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Search for "inflammation" in Full Text gives 86 result(s) in Beilstein Journal of Organic Chemistry.
Biosynthesis of α-pyrones
Beilstein J. Org. Chem. 2016, 12, 571–588, doi:10.3762/bjoc.12.56
- involved in inflammation reactions. The authors isolated 23, 24 and 27 from the feces of Trogopterus xanthipes (flying squirrel) by bioactivity-guided fractionation, and determined IC50 values for the pure compounds to be in the low mM range (1.33, 1.07 and 2.33 mM, respectively) [31]. Also estrogenic and
Physical properties and biological activities of hesperetin and naringenin in complex with methylated β-cyclodextrin
Beilstein J. Org. Chem. 2015, 11, 2763–2773, doi:10.3762/bjoc.11.297
- the effect of free compounds and their inclusion complexes on inflammation as described previously [59]. Cells were seeded at a density of 2 × 106 cells per well in 24 well plates, and incubated at 37 °C for 24 hours. After that, samples were added to obtain a final concentration of 0.1, 0.05 and
Structure and conformational analysis of spiroketals from 6-O-methyl-9(E)-hydroxyiminoerythronolide A
Beilstein J. Org. Chem. 2015, 11, 1447–1457, doi:10.3762/bjoc.11.157
- well as inflammation [36][37][38]. In the search for novel scaffolds to be used as a fresh starting point for further derivatisation [39], we explored modifications to the macrocyclic ring. Oxidative deoximation of 1 in mild acidic media, shown in Scheme 1, led us to an unexpected macrolide-spiroketal
Synthesis of alpha-tetrasubstituted triazoles by copper-catalyzed silyl deprotection/azide cycloaddition
Beilstein J. Org. Chem. 2015, 11, 1425–1433, doi:10.3762/bjoc.11.154
- cruzi, which causes Chagas’ disease [6]. An alpha-tetrasubstituted triazole that inhibits cathepsin S can potentially treat ailments ranging from inflammation to autoimmune disorders [7][8]. The core of the cathepsin S inhibitor is synthesized in six steps. Synthesis and isolation of an N-sulfinyl
Regulation of integrin and growth factor signaling in biomaterials for osteodifferentiation
Beilstein J. Org. Chem. 2015, 11, 773–783, doi:10.3762/bjoc.11.87
- ); be timed biodegradable; neither cause acute nor chronic inflammation; be easily stored and handled (sterilized); and the last be cost-effective [75][80]. The present delivery systems and methods have been systematically reviewed in recent literature [8][9][81]. In brief, growth factors in living
Discrete multiporphyrin pseudorotaxane assemblies from di- and tetravalent porphyrin building blocks
Beilstein J. Org. Chem. 2015, 11, 748–762, doi:10.3762/bjoc.11.85
- significant attention mediated in particular by the desire to understand biological phenomena, such as virus docking to cells [27], toxin inhibition [28], or leucocyte recruitment in inflammation processes of the endothelium [29]. Multivalency has also inspired synthetic supramolecular architecture as it not
Selective methylation of kaempferol via benzylation and deacetylation of kaempferol acetates
Beilstein J. Org. Chem. 2015, 11, 288–293, doi:10.3762/bjoc.11.33
- kaempferol have attracted attention for a long time due to their broad spectrum of biological activities, including induction of apoptosis in adipocytes, anti-inflammation and anti-atherogenic properties [6][7]. 3-O-Methylkaempferol evidently possesses antiviral [8], antimicrobial [9] and cytotoxic [10
Natural phenolic metabolites with anti-angiogenic properties – a review from the chemical point of view
Beilstein J. Org. Chem. 2015, 11, 249–264, doi:10.3762/bjoc.11.28
- from preexisting ones. Under physiological conditions, angiogenesis is vital for foetal development, tissue regeneration and wound healing. From a pathophysiologic perspective, massive vascular growth or abnormal shape formation promotes many ailments including cancer, inflammation, and eye illnesses
Effects of RAMEA-complexed polyunsaturated fatty acids on the response of human dendritic cells to inflammatory signals
Beilstein J. Org. Chem. 2014, 10, 3152–3160, doi:10.3762/bjoc.10.332
- component of the phospholipid membranes found everywhere in the body [2]. Changes in the balance of n−3 and n−6 PUFAs in the diet upon low intake of n−3 PUFAs have been linked to several inflammation-related chronic diseases and certain mental illnesses [3]. Greenland Inuits with traditionally high seafood
- diseases [7]. Intake of dietary fats may influence inflammation in the gastrointestinal tract. In a long-term study conducted on 170 805 women a reduced risk of ulcerative colitis was observed for the participants with high intake of n−3 PUFAs [8]. The fatty acid composition of the diet, in particular, the
- proportion of different types of PUFAs, has an influence on the fatty acid composition of immune cells which is a chemical trigger for immune response, such as inflammation [9]. Supplementation of the diet of healthy human volunteers with n−3 PUFAs was unambiguously beneficial: the number of monocytes and
The Shono-type electroorganic oxidation of unfunctionalised amides. Carbon–carbon bond formation via electrogenerated N-acyliminium ions
