Visualizing nanostructures in supramolecular hydrogels: a correlative study using confocal and cryogenic scanning electron microscopy

• Shaun M. Smith,
• Ferdinando Malagreca,
• Jacqueline Hicks,
• Giuseppe Mantovani,
• David B. Amabilino,
• Christopher Parmenter and
• Lluïsa Pérez-García

Beilstein J. Nanotechnol. 2025, 16, 2274–2284, doi:10.3762/bjnano.16.156

• material. The application of confocal microscopy, stimulated emission depletion (STED) microscopy, and conventional transmission electron microscopy (TEM) to a supramolecular peptide material has been shown to allow for sub-diffraction resolution imaging of fibre morphology in situ without covalent

• result in phase separation whereby the water freezes, first expelling the ethanol into concentrated domains, which alters microscale material morphology. Such a phenomenon has been exploited for the fractional freezing of water–ethanol mixtures and in liposomal formulations containing water and DMSO [36

• confocal conditions. Importantly, no material is seen in between the fibres, indicating that the ZnPc is bound to the gelator. There is little observable difference in the gel morphology between the gel containing ZnPc and that containing DPP-BC, with both exhibiting long, curving fibres characteristic of

Geometry-controlled engineering of the low-temperature proximity effect in normal metal–superconductor junctions

• Munisa A. Tomayeva,
• Vyacheslav D. Neverov,
• Andrey V. Krasavin,
• Alexei Vagov and
• Mihail D. Croitoru

Beilstein J. Nanotechnol. 2025, 16, 2265–2273, doi:10.3762/bjnano.16.155

• Gennes equations; normal metal–superconductor junction; order parameter; proximity effect; superconductivity; Introduction When a superconductor (SC) is brought into contact with a normal metal (NM) or a ferromagnet (FM), Cooper pairs penetrate the adjacent material, imparting superconducting properties

• to it. This phenomenon, known as the proximity effect, enables normal material to support supercurrents and to exhibit a reduced density of states near the Fermi level, where a gap opens in the single-particle spectrum as electrons form into Cooper pairs [1][2][3][4]. At the same time, unpaired

• superconducting correlations in the NM is a hallmark of the proximity effect [14][15][16]. The pair correlations continuously decrease from their bulk value deep inside the superconductor, leak into the normal material, and eventually vanish at a distance much larger than ξn far inside the NM [7][17][18]. The

Chiral plasmonic nanostructures fabricated with circularly polarized light

• Tian Qiao and
• Ming Lee Tang

Beilstein J. Nanotechnol. 2025, 16, 2245–2264, doi:10.3762/bjnano.16.154

• -induced growth of cPNSs in the same year [20]. CPL offers several advantages over the chiral chemical precursors used in the seeded growth approach. First, CPL is traceless. Turning off the CPL removes its influence on the material system, which can simplify the characterization of the material’s

• magnetic fields, respectively. Derived by Tang and Cohen [119], the optical chirality is relevant to gλ, the fractional difference in rates of excitation of a small molecule between LCPL and RCPL at wavelength λ through Equation 2, where gCPL is the material dissymmetry factor, c is the speed of light, Ue

• orientation of the polarization plane of linearly polarized light when traveling through a chiral medium. It is related to the real part of the material refractive index, and a chiral material has a different index for LCPL and RCPL. CB is measured through ORD expressed by Equation 3: where nRCPL and nLCPL

Optical bio/chemical sensors for vitamin B₁₂ analysis in food and pharmaceuticals: state of the art, challenges, and future outlooks

• Seyed Mohammad Taghi Gharibzahedi and
• Zeynep Altintas

Beilstein J. Nanotechnol. 2025, 16, 2207–2244, doi:10.3762/bjnano.16.153

• -based AuNP colorimetric biosensors In this sensing system, the recognition material is the RNA aptamer, the indicator material is the gold nanoparticle (AuNP), and the sensing signal is colorimetric. The excellent optical-electronic characteristics of AuNPs have been recently considered in point-of-care

