Biomimetic nanoparticles in cancer photodynamic therapy: a review of targeted delivery systems and therapeutic outcomes

• Valentina I. Gorbacheva,
• Alexey S. Grabovoy,
• Polina S. Marukhina,
• Anastasiia O. Syrocheva and
• Ekaterina P. Kolesova

Beilstein J. Nanotechnol. 2026, 17, 396–422, doi:10.3762/bjnano.17.27

• ][167][168][169] within the hypoxic microenvironment, (iii) reduction of oxygen consumption by tumor cells [170][171][172], and (iv) suppression of hypoxia-inducible factor 1 (HIF-1) activity in the tumor [173][174]. Typically, these nanoparticles consist of a functional core, perfluorocarbons (PFCs

• with perfluorotributylamine (PFTBA) as an oxygen carrier. The nanoparticles were further coated with a 4T1 CCM to enable targeting. Direct oxygen delivery to the tumor via PFTBA resulted in a significant reduction of hypoxia, and immunofluorescence staining revealed a tenfold decrease in hypoxic

• in tumor tissue, whereas non-coated particles also distributed to the liver and kidneys. Fourteen days post-treatment, a threefold reduction in tumor volume was observed [177]. An alternative strategy has also been described, wherein the photosensitizer ICG is encapsulated within a zirconium-based

Eco-efficient materials for agricultural crops based on a mineral rich in MOR- and HEU-type zeolites

• Esperanza Yamile de la Nuez-Pantoja,
• Inocente Rodríguez-Iznaga,
• Gerardo Rodríguez-Fuentes,
• Vitalii Petranovskii,
• Ariel Martínez García,
• José Juan Calvino Gámez and
• Daniel Goma Jiménez

Beilstein J. Nanotechnol. 2026, 17, 381–395, doi:10.3762/bjnano.17.26

• urea to obtain modified materials leads to a decrease in the value of these surface parameters. This is a result of the presence of nitrogen and phosphorus species adsorbed and occluded on the surface of these materials, as previously shown. This double treatment can be translated into a reduction in

Interconnection morphology effects on the radio frequency response of carbon nanotube sponges

• Manuela Scarselli,
• Javad Rezvani,
• Zeno Zuccari,
• Mattia Scagliotti and
• Simone Tocci

Beilstein J. Nanotechnol. 2026, 17, 343–351, doi:10.3762/bjnano.17.23

• the G band at 1587 ± 2 cm−1. We did not observe any appreciable shift of these two components in the treated sample. By comparing the outcome of the fit procedure, we estimated from the area of the two peaks a reduction of the D band after the ethanol treatment of 20% ± 1% and a corresponding increase

Beam shaping techniques for pulsed laser ablation in liquids: Unlocking tunable control of nanoparticle synthesis in liquids

• Sergio Molina-Prados,
• Nadezhda M. Bulgakova,
• Alexander V. Bulgakov,
• Jesus Lancis,
• Gladys Mínguez Vega and
• Carlos Doñate-Buendia

Beilstein J. Nanotechnol. 2026, 17, 309–342, doi:10.3762/bjnano.17.22

• presence of terbium NPs. When the fluence increases from 60 to 140 J·cm−2, the radical yield with oxidised NPs rises by over an order of magnitude [114][115]. Moreover, according to Davletshin et al., plasmonic coupling in aqueous Au nanospheres leads to enhanced local fields. This leads to a reduction via

• modification through confinement, plasma–liquid interactions, and cavitation bubbles. Dittrich et al. found that the ablation threshold for Au in air is ca. 1.9 times higher than in water [136], and Sun et al. reported a reduction from 2.22 J·cm−2 (air) to 1.02 J·cm−2 (liquid-assisted) [137]. Therefore, the

• size and shape uniformity, although further studies are needed to elucidate the mechanisms involved. In addition to PLAL, related approaches such as laser fragmentation in liquids (LFL) can also be employed, in which preformed colloidal NPs are irradiated to induce size reduction or reshaping. Zheng et