Beilstein J. Org. Chem. 2014, 10, 3056–3072, doi:10.3762/bjoc.10.323
- important target in the inflammation response (Scheme 18). The α-methoxy group introduced could then be intercepted via an N-acyliminium ion intermediate with a variety of C–C bond forming reagents. The compounds prepared were interrogated for bioactivity against α-L-fucosidase and related targets and IC50
A one-pot multistep cyclization yielding thiadiazoloimidazole derivatives
Beilstein J. Org. Chem. 2014, 10, 2989–2996, doi:10.3762/bjoc.10.317
- ], acetylcholinesterase inhibitors [3], and antibacterial agents [4][5]. Due to the strong inhibitory activity of 1,2,4-thiadiazoles against kinase-3β, they can be used for treatment of diabetes (type II) and chronic inflammation [6][7]. Therefore, their synthesis is a field of continuing interest for many chemists [1][8
Application of cyclic phosphonamide reagents in the total synthesis of natural products and biologically active molecules
Beilstein J. Org. Chem. 2014, 10, 1848–1877, doi:10.3762/bjoc.10.195
- inflammation and traumatic bleeding. The leaves and stems of this plant contain oleoside-type secoiridoid glucosides with structurally interesting tetrasubstituted cyclopentanoid monoterpene units [116]. Two representative examples of these glycosides are nudifloside A (151) and D (13), which share a common
Synthesis of rigid p-terphenyl-linked carbohydrate mimetics
Beilstein J. Org. Chem. 2014, 10, 1749–1758, doi:10.3762/bjoc.10.182
- involved in different diseases such as cancer [4], inflammation [5], and infections [6]. However, the use of carbohydrates as drugs has been strongly limited due to the hydrolytic lability of the glycosidic bond [7] and the weak binding affinities of single molecules. With the development of artificial C
Clicked and long spaced galactosyl- and lactosylcalix[4]arenes: new multivalent galectin-3 ligands
Beilstein J. Org. Chem. 2014, 10, 1672–1680, doi:10.3762/bjoc.10.175
- activation, cell growth, differentiation and apoptosis. Among different families of lectins, the ones showing a selectivity for β-D-galactoside and β-D-galactose-terminating oligosaccharides are called galectins and play important roles in a series of pathological events such as inflammation, fibrosis, heart
Automated solid-phase peptide synthesis to obtain therapeutic peptides
Beilstein J. Org. Chem. 2014, 10, 1197–1212, doi:10.3762/bjoc.10.118
- osteoporosis, cardiovascular diseases and inflammation can be treated by peptide-based drugs [4][5]. Within the last decades, the fast development of omics technologies such as genomics, proteomics and transcriptomics led to the identification of a great number of target peptides or proteins [6]. This trend
Total synthesis of the endogenous inflammation resolving lipid resolvin D2 using a common lynchpin
Beilstein J. Org. Chem. 2013, 9, 2762–2766, doi:10.3762/bjoc.9.310
- Abstract The total synthesis of the endogenous inflammation resolving eicosanoid resolvin D2 (1) is described. The key steps involved a Wittig reaction between aldehyde 5 and the ylide derived from phosphonium salt 6 to give enyne 17 and condensation of the same ylide with aldehyde 7 to afford enyne 11
- ; resolvin D2; Sonogashira coupling; total synthesis; Wittig reaction; Introduction The resolution of inflammation is a tightly governed active process effectively mediated by a range of bioactive polyunsaturated fatty acids, peptides and proteins. In 2002, a new family of endogenously generated lipid
- mediators involved in the resolution of inflammation named the resolvins (resolution phase interaction products) were identified by Serhan and co-workers in the inflammatory exudates of aspirin treated mice [1][2][3]. The resolvins are divided into 2 groups, the D-series resolvins D2 (1) and D1 (2) [3
Total synthesis of (−)-epimyrtine by a gold-catalyzed hydroamination approach
Beilstein J. Org. Chem. 2013, 9, 2042–2047, doi:10.3762/bjoc.9.242
- alkaloid; total synthesis; Findings (−)-Epimyrtine, isolated from Vaccinium myrtillus (Ericaceae) [1][2], is a quinolizidine alkaloid. This alkaloid family exhibits potential pharmacological properties such as anticancer, antibacterial, antiviral and anti-inflammation activities [3][4][5]. This alkaloid
Synthesis and quantitative structure–activity relationship study of substituted imidazophosphor ester based tetrazolo[1,5-b]pyridazines as antinociceptive/anti-inflammatory agents
Beilstein J. Org. Chem. 2013, 9, 1730–1736, doi:10.3762/bjoc.9.199
- , showed a notable antinociceptive and anti-inflammatory activity without toxic side-effects. Keywords: antinociceptive/anti-inflammatory agents; imidazophosphor esters; phosphonyl carbanions; ring closure; tetrazolo[1,5-b]pyridazine; Introduction Inflammation is a characteristic feature of disease
- the cyclooxygenase (COX) enzymes. Later on, it was reported that the second isoform of cyclooxygenase (COX-2) has a better effect on the inflammation with fewer side-effects [6][7][8][9]. Despite their widespread use, none of the presently available agents is ideal; each has its own shortcomings [3
