Ultrathin water layers on mannosylated gold nanoparticles

• Maiara A. Iriarte Alonso,
• Jorge H. Melillo,
• Silvina Cerveny,
• Yujin Tong and
• Alexander M. Bittner

Beilstein J. Nanotechnol. 2025, 16, 2183–2198, doi:10.3762/bjnano.16.151

• , while size and morphology under completely dry conditions were measured by electron microscopy. DLS yields a hydrodynamic diameter of the PEG AuNPs of 67.7 ± 9.4 nm and a polydispersity index (PDI) of 0.35. However, the size distribution (Figure 2) reaches a maximum at 41.1 ± 4.2 nm. In contrast, the

• concentration of carboxylate) exhibit a lower ZP (approx. −45 mV) at the same pH [1]. To obtain a clearer view of the size distribution, we used SEM to evaluate particle sizes and morphologies in high vacuum (i.e., for completely dried samples). By adjusting a Gaussian fit to the histograms (Figure 3), the

Quality by design optimization of microemulsions for topical delivery of Passiflora setacea seed oil

• Daniel T. Pereira,
• Douglas Dourado,
• Danielle T. Freire,
• Dayanne L. Porto,
• Cícero F. S. Aragão,
• Myla L. de Souza,
• Guilherme R. S. de Araujo,
• Ana Maria Costa,
• Wógenes N. Oliveira,
• Anne Sapin-Minet,
• Éverton N. Alencar and
• Eryvaldo Sócrates T. Egito

Beilstein J. Nanotechnol. 2025, 16, 2116–2131, doi:10.3762/bjnano.16.146

• accurately reflect the true droplet size distribution in the MEgel. This phenomenon is evident from the apparent increase in mean hydrodynamic diameter to 45.1 nm and PdI to 0.27, which is attributed to NaCMC matrix scattering rather than actual droplet growth [40]. A comparison of the hydrodynamic diameter

Rapid synthesis of highly monodisperse AgSbS₂ nanocrystals: unveiling multifaceted activities in cancer therapy, antibacterial strategies, and antioxidant defense

• Funda Ulusu,
• Adem Sarilmaz,
• Yakup Ulusu,
• Faruk Ozel and
• Mahmut Kus

Beilstein J. Nanotechnol. 2025, 16, 2105–2115, doi:10.3762/bjnano.16.145

• , indicating robust crystallization. Moreover, the presence of prominent peaks aligning with (220), (311), (420), and (511) planes confirmed alignment with XRD results. Furthermore, utilizing particle size distribution analysis, the crystallite size of average particles was estimated, as illustrated in the

• inset in Figure 2c. The particle size distribution graphs in this image unequivocally affirmed the successful attainment of the desired homogeneity. Biological applications Antibacterial activity of AgSbS2 NCs Disc diffusion. The antimicrobial activity of AgSbS2 NCs at a concentration of 10 mg/mL

Stereodiscrimination of guests in chiral organosilica aerogels studied by ESR spectroscopy

• Sebastian Polarz,
• Yasar Krysiak,
• Martin Wessig and
• Florian Kuhlmann

Beilstein J. Nanotechnol. 2025, 16, 2034–2054, doi:10.3762/bjnano.16.140

Laser ablation in liquids for shape-tailored synthesis of nanomaterials: status and challenges

• Natalie Tarasenka

Beilstein J. Nanotechnol. 2025, 16, 1963–1997, doi:10.3762/bjnano.16.137

• of NP size and size distribution. As a result, the crucial experimental parameters were determined providing strategies to reduce the formation of large NPs and to produce monodisperse small nanocrystals [1][5]. However, the goal of controlled nanomaterials synthesis by PLAL is still not completely

PEGylated lipids in lipid nanoparticle delivery dynamics and therapeutic innovation

• Peiyang Gao

Beilstein J. Nanotechnol. 2025, 16, 1914–1930, doi:10.3762/bjnano.16.133

• particle size decreasing from 173.9 nm at 1 mol % to 109.1 nm at 5 mol %. Meanwhile, the PDI increased modestly from 0.060 to 0.146 with the increase of PEG density from 1 to 5 mol %, indicating a slight broadening in size distribution and less LNP homogeneity at higher PEG levels. The surface charge on

• ]. Some PEG lipids exhibit sensitivity in encapsulation efficiency at higher PEG molar fraction, while others can maintain stable payload encapsulation regardless of PEG density. Likewise, changes in size distribution and surface charge can be modest or pronounced depending on the specific PEG lipid

Targeting the vector of arboviruses Aedes aegypti with nanoemulsions based on essential oils: a review with focus on larvicidal and repellent properties