Fast vortex dynamics and relaxation times in NbRe-based heterostructures

• Francesco De Chiara,
• Zahra Makhdoumi Kakhaki,
• Francesco Avitabile,
• Francesco Colangelo,
• Abhishek Kumar,
• Carmine Attanasio and
• Carla Cirillo

Beilstein J. Nanotechnol. 2026, 17, 292–302, doi:10.3762/bjnano.17.20

• ]. The enhancement of vortex dynamics and the reduction of τE are strongly linked to the optimization of quasiparticle relaxation mechanisms. Excited quasiparticles can relax primarily through two processes, namely thermal electron–phonon (e–ph) interaction and electron–electron (e–e) recombination [1

• superconducting correlations are induced. In particular, Ryan and Chandrasekhar [26] have shown that a thin disordered normal layer enhances the inelastic scattering rate, leading to a significant reduction of the effective relaxation time without degrading superconductivity. This finding supports the idea that

• characterization The normalized resistive transitions, R/R10K, of the two microbridges are reported in Figure 1a. The critical temperatures are = 6.8 K and = 5.6 K. The obtained values are smaller than those reported for NbRe thin films of similar thickness [19][22], with a stronger reduction observed in the

Advancing nanolithography: a comprehensive review of materials for local anodic oxidation with AFM

• Matteo Lorenzoni

Beilstein J. Nanotechnol. 2026, 17, 275–291, doi:10.3762/bjnano.17.19

• conductivity and mobility. Reversing the bias in a standard LAO setup enables the restoration of conductivity in GO layers or flakes through a localized reduction reaction [87][103] or a localized catalytic reaction [104]. In Figure 5a,b, we show a conductive AFM image of a single restored rGO feature [87

• ] obtained after local reduction by SPL, with a lateral size below 100 nm. Even better results on GO, in terms of lateral resolution, have been achieved by thermochemical nanolithography [105]. The electrical properties of rGO patterns obtained in both ways (electrochemically and thermochemically) are

Gold nanoparticle-decorated reduced graphene oxide as a highly effective catalyst for the selective α,β-dehydrogenation of N-alkyl-4-piperidones

• Brenda Flore Kenyim,
• Mihir Tzalis,
• Marilyn Kaul,
• Robert Oestreich,
• Aysenur Limon,
• Chancellin Pecheu Nkepdep and
• Christoph Janiak

Beilstein J. Nanotechnol. 2026, 17, 218–238, doi:10.3762/bjnano.17.15

• environments, their tunable surface area and surface chemistry, and electrical conductivity [18][19]. To deposit metal NPs onto a carbon support, procedures such as adsorption or reduction–deposition (RD), co-precipitation, impregnation, and deposition precipitation (DP) are commonly employed [6][19]. Carbon

• then deposited onto the carbon material. The synthesis of the Au@SiW9/carbon composites was done by the DP method as shown in Figure 1c. The POM salt (SiW9), the gold precursor (KAuCl4), and the carbon material were combined in a solution–dispersion, and the reduction was induced with NaBH4. Synthesis

• ) in the solution, and allowing POM salt and gold precursor to adsorb onto the carbon surface or in the pores; then, the reduction with NaBH4 is induced to form Au@SiW9/AC, Au@SiW9/rGO, Au@SiW9/CB. Unlike the RD method, where the reduction of the tetrachloridoaurate(III) ions to metallic gold occurs in

Safe and sustainable by design with ML/AI: A transformative approach to advancing nanotechnology

• Georgia Melagraki

Beilstein J. Nanotechnol. 2026, 17, 176–185, doi:10.3762/bjnano.17.11

• failures, and aligns with the 3Rs principle (Replacement, Reduction and Refinement), favouring in silico and in vitro approaches over animal testing. The emergence of deep learning techniques, including convolutional neural networks (CNNs) and recurrent neural networks (RNNs), has further heightened the

From shield to spear: Charge-reversible nanocarriers in overcoming cancer therapy barriers