- ]. Subsequently, to improve the efficacy/safety profile of new NSAIDs, the structural–activity relationship (SAR) has been extensively studied, taking into account up-to-date knowledge about the mechanism of inflammation that balanced the inhibition of COX-1, COX-2, and lipoxygenase (LOX) [10][11][12]. As a part
Amyloid-β probes: Review of structure–activity and brain-kinetics relationships
Beilstein J. Org. Chem. 2013, 9, 1012–1044, doi:10.3762/bjoc.9.116
- neurons and acetylcholine (ACh) levels, plaques caused by aggregation of the protein fragment amyloid-β (Aβ), tangles associated with irregular phosphorylation of tau protein, inflammation and increased oxidative stress from reactive oxygen species (ROS), as well as dyshomeostasis and
Synthesis and physicochemical characterization of novel phenotypic probes targeting the nuclear factor-kappa B signaling pathway
Beilstein J. Org. Chem. 2013, 9, 900–907, doi:10.3762/bjoc.9.103
- center’s efforts. Within the realm of immunology and inflammation research, many cellular pathways leading to the activation of NF-κB family of transcription factors have been identified and several excellent reviews are available [2][3][4][5]. In general, these pathways have been shown to participate in
- host defense, immunity, and inflammation and even have implications in cancer. Thus, dysregulation of NF-κB activity contributes to numerous autoimmune and inflammatory disease states. With this, the availability of new chemical pathway probes will further enhance understanding of this complex network
Recent progress in the discovery of small molecules for the treatment of amyotrophic lateral sclerosis (ALS)
Beilstein J. Org. Chem. 2013, 9, 717–732, doi:10.3762/bjoc.9.82
- characterized in ALS, including, but not limited to glutamate toxicity, protein misfolding and aggregation, endoplasmic reticulum (ER) stress, loss of trophic factors, oxidative stress, inflammation, disrupted protein trafficking, and mitochondrial dysfunction [5]. Therapeutic development has been based around
- with GSK-3 inhibitors reduced markers of inflammation in the spinal cord [63], suggesting a reduction in glial reactivity. Reduction in oxidative stress and inflammation Another hallmark of ALS is chronic neuronal exposure to oxidative stress and inflammation and thus several treatment strategies are
- , oxidative stress, inflammation, and mitochondrial dysfunction. Although some cases of ALS can be attributed to known gene mutations, the cause of ALS remains largely undefined. Therefore, current treatment strategies for ALS involve the targeting of specific cellular dysfunctions. As mutations in the SOD1
End-labeled amino terminated monotelechelic glycopolymers generated by ROMP and Cu(I)-catalyzed azide–alkyne cycloaddition
Beilstein J. Org. Chem. 2013, 9, 608–612, doi:10.3762/bjoc.9.66
- cyclooctenes have been used to examine the role of glycans in such processes such as neurite outgrowth [4], bacterial motility [5], and inflammation [6]. ROMP polymers with pendant reactive functional groups, such as N-hydroxysuccinimide (NHS) or nitrophenyl esters, are useful materials since the pendant
Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide
Beilstein J. Org. Chem. 2013, 9, 270–277, doi:10.3762/bjoc.9.33
- treatment is conducted when patients respond inadequately to medical therapy. However, invasive mechanical ventilation can damage the lungs physically by overpressurizing lung tissue or due to inflammation. This may lead to exacerbation of lung dysfunction or even to multiple-organ failure [2][3]. The
Cyclodextrin-based nanosponges as drug carriers
Beilstein J. Org. Chem. 2012, 8, 2091–2099, doi:10.3762/bjoc.8.235
- and prolonged ASA release from pyromellitic cross-linked β-cyclodextrin nanosponges over a long period, i.e., 24 hours. In carrageenan-induced rat paw edema, administration of ASA as a nanosponge formulation administered by oral gavage reduced inflammation significantly (P < 0.01 and P < 0.05
Enantioselective total synthesis of (R)-(−)-complanine
Beilstein J. Org. Chem. 2012, 8, 1695–1699, doi:10.3762/bjoc.8.192
- complanata, and known to be a causative agent in inflammation. An organocatalytic, asymmetric oxyamination of a homoconjugated all-Z-dienal intermediate provides versatile and efficient access to the natural product. Keywords: complanine; enantioselective synthesis; marine fireworm; nitrosoaldol
- ; organocatalysis; Introduction The marine fireworm Eurythoe complanata resides in the shallow water and sands of temperate and sub-tropical regions. Its small setae cause skin inflammation upon contact, the causative agent having been identified as complanine. This novel amphipathic substance was first isolated
- from Eurythoe complanata in 2008, by Nakamura and Uemura [1]. Complanine induces inflammation by activating PKC (protein kinase C) in the presence of Ca2+ and TPA (12-O-tetradecanoylphorbol 13-acetate). PKC plays an important role in inflammation, namely through control of signal transduction cascades
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