Stimuli-responsive oligonucleotides in prodrug-based approaches for gene silencing

• Françoise Debart,
• Christelle Dupouy and
• Jean-Jacques Vasseur

Beilstein J. Org. Chem. 2018, 14, 436–469, doi:10.3762/bjoc.14.32

• . Light-responsive ONs Compared to other stimuli used to generate ONs that act as gene regulator, light is the external physical regulatory element that is most used. Actually, photoirradiation is the major and simplest method to temporally and spatially regulate the activity of photoresponsive ONs that

• suitable reagent, which generally is a diazo derivative bearing a photoresponsive moiety, or b) incorporation of an appropriate photocaged phosphoramidite during the solid-supported ON synthesis [73][78]. The advantage of the first approach is that the functionalization results from a reaction with

• activation induces the release of photoresponsive moieties during photoirradiation, yielding a lower extent of GFP expression in HeLa cells [72]. Later, Mc Master showed that it is not necessary to heavily modify siRNA because a single photoresponsive unit (biotin linked to nitrophenylethyl, Figure 4) at the

The role of alkyl substituents in deazaadenine-based diarylethene photoswitches

• Christopher Sarter,
• Michael Heimes and
• Andres Jäschke

Beilstein J. Org. Chem. 2016, 12, 1103–1110, doi:10.3762/bjoc.12.106

• DNA photoswitches for the application in bionanotechnology and synthetic biology. Keywords: diarylethene; nucleoside; electrocyclic rearrangement; photochromism; photoswitch; Introduction Most biomacromolecules are per se not responsive to light. Their conversion into photoresponsive molecules opens

Synthesis of photoresponsive cholesterol-based azobenzene organogels: dependence on different spacer lengths

• Yuchun Ren,
• Bin Wang and
• Xiuqing Zhang

Beilstein J. Org. Chem. 2015, 11, 1089–1095, doi:10.3762/bjoc.11.122

• designed and synthesized. The molecular structures were confirmed by 1H NMR and 13C NMR spectroscopy. The rapid and reversible photoresponsive properties of the compounds were investigated by UV–vis spectroscopy. Their thermal phase behaviors were studied by DSC. The length of the spacer plays a crucial

• ; organogel; photoresponsive; Introduction In the past few decades, low molecular mass organic gelators (LMOGs) have attracted increasing attention not only for basic self-assembly behavior but also for their potential application in areas such as templates [1], light harvesting [2], fluorescent scensing [3

• semicarbazide–azobenzene-based gelators [24]. A new multistimuli photoresponsive organogel containing azobenzene groups was designed and studied by D. Zhu and his co-workers [25]. Q. Zhang synthesized a series of new symmetric dicholesterol-linked gelators [26]. Upon UV–vis irradiation of the gels, a reversible

Synthetic strategies for the fluorescent labeling of epichlorohydrin-branched cyclodextrin polymers

• Milo Malanga,
• Mihály Bálint,
• István Puskás,
• Kata Tuza,
• Tamás Sohajda,
• László Jicsinszky,
• Lajos Szente and
• Éva Fenyvesi

Beilstein J. Org. Chem. 2014, 10, 3007–3018, doi:10.3762/bjoc.10.319

• their spectroscopic properties thus generating chemosensors, biological tools for visualization and sophisticated photoresponsive devices. Cyclodextrin polymers, due to the cooperative interactions, exhibit additional properties compared to their monomeric counterpart. These macromolecules can be

Synthesis, photophysical and electrochemical characterization of terpyridine-functionalized dendritic oligothiophenes and their Ru(II) complexes

• Amaresh Mishra,
• Elena Mena-Osteritz and
• Peter Bäuerle

Beilstein J. Org. Chem. 2013, 9, 866–876, doi:10.3762/bjoc.9.100

• the tpy-ethynyl type have proven to be very useful and provide a library of photoresponsive complexes derived from the basic Ru(II)-tpy type module [23][24][25][26][27]. Recently, tpy-complexes that incorporate π-conjugated thiophene or thienylene-ethynylene units became available, and the study of

Design and synthesis of a photoswitchable guanidine catalyst

• Philipp Viehmann and
• Stefan Hecht

Beilstein J. Org. Chem. 2012, 8, 1825–1830, doi:10.3762/bjoc.8.209

• [17], TBD is a difficult target for the incorporation of photoresponsive switches. Recent work indicates that the activation mechanism for acyclic guanidines, such as guanidine 1 (Scheme 1), is strongly dependent on the formation of hydrogen bridges to monomer and initiator [18]. Note that with

SbCl₃-catalyzed one-pot synthesis of 4,4′-diaminotriarylmethanes under solvent-free conditions: Synthesis, characterization, and DFT studies

• Ghasem Rezanejade Bardajee

Beilstein J. Org. Chem. 2011, 7, 135–144, doi:10.3762/bjoc.7.19

• , inks, crayons, typewritten ribbons, and photoimaging systems [1][2][3]. These compounds have been employed as dye precursors in nanocomposite preparations [4], in photoresponsive polymers [5], and as the thermal iniferter (initiator–transfer–terminator agent) in pseudo-living radical polymerizations [6