2 article(s) from Pohl, Radek
Selected alkaloids containing the pyrrolidone motif.
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A) Classical γ-lactam synthesis by atom transfer radical cyclizations; B) previously developed tand...
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X-ray crystal structure of the major (2R,4S)-alkoxyamine hydrochloride derived from 9j. Displacemen...
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Formation of the α-(aminoxy)amides 9o,p.
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X-ray crystal structure of the minor cis-diastereomers of the keto lactam 13j (left) and the hydrox...
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Thermal radical cyclization reactions of amides 9l–p bearing cyclic units. Conditions: a) t-BuOH, 1...
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Epimerization of spirolactams 12m,n.
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The Dess–Martin oxidation of lactams 12l–o. Conditions: a) DMP (1.3 equiv), t-BuOH (10 mol %), CH2Cl...
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Selected transformations of the lactams trans-12b and 12o.
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Diastereoselectivity for the formation of α-(aminoxy)amides 9i–k.
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Rationalization of the diastereoselectivity for the formation of the α-(aminoxy)amide 9l.
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Rationalization of the thermal radical cyclization diastereoselectivity of alkoxyamines 9a–k. (S)-C...
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The stereochemical course for the formation of products 12m,n by thermal radical cyclization of alk...
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Formation of bicycles 12o,p.
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Beilstein J. Org. Chem. 2021, 17, 688–704, doi:10.3762/bjoc.17.58
Examples of biologically active acyclic and cyclic nucleotide analogs.
The pyrrolidine nucleotide analogs investigated in this study.
The synthesis of pyrrolidine nucleotides 7–14.
The numbering of the pyrrolidine ring, the nucleobase and the endocyclic phase angles for the purpo...
The aliphatic part (pyrrolidine protons) of the 1H NMR spectra of 9 measured in D2O at different pD...
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Changes of selected 1H and 13C chemical shifts of 9 upon pD change.
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The deuteration equilibria of phosphonomethyl derivatives 7–10.
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The aliphatic part (pyrrolidine protons) of the 1H NMR spectra of 13 measured in D2O at different p...
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Amide rotamers of phosphonoformyl derivatives 11–14.
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The 31P NMR spectra (202.3 MHz) of 14 measured (the black curve) and simulated (the red curve) at v...
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A part of the H,C-HSQC spectrum of derivative 13, showing the assignment of rotamers A and B.
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The pseudorotation pathway of the pyrrolidine ring in the compounds studied. The sign B stands for ...
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An example of the stereospecific assignment of pyrrolidine-ring protons of 14 in the H,H-ROESY spec...
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The energy profile of the five-membered pyrrolidine ring pseudorotation for adenine derivatives 9 a...
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The most stable conformations of adenine derivatives 9 and 13A calculated by the B3LYP/6-31++G* met...
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Beilstein J. Org. Chem. 2014, 10, 1967–1980, doi:10.3762/bjoc.10.205
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