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Search for "convergent synthesis" in Full Text gives 35 result(s) in Beilstein Journal of Organic Chemistry.
Human dendritic cell activation induced by a permannosylated dendron containing an antigenic GM3-lactone mimetic
Beilstein J. Org. Chem. 2014, 10, 1317–1324, doi:10.3762/bjoc.10.133
- strategies based on dendritic cells (DCs) armed with specific tumor antigens have been widely exploited due the properties of these immune cells in coordinating an innate and adaptive response. Here, we describe the convergent synthesis of the bifunctional multivalent glycodendron 5, which contains nine
- the convergent synthesis of the bifunctional multivalent glycodendron 5 (Scheme 1) and on human DC activation and related mixed-lymphocyte reaction (MLR) induced by the antigenic glycodendron 5. Results and Discussion Glycodendron 5 (Scheme 1) is a bifunctional compound containing nine residues of
- data gathered in the experiments outlined here we conclude that the maturation/stimulation of DCs is specifically linked to the presence of the mimetic antigen residue and not determined by the scaffold alone. Conclusion Here, we reported on the convergent synthesis of the ditopic multivalent
Convergent synthesis of a tetrasaccharide repeating unit of the O-specific polysaccharide from the cell wall lipopolysaccharide of Azospirillum brasilense strain Sp7
Beilstein J. Org. Chem. 2014, 10, 293–299, doi:10.3762/bjoc.10.26
- -700054, India 10.3762/bjoc.10.26 Abstract A straightforward convergent synthesis has been carried out for the tetrasaccharide repeating unit of the O-specific cell wall lipopolysaccharide of the strain Sp7 of Azospirillum brasilense. The target tetrasaccharide has been synthesized from suitably
- summary, a straightforward and convergent synthesis of the tetrasaccharide 1 as its 2-aminoethyl glycoside corresponding to the O-specific polysaccharide of the LPS of A. brasilense strain Sp7 has been presented. The use of thioglycosides both as glycosyl donor and acceptor according to the concept of the
Total synthesis and biological evaluation of fluorinated cryptophycins
Beilstein J. Org. Chem. 2012, 8, 2060–2066, doi:10.3762/bjoc.8.231
- pentafluorophenylalanine building block 26. Reagents and conditions: (a) pyridine, trichloroethanol, DCC, CH2Cl2, 0 °C, 20 h; (b) 1. TFA, rt, 2 h; 2. NEt3, acryloylchloride, CH2Cl2, 0 °C, 7 h. Convergent synthesis of the pentafluorinated cryptophycin 31. Reagents and conditions: (a) Grubbs II catalyst, CH2Cl2, reflux, 16
Convergent synthesis of the tetrasaccharide repeating unit of the cell wall lipopolysaccharide of Escherichia coli O40
Beilstein J. Org. Chem. 2012, 8, 2053–2059, doi:10.3762/bjoc.8.230
Synthesis of multivalent host and guest molecules for the construction of multithreaded diamide pseudorotaxanes
Beilstein J. Org. Chem. 2012, 8, 234–245, doi:10.3762/bjoc.8.24
- utilized to couple the binding sites to appropriate spacer groups. Through this “Lego” or “toolbox” approach, the convergent synthesis of host and guests with a well-defined number of the binding sites is possible. In addition, the spatial arrangement of the binding sites can be controlled through the
Convergent synthesis of the tetrasaccharide repeating unit of the O-antigen of Shigella boydii type 9
Beilstein J. Org. Chem. 2011, 7, 1182–1188, doi:10.3762/bjoc.7.137
- towards the preparation of glycoconjugates, we report herein a convergent chemical synthesis of the tetrasaccharide as its 4-methoxyphenyl glycoside 1 corresponding to the O-antigen of Shigella boydii type 9 using a [2 + 2] block glycosylation strategy (Figure 2). Results and Discussion The convergent
- synthesis of the target tetrasaccharide 1 as its 4-methoxyphenyl glycoside has been achieved applying a number of recently developed elegant reaction methodologies. A number of notable features are present in the synthetic strategy, which are (a) convergent [2 + 2] block glycosylation; (b) application of
An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals
Beilstein J. Org. Chem. 2011, 7, 442–495, doi:10.3762/bjoc.7.57
Polar tagging in the synthesis of monodisperse oligo(p-phenyleneethynylene)s and an update on the synthesis of oligoPPEs
Beilstein J. Org. Chem. 2010, 6, No. 57, doi:10.3762/bjoc.6.57
- severe structural defect. Polar tags in the side chain In spite of its efficiency, the divergent-convergent synthesis of oligoPPEs involves considerable effort, especially as a result of the chromatography which is required after each alkynyl–aryl coupling. In the case of the synthesis of oligoPPEs with
Convergent syntheses of LeX analogues
Beilstein J. Org. Chem. 2010, 6, No. 17, doi:10.3762/bjoc.6.17
- efficient and convergent preparation of these three Lex analogues. Keywords: Birch reduction; convergent synthesis; desulfurization; Lewis X; Introduction Our group is involved in the design of new anti-cancer vaccines based on the Tumor Associated Carbohydrate Antigen (TACA) dimeric Lex (dimLex) [1][2][3
- ][30][31][32][33][34]; 3. a block approach in which a lactosamine derivative prepared from lactose is subjected to fucosylation at O-3 [35][36]. Whereas these reports usually describe the preparation of one compound to be used in a specific experiment, we describe here the convergent synthesis of the
- 1264.5509. Structure of Lex analogues 1–3. Monosaccharide glycosyl acceptors (4–6) and donors (7–9) used in this study. Synthesis of monosaccharide glycosyl acceptors 4–6. Synthesis of the galactosyl donor 8. Convergent synthesis of trisaccharides 29–32. Proposed mechanism for the desulfurization of
Sordarin, an antifungal agent with a unique mode of action
Beilstein J. Org. Chem. 2008, 4, No. 31, doi:10.3762/bjoc.4.31
- resulted in quantitative formation of sordaricin methyl ester. Nucleophilic cleavage of the methyl ester by n-PrSNa led to sordaricin (2). In short, a convergent synthesis of sordaricin was accomplished in 27 steps and in 3% overall yield from (+)- and (−)-oxodicyclopentadiene (21). Narasaka’s synthesis of
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