• Madhuri Yeduvaka,
• Pooja Mittal,
• Ameer Boyalakuntla,
• Usman Bee Shaik,
• Himanshu Sharma,
• Thakur Gurjeet Singh,
• Siva Nageswara Rao Gajula and
• Lakshmi Vineela Nalla

Beilstein J. Nanotechnol. 2026, 17, 159–175, doi:10.3762/bjnano.17.10

• tumours, undergoing enzymatic cleavage of peptide bonds which causes nanocarrier destabilization, charge reversal, and size reduction. These transformations triggered drug release within the tumour tissue and improved nuclear targeting, optimizing therapeutic efficacy [50]. Thereafter, a study by Lin et

• al. developed MMP-2-responsive PEG-coated nanocarriers that, upon peptide cleavage, underwent PEG detachment, charge reversal, and size reduction, enhancing cellular uptake and tumour-specific drug release. This system effectively inhibited tumour growth with minimal systemic toxicity in mice [51

• normal cells [69]. Wang et al. developed a pH/hypoxia synergistic nanocarrier technology, which, with the aid of azo and sulfamide-based zwitterions, achieved targeted medication release and deep tumour penetration [70]. Miao et al. designed a pH/reduction-sensitive, charge-reversal PMAABACy/CS/CS-DMMA

Influence of surface characteristics on the in vitro stability and cell uptake of nanoliposomes for brain delivery

• Dushko Shalabalija,
• Ljubica Mihailova,
• Nikola Geskovski,
• Andreas Zimmer,
• Otmar Geiss,
• Sabrina Gioria,
• Diletta Scaccabarozzi and
• Marija Glavas Dodov

Beilstein J. Nanotechnol. 2026, 17, 139–158, doi:10.3762/bjnano.17.9

• to less efficient binding with protein targets that would work as ligands for receptor-mediated transport and delivery, finally resulting in partial inhibition and reduction of cellular uptake ([24]). Taken into consideration all aforementioned, it can be summarized that cellular transport and

Capabilities of the 3D-MLSI software tool in superconducting neuron design

• Irina E. Tarasova,
• Nikita S. Shuravin,
• Liubov N. Karelina,
• Fedor A. Razorenov,
• Evgeny N. Zhardetsky,
• Aleksandr S. Ionin,
• Mikhail M. Khapaev and
• Vitaly V. Bol’ginov

Beilstein J. Nanotechnol. 2026, 17, 122–138, doi:10.3762/bjnano.17.8

• dielectric layers are planarized, as is done, for example, in the process described in [6]. One more important feature of the program is non-uniform meshing related to the Triangle meshing engine [52]. It allows for a reduction of allocated memory and solution time, and provides better accuracy as well

Development and in vitro evaluation of liposomes and immunoliposomes containing 5-fluorouracil and R-phycoerythrin as a potential phototheranostic system for colorectal cancer

• Raissa Rodrigues Camelo,
• Vivianne Cortez Sombra Vandesmet,
• Octavio Vital Baccallini,
• José de Brito Vieira Neto,
• Thais da Silva Moreira,
• Luzia Kalyne Almeida Moreira Leal,
• Claudia Pessoa,
• Daniel Giuliano Cerri,
• Maria Vitória Lopes Badra Bentley,
• Josimar O. Eloy,
• Ivanildo José da Silva Júnior and
• Raquel Petrilli

Beilstein J. Nanotechnol. 2026, 17, 97–121, doi:10.3762/bjnano.17.7

• CCR cell line, the IC50 values for immunoliposomes were higher than those for liposomes. Also, for phototoxicity experiments it was found a reduction in IC50 for all groups tested. The internalization of R-PE was verified, highlighting a greater internalization in the immunoliposome within 24 h. Thus

• potential application in cancer treatment, ranging from in vitro cell programmed death induction in the liver, lung, and gastric cancer cells [12] to in vivo reduction in nodule number and liver weight in rats [13]. In addition, R-PE also has a photosensitizing role that can be explored in photodynamic