• Laryssa Ferreira do Nascimento Silva,
• Douglas Dourado,
• Thayse Silva Medeiros,
• Mariana Alice Gonzaga Gabú,
• Maria Cecilia Queiroga dos Santos,
• Daiane Rodrigues dos Santos,
• Mylena Lemos dos Santos,
• Gabriel Bezerra Faierstein,
• Rosângela Maria Rodrigues Barbosa and
• Fabio Rocha Formiga

Beilstein J. Nanotechnol. 2025, 16, 1894–1913, doi:10.3762/bjnano.16.132

Phytol-loaded soybean oil nanoemulsion as a promising alternative against Leishmania amazonensis

• Victória Louise Pinto Freire,
• Mariana Farias Alves-Silva,
• Johny W. de Freitas Oliveira,
• Matheus de Freitas Fernandes-Pedrosa,
• Alianda Maira Cornélio,
• Marcelo de Souza-Silva,
• Thayse Silva Medeiros and
• Arnóbio Antônio da Silva Junior

Beilstein J. Nanotechnol. 2025, 16, 1826–1836, doi:10.3762/bjnano.16.126

• shown in the size distribution graph (Figure 1b). Moreover, the zeta potential (ZP) of both samples was around −20 mV, with no significant changes upon phytol loading. To evaluate the shape and morphological characteristics of the nanoemulsions, transmission electron microscopy (TEM) analysis was

• performed. The results revealed nanodroplets with spherical and oval shapes and a homogeneous size distribution, with diameters up to 250 nm, consistent with the dynamic light scattering (DLS) data (Figure 1c,d). Colloidal and physicochemical stability The colloidal and physicochemical stability of the NEs

• considered statistically significant for p < 0.05. Schematic illustration of PHYT-NE preparation: (a) size distribution of nanodroplets (b) and morphological aspects of blank-NE (c) and PHYT-NE (d). Figure 1a) is adapted from Servier Medical Art (https://smart.servier.com/), licensed under CC BY 4.0 (https

Multifunctional anionic nanoemulsion with linseed oil and lecithin: a preliminary approach for dry eye disease

• Niédja Fittipaldi Vasconcelos,
• Almerinda Agrelli,
• Rayane Cristine Santos da Silva,
• Carina Lucena Mendes-Marques,
• Isabel Renata de Souza Arruda,
• Priscilla Stela Santana de Oliveira,
• Mércia Liane de Oliveira and
• Giovanna Machado

Beilstein J. Nanotechnol. 2025, 16, 1711–1733, doi:10.3762/bjnano.16.120

• resulting formulations, including their thermodynamic stability, size distribution, and optical clarity [47][48]. The packing parameter concept (PPC) provides a theoretical framework for predicting the geometry of amphiphilic systems, based on the ratio of the surfactant molecule’s total volume, the area of

Prospects of nanotechnology and natural products for cancer and immunotherapy

• Jan Filipe Andrade Santos,
• Marcela Bernardes Brasileiro,
• Pamela Danielle Cavalcante Barreto,
• Ligiane Aranha Rocha and
• José Adão Carvalho Nascimento Júnior

Beilstein J. Nanotechnol. 2025, 16, 1644–1667, doi:10.3762/bjnano.16.116

• inhibition of cancer cell migration, invasion, and metastasis [122][123]. The patent characterizes the NPs through DLS and TEM, confirming a uniform size distribution. Additionally, in vitro studies using MCF-7 breast cancer cells demonstrated inhibition of cell proliferation, with the NP inducing apoptosis

• nanoparticles demonstrated stability, spherical shape, and homogeneous size distribution. The use of nanoparticles with sterol compounds associated with Ce6 yielded higher tumor inhibition rates compared to the isolated compounds, especially the nanocarrier with ergosterol, which reached a rate of 86.4% [27][64

Venom-loaded cationic-functionalized poly(lactic acid) nanoparticles for serum production against Tityus serrulatus scorpion

• Philippe de Castro Mesquita,
• Karla Samara Rocha Soares,
• Manoela Torres-Rêgo,
• Emanuell dos Santos-Silva,
• Mariana Farias Alves-Silva,
• Alianda Maira Cornélio,
• Matheus de Freitas Fernandes-Pedrosa and
• Arnóbio Antônio da Silva-Júnior

Beilstein J. Nanotechnol. 2025, 16, 1633–1643, doi:10.3762/bjnano.16.115

• 165 nm and a positive zeta potential of 7.0 mV. After the addition of venom, the PLA nanoparticles loaded with T. serrulatus venom proteins remained with a narrow particle size distribution. Moreover, an increase in size of the particles occurred after the addition of the venom for both concentrations