• significant difference in the detected amounts of MeCbl among the utilized diagnostic assays [78]. Small-molecule-based colorimetric chemosensors for cobalt/VB12 detection In this class, the recognition material is a small-molecule receptor (chemosensor), the indicator material is its intrinsic chromophore or

• phenols in a diazotization-like process produced a range of azo derivatives, 3-(diazenyl)-2-(styryl)quinazolin-4(3H)-one for detecting metal ions of Co2+ and Fe2+, where the azo-quinazolinone acted as the recognition material, the azo chromophore acted as the indicator, and the sensing readout was a

Missing links in nanomaterials research impacting productivity and perceptions

• Santosh K. Tiwari and
• Nannan Wang

Beilstein J. Nanotechnol. 2025, 16, 2168–2176, doi:10.3762/bjnano.16.149

• technology to catch up with his ideas, his foresight catalyzed a profound shift in the way scientists approached the material world. What was once philosophical became increasingly feasible and eventually tangible. Since then, various aspects of nanoscience and nanotechnology have evolved, ranging from the

• acceleration after the discovery of fullerene by Kroto and co-workers in 1985 and witnessed an even more rapid surge following the discovery of graphene and the award of the Physics Nobel Prize in 2010 [6][7]. Graphene is often referred to as a “wonder material” due to its seemingly infinite potential in

Microplastic pollution in Himalayan lakes: assessment, risks, and sustainable remediation strategies

• Sameeksha Rawat,
• S. M. Tauseef and
• Madhuben Sharma

Beilstein J. Nanotechnol. 2025, 16, 2144–2167, doi:10.3762/bjnano.16.148

• , attack the polymer chains of MPs. They either break the chains into smaller pieces or mineralize them into CO2 and water. A lot of research is being done on the photocatalytic properties of nanomaterials like TiO2, graphene oxide (GO), and ZnO. An excellent material for breaking down MPs in water systems

Electron transport through nanoscale multilayer graphene and hexagonal boron nitride junctions

• Aleksandar Staykov and
• Takaya Fujisaki

Beilstein J. Nanotechnol. 2025, 16, 2132–2143, doi:10.3762/bjnano.16.147

• perpendicular to the layers in the stacking direction. We compared the decay of the current with the number of layers and evaluated the ability of h-BN to filter currents as a material coating. To investigate the effect of disorder, we included two major defects in the graphene lattice, namely, nitrogen doping

• ) is a material that shares many structural and electronic properties with graphite. It is isoelectronic to graphene with N contributing two electrons to the π-conjugated bond and B contributing zero electrons, as opposed to graphene, where each C atom contributes one electron. The h-BN structure is

• composed of polar bonds with N acting as electron donor and B acting as electron acceptor. Unlike graphene and graphite, h-BN shows high resistivity and is a large-bandgap semiconductor [17]. h-BN has a wide range of applications due to its unique properties [18]. It is used as a substrate material for

Quality by design optimization of microemulsions for topical delivery of Passiflora setacea seed oil

• Daniel T. Pereira,
• Douglas Dourado,
• Danielle T. Freire,
• Dayanne L. Porto,
• Cícero F. S. Aragão,
• Myla L. de Souza,
• Guilherme R. S. de Araujo,
• Ana Maria Costa,
• Wógenes N. Oliveira,
• Anne Sapin-Minet,
• Éverton N. Alencar and
• Eryvaldo Sócrates T. Egito

Beilstein J. Nanotechnol. 2025, 16, 2116–2131, doi:10.3762/bjnano.16.146

• quantitatively evaluate these risks. A three-level interdependence scale (1: low, 3: medium, 9: high) was applied to assess the relationship between the QTPP and CQAs (Supporting Information File 1, Table S1), as well as between the CQAs and the critical material attributes (CMAs) and critical process parameters

Rapid synthesis of highly monodisperse AgSbS₂ nanocrystals: unveiling multifaceted activities in cancer therapy, antibacterial strategies, and antioxidant defense

