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Search for "nematode" in Full Text gives 7 result(s) in Beilstein Journal of Organic Chemistry.
Using UHPLC–MS profiling for the discovery of new sponge-derived metabolites and anthelmintic screening of the NatureBank bromotyrosine library
Beilstein J. Org. Chem. 2022, 18, 1544–1552, doi:10.3762/bjoc.18.164
- ]. Thus, the chemical structure 1 was assigned as 5-debromopurealidin H. Due to our interest in discovering new anthelmintics from marine sources [22][23][24][25][26], we decided to test these compounds for their nematocidal activity against Haemonchus contortus, a highly pathogenic parasitic nematode of
- -debromopurealidin H (1), had activity against larvae of the parasitic nematode, H. contortus. Definitive structure assignments for the unidentified metabolites from the I. basta extract would require recollection of this sponge, which is currently not feasible. Additional Verongida extracts used in the UHPLC–MS
- for C14H1779BrN5O3, 382.0509). Ianthesine E (2): Yellow film; + 76.3 (c 0.4 in MeOH), lit. + 50.6 (c 0.3 in MeOH) [15]; (+)-LRESIMS m/z 714/716/718/720/722 (1:4:6:4:1) [M + H]+, (−)-LRESIMS m/z 792/794/796/798/800 (1:4:6:4:1) [M − H]−. Preparation of nematode larvae for bioassays Haemonchus
Natural products in the predatory defence of the filamentous fungal pathogen Aspergillus fumigatus
Beilstein J. Org. Chem. 2021, 17, 1814–1827, doi:10.3762/bjoc.17.124
- have been widely used for the identification of virulence attributes of pathogenic fungi, including Aspergillus spp., for their similarity with human phagocytic cells [32]. Nevertheless, the precise identity of amoeboid, nematode and arthropod predators that target filamentous fungi in their
Anthelmintic drug discovery: target identification, screening methods and the role of open science
Beilstein J. Org. Chem. 2020, 16, 1203–1224, doi:10.3762/bjoc.16.105
- been much progress in creating more potent and selective derivatives. This work exemplifies how open science approaches can catalyse drug discovery against neglected diseases. Keywords: anthelmintic; antiparasitic; cestode; nematode; trematode; Review The need for anthelmintic drug discovery
- most promising compounds and to reduce the redundancy of effort. Such a collaborative data-sharing structure must be a priority for the field. C. elegans: a model organism for parasitology and an exemplar of an open community C. elegans as a model nematode Caenorhabditis elegans (C. elegans) is a non
- -parasitic nematode worm that is found worldwide and was selected by Sydney Brenner as a genetic model organism for biological research with strong potential to contribute to our understanding of developmental biology and neurobiology [84]. In 1998 it became the first complex eukaryote to have its genome
Fabclavine diversity in Xenorhabdus bacteria
Beilstein J. Org. Chem. 2020, 16, 956–965, doi:10.3762/bjoc.16.84
- of the insect by the nematode, the bacteria are released from the nematode gut into the insect hemocoel where they start producing a diversity of different natural products to suppress the immune response and to kill the insects, to defend the carcass against food competitors, and to trigger the
- development of the nematode [5][13]. The general interest on Photorhabdus and Xenorhabdus increased in recent years, not only because of their large number of SMs, but also due to their easy-to-handle cultivation under laboratory conditions in combination with the accessibility for genetic manipulations such
Synthesis and SAR of the antistaphylococcal natural product nematophin from Xenorhabdus nematophila
Beilstein J. Org. Chem. 2019, 15, 535–541, doi:10.3762/bjoc.15.47
- soil-living nematodes of the genera Steinernema [2][3]. During a complex life cycle the nematode–bacteria pair infects and kills insect larvae, whereby Xenorhabdus produce a broad range of natural products with antimicrobial properties [4][5][6][7][8]. As the Steinernema–Xenorhabdus complex is not
- pathogenic against humans, they are widely used as biocontrol agents in agriculture [9]. Natural products produced by bacteria play an important role in the bacteria/nematode/insect life cycle and most natural products are non-ribosomal peptides (NRP), e.g., rhabdopeptides [10][11] and polyketide–NRP hybrids
- nevaltophines act as prophenoloxidase activators, it is suggested that they have a specific role in the bacteria/nematode/insect symbiosis. Little or nothing is known about the mode of action of this simple amide against S. aureus. Structure–bioactivity studies revealed that the α-keto moiety and the amide
Hydrophobic analogues of rhodamine B and rhodamine 101: potent fluorescent probes of mitochondria in living C. elegans
Beilstein J. Org. Chem. 2012, 8, 2156–2165, doi:10.3762/bjoc.8.243
- -shifted absorbance and emission spectra (5–9 nm), modest reductions in molar extinction coefficent and quantum yield, and enhanced partitioning into octanol compared with aqueous buffer of 10-fold or more. Comparison of living C. elegans (nematode roundworm) animals treated with the classic fluorescent
- , including ischemia, neurodegeneration, metabolic disease, and cancer [19][20]. In vivo, the pharmacokinetics of some rhodamines have been evaluated [21][22][23], and some have been used for imaging of mitochondria in the optically transparent model organism C. elegans (nematode worm) [24][25]. However
Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum
Beilstein J. Org. Chem. 2012, 8, 528–533, doi:10.3762/bjoc.8.60
- may be required for different stages of this life cycle, including the symbiotic stage (towards the nematode) or pathogenic stage (towards the insect prey) [1][2][3]. Until three years ago, the natural products extracted from Xenorhabdus and its close neighbour Photorhabdus were only low-molecular
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