Photocatalytic degradation of ofloxacin in water assisted by TiO₂ nanowires on carbon cloth: contributions of H₂O₂ addition and substrate absorbability

• Iram Hussain,
• Lisha Zhang,
• Zhizhen Ye and
• Jin-Ming Wu

Beilstein J. Nanotechnol. 2025, 16, 1567–1579, doi:10.3762/bjnano.16.111

• pore size distribution, which shows a sharp peak at approximately 4.0 nm, suggesting a uniform pore size. The corresponding pore size distribution curve (Figure 3b, inset) indicates a mesoporous structure. Before calcination, the BET surface area of the titanate on carbon cloth was found to be 3.9 m2·g

• . (b) Low-temperature nitrogen adsorption–desorption isotherm of CC/NW-450 °C. The inset shows the corresponding pore size distribution curve. XPS spectra of CC/NW-450 °C and CC/HTNW. (a) Survey spectra and detailed XPS spectra of (b) C 1s, (c) O 1s, and (d) Ti 2p. (a) Photocatalytic degradation of

Laser processing in liquids: insights into nanocolloid generation and thin film integration for energy, photonic, and sensing applications

• Akshana Parameswaran Sreekala,
• Pooja Raveendran Nair,
• Jithin Kundalam Kadavath,
• Bindu Krishnan,
• David Avellaneda Avellaneda,
• M. R. Anantharaman and
• Sadasivan Shaji

Beilstein J. Nanotechnol. 2025, 16, 1428–1498, doi:10.3762/bjnano.16.104

• specific applications will be crucial for realizing the full potential of laser-based techniques and addressing challenges in LAL such as low productivity, high energy consumption, and wide size distribution. Additionally, advancing in situ characterization methods, such as time-resolved shadowgraphy [26

• laser irradiation to fragment larger NPs suspended in a colloidal solution, resulting in smaller NPs with a narrow size distribution. LFL is particularly beneficial as a post-processing tool for NPs produced by PLAL, a technique which often results in broader or bimodal size distributions as discussed

• crystallographic structure. The findings suggest that smaller particle sizes are primarily achieved by increasing the number of laser pulses, though there is a limit to the number of pulses that should be applied. Furthermore, the energy output notably influenced the size distribution, with higher energy leading

Photochemical synthesis of silver nanoprisms via green LED irradiation and evaluation of SERS activity

• Tuan Anh Mai-Ngoc,
• Nhi Kieu Vo,
• Cong Danh Nguyen,
• Thi Kim Xuan Nguyen and
• Thanh Sinh Do

Beilstein J. Nanotechnol. 2025, 16, 1417–1427, doi:10.3762/bjnano.16.103

• these results, we conclude that 72 h represents the optimal irradiation time for the complete transformation of silver seeds into silver nanoplates in this study. From the FESEM images and particle size distribution graph after 12 h of LED irradiation in Figure 3, it is observed that the particle sizes

• performed (HORIBA XploRA ONE TM, France) using a 532 nm laser source and a 10× magnification microscope. Measurements were taken at ten random positions, and the average intensity was recorded. (a) UV–vis spectrum, (b) TEM image and (c) size distribution of seeds. UV–vis spectra of silver nanoparticles at

• spectra of the AgNPs seed shown in the Figure 1a displayed a single peak at 400 nm, indicating the presence of spherical silver nanoparticles with small sizes, consistent with studies in the literature [4][6][7]. The sample exhibited the characteristic yellow color of AgNPs. The TEM image and size

The role of biochar in combating microplastic pollution: a bibliometric analysis in environmental contexts

• Tuan Minh Truong Dang,
• Thao Thu Thi Huynh,
• Guo-Ping Chang-Chien and
• Ha Manh Bui

Beilstein J. Nanotechnol. 2025, 16, 1401–1416, doi:10.3762/bjnano.16.102

• -stable aggregates by approximately 20% and a decline in saturated hydraulic conductivity by up to 70%. Moreover, the water content in soil at field capacity decreases between 10% and 65%, depending on soil texture, MP concentration, and size distribution [56]. Biochar application has shown potential in

Ferroptosis induction by engineered liposomes for enhanced tumor therapy

• Alireza Ghasempour,
• Mohammad Amin Tokallou,
• Mohammad Reza Naderi Allaf,
• Mohsen Moradi,
• Hamideh Dehghan,
• Mahsa Sedighi,
• Mohammad-Ali Shahbazi and
• Fahimeh Lavi Arab