• Funda Ulusu,
• Adem Sarilmaz,
• Yakup Ulusu,
• Faruk Ozel and
• Mahmut Kus

Beilstein J. Nanotechnol. 2025, 16, 2105–2115, doi:10.3762/bjnano.16.145

• reducing capacity. Conclusion Ag-based materials, which are well known for their antibacterial properties, have been the subject of many studies. Therefore, in this study, AgSbS2 NCs belonging to the Ag-based chalcogenide material family were produced using the hot-injection method to examine their

Toward clinical translation of carbon nanomaterials in anticancer drug delivery: the need for standardisation

• Michał Bartkowski,
• Francesco Calzaferri and
• Silvia Giordani

Beilstein J. Nanotechnol. 2025, 16, 2092–2104, doi:10.3762/bjnano.16.144

• CNMs for drug delivery presents several practical and economic challenges. These include high equipment and raw material costs, limited yields, quality control issues, and environmental and safety concerns. Addressing these barriers requires targeted innovation in synthesis methods, improved

• responses [37]. In contrast, a recent first-in-human investigation of thin, highly purified graphene oxide nanosheets reported that acute inhalation was well tolerated, showing no adverse effects on lung function, cardiovascular health, or systemic inflammatory markers [28]. Even within the same material

• , and material purity are essential for translational development. Contaminants such as carboxylated carbonaceous fragments (CCFs) may be introduced during synthesis and processing, and these impurities can alter biological responses or induce toxicity. Their detection and removal should form a routine

Calibration of piezo actuators and systems by dynamic interferometry

• Knarik Khachatryan and
• Michael Reichling

Beilstein J. Nanotechnol. 2025, 16, 2086–2091, doi:10.3762/bjnano.16.143

• calibration factor differs from the nominal value by more than a factor of two might be due to the manufacturing tolerance; but, more likely, it can be explained by a depolarization of the tube piezo material as it has been subject to many heating cycles for bakeout of the UHV chamber. Next, we investigate

Multifrequency AFM integrating PeakForce tapping and higher eigenmodes for heterogeneous surface characterization

• Yanping Wei,
• Jiafeng Shen,
• Yirong Yao,
• Xuke Li,
• Ming Li and
• Peiling Ke

Beilstein J. Nanotechnol. 2025, 16, 2077–2085, doi:10.3762/bjnano.16.142

• ) technique that synergistically integrates PeakForce tapping mode with higher eigenmode vibrations to achieve simultaneous high-resolution topographical imaging and to access additional contrast channels for distinguishing material regions or compositions. Unlike conventional multimodal AFM, our method

• mappings obtained via the PeakForce tapping method. Furthermore, the technique’s dual capability, that is, quantitative mechanics via quasi-static force curves and qualitative material-sensitive information via eigenmode vibration signals, facilitates effective compositional differentiation in

• heterogeneous nanomaterials while significantly simplifying the requirements for probe selection, which are typically necessary for material differentiation via the standard PeakForce tapping method. This innovation enhances the technique’s practicality and extends compatibility to a wider array of probe types

Molecular and mechanical insights into gecko seta adhesion: multiscale simulations combining molecular dynamics and the finite element method

• Yash Jain,
• Saeed Norouzi,
• Tobias Materzok,
• Stanislav N. Gorb and
• Florian Müller-Plathe

Beilstein J. Nanotechnol. 2025, 16, 2055–2076, doi:10.3762/bjnano.16.141

• natural hierarchy of real gecko setae, which includes finer branches, varying cross sections, and region-specific material anisotropy. Real setae possess complex cross-sectional shapes and non-uniform branching angles, which could lead to variations in force distributions. Nonetheless, this idealized

• material may exhibit anisotropy and viscoelastic or even plastic behavior, especially under rapid loading. Our FE mesh is presently limited to a linear-elastic, isotropic constitutive law, with parameters E and ν matching those of our molecular keratin spatula model [11][12]. These values were derived in a

• bottom-up manner from atomistic simulations that reproduced experimental data [8][38][39]. For each of our simulations, we sampled E and ν from normal distributions with the same mean and standard deviations as our mesoscale spatula model. Table 2 summarizes the material parameters used for our FE mesh

