Ultrathin water layers on mannosylated gold nanoparticles

• Maiara A. Iriarte Alonso,
• Jorge H. Melillo,
• Silvina Cerveny,
• Yujin Tong and
• Alexander M. Bittner

Beilstein J. Nanotechnol. 2025, 16, 2183–2198, doi:10.3762/bjnano.16.151

• /mL) was loaded in a previously Milli Q-washed microcuvette at 25 °C and a detection angle of 173°. For ZP, 700 µL of the sample was loaded in a dip-cell cuvette. Three runs were performed in three replicates, resulting in nine measurements per sample. The hydrodynamic diameter (z-average) and the NP

Microplastic pollution in Himalayan lakes: assessment, risks, and sustainable remediation strategies

• Sameeksha Rawat,
• S. M. Tauseef and
• Madhuben Sharma

Beilstein J. Nanotechnol. 2025, 16, 2144–2167, doi:10.3762/bjnano.16.148

• ) spectroscopy is used regularly to identify the chemical structure of MPs [34]. One of the most important developments for nanoplastic detection in complex environmental matrices is micro-FTIR to analyze particles smaller than 10 µm [35]. Raman spectroscopy improves on FTIR by using higher resolution and the

• technologies are also required since it is challenging to transport samples to well-equipped laboratories from distant locations. Another challenge is that natural particulate matter such as minerals, biological debris, and glacial silt can lead to the interference of MP detection. MPs must be separated by

• , populations residing around Himalayan lakes and dependent on these freshwater basins for agriculture, drinking water, and fishery resources are more likely to be exposed to MPs. Although comprehensive data on MP bioaccumulation in Himalayan populations are currently lacking, the detection of MPs in Himalayan

Quality by design optimization of microemulsions for topical delivery of Passiflora setacea seed oil

• Daniel T. Pereira,
• Douglas Dourado,
• Danielle T. Freire,
• Dayanne L. Porto,
• Cícero F. S. Aragão,
• Myla L. de Souza,
• Guilherme R. S. de Araujo,
• Ana Maria Costa,
• Wógenes N. Oliveira,
• Anne Sapin-Minet,
• Éverton N. Alencar and
• Eryvaldo Sócrates T. Egito

Beilstein J. Nanotechnol. 2025, 16, 2116–2131, doi:10.3762/bjnano.16.146

• , Agilent – Santa Clara, USA) coupled with a mass spectrometer (5977B GC/MSD, Agilent – Santa Clara, USA). Prior to injection, samples were dissolved in 1 mL of n-heptane. The GC system operated with helium as the carrier gas at a flow rate of 1 mL·min−1. The injection and detection temperatures were set at

Rapid synthesis of highly monodisperse AgSbS₂ nanocrystals: unveiling multifaceted activities in cancer therapy, antibacterial strategies, and antioxidant defense

• Funda Ulusu,
• Adem Sarilmaz,
• Yakup Ulusu,
• Faruk Ozel and
• Mahmut Kus

Beilstein J. Nanotechnol. 2025, 16, 2105–2115, doi:10.3762/bjnano.16.145

• , these materials have also been used in various imaging applications for the detection of cancer cells. Ag2Te and Ag2S nanocrystals (NCs) were used in cancer imaging studies by Nieves and colleagues. In this study, computed tomography contrasts changes of NCs injected into mice were examined at 2 and 24

Toward clinical translation of carbon nanomaterials in anticancer drug delivery: the need for standardisation

• Michał Bartkowski,
• Francesco Calzaferri and
• Silvia Giordani

Beilstein J. Nanotechnol. 2025, 16, 2092–2104, doi:10.3762/bjnano.16.144

• , and material purity are essential for translational development. Contaminants such as carboxylated carbonaceous fragments (CCFs) may be introduced during synthesis and processing, and these impurities can alter biological responses or induce toxicity. Their detection and removal should form a routine

Calibration of piezo actuators and systems by dynamic interferometry

• Knarik Khachatryan and
• Michael Reichling

Beilstein J. Nanotechnol. 2025, 16, 2086–2091, doi:10.3762/bjnano.16.143

• detection. The fine-positioning z-piezo of the fiber is calibrated by the analysis of measurements of the dynamic interferometer response signal recorded for various cantilever oscillation amplitudes and varied distances between the cantilever and the fiber end. Furthermore, we demonstrate the cantilever

