Reactive intermediates part I: radicals

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Editor: Prof. Tehshik P. Yoon
University of Wisconsin-Madison
 
Open-shelled, odd-electron organic molecules were once believed to be so unstable that they could not exist or that their reactions would always be uncontrolled. However, beginning with Gomberg’s description of the chemistry of triphenylmethyl radical, a wide range of important reactions have been shown to involve radical intermediates. These span examples from classical photochemically and thermolytically initiated organoradical chemistry, transition metal chemistry, electrochemistry, biological chemistry, and modern photoredox chemistry. Indeed, organic radical chemistry is among the most active research areas in contemporary organic chemistry. This thematic issue highlights the current progress in this field and provide a cross-section of the diverse research questions that motivating the growing activity in radical chemistry.

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Photocatalyic Appel reaction enabled by copper-based complexes in continuous flow

  • Clémentine Minozzi,
  • Jean-Christophe Grenier-Petel,
  • Shawn Parisien-Collette and
  • Shawn K. Collins

Beilstein J. Org. Chem. 2018, 14, 2730–2736, doi:10.3762/bjoc.14.251

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Published 30 Oct 2018

Copper(I)-catalyzed tandem reaction: synthesis of 1,4-disubstituted 1,2,3-triazoles from alkyl diacyl peroxides, azidotrimethylsilane, and alkynes

  • Muhammad Israr,
  • Changqing Ye,
  • Munira Taj Muhammad,
  • Yajun Li and
  • Hongli Bao

Beilstein J. Org. Chem. 2018, 14, 2916–2922, doi:10.3762/bjoc.14.270

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Published 23 Nov 2018

Degenerative xanthate transfer to olefins under visible-light photocatalysis

  • Atsushi Kaga,
  • Xiangyang Wu,
  • Joel Yi Jie Lim,
  • Hirohito Hayashi,
  • Yunpeng Lu,
  • Edwin K. L. Yeow and
  • Shunsuke Chiba

Beilstein J. Org. Chem. 2018, 14, 3047–3058, doi:10.3762/bjoc.14.283

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Published 13 Dec 2018

Tandem copper and photoredox catalysis in photocatalytic alkene difunctionalization reactions

  • Nicholas L. Reed,
  • Madeline I. Herman,
  • Vladimir P. Miltchev and
  • Tehshik P. Yoon

Beilstein J. Org. Chem. 2019, 15, 351–356, doi:10.3762/bjoc.15.30

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Published 05 Feb 2019

A diastereoselective approach to axially chiral biaryls via electrochemically enabled cyclization cascade

  • Hong Yan,
  • Zhong-Yi Mao,
  • Zhong-Wei Hou,
  • Jinshuai Song and
  • Hai-Chao Xu

Beilstein J. Org. Chem. 2019, 15, 795–800, doi:10.3762/bjoc.15.76

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Published 28 Mar 2019

Photochemical generation of the 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) radical from caged nitroxides by near-infrared two-photon irradiation and its cytocidal effect on lung cancer cells

  • Ayato Yamada,
  • Manabu Abe,
  • Yoshinobu Nishimura,
  • Shoji Ishizaka,
  • Masashi Namba,
  • Taku Nakashima,
  • Kiyofumi Shimoji and
  • Noboru Hattori

Beilstein J. Org. Chem. 2019, 15, 863–873, doi:10.3762/bjoc.15.84

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Published 10 Apr 2019

Vicinal difunctionalization of alkenes by four-component radical cascade reaction of xanthogenates, alkenes, CO, and sulfonyl oxime ethers

  • Shuhei Sumino,
  • Takahide Fukuyama,
  • Mika Sasano,
  • Ilhyong Ryu,
  • Antoine Jacquet,
  • Frédéric Robert and
  • Yannick Landais

Beilstein J. Org. Chem. 2019, 15, 1822–1828, doi:10.3762/bjoc.15.176

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Published 31 Jul 2019
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