Stereodiscrimination of guests in chiral organosilica aerogels studied by ESR spectroscopy

• Sebastian Polarz,
• Yasar Krysiak,
• Martin Wessig and
• Florian Kuhlmann

Beilstein J. Nanotechnol. 2025, 16, 2034–2054, doi:10.3762/bjnano.16.140

• available material confirmed the method’s reliability. The data underline how crucial the choice of the right solvent is if one wants to reach sufficient selectivity. Together with a series of custom-made organosilica aerogels, it is shown that adjusting solvent and surface properties so that the two

• enantiomers (+) and (−) experience a different chemical environment is key. Otherwise, there might be a dynamic equilibrium between surface-adsorbed and mobile spin probes without stereodifferentiation. With this knowledge, it was possible to reach higher selectivity values than for the commercial material. A

• Kotov and coworkers [4]. Chiral optical materials have unique optical activity, displaying phenomena such as circular dichroism and optical rotation. These characteristics are harnessed in applications like sensors, optical devices, and polarized materials. Material chirality can also lead to unusual

Beyond the shell: exploring polymer–lipid interfaces in core–shell nanofibers to carry hyaluronic acid and β-caryophyllene

• Aline Tavares da Silva Barreto,
• Francisco Alexandrino-Júnior,
• Bráulio Soares Arcanjo,
• Paulo Henrique de Souza Picciani and
• Kattya Gyselle de Holanda e Silva

Beilstein J. Nanotechnol. 2025, 16, 2015–2033, doi:10.3762/bjnano.16.139

• encapsulated within a PLA shell, highlighting substantial potential for biomedical applications by overcoming key material integration hurdles. Keywords: co-axial nanofibers; electrospinning; hybrid nanosystem; nanofibers; nanoemulsion; poly(lactic acid); Introduction Driven by the significant potential of

• process variables, such as high voltage, flow rate, and the distance from the Taylor cone to the collector, which significantly impacts nanofiber morphology [17]. Furthermore, selection of the material to be electrospun is crucial, requiring control over key attributes such as molecular weight, polymer

• the shell and core flow rates is crucial to ensure proper incorporation of the core material. When this ratio is excessively high, the core flow becomes insufficient relative to the shell flow, resulting in fibers with a discontinuous or poorly defined core [50]. Conversely, when the core flow is too

The cement of the tube-dwelling polychaete Sabellaria alveolata: a complex composite adhesive material

• Emilie Duthoo,
• Aurélie Lambert,
• Pierre Becker,
• Carla Pugliese,
• Jean-Marc Baele,
• Arnaud Delfairière,
• Matthew J. Harrington and
• Patrick Flammang

Beilstein J. Nanotechnol. 2025, 16, 1998–2014, doi:10.3762/bjnano.16.138

• and that of the cement suggests that the inclusions of the heterogeneous granules would inflate through a still unexplained process to form hollow spheroids dispersed in the cement matrix, leading to the formation of a complex composite material. Keywords: adhesive protein; Annelida; biological

• material; Polychaeta; protein phosphorylation; Introduction Many invertebrate marine organisms have adhesive mechanisms that allow them to firmly attach to various substrates in a wet and salty environment [1][2]. This remarkable ability has raised the interest of scientists in developing bio-inspired

• adhesive systems are remarkably similar although some differences have been noted such as the absence of sulfated polysaccharides in S. alveolata [31]. Production of a solid composite material forming highly resistant cement spots The ultrastructural study (SEM and TEM) of the adhesive system of S

Laser ablation in liquids for shape-tailored synthesis of nanomaterials: status and challenges

• Natalie Tarasenka

Beilstein J. Nanotechnol. 2025, 16, 1963–1997, doi:10.3762/bjnano.16.137

• target surface. The current understanding of the mechanisms of PLAL distinguishes the process depending on the laser pulse duration (Figure 1a). For the ultrashort pulses (femtosecond duration) the interaction of the ejected material with the laser pulse can be neglected. For longer laser pulses