• ; Introduction Interferometric displacement detection stands as a cornerstone in high-precision techniques employed in cantilever-based atomic force microscopy (AFM), since its early days [1][2][3][4][5][6]. This method of cantilever displacement detection is specifically well suited for non-contact atomic force

• the fiber end. Controlling and stabilizing the fiber–cantilever distance is of principal importance for the accurate operation of the interferometric detection system [16]. Here, we address the aspect of calibrating the z-motion of the fiber tube piezo [17][18] with high accuracy to ensure full

Multifrequency AFM integrating PeakForce tapping and higher eigenmodes for heterogeneous surface characterization

• Yanping Wei,
• Jiafeng Shen,
• Yirong Yao,
• Xuke Li,
• Ming Li and
• Peiling Ke

Beilstein J. Nanotechnol. 2025, 16, 2077–2085, doi:10.3762/bjnano.16.142

• channels after the pre-amplifier for dedicated, parallel processing of PFT feedback path and high-eigenmode detection path. The channel of the PFT feedback path is processed by the system’s built-in PeakForce electronics. A low-pass filter (200 kHz cut-off) and synchronization algorithms suppress high

• -frequency noise and baseline drift, ensuring stable force feedback for accurate topography and quantitative mechanical mapping. These processing routines are factory-implemented and operate transparently to the user [23]. The unfiltered signal branch of the high-eigenmode detection path is routed directly

• “Experimental setup” effectively separates the composite cantilever deflection signal into two independent channels. The low-frequency path secures stable topographic feedback, while the high-frequency path preserves the eigenmode signals for material-sensitive detection. This combination of physical damping

Laser ablation in liquids for shape-tailored synthesis of nanomaterials: status and challenges

• Natalie Tarasenka

Beilstein J. Nanotechnol. 2025, 16, 1963–1997, doi:10.3762/bjnano.16.137

Low-temperature AFM with a microwave cavity optomechanical transducer

• Ermes Scarano,
• Elisabet K. Arvidsson,
• August K. Roos,
• Erik Holmgren,
• Riccardo Borgani,
• Mats O. Tholén and
• David B. Haviland

Beilstein J. Nanotechnol. 2025, 16, 1873–1882, doi:10.3762/bjnano.16.130

• force-sensor design is a significant improvement over piezoelectric force sensors commonly used in low-temperature AFM. We discuss the potential for further improvement of the sensor design to achieve optimal detection at the standard quantum limit. We demonstrate AFM operation with surface-tracking

• fulfills the specific requirements of the application. The latter is indeed the case for force sensing in atomic force microscopy (AFM). Force transduction at maximum sensitivity requires detecting the position of a “test mass”, while minimizing the added noise introduced by the detection itself [14][15

• -independent added noise of the detection SVV [V2/Hz], which is converted to an equivalent deflection noise via the detector responsivity α [V/m]: Neglecting back action, the noise-equivalent force for a given measurement bandwidth Δf is given by This quantity is minimized at the mechanical resonance

Current status of using adsorbent nanomaterials for removing microplastics from water supply systems: a mini review

• Nguyen Thi Nhan and
• Tran Le Luu

Beilstein J. Nanotechnol. 2025, 16, 1837–1850, doi:10.3762/bjnano.16.127

• ]. Finally, along with the development of information technology, the application of artificial intelligence (AI) and machine learning (ML) can transform water treatment. Leveraging pattern detection, ML simplifies MP classification and enhances nanomaterial identification, improving research efficiency and

Phytol-loaded soybean oil nanoemulsion as a promising alternative against Leishmania amazonensis

• Victória Louise Pinto Freire,
• Mariana Farias Alves-Silva,
• Johny W. de Freitas Oliveira,
• Matheus de Freitas Fernandes-Pedrosa,
• Alianda Maira Cornélio,
• Marcelo de Souza-Silva,
• Thayse Silva Medeiros and
• Arnóbio Antônio da Silva Junior

Beilstein J. Nanotechnol. 2025, 16, 1826–1836, doi:10.3762/bjnano.16.126

• using a Zetasizer Nano ZS instrument (Malvern Instruments, UK) at 25 ± 2 °C, with a detection wavelength of 633 nm and a backscattering angle of 173°. The zeta potential was assessed via electrophoretic mobility measurements using the same equipment under identical temperature conditions. For both

Electrical, photocatalytic, and sensory properties of graphene oxide and polyimide implanted with low- and medium-energy silver ions

• Josef Novák,
• Eva Štěpanovská,
• Petr Malinský,
• Vlastimil Mazánek,
• Jan Luxa,
• Ulrich Kentsch and
• Zdeněk Sofer

