homologues have been retrieved

Laser ablation in liquids for shape-tailored synthesis of nanomaterials: status and challenges

• Natalie Tarasenka

Beilstein J. Nanotechnol. 2025, 16, 1963–1997, doi:10.3762/bjnano.16.137

Evaluating metal-organic precursors for focused ion beam-induced deposition through solid-layer decomposition analysis

• Benedykt R. Jany,
• Katarzyna Madajska,
• Aleksandra Butrymowicz-Kubiak,
• Franciszek Krok and
• Iwona B. Szymańska

Beilstein J. Nanotechnol. 2025, 16, 1942–1951, doi:10.3762/bjnano.16.135

• irradiation differs from gas-phase deposition, we think that our method can be employed to optimize pre-screen and score new potential precursors for FIB applications by significantly reducing the time required and conserving valuable resources. Keywords: backscattered electrons (BSE); carboxylates; energy

• tested in FEBID processes. Preliminary studies of new or potential FEBID precursors employ electron ionization mass spectrometry and gas-phase cross-beam experiments (dissociative ionization and dissociative electron attachment), but more informative are investigations into the interactions of molecules

• complex with the same carboxylate and pentafluoropropamidine [Cu2(NH2(NH=)CC2F5)2(µ-O2CC2F5)4] [32], as new potential precursors for the applications in focus ion beam induced deposition (FIBID) using gallium ions. We focused on a commonly used 30 keV FIB ion beam energy in our systematic decomposition

PEGylated lipids in lipid nanoparticle delivery dynamics and therapeutic innovation

• Peiyang Gao

Beilstein J. Nanotechnol. 2025, 16, 1914–1930, doi:10.3762/bjnano.16.133

• chains arrange on the nanoparticle surface and the potential impacts on LNPs’ physicochemical properties by varying surface PEG density or PEG chemistry. Subsequently, PEG conformations are discussed in terms of their modulation of protein corona formation, cellular uptake, and immunogenic responses

• properties of LNPs including particle size, surface charge, and encapsulation efficiency. Subsequent sections explore the roles of PEG lipids in modulating protein corona formation and cellular uptake. The latter parts highlight the potential of functionalized PEG lipids for targeted delivery and the

• , functionalized PEG lipids can serve as anchors not only for targeting moieties but also for ligands to reduce immune clearance and extend blood circulation [40][42][47][49][55]. Although functionalized PEG lipids have great potential for LNP surface modifications, recent studies have emphasized the importance of

Targeting the vector of arboviruses Aedes aegypti with nanoemulsions based on essential oils: a review with focus on larvicidal and repellent properties

• Laryssa Ferreira do Nascimento Silva,
• Douglas Dourado,
• Thayse Silva Medeiros,
• Mariana Alice Gonzaga Gabú,
• Maria Cecilia Queiroga dos Santos,
• Daiane Rodrigues dos Santos,
• Mylena Lemos dos Santos,
• Gabriel Bezerra Faierstein,
• Rosângela Maria Rodrigues Barbosa and
• Fabio Rocha Formiga

Beilstein J. Nanotechnol. 2025, 16, 1894–1913, doi:10.3762/bjnano.16.132

• release, and protection against degradation. Nanoemulsions are colloidal systems with droplets of 20 to 500 nm, which improve the dispersion of the compounds, protect their active properties, and enhance their efficacy. This review addresses the potential of nanoemulsions as efficient carriers of EOs, and

• review focuses on mapping nanoemulsions based on essential oils and their potential as an innovative strategy for controlling Aedes aegypti and consequently related arboviruses. Review Aedes aegypti: General aspects and control strategies Insects are important vectors in the transmission of bacteria and

• bites and, consequently, the transmission of diseases [10][24]. Despite the potential of essential oils, their use in vector control faces several limitations. The high volatility of the active compounds can reduce long-term efficacy, requiring frequent reapplications. In addition, the low polarity of

Programmable soliton dynamics in all-Josephson-junction logic cells and networks

• Vsevolod I. Ruzhickiy,
• Anastasia A. Maksimovskaya,
• Sergey V. Bakurskiy,
• Andrey E. Schegolev,
• Maxim V. Tereshonok,
• Mikhail Yu. Kupriyanov,
• Nikolay V. Klenov and
• Igor I. Soloviev

Beilstein J. Nanotechnol. 2025, 16, 1883–1893, doi:10.3762/bjnano.16.131

• ; superconducting neural networks; Introduction The rapid advancement of Josephson junction (JJ) logic circuits [1][2][3][4][5] and neuromorphic networks [6][7][8][9] holds transformative potential for ultra-low-power computing. However, achieving scalable integration remains a critical bottleneck, as conventional

• to its initial physical state. The behavior of the KICK in the T-Mode, which enables its use as a T-flip-flop, is detailed in Figure 2d. This mode is defined by the existence of two distinct stable states, physically corresponding to a bistable potential landscape created by the KICK architecture