• slight reduction in vesicle size compared to previous reports can be possibly due to the presence of DSPE–PEG [34]. The incorporation of hydrophilic molecules into liposomal formulations does not necessarily result in an increase in vesicle size [42]. For instance, liposomes composed of HSPC 50 and

Functional surface engineering for cultural heritage protection: the role of superhydrophobic and superoleophobic coatings – a comprehensive review

• Giuseppe Cesare Lama,
• Marino Lavorgna,
• Letizia Verdolotti,
• Federica Recupido,
• Giovanna Giuliana Buonocore and
• Bharat Bhushan

Beilstein J. Nanotechnol. 2026, 17, 63–96, doi:10.3762/bjnano.17.6

• . However, since the bulk-modified samples exhibited a more compact microstructure, mechanical tests resulted in an increased compressive strength for these samples, suggesting stronger structural reinforcement, an improved heat resistance, and a reduction in open pores and surface area, contributing to

Subdigital integumentary microstructure in Cyrtodactylus (Squamata: Gekkota): do those lineages with incipiently expressed toepads exclusively exhibit adhesive setae?

• Philipp Ginal,
• Yannick Ecker,
• Timothy Higham,
• L. Lee Grismer,
• Benjamin Wipfler,
• Dennis Rödder,
• Anthony Russell and
• Jendrian Riedel

Beilstein J. Nanotechnol. 2026, 17, 38–56, doi:10.3762/bjnano.17.4

• species showing secondary reduction of setae in the seta-group (C. pharbaungensis and C. zebraicus), which show no increase or secondary reduction in these measurements. The seta-bearing intertidal species, C. seribuatensis, did not exhibit a reduction of these traits. Only the terrestrial C

• . brevidactylus Bauer, 2002 [66], the karst species C. chrysopylos Bauer, 2003 [67] (both sharing the prong microstructure type with the khasiensis group of which they are a part), and the terrestrial, spine-bearing C. jeyporensis (triedrus group) did not show a reduction or an increase (C. brevidactylus for

• evolved setae independently from all other species, is isolated in its morphospace, having the lowest value on PC1 for seta-bearing species (Figure 4B). Furthermore, one secondary reduction from setae back to spines (C. zebraicus) and prongs (C. pharbaungensis) is indicated. The PMS analysis shows that

Reduced graphene oxide paper electrode for lithium-ion cells – towards optimized thermal reduction

• Agata Pawłowska,
• Magdalena Baran,
• Stefan Marynowicz,
• Aleksandra Izabela Banasiak,
• Adrian Racki,
• Adrian Chlanda,
• Tymoteusz Ciuk,
• Marta Wolczko and
• Andrzej Budziak

Beilstein J. Nanotechnol. 2026, 17, 24–37, doi:10.3762/bjnano.17.3

• electrode material in lithium-ion cells. Mildly reduced graphene oxide paper underwent further thermal reduction steps. The structural and chemical properties of the obtained materials were determined using Raman and Fourier-transform infrared spectroscopies and elemental combustion analysis. The morphology

• . Keywords: electrode material; graphene paper; lithium-ion batteries; reduced graphene oxide; thermal reduction; Introduction Electrode materials comprising reduced graphene oxide (rGO) for energy storage in lithium-ion-based or sodium-ion-based technologies have been the subject of over 3800 publications

• with the oxygen in the ketone groups and the electrons from the external circuit, creating Li-terminated chains. From a practical point of view, it is crucial to ensure an increased number of ketone groups by optimizing the reduction process of graphene oxide. Acik et al. presented a detailed

Quantitative estimation of nanoparticle/substrate adhesion by atomic force microscopy

• Aydan Çiçek,
• Markus Kratzer,
• Christian Teichert and
• Christian Mitterer

Beilstein J. Nanotechnol. 2026, 17, 1–14, doi:10.3762/bjnano.17.1

• displaced, vanishing from one scan line to the other. The corresponding 3D image in Figure 2e indicates a change in the NP’s position relative to the substrate. The reduction in height from 7 to 5 nm is interpreted as the initial stage of NP displacement, where the particle starts moving before the tip has

