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Search for "pharmacological activity" in Full Text gives 35 result(s) in Beilstein Journal of Organic Chemistry.
Synthesis of a deuterated probe for the confocal Raman microscopy imaging of squalenoyl nanomedicines
Beilstein J. Org. Chem. 2016, 12, 1127–1135, doi:10.3762/bjoc.12.109
- , the use of fluorescent probes requires the covalent binding of large dye molecules (bodipy, cyanine, rhodamine etc, ...) to the drug conjugate, thus potentially modifying its physicochemical profile as well as the in vivo fate and the pharmacological activity. A simple encapsulation of an amphiphilic
Natural phenolic metabolites with anti-angiogenic properties – a review from the chemical point of view
Beilstein J. Org. Chem. 2015, 11, 249–264, doi:10.3762/bjoc.11.28
- discussed. Thirteen representatives from eight different natural or natural-like phenolic subclasses are presented with an emphasis on their synthesis and methods to modify the parent compounds. When available, the consequence of structural variation on the pharmacological activity of the molecules is
- therapy of pathologically-induced angiogenesis [7][8]. Among such natural products, phenolic or polyphenolic compounds with anti-angiogenic properties have been investigated and the opinion regarding their potential pharmacological impact has changed over the years. While the pharmacological activity of
- , specifically addressing their chemistry, synthesis and possible structure modifications. Nevertheless, it should be mentioned that the selection of compounds for this review is based on the reports of their pharmacological activity. As the term “anti-angiogenic compound” is not clearly defined and somewhat
Synthesis and characterization of a new photoinduced switchable β-cyclodextrin dimer
Beilstein J. Org. Chem. 2014, 10, 2874–2885, doi:10.3762/bjoc.10.304
- well-defined structure, low toxicological or pharmacological activity, and good solubility in water. For example, the inclusion of active substances in CDs can reduce their undesirable storage or metabolism degradation, which has led research on CDs to focus on controlled drug delivery [4]. In the food
Consecutive isocyanide-based multicomponent reactions: synthesis of cyclic pentadepsipeptoids
Beilstein J. Org. Chem. 2014, 10, 1017–1022, doi:10.3762/bjoc.10.101
- structures are outlined in Figure 2. Results and Discussion In continuing our research on the synthesis of peptoids with potential pharmacological activity [12][17][18][44][45] and using a fast and efficient microwave-assisted synthesis of peptoids [15][17][18], we decided to carry out the synthesis of
Raman spectroscopy as a tool for monitoring mesoscale continuous-flow organic synthesis: Equipment interface and assessment in four medicinally-relevant reactions
Beilstein J. Org. Chem. 2013, 9, 1843–1852, doi:10.3762/bjoc.9.215
- -ketoesters and aromatic aldehydes to yield dihydropyrimidines has received significant attention, these products having pharmacological activity including calcium channel modulation, mitotic kinesin Eg5 inhibition, and antiviral and antibacterial activity [49][50]. The Biginelli reaction has been performed
Facile synthesis of functionalized spiro[indoline-3,2'-oxiran]-2-ones by Darzens reaction
Beilstein J. Org. Chem. 2013, 9, 918–924, doi:10.3762/bjoc.9.105
- ]. The unique structures and the highly pronounced pharmacological activity displayed by the spirooxindoles have made them attractive synthetic targets [6][7][8][9]. In various heterocyclic and carbocyclic spirooxindoles, the spiro-oxirane-oxindoles are a particular class of compounds with both spiro
Advances in synthetic approach to and antifungal activity of triazoles
Beilstein J. Org. Chem. 2011, 7, 668–677, doi:10.3762/bjoc.7.79
- ., triazole, oxadiazole dithiazole and thiadiazole with three heteroatoms at symmetrical or asymmetrical positions have been studied because of their interesting pharmacological properties. In this article our emphasis is on synthetic development and pharmacological activity of the triazole moiety which
- exhibit a broad spectrum of pharmacological activity such as antifungal, antibacterial, anti-inflammatory and anticancer etc. Triazoles have increased our ability to treat many fungal infections, for example, candidiasis, cryptococcal meningitis, aspergillosis etc. However, mortality due to these
Aromatic and heterocyclic perfluoroalkyl sulfides. Methods of preparation
Beilstein J. Org. Chem. 2010, 6, 880–921, doi:10.3762/bjoc.6.88
- perfluoroalkyl thio substituents are illustrated in Figure 4 and Figure 5 along with their pharmacological functions [7][8][9][10][11]. These examples represent only a small number of the vast array of organic compounds with SRF, SORF or SO2RF groups which display pharmacological activity and interest in such
An efficient synthesis of novel pyrano[2,3-d]- and furopyrano[2,3-d]pyrimidines via indium- catalyzed multi- component domino reaction
Beilstein J. Org. Chem. 2006, 2, No. 11, doi:10.1186/1860-5397-2-11
- uracils. A number of compounds having these systems are synthesized with diverse pharmacological activity. [24][25] For the preparation of these complex molecules, there has been remarkable interest in the synthetic manipulations of uracils.[26] Also the synthetic exploitation of the nucleophilic double
Synthesis of phosphorothioates using thiophosphate salts
Beilstein J. Org. Chem. 2006, 2, No. 4, doi:10.1186/1860-5397-2-4
- derivatives are of interest as effective pesticides. [5][6][7][8] In recent years a number of phosphorothioates have been introduced as potential chemotherapeutic agent. [9][10][11][12] Despite their wide range of pharmacological activity, industrial and synthetic applications, the synthesis of
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