• soliton’s energy is large enough to overcome any potential barrier presented by the KICK, ensuring transmission regardless of the inductance value. This results in a universal Open mode at high rates. Crucially, this high-energy passage is not inert; if the KICK is in a bistable regime (such as the T-Mode

Low-temperature AFM with a microwave cavity optomechanical transducer

• Ermes Scarano,
• Elisabet K. Arvidsson,
• August K. Roos,
• Erik Holmgren,
• Riccardo Borgani,
• Mats O. Tholén and
• David B. Haviland

Beilstein J. Nanotechnol. 2025, 16, 1873–1882, doi:10.3762/bjnano.16.130

• force-sensor design is a significant improvement over piezoelectric force sensors commonly used in low-temperature AFM. We discuss the potential for further improvement of the sensor design to achieve optimal detection at the standard quantum limit. We demonstrate AFM operation with surface-tracking

Self-assembly and adhesive properties of Pollicipes pollicipes barnacle cement protein cp19k: influence of pH and ionic strength

• Shrutika Sawant,
• Anne Marie Power and
• J. Gerard Wall

Beilstein J. Nanotechnol. 2025, 16, 1863–1872, doi:10.3762/bjnano.16.129

• potential to form amyloid-like fibrillar aggregates, a structural motif increasingly implicated in barnacle adhesion [33][34]. Amyloid fibres are characterised by their β-sheet-rich architecture and have been linked to increased cohesive strength and durability in marine adhesives [35][36]. In the present

On the road to sustainability – application of metallic nanoparticles obtained by green synthesis in dentistry: a scoping review

• Lorena Pinheiro Vasconcelos Silva,
• Joice Catiane Soares Martins,
• Israel Luís Carvalho Diniz,
• Júlio Abreu Miranda,
• Danilo Rodrigues de Souza,
• Éverton do Nascimento Alencar,
• Moan Jéfter Fernandes Costa and
• Pedro Henrique Sette-de-Souza

Beilstein J. Nanotechnol. 2025, 16, 1851–1862, doi:10.3762/bjnano.16.128

• , particularly in dentistry. This scoping review examines the rising focus on these nanoparticles regarding their antimicrobial, regenerative, and therapeutic potential in dental applications. Among the metals studied, silver and zinc oxide nanoparticles dominate because of their broad-spectrum antimicrobial

• content. Despite promising results, gaps remain, such as the predominance of in vitro studies (68.7%) and insufficient cytotoxicity assessments (47.8%), underscoring the need for translational research. This review highlights the transformative potential of green-synthesized nanoparticles in dentistry

• properties that enhance their versatility across multiple applications [23][24][25]. Biosynthesized AgNPs have been assessed regarding their antimicrobial, antioxidant, and anticancer effects, as well as for their therapeutic potential in treating dermatitis and other conditions [26]. Studies have

Current status of using adsorbent nanomaterials for removing microplastics from water supply systems: a mini review

• Nguyen Thi Nhan and
• Tran Le Luu

Beilstein J. Nanotechnol. 2025, 16, 1837–1850, doi:10.3762/bjnano.16.127

• sustainable strategies to deal with this matter. Many studies have shown that adsorbent nanomaterials have potential for the removal of MPs from water. This review evaluates the current status of using adsorbent nanomaterials in removing MPs from water supply systems. It discusses the occurrences and removal

• can recovery. Their effectiveness depends on material properties and environmental factors, but challenges remain in scale-up and related risks. Adsorbent nanomaterials show promising potential to enhance MP removal through specific properties. Although some related risks are discussed, these

• daily life, and the potential application of adsorbent nanomaterials for MP removal. Sajid et al. provided an overview of various adsorbent materials and their efficiency [24]. However, the authors do not deeply explore the potential challenges related to large-scale applications or the integration of

Phytol-loaded soybean oil nanoemulsion as a promising alternative against Leishmania amazonensis

• Victória Louise Pinto Freire,
• Mariana Farias Alves-Silva,
• Johny W. de Freitas Oliveira,
• Matheus de Freitas Fernandes-Pedrosa,
• Alianda Maira Cornélio,
• Marcelo de Souza-Silva,
• Thayse Silva Medeiros and
• Arnóbio Antônio da Silva Junior

Beilstein J. Nanotechnol. 2025, 16, 1826–1836, doi:10.3762/bjnano.16.126

• least 30 days of storage and at least 15 days even under stress conditions, with no signs of macroscopic instability or changes in droplet size. The cytocompatibility of NEs was confirmed in 3T3 fibroblasts at the concentrations tested, indicating potential safety for in vivo trials. Notably, PHYT-NE

• promastigotes represents a limitation, this model was used as a proof-of-concept, with promising evidence of the potential of PHYT-NE. Future studies in macrophage models infected with intracellular amastigotes will be essential to confirm the observed efficacy and validate the potential of PHYT-NE as a safe

• potential. For example, da Silva and colleagues (2015) [17] showed that a phytol-rich fraction extracted from Lacistema pubescens exhibited potent activity against Leishmania amazonensis promastigotes and intracellular amastigotes. However, the high lipophilicity of the phytol significantly limits its