Beilstein J. Nanotechnol. 2025, 16, 1325–1349, doi:10.3762/bjnano.16.97

• light scattering (DLS) is commonly used to determine liposome size and size distribution. Transmission electron microscopy (TEM) and atomic force microscopy (AFM) can be used to image liposome morphology and determine lamellarity. Zeta potential measurements assess the surface charge of liposomes, which

• a crucial parameter that influences their biodistribution, cellular uptake, and drug release. DLS is a widely used technique to determine the size distribution of liposomes in solution [110][125]. DLS measures the fluctuations in light intensity generated by the Brownian motion of liposome particles

Acrocomia aculeata oil-loaded nanoemulsion: development, anti-inflammatory properties, and cytotoxicity evaluation

• Verónica Bautista-Robles,
• Hady Keita,
• Edgar Julián Paredes Gamero,
• Layna Tayná Brito Leite,
• Jessica de Araújo Isaías Muller,
• Mônica Cristina Toffoli Kadri,
• Ariadna Lafourcade Prada and
• Jesús Rafael Rodríguez Amado

Beilstein J. Nanotechnol. 2025, 16, 1277–1288, doi:10.3762/bjnano.16.93

• requires the determination of key formulation parameters, including the required hydrophilic–lipophilic balance (HLBr), droplet size, and polydispersity index (PDI) [42][43][44]. In this study, the Acrocomia aculeata oil nanoemulsion (AANE) exhibited a uniform droplet size distribution and a stable PDI

• do Sul, Brazil (Reference number: 1.250/2022). Droplet size and polydispersity index of nanoemulsions versus the hydrophilic–lipophilic balance of the surfactant system used for the preparation. HLBr: required hydrophilic-lipophilic balance. Droplet size distribution and zeta potential of the

Investigation of the solubility of protoporphyrin IX in aqueous and hydroalcoholic solvent systems

• Michelly de Sá Matsuoka,
• Giovanna Carla Cadini Ruiz,
• Marcos Luciano Bruschi and
• Jéssica Bassi da Silva

Beilstein J. Nanotechnol. 2025, 16, 1209–1215, doi:10.3762/bjnano.16.89

• of solubility were later contradicted by particle size distribution analysis. Figure 2 shows the solubility behavior of PpIX in water and EtOHabs, with mean concentrations of 0.497 ± 0.054 mg/mL in water, and 0.179 ± 0.004 mg/mL in EtOHabs. In contrast, the systems containing 0.4 mg/mL of PpIX in

Chitosan nanocomposite containing rotenoids: an alternative bioinsecticidal approach for the management of Aedes aegypti

• Maria A. A. Bertonceli,
• Vitor D. C. Cristo,
• Ivo J. Vieira,
• Francisco J. A. Lemos,
• Arnoldo R. Façanha,
• Raimundo Braz-Filho,
• Gustavo V. T. Batista,
• Luis G. M. Basso,
• Sérgio H. Seabra,
• Thalya S. R. Nogueira,
• Felipe F. Moreira,
• Arícia L. E. M. Assis,
• Antônia E. A. Oliveira and
• Kátia V. S. Fernandes

Beilstein J. Nanotechnol. 2025, 16, 1197–1208, doi:10.3762/bjnano.16.88

• expressed as a percentage relative to the negative control. Statistical analysis was performed using one-way ANOVA followed by Tukey’s multiple comparison test (p < 0.05) with the GraphPad Prism 10 software. Size distribution and zeta potential of nanoparticles. A) Conventional ionic gelation of CS/TPP

Crystalline and amorphous structure selectivity of ignoble high-entropy alloy nanoparticles during laser ablation in organic liquids is set by pulse duration

• Robert Stuckert,
• Felix Pohl,
• Oleg Prymak,
• Ulrich Schürmann,
• Christoph Rehbock,
• Lorenz Kienle and
• Stephan Barcikowski

Beilstein J. Nanotechnol. 2025, 16, 1141–1159, doi:10.3762/bjnano.16.84

• amorphous ns-ablated particles. Based on these findings we can conclude that the pronounced differences in crystallinity in the samples cannot be explained by differences in particle diameters. However, a certain width of the size distribution curves indicated by the polydispersity indices (PDI) (PDI = 0.31

• solid solution fcc structure, whereas this study was more focused on the applicability in catalysis [18]. By irradiating metal chloride salts, premixed in ethanol and then added to a hexane solution with oleic acid present, Wang et al. successfully synthesized PtIrCuNiCr NPs with a narrow size

• distribution and uniformly mixed elements within the generated nanoparticles [62]. Recently, Tahir et al. conducted ps-LAL on the CrMnFeCoNi system in ethanol and varied production methods for the bulk targets, showing uniformly mixed HEA NPs with an fcc structure and indications for a minor fraction of

