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Search for "cytoskeleton" in Full Text gives 12 result(s) in Beilstein Journal of Organic Chemistry.
Asymmetric synthesis of a stereopentade fragment toward latrunculins
Beilstein J. Org. Chem. 2023, 19, 428–433, doi:10.3762/bjoc.19.32
- ng/ mL [2]. It was rapidly demonstrated that the toxins target the cytoskeleton and inhibit the actin polymerization by specifically sequestering the G-actin monomers with a high affinity [4], unlike cytochalasin D that targets the actin filament [5]. Structure–activity relationships have also been
Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities
Beilstein J. Org. Chem. 2023, 19, 399–427, doi:10.3762/bjoc.19.31
- cancer cell growth when compared with compounds 2 and 28, due the same lack of phosphatase cited before. It is worth to note that the mechanism of action for these compounds is attributed to their ability to interfere in the dynamics of tubulin, a protein involved in the formation of the cytoskeleton
Potent hemithioindigo-based antimitotics photocontrol the microtubule cytoskeleton in cellulo
Beilstein J. Org. Chem. 2020, 16, 125–134, doi:10.3762/bjoc.16.14
- cytoskeleton research. Additionally, as the hemithioindigo scaffold allows photoswitchable bioactivity for substituent patterns inaccessible to the majority of current photopharmaceuticals, wider adoption of the hemithioindigo scaffold may significantly expand the scope of cellular and in vivo targets
- addressable by photopharmacology. Keywords: antimitotics; cytoskeleton; hemithioindigo; photopharmacology; photoswitch; Introduction The cytoskeletal scaffolding protein tubulin, a heterodimer consisting of α and β subunits, each of various isotypes, reversibly assembles into giant non-covalent polymeric
- neurons; the regulation and functioning of these processes is still not satisfactorily understood [1][2][3][4]. The MT cytoskeleton is a finely tuned complex system that is highly conserved through evolution. Direct genetic modifications of tubulin that affect its functions risk causing a diversity of
Comparative cell biological study of in vitro antitumor and antimetastatic activity on melanoma cells of GnRH-III-containing conjugates modified with short-chain fatty acids
Beilstein J. Org. Chem. 2018, 14, 2495–2509, doi:10.3762/bjoc.14.226
- responsiveness of A2058 cells. Our present results are in harmony with studies demonstrating the migration inhibitory effect of GnRH agonists on melanoma [25] and prostate cancer cell lines [54][55]. These studies also suggested that modulation of cell adhesion or actin cytoskeleton remodelling (morphological
On the design principles of peptide–drug conjugates for targeted drug delivery to the malignant tumor site
Beilstein J. Org. Chem. 2018, 14, 930–954, doi:10.3762/bjoc.14.80
- general, the ‘integrin’ nomenclature was first used in 1987 to describe a family of receptors, appearing as heterodimers of noncovalently associated α and β subunits, able to link the extracellular matrix (ECM) with the intracellular cytoskeleton to mediate cell adhesion, migration and proliferation [42
The chemistry and biology of mycolactones
Beilstein J. Org. Chem. 2017, 13, 1596–1660, doi:10.3762/bjoc.13.159
- might be crucial for Buruli ulcer pathogenesis [35][81]. With increasing concentrations, the cytotoxic effects of mycolactone become more prominent. These are typically accompanied by a profound structural change in the cytoskeleton followed by cell cycle arrest in the G0/G1 phase. Ultimately, cell
- neuronal Wiskott–Aldrich syndrome protein (N-WASP) that were discovered by Demangel and co-workers in 2013 based on experiments with a biotinylated mycolactone probe [93]. The WAS family comprises five scaffolding proteins that are crucially involved in the dynamic remodeling of the actin cytoskeleton [94
How and why kinetics, thermodynamics, and chemistry induce the logic of biological evolution
Beilstein J. Org. Chem. 2017, 13, 665–674, doi:10.3762/bjoc.13.66
- (Figure 1B). These structures therefore result from dissipative self-assembly for which fascinating examples have been provided in the recent literature [19][20][21]. In biology, one of the most typical examples of this kind of assembly processes can be found in the dynamics of the cytoskeleton. However
Versatile synthesis of the signaling peptide glorin
Beilstein J. Org. Chem. 2017, 13, 247–250, doi:10.3762/bjoc.13.27
- actin cytoskeleton organization, as a model gene. Upon glorin (1) exposure, this gene was found to be up-regulated by about 50-fold [11]. To this end, the compounds were dissolved in DMSO/water and added in two 1 μM portions (30 min apart) to a suspension of starving P. pallidum. After 1 h, the cells
Regulation of integrin and growth factor signaling in biomaterials for osteodifferentiation
Beilstein J. Org. Chem. 2015, 11, 773–783, doi:10.3762/bjoc.11.87
- cells [18]. Therefore, the integrins serve to link the two compartments, namely the ECM and the intracellular actin filamentous cytoskeleton across the plasma membrane. The interactions between integrins and ligands result in two major functions. First, the interactions physically integrate the ECM
- -bound cells and their cytoskeleton. Second, the signals resulting from these interactions enable cells to sense the chemical and mechanical properties of the microenvironment (niche) and to respond by activating signaling systems for regulating the cell fate [19]. Conversely, the contraction of the
- attached cytoskeleton pulls integrins together into larger adhesive clusters [7]. The type of the integrin–ligand interactions and the integrin–ligand pairs have been well described in previous reviews [18][20]. Most integrin receptors can bind a wide variety of ligands. Many ECM ligands and cell surface
Synthesis of the B-seco limonoid core scaffold
Beilstein J. Org. Chem. 2014, 10, 194–208, doi:10.3762/bjoc.10.15
- ], antimalaria and anticancer [10][11][22][23][24][25] as well as diverse further bioactivities. Recently it was discovered that prieurianin (2) impairs the actin cytoskeleton by a mechanism that does not involve direct interaction with actin suggesting that its mode of action differs from previously known
Design and synthesis of tag-free photoprobes for the identification of the molecular target for CCG-1423, a novel inhibitor of the Rho/MKL1/SRF signaling pathway
Beilstein J. Org. Chem. 2013, 9, 966–973, doi:10.3762/bjoc.9.111
- current hypothesis regarding the mechanism of action of 1 (redistribution of MKL primarily into the cytosol), which may require an intact actin cytoskeleton or nucleus. We thus elected to design photoaffinity probes that were tag-free, i.e., lacking either a biotin or fluorescent tag [17]. There are a
Chemical modification allows phallotoxins and amatoxins to be used as tools in cell biology
Beilstein J. Org. Chem. 2012, 8, 2072–2084, doi:10.3762/bjoc.8.233
- interaction is specific, since RNA-polymerases I are not inhibited at all, whereas RNA-polymerases III are inhibited at amanitin concentrations ca. 1000 times higher than for RNA-polymerases II [2][3]. The fact that both the cytoskeleton and the eukaryotic transcription machine are complex structures and
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