• (nanosecond), this interaction should be taken into account, resulting in the ionization and heating of the ejected material. The initial stages of interaction of a laser beam with a solid target are strongly dependent on laser pulse duration and fluence, surrounding liquid, target morphology and composition

• generation of shockwaves and formation of cavitation bubbles, which typically have a lifetime of several microseconds. During its evolution, the cavitation bubble expands to reach the equilibrium with the confining liquid, after which the shrinking stage begins, which involves the ablated material moving

Mechanical property measurements enabled by short-term Fourier-transform of atomic force microscopy thermal deflection analysis

• Thomas Mathias,
• Roland Bennewitz and
• Philip Egberts

Beilstein J. Nanotechnol. 2025, 16, 1952–1962, doi:10.3762/bjnano.16.136

• reference material, rather than calculated directly from the dynamics models of the cantilever. We measured the cantilever displacement with very high sampling frequencies over the course of the experiment and captured its oscillations that result from thermal energy. Using short-term Fourier

• dynamic mechanics models relating the contact stiffness of the tip/cantilever pressing into a surface with the oscillation frequency of the cantilever and show that they did not accurately model the experiment. Several material combinations of tip and sample were examined; tip size and cantilever

• used to determine the size of the tip–sample contact, assuming the relevant material parameters of the system examined. Finally, the same experiment and data analysis was performed with other substrates and AFM tip materials to further explore the analytical CR-AFM models. Methods Experimental design

Evaluating metal-organic precursors for focused ion beam-induced deposition through solid-layer decomposition analysis

• Benedykt R. Jany,
• Katarzyna Madajska,
• Aleksandra Butrymowicz-Kubiak,
• Franciszek Krok and
• Iwona B. Szymańska

Beilstein J. Nanotechnol. 2025, 16, 1942–1951, doi:10.3762/bjnano.16.135

• significant beam-induced substrate defects (e.g., Ga atom implantation). Additionally, material growth is required to compete with the FIB milling process [4][9]. The use of ions instead of electrons, like in FEBID, offers several benefits, including enhanced film quality and adhesion, better control over the

• growth process, and greater flexibility in material selection (the ability to deposit a variety of different materials). The usage of ions opens new possibilities for materials development and applications [20][21]. Until now, the development of FEBID has relied on precursors used for chemical vapor

• backscattered electron (SEM BSE) analysis. For each studied precursor, an optimal ion fluence was determined, defined as the ion fluence at which the sputtering of the formed metal-rich structures becomes the dominant process, exceeding the rate of precursor decomposition and material buildup. While sputtering

Quantum circuits with SINIS structures

• Mikhail Tarasov,
• Mikhail Fominskii,
• Aleksandra Gunbina,
• Artem Krasilnikov,
• Maria Mansfeld,
• Dmitrii Kukushkin,
• Andrei Maruhno,
• Valeria Ievleva,
• Mikhail Strelkov,
• Daniil Zhogov,
• Konstantin Arutyunov,
• Vyacheslav Vdovin,
• Vladislav Stolyarov and
• Valerian Edelman

Beilstein J. Nanotechnol. 2025, 16, 1931–1941, doi:10.3762/bjnano.16.134

• power, Pbg is the background radiation power, ΣΛ(Te5 − Tph5) is the heat flux from electrons to phonons, Σ is the material constant, Λ is the absorber volume, Te and Tph are, respectively, the electron and phonon temperatures of the absorber, and Pcool is the electron cooling power. In other cases, it

Targeting the vector of arboviruses Aedes aegypti with nanoemulsions based on essential oils: a review with focus on larvicidal and repellent properties

• Laryssa Ferreira do Nascimento Silva,
• Douglas Dourado,
• Thayse Silva Medeiros,
• Mariana Alice Gonzaga Gabú,
• Maria Cecilia Queiroga dos Santos,
• Daiane Rodrigues dos Santos,
• Mylena Lemos dos Santos,
• Gabriel Bezerra Faierstein,
• Rosângela Maria Rodrigues Barbosa and
• Fabio Rocha Formiga