• partial penetration, removal, or reduction cannot be excluded. We did not detect changes in the roughness between pristine and plasma-treated surfaces (RMS < 0.2 nm at 5 × 5 µm area) that would contribute to a change in friction. Interfacial redox reactions between the copper NP and the wafer surface

Improving magnetic properties of Mn- and Zn-doped core–shell iron oxide nanoparticles by tuning their size

• Dounia Louaguef,
• Ghouti Medjahdi,
• Sébastien Diliberto,
• Klaus M. Seemann,
• Thomas Gries,
• Joelle Bizeau,
• Damien Mertz,
• Eric Gaffet and
• Halima Alem

Beilstein J. Nanotechnol. 2025, 16, 2285–2295, doi:10.3762/bjnano.16.157

• ± 1.7, and 45.0 ± 1.2 nm exhibited Ms values of 0.012, 0.031, 0.12, and 7 A·m2·kg−1, respectively (Table 3). Similar trends have been reported in the literature, where larger particle sizes lead to higher Ms values due to the reduction of surface spin canting and the improved alignment of magnetic

Geometry-controlled engineering of the low-temperature proximity effect in normal metal–superconductor junctions

• Munisa A. Tomayeva,
• Vyacheslav D. Neverov,
• Andrey V. Krasavin,
• Alexei Vagov and
• Mihail D. Croitoru

Beilstein J. Nanotechnol. 2025, 16, 2265–2273, doi:10.3762/bjnano.16.155

• time, the coupling between these confined modes on the NM side and the continuum modes on the SC side weakens because of increasing momentum mismatch, which suppresses the transmission probability of the channels through the interface. Together, the reduction in channel number and the suppressed

Chiral plasmonic nanostructures fabricated with circularly polarized light

• Tian Qiao and
• Ming Lee Tang

Beilstein J. Nanotechnol. 2025, 16, 2245–2264, doi:10.3762/bjnano.16.154

• ][101][102]. When the localized surface plasmon resonance of metal seeds is excited, hot electrons reduce Ag+ or from solution and deposit metallic Ag and Au. However, various studies in the past two decades on the plasmon-mediated reduction of Ag(I) and Au(III) have demonstrated a weak dependence of

• distribution of PVP. Ag(I) and Au(III) reduction potentials suggest their reduction is relatively not energetically demanding. (AgCl/Ag: 0.80 V vs SHE and /Au: 0.99 V vs SHE) [101]. As discussed in Section 2.1, these reactions can be triggered by warm electrons far from the hot spots. Indeed, [101] inferred

• that the sites of Au deposition ( reduction) are the locations of electrons from the nanoparticle transferred via PVP. Researchers made similar observations when electron beam lithography resist was exposed to hot electrons from AuNRs [86]. This study found hydrogen silsesquioxane underwent water

Optical bio/chemical sensors for vitamin B₁₂ analysis in food and pharmaceuticals: state of the art, challenges, and future outlooks

• Seyed Mohammad Taghi Gharibzahedi and
• Zeynep Altintas

Beilstein J. Nanotechnol. 2025, 16, 2207–2244, doi:10.3762/bjnano.16.153

• ), and fatigue reduction [2][36]. VB12 deficiency represents a significant global public health concern, impacting approx. 6% of the global population and 1.6% to 10% of European communities [37]. The different demographic data showed that the most vulnerable groups to VB12 deficiency comprise geriatric

Electromagnetic study of a split-ring resonator metamaterial with cold-electron bolometers

• Ekaterina A. Matrozova,
• Alexander V. Chiginev,
• Leonid S. Revin and
• Andrey L. Pankratov

