Recent developments in chemical diversity

  1. editorImage
  1. Editor: John A. Porco Jr.
    Boston University

Diversity-oriented synthesis (DOS) is an important field involving the synthesis of libraries of diverse small molecules for applications including biological screening. The last decade has witnessed major progress in the field, with continued emphasis on structural and functional diversity for DOS library construction, leading to recent successes of biologically active molecules obtained from DOS compound collections. In the original paradigm for DOS, compound and library design were often based on the incorporation of functional, skeletal, and stereochemical diversity elements. An emerging theme in the area involves the development of novel reaction methodologies as a means to access or discover new “chemotypes”, advancing alongside the technology that enables progress in this area. In this way, organic chemists are empowered by the paradigm of “chemical diversity as a function of novel chemical reactions”, exploring a diverse repertoire of approaches to achieve their goals.

  • Editorial
  • Published 06 Jun 2012

Beilstein J. Org. Chem. 2012, 8, 827–828, doi:10.3762/bjoc.8.92

An intramolecular inverse electron demand Diels–Alder approach to annulated α-carbolines

  1. Zhiyuan Ma,
  2. Feng Ni,
  3. Grace H. C. Woo,
  4. Sie-Mun Lo,
  5. Philip M. Roveto,
  6. Scott E. Schaus and
  7. John K. Snyder
  • Full Research Paper
  • Published 06 Jun 2012

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2012, 8, 829–840, doi:10.3762/bjoc.8.93

Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors

  1. Chao Che,
  2. Song Li,
  3. Bo Yang,
  4. Shengchang Xin,
  5. Zhixiong Yu,
  6. Taofeng Shao,
  7. Chuanye Tao,
  8. Shuo Lin and
  9. Zhen Yang
  • Full Research Paper
  • Published 06 Jun 2012

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2012, 8, 841–849, doi:10.3762/bjoc.8.94

Two-directional synthesis as a tool for diversity-oriented synthesis: Synthesis of alkaloid scaffolds

  1. Kieron M. G. O’Connell,
  2. Monica Díaz-Gavilán,
  3. Warren R. J. D. Galloway and
  4. David R. Spring
  • Full Research Paper
  • Published 06 Jun 2012

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2012, 8, 850–860, doi:10.3762/bjoc.8.95

Parallel and four-step synthesis of natural-product-inspired scaffolds through modular assembly and divergent cyclization

  1. Hiroki Oguri,
  2. Haruki Mizoguchi,
  3. Hideaki Oikawa,
  4. Aki Ishiyama,
  5. Masato Iwatsuki,
  6. Kazuhiko Otoguro and
  7. Satoshi Ōmura
  • Full Research Paper
  • Published 22 Jun 2012

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2012, 8, 930–940, doi:10.3762/bjoc.8.105

  • Letter
  • Published 02 Jul 2012

Beilstein J. Org. Chem. 2012, 8, 986–993, doi:10.3762/bjoc.8.111

Parallel solid-phase synthesis of diaryltriazoles

  1. Matthias Wrobel,
  2. Jeffrey Aubé and
  3. Burkhard König
  • Full Research Paper
  • Published 06 Jul 2012

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2012, 8, 1027–1036, doi:10.3762/bjoc.8.115

Synthesis and in silico screening of a library of β-carboline-containing compounds

  1. Kay M. Brummond,
  2. John R. Goodell,
  3. Matthew G. LaPorte,
  4. Lirong Wang and
  5. Xiang-Qun Xie
  • Full Research Paper
  • Published 10 Jul 2012

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2012, 8, 1048–1058, doi:10.3762/bjoc.8.117

Synthesis of a library of tricyclic azepinoisoindolinones

  1. Bettina Miller,
  2. Shuli Mao,
  3. Kara M. George Rosenker,
  4. Joshua G. Pierce and
  5. Peter Wipf
  • Full Research Paper
  • Published 13 Jul 2012

Beilstein J. Org. Chem. 2012, 8, 1091–1097, doi:10.3762/bjoc.8.120

  • Full Research Paper
  • Published 26 Jul 2012

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2012, 8, 1191–1199, doi:10.3762/bjoc.8.132

Palladium-catalyzed substitution of (coumarinyl)methyl acetates with C-, N-, and S-nucleophiles

  1. Kalicharan Chattopadhyay,
  2. Erik Fenster,
  3. Alexander J. Grenning and
  4. Jon A. Tunge
  • Full Research Paper
  • Published 27 Jul 2012

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2012, 8, 1200–1207, doi:10.3762/bjoc.8.133

Photochemistry with laser radiation in condensed phase using miniaturized photoreactors

  1. Elke Bremus-Köbberling,
  2. Arnold Gillner,
  3. Frank Avemaria,
  4. Céline Réthoré and
  5. Stefan Bräse
  • Full Research Paper
  • Published 31 Jul 2012

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2012, 8, 1213–1218, doi:10.3762/bjoc.8.135

Exploring chemical diversity via a modular reaction pairing strategy

  1. Joanna K. Loh,
  2. Sun Young Yoon,
  3. Thiwanka B. Samarakoon,
  4. Alan Rolfe,
  5. Patrick Porubsky,
  6. Benjamin Neuenswander,
  7. Gerald H. Lushington and
  8. Paul R. Hanson
  • Full Research Paper
  • Published 15 Aug 2012

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2012, 8, 1293–1302, doi:10.3762/bjoc.8.147

Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations

  1. Bo Leng,
  2. Stephanie Chichetti,
  3. Shun Su,
  4. Aaron B. Beeler and
  5. John A. Porco Jr.
  • Full Research Paper
  • Published 20 Aug 2012

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2012, 8, 1338–1343, doi:10.3762/bjoc.8.153

Automated three-component synthesis of a library of γ-lactams

  1. Erik Fenster,
  2. David Hill,
  3. Oliver Reiser and
  4. Jeffrey Aubé
  • Full Research Paper
  • Published 19 Oct 2012

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2012, 8, 1804–1813, doi:10.3762/bjoc.8.206

Keep Informed

RSS Feed

Subscribe to our Latest Articles RSS Feed.

Subscribe

Follow the Beilstein-Institut

LinkedIn

Twitter: @BeilsteinInst