Beilstein J. Nanotechnol. 2025, 16, 1894–1913, doi:10.3762/bjnano.16.132

• distributed in Brazil, Ecuador, Peru, and other countries [124][125]. The plant material was collected in the state of Amapá (Brazil), and the morphotypes were differentiated by morphological characteristics and chemical composition determined by GC-MS. The morphotype A presented β-caryophyllene (45.93%) and

Self-assembly and adhesive properties of Pollicipes pollicipes barnacle cement protein cp19k: influence of pH and ionic strength

• Shrutika Sawant,
• Anne Marie Power and
• J. Gerard Wall

Beilstein J. Nanotechnol. 2025, 16, 1863–1872, doi:10.3762/bjnano.16.129

• secretion into the higher pH/similar salt concentration seawater, rPpolcp19k-his samples that had undergone assembly into fibrils for 21 days at pH 4.0, 150 mM NaCl were transferred into a pH 8.0, 600 mM NaCl environment prior to investigation of adhesion. Similar aggregates of proteinaceous material were

• accelerating voltage of 80 kV, and images were acquired at 3000× and 20000× magnifications. Each sample was initially scanned throughout at 3000× magnification to identify proteinaceous material; 10–15 TEM fields were then captured at 20000× magnification, and representative images containing protein, if

On the road to sustainability – application of metallic nanoparticles obtained by green synthesis in dentistry: a scoping review

• Lorena Pinheiro Vasconcelos Silva,
• Joice Catiane Soares Martins,
• Israel Luís Carvalho Diniz,
• Júlio Abreu Miranda,
• Danilo Rodrigues de Souza,
• Éverton do Nascimento Alencar,
• Moan Jéfter Fernandes Costa and
• Pedro Henrique Sette-de-Souza

Beilstein J. Nanotechnol. 2025, 16, 1851–1862, doi:10.3762/bjnano.16.128

• goals. These findings affirm that green nanotechnology represents a paradigm shift in dental material innovation, offering promising avenues to enhance oral health outcomes while integrating ecological responsibility. Future research must prioritize translational approaches, including comprehensive

Current status of using adsorbent nanomaterials for removing microplastics from water supply systems: a mini review

• Nguyen Thi Nhan and
• Tran Le Luu

Beilstein J. Nanotechnol. 2025, 16, 1837–1850, doi:10.3762/bjnano.16.127

• can recovery. Their effectiveness depends on material properties and environmental factors, but challenges remain in scale-up and related risks. Adsorbent nanomaterials show promising potential to enhance MP removal through specific properties. Although some related risks are discussed, these

• distribution pipeline network. Depending on different characteristics, including the material of pipeline, distance of transportation, analytical methods, and the size of the MPs targeted, the concentration of MPs in water will fluctuate, as shown in Table 1. Research indicated that raw water sources (rivers

• ]. Recently, Yan et al. developed a reduced graphene oxide (S-rGO) membrane with small lateral size and a rejection rate of up to 99.9% while maintaining high water permeability (236.2 L·m−2·h−1·bar−1) [56]. As another type of material belonging to carbon-based adsorbents, CNTs have also gained attention

Phytol-loaded soybean oil nanoemulsion as a promising alternative against Leishmania amazonensis

• Victória Louise Pinto Freire,
• Mariana Farias Alves-Silva,
• Johny W. de Freitas Oliveira,
• Matheus de Freitas Fernandes-Pedrosa,
• Alianda Maira Cornélio,
• Marcelo de Souza-Silva,
• Thayse Silva Medeiros and
• Arnóbio Antônio da Silva Junior

Beilstein J. Nanotechnol. 2025, 16, 1826–1836, doi:10.3762/bjnano.16.126

• and in vivo investigations to confirm its efficacy, tissue distribution, and mechanism of action. Experimental Material ʟ-α-Phosphatidylcholine (95%) (Avanti Polar lipids, United States); polaxamer 407 (Sigma-Aldrich, Brazil); glycerin (Vetec, Brazil); phytol (97%), mixture of isomers (Sigma-Aldrich