Beilstein J. Nanotechnol. 2025, 16, 1794–1811, doi:10.3762/bjnano.16.123

• of GO and PI. Elemental and structural changes induced by implantation were analyzed using Rutherford backscattering spectroscopy, elastic recoil detection analysis, Raman spectroscopy, Fourier-transform infrared spectroscopy, and X-ray photoelectron spectroscopy. Surface morphology was assessed via

• detection analysis (ERDA). The other analytical methods used were Raman spectroscopy, Fourier-transform infrared spectroscopy and X-ray photo-electron spectroscopy (XPS). The electrical properties were investigated by the two-point method. The photocatalytic properties were tested in a dark chamber by

Advances of aptamers in esophageal cancer diagnosis, treatment and drug delivery

• Yang Fei,
• Hui Xu,
• Chunwei Zhang,
• Jingjing Wang and
• Yong Jin

Beilstein J. Nanotechnol. 2025, 16, 1734–1750, doi:10.3762/bjnano.16.121

• , leveraging the high target specificity of well-selected aptamers may bring new breakthroughs in the diagnosis, treatment and drug delivery of EC. Keywords: aptamers; detection; drug delivery; esophageal cancer; esophageal squamous cell carcinoma; therapy; Review 1 Introduction Esophageal cancer (EC) is

• subtle, frequently escaping clinical detection. Definitive diagnosis typically requires upper gastrointestinal endoscopy to identify potential early neoplastic changes [7][8]. Barrett’s esophagus is generally considered to be a precancerous lesion of EAC [9][10], while esophageal intraepithelial

• structural modification. [26]. Aptamer-based biosensors [27] fully utilize these characteristics by combining various signal amplification techniques and nanomaterials (such as metal nanoparticles, quantum dots, silica nanoparticles, and carbon nanotubes), enabling highly sensitive detection of biomarkers

Multifunctional anionic nanoemulsion with linseed oil and lecithin: a preliminary approach for dry eye disease

• Niédja Fittipaldi Vasconcelos,
• Almerinda Agrelli,
• Rayane Cristine Santos da Silva,
• Carina Lucena Mendes-Marques,
• Isabel Renata de Souza Arruda,
• Priscilla Stela Santana de Oliveira,
• Mércia Liane de Oliveira and
• Giovanna Machado

Beilstein J. Nanotechnol. 2025, 16, 1711–1733, doi:10.3762/bjnano.16.120

• . These characterizations were performed to ensure the quality and stability of the formulations and to evaluate their suitability for ophthalmic applications. Gas chromatograph with flame ionization detection (GC-FID) LO’s fatty acid methyl esters were transesterified as described in [37][38]. Briefly, 1

• phase. The supernatant was washed three times with 10% (w/v) citric acid and then concentrated via rotary evaporation. A 2 µL aliquot of the supernatant was injected in split injection mode (1:10 in ethyl acetate) into a gas chromatograph with flame ionization detection (GC-FID) model 7290 A (Agilent

• Instruments, UK) at 25 °C. Before analysis, the samples were diluted 1:1000 with Milli-Q water, a standard dilution used to prevent multiple scattering without compromising micelle integrity. Measurements were performed at a 173° backscatter detection angle. Zeta potential and electrical conductivity were

Ambient pressure XPS at MAX IV

• Mattia Scardamaglia,
• Ulrike Küst,
• Alexander Klyushin,
• Rosemary Jones,
• Jan Knudsen,
• Robert Temperton,
• Andrey Shavorskiy and
• Esko Kokkonen

Beilstein J. Nanotechnol. 2025, 16, 1677–1694, doi:10.3762/bjnano.16.118

• flakes partially covering an Ir(111) surface, as illustrated in Figure 3 [28]. Although the reaction products (H2O and CO2) were below the APXPS detection limit, the C 1s signal proved sensitive enough to monitor the dynamics of undercover catalysis during gas pulsing (see Figure 4). Their results

• photocatalyst, it is essential to combine the photocatalyst’s performance with mechanistic knowledge under operando reaction conditions. APXPS is uniquely suited to investigate such systems. Its surface sensitivity enables the detection of charge transfer processes, reaction intermediates, and active sites

• interface phenomena under realistic environmental conditions. At MAX IV, the synergy between fourth-generation synchrotron source brightness and beamline-specific developments, such as advanced electron analyzers, tailored AP cells, and time-resolved detection schemes, has enabled operando and in situ

Prospects of nanotechnology and natural products for cancer and immunotherapy

• Jan Filipe Andrade Santos,
• Marcela Bernardes Brasileiro,
• Pamela Danielle Cavalcante Barreto,
• Ligiane Aranha Rocha and
• José Adão Carvalho Nascimento Júnior

Beilstein J. Nanotechnol. 2025, 16, 1644–1667, doi:10.3762/bjnano.16.116

• spectroscopy, TEM, DLS, X-ray diffraction (XRD), and Fourier-transform infrared (FTIR) spectroscopy, revealing a polygonal or oval morphology. To evaluate the antitumor effects, cytotoxicity assays, cellular uptake assays, apoptosis detection, ROS production, qRT-PCR, and Western blotting for gene and protein

• , lignin, cellulose, and starch [155][156]. Furthermore, quantum nanoparticles offer advantages for cancer treatment. They can manipulate emission properties near the infrared region, improving drug targeting and solubility, enhancing tumor detection, and reducing adverse effects on adjacent healthy

Venom-loaded cationic-functionalized poly(lactic acid) nanoparticles for serum production against Tityus serrulatus scorpion

• Philippe de Castro Mesquita,
• Karla Samara Rocha Soares,
• Manoela Torres-Rêgo,
• Emanuell dos Santos-Silva,
• Mariana Farias Alves-Silva,
• Alianda Maira Cornélio,
• Matheus de Freitas Fernandes-Pedrosa and
• Arnóbio Antônio da Silva-Júnior

Beilstein J. Nanotechnol. 2025, 16, 1633–1643, doi:10.3762/bjnano.16.115

• the plate was incubated at 37 °C for 1 hour. The plate was washed and 50 µL/well of diluted detection antibodies was added and incubated for 3 h. The plate was then washed again, the substrate was added, and the plate was incubated at room temperature for 15 min. The reaction was stopped (H2SO4 4 M

Nanotechnology-based approaches for the removal of microplastics from wastewater: a comprehensive review

• Nayanathara O Sanjeev,
• Manjunath Singanodi Vallabha and
• Rebekah Rubidha Lisha Rabi

Beilstein J. Nanotechnol. 2025, 16, 1607–1632, doi:10.3762/bjnano.16.114

• effectively removing MPs, especially those in the nanosize range. This review presents a detail analysis of the sources, pathways, detection methods, and health impact of MPs, while emphasizing the emerging role of nanotechnology in their remediation. Nanomaterials, including nanoadsorbents, photocatalysts

• various nanoenabled treatment strategies such as adsorption, photocatalysis, and membrane filtration using materials like metal-organic frameworks, carbon-based nanomaterials, MXenes, and metal oxides. It also highlights recent innovations such as microrobotic systems and AI-assisted detection frameworks

• synthesis and characterisation techniques have enabled the detection of materials at the nanoscale, unlocking new opportunities across various streams. In the field of water treatment, nanotechnology is gaining wide attention due to its enhanced efficiency, effectiveness, affordability, and durability. The

Bioinspired polypropylene-based functionally graded materials and metamaterials modeling the mistletoe–host interface

• Lina M. Rojas González,
• Naeim Ghavidelnia,
• Christoph Eberl and
• Max D. Mylo

Beilstein J. Nanotechnol. 2025, 16, 1592–1606, doi:10.3762/bjnano.16.113

• the GOM correlate software for DIC analysis (version 2018, GOM GmbH, Braunschweig, Germany). A facet size of 20 pixels and a point distance of 14 pixels was used for surface detection, using an image in the undeformed state as reference. The principal engineering strain in the direction of deformation

Cross-reactivities in conjugation reactions involving iron oxide nanoparticles

• Shoronia N. Cross,
• Katalin V. Korpany,
• Hanine Zakaria and
• Amy Szuchmacher Blum

Beilstein J. Nanotechnol. 2025, 16, 1504–1521, doi:10.3762/bjnano.16.106

• amides [57]. While FTIR provides some evidence of PPA coupling to the IONP surface, it is not conclusive; thus, we turned to an indirect means of detection by utilizing the CuAAC coupling reaction to bind Cy5-azide dye to the alkyne groups on the IONP surface, if present. The dye can then be detected

• down to 1 mM, limited by the detection limit of Cy5. Our investigation into the EDC coupling of several primary amine-containing dyes shows that care must be taken in choosing an appropriate amine for coupling, as the structure can inhibit coupling through either steric or electronic effects. Our

Nanomaterials for biomedical applications

• Iqra Zainab,
• Zohra Naseem,
• Syeda Rubab Batool,
• Filippo Pierini,
• Seda Kizilel and
• Muhammad Anwaar Nazeer

Beilstein J. Nanotechnol. 2025, 16, 1499–1503, doi:10.3762/bjnano.16.105

• usage in everyday healthcare is becoming more evident. Liposomes and polymeric nanoparticles are already being used in certain cancer and vaccine treatments [41]. Detection of diseases at an early stage is becoming more possible with gold nanoparticles or quantum dots. Scaffolds made from nanofibers and

Laser processing in liquids: insights into nanocolloid generation and thin film integration for energy, photonic, and sensing applications

• Akshana Parameswaran Sreekala,
• Pooja Raveendran Nair,
• Jithin Kundalam Kadavath,
• Bindu Krishnan,
• David Avellaneda Avellaneda,
• M. R. Anantharaman and
• Sadasivan Shaji

Beilstein J. Nanotechnol. 2025, 16, 1428–1498, doi:10.3762/bjnano.16.104

• (e.g., nanoparticles, nanocubes, nanorods, and nanocomposites) [5]. The developments in LAL have demonstrated its ability to synthesize functionalized nanostructures with special morphologies, microstructures, and phases, which hold promise for applications in optics, detection, and biological fields

Photochemical synthesis of silver nanoprisms via green LED irradiation and evaluation of SERS activity

• Tuan Anh Mai-Ngoc,
• Nhi Kieu Vo,
• Cong Danh Nguyen,
• Thi Kim Xuan Nguyen and
• Thanh Sinh Do

Beilstein J. Nanotechnol. 2025, 16, 1417–1427, doi:10.3762/bjnano.16.103

• enhancement factor of 1.15 × 106, enabling detection limits down to 10−9 M. These findings demonstrate that green LED-mediated synthesis provides a simple, environmentally friendly route to fabricate high-yield AgNPrs with superior SERS capabilities, suitable for ultrasensitive chemical and biological sensing

• various solid supports such as glass [11], quartz, silicon, or aluminum foil [12]. A recent trend in the development of practical SERS substrates emphasizes flexibility and portability for field-deployable Raman detection. Accordingly, several groups have developed paper-based [13] or cotton-based [14

• confirm that AgNPrs exhibited superior SERS performance, consistent with prior studies investigating the direct SERS detection of 4-MBA [18][19]. Due to their anisotropic structure, AgNPrs concentrate surface electrons and form electromagnetic “hot spots” at the edges and tip of the nanoprisms [22][24][25

The role of biochar in combating microplastic pollution: a bibliometric analysis in environmental contexts

• Tuan Minh Truong Dang,
• Thao Thu Thi Huynh,
• Guo-Ping Chang-Chien and
• Ha Manh Bui

Beilstein J. Nanotechnol. 2025, 16, 1401–1416, doi:10.3762/bjnano.16.102

• thickness reflects the strength of relationships between nodes [28]. The betweenness centrality of a node was defined using the Kleinberg burst detection algorithm, measuring the node’s influence within the network. The centrality value δs*ν was calculated as: Nodes with high centrality values are

• towards nanoscale MP removal due to their hazardous implications. However, NP detection remains complex, requiring state-of-the-art methodologies [30]. For soil matrices, studies aim to enhance soil properties, enzyme activity and beneficial microbial communities, ultimately improving crop productivity

Parylene-coated platinum nanowire electrodes for biomolecular sensing applications

• Chao Liu,
• Peker Milas,
• Michael G. Spencer and
• Birol Ozturk

Beilstein J. Nanotechnol. 2025, 16, 1392–1400, doi:10.3762/bjnano.16.101

• testing with glucose and dopamine demonstrate limits of detection of 30 nM and 0.01 mM, respectively. The R-squared values for peak current versus concentration are 0.985 and 0.994, indicating strong linear correlations. These nanoscale electrodes hold great promise for single-cell biosensing applications

• , with diameters ranging from 0.4 to 100 nm and lengths extending from a few micrometers to several centimeters [7]. The functionalization of CNTs is achieved by surface modification through various methods including covalent bonding, adsorption, and detection group attachment [7][8]. Palve et al

• . developed a glucose sensor using copper nanowires and CNTs, achieving a limit of detection as low as 0.3 nM, highlighting the remarkable sensitivity of CNT-based electrodes [9]. Nevertheless, several studies reported the toxicity of CNTs for tissues and cells including loss of cellular integrity, DNA damage