Beilstein J. Nanotechnol. 2025, 16, 2199–2206, doi:10.3762/bjnano.16.152

• bandwidth. The trade-off between the bandwidth expansion due to miniaturization and the reduction in absorption efficiency determined by the Airy spot size of the coupling lens is investigated. To solve this issue, a simultaneous miniaturization of the size of the entire structure with an increase in the

• transition from a single-ring antenna to a double split-ring resonator design, while keeping the number of elements constant, resulted in a significant improvement in performance. The addition of the inner ring, which increases the total capacitance of the resonant element, leads to a slight reduction of the

• are governed by the requirement to fill the Airy spot of the silicon lens. If the total array size is smaller than the Airy spot, a portion of the incident signal will not interact with the metamaterial, instead scattering into the surrounding space. Our simulations confirm this principle: A reduction

Ultrathin water layers on mannosylated gold nanoparticles

• Maiara A. Iriarte Alonso,
• Jorge H. Melillo,
• Silvina Cerveny,
• Yujin Tong and
• Alexander M. Bittner

Beilstein J. Nanotechnol. 2025, 16, 2183–2198, doi:10.3762/bjnano.16.151

• on the selected single particles (Figure 7, see also related scans in Supporting Information File 1, Figure S4). The particle height of 16.7 ± 1.6 nm increases by 0.3 nm under medium and by 1.6 nm under high humidity. The PEG AuNPs of 13.3 ± 1.0 nm show an apparent slight reduction by 0.3 nm, but

• organic content). Synthesis of gold nanoparticles Gold nanoparticles were synthesized by the Bio Nano Plasmonics Lab at CIC biomaGUNE according to [10]. Both PEG AuNPs and dimanno-AuNPs were obtained by reduction of AuCl4− with BH4− in the presence of the corresponding thiol ligands. For the PEG AuNPs, a

Hartree–Fock interaction in superconducting condensate fractals

• Edward G. Nikonov,
• Yajiang Chen,
• Mauro M. Doria and
• Arkady A. Shanenko

Beilstein J. Nanotechnol. 2025, 16, 2177–2182, doi:10.3762/bjnano.16.150

• the system’s quasiperiodicity, reflecting a general feature of superconducting quasicrystals. The enhancement of these oscillations leads to a reduction of the critical temperature, which can be pronounced depending on the model’s microscopic parameters. We also find that the critical exponent β of

Microplastic pollution in Himalayan lakes: assessment, risks, and sustainable remediation strategies

• Sameeksha Rawat,
• S. M. Tauseef and
• Madhuben Sharma

Beilstein J. Nanotechnol. 2025, 16, 2144–2167, doi:10.3762/bjnano.16.148

• been compared with rivers in temperate zones, where improved waste management systems cause a reduction in MP accumulation. According to Bhaduri et al., this disparity reflects how essential cooperating waste management policies and plans are in the Himalayas to prevent MP pollution [25]. Matta et al

• Treaty with an aim to constitute legally binding plastic reduction instruments along with MP reduction. Consequently, the European Union (EU) also deliberately limited incorporated MPs in the EU Microplastic Restriction Proposal of the REACH regulation of cosmetics, cleaning products, and agricultural

Quality by design optimization of microemulsions for topical delivery of Passiflora setacea seed oil

• Daniel T. Pereira,
• Douglas Dourado,
• Danielle T. Freire,
• Dayanne L. Porto,
• Cícero F. S. Aragão,
• Myla L. de Souza,
• Guilherme R. S. de Araujo,
• Ana Maria Costa,
• Wógenes N. Oliveira,
• Anne Sapin-Minet,
• Éverton N. Alencar and
• Eryvaldo Sócrates T. Egito

Beilstein J. Nanotechnol. 2025, 16, 2116–2131, doi:10.3762/bjnano.16.146

• difference (p < 0.05) in pH compared with earlier time points. Although the reduction was modest, from pH 6.4 ± 0.1 to 5.9 ± 0.3, it is hypothesized to result from a combination of physicochemical and microbiological factors [42]. One possible explanation involves the oxidative or hydrolytic degradation of