Fabrication of metal complex phthalocyanine and porphyrin nanoparticle aqueous colloids by pulsed laser fragmentation in liquid and their potential application to a photosensitizer for photodynamic therapy

• Taisei Himeda,
• Risako Kunitomi,
• Ryosuke Nabeya,
• Tamotsu Zako and
• Tsuyoshi Asahi

Beilstein J. Nanotechnol. 2025, 16, 1088–1096, doi:10.3762/bjnano.16.80

• . The nanoparticles having strong absorption in the NIR region (700 to 900 nm) were successfully prepared by PLFL, and the colloids remained stably dispersed over a period of at least one week. Particle size and size distribution determined by DLS measurements depended on the molecules. The compound

• -dependent diameters were estimated to be 40 to 80 nm from the number-weighted size distributions by DLS measurements (see Figure S2, Supporting Information File 1). The Z-average values suggest that AlClPc and PtOEP have a narrower size distribution than FePc, CoPc, and ZnPc. In general, molecular

A calix[4]arene-based supramolecular nanoassembly targeting cancer cells and triggering the release of nitric oxide with green light

• Cristina Parisi,
• Loredana Ferreri,
• Tassia J. Martins,
• Francesca Laneri,
• Samantha Sollima,
• Antonina Azzolina,
• Antonella Cusimano,
• Nicola D’Antona,
• Grazia M. L. Consoli and
• Salvatore Sortino

Beilstein J. Nanotechnol. 2025, 16, 1003–1013, doi:10.3762/bjnano.16.75

• inset shows the size distribution of the same solution of 1 obtained by DLS. (B) Fluorescence emission spectrum, λexc = 467 nm, of 1 as in (A). The inset shows the fluorescence decay and the related fitting of the same solutions recorded at λexc = 455 nm and λem = 550 nm. T = 25 °C. Cell viability

• observed upon exposure of an air-equilibrated NOPD 2 (100 µM) solution at λexc = 420 nm after 0, 6, 11, 20, 30, 40, 60, 80, 100, 130, and 160 min. (A) Absorption spectrum of the supramolecular complex 1·2 in water; [1] = 50 µM; [2] = 40 µM. The inset shows the size distribution of the same solution of 1·2

Time-resolved probing of laser-induced nanostructuring processes in liquids

• Maximilian Spellauge,
• David Redka,
• Mianzhen Mo,
• Changyong Song,
• Heinz Paul Huber and
• Anton Plech

Beilstein J. Nanotechnol. 2025, 16, 968–1002, doi:10.3762/bjnano.16.74

Shape, membrane morphology, and morphodynamic response of metabolically active human mitochondria revealed by scanning ion conductance microscopy

• Eric Lieberwirth,
• Anja Schaeper,
• Regina Lange,
• Ingo Barke,
• Simone Baltrusch and
• Sylvia Speller

Beilstein J. Nanotechnol. 2025, 16, 951–967, doi:10.3762/bjnano.16.73

•  3c. The average values of apparent height, diameter, and volume are compared. Irregular mitochondria tend to be smaller with reduced statistical significance (Welch’s t-test). The size distribution of metabolically active mitochondria is bimodal, that is, diameters predominantly fell into two

Synthesis of biowaste-derived carbon-dot-mediated silver nanoparticles and the evaluation of electrochemical properties for supercapacitor electrodes

• Navya Kumari Tenkayala,
• Chandan Kumar Maity,
• Md Moniruzzaman and
• Subramani Devaraju

Beilstein J. Nanotechnol. 2025, 16, 933–943, doi:10.3762/bjnano.16.71

• distribution of PG-CDs-AgNPs was responsible for the enhanced surface area [35]. The pore size distribution plot of PG-CDs-AgNPs suggests the mesoporous characteristics (Supporting Information File 1, Figure S1b), which, via the diffusion of electrolyte ions, is highly efficient for electrochemical charge

• storage. The size distribution, morphology, and crystallinity of PG-CDs-AgNPs were further characterized by SEM and TEM analysis. The SEM image of PG-CDs-AgNPs (Supporting Information File 1, Figure S2a) reveals that PG-CDs-AgNPs possess spherical and distorted spherical structure. Supporting Information

• well-resolved lattice spacing of 0.24 nm equivalent to (111) lattice planes of silver [36]. The clear visible lattice fringe indicates that the particles are crystalline. The average particle size distribution histogram depicted that the diameter of PG-CDs-AgNPs were approximately 9–10 nm, as depicted