Involvement of two uptake mechanisms of gold and iron oxide nanoparticles in a co-exposure scenario using mouse macrophages

• Dimitri Vanhecke,
• Dagmar A. Kuhn,
• Dorleta Jimenez de Aberasturi,
• Sandor Balog,
• Ana Milosevic,
• Dominic Urban,
• Diana Peckys,
• Niels de Jonge,
• Wolfgang J. Parak,
• Alke Petri-Fink and
• Barbara Rothen-Rutishauser

Beilstein J. Nanotechnol. 2017, 8, 2396–2409, doi:10.3762/bjnano.8.239

• diagnostic and therapeutic applications [4]. There is convincing evidence that the physico-chemical properties of NPs, such as size, shape, material, and surface functionalization, strongly influence uptake and intracellular trafficking of NPs [5][6][7]. The uptake of NPs occurs via endocytotic pathways

Carbon nano-onions as fluorescent on/off modulated nanoprobes for diagnostics

• Stefania Lettieri,
• Marta d’Amora,
• Adalberto Camisasca,
• Alberto Diaspro and
• Silvia Giordani

Beilstein J. Nanotechnol. 2017, 8, 1878–1888, doi:10.3762/bjnano.8.188

• procedure [25][26]. The condensation with dimethylaminobenzaldehyde led to the NIR-BODIPY derivative 3. The surface functionalization of 5 nm pristine CNOs (p-CNOs), synthetized by thermal annealing of d-NDs, was obtained by an oxidation process using a 3 M solution of nitric acid under reflux condition

• functionalization of the CNOs. The high degree of surface functionalization of the oxi-CNOs and the successful attachment of the dye molecules on the oxi-CNOs was observed by TGA analysis. The TGA spectrum of the oxi-CNOs performed in air (Figure 3, blue) showed a decrease in decomposition temperature from 686 °C

• -CNOs-1b had a λem of 633 upon photoexcitation of 600 nm in DMSO. Hence, the ICT characteristics of the dye are preserved on the CNOs. Characterization of CNOs Oxi- and fluo-CNOs were characterized by thermogravimetric analysis (TGA) and Raman spectroscopy to prove the successful surface

Fluorination of vertically aligned carbon nanotubes: from CF₄ plasma chemistry to surface functionalization

• Claudia Struzzi,
• Mattia Scardamaglia,
• Jean-François Colomer,
• Alberto Verdini,
• Luca Floreano,
• Rony Snyders and
• Carla Bittencourt

Beilstein J. Nanotechnol. 2017, 8, 1723–1733, doi:10.3762/bjnano.8.173

Uptake and intracellular accumulation of diamond nanoparticles – a metabolic and cytotoxic study

• Antonín Brož,
• Lucie Bačáková,
• Pavla Štenclová,
• Alexander Kromka and
• Štěpán Potocký

Beilstein J. Nanotechnol. 2017, 8, 1649–1657, doi:10.3762/bjnano.8.165

• impurities, and surface functionalization groups. Adverse effects on cell viability have been reported when using DNDs [24][28][29][30][31][32], while HPHT NDs often appear to be nontoxic [33][34]. Factors influencing the cytotoxicity of nanoparticles are their size [24][35][36] and surface functionalization

Surface functionalization of 3D-printed plastics via initiated chemical vapor deposition

• Christine Cheng and
• Malancha Gupta

Beilstein J. Nanotechnol. 2017, 8, 1629–1636, doi:10.3762/bjnano.8.162

• 3DP applications, because it allows for tuning of bulk properties, such as cost-effectiveness or structural rigidity, independently of sophisticated surface functionalization. For example, in scaffolds for bone tissue engineering, angiogenesis is a major challenge, because printed scaffolds have

• hydrophobic surface properties and do not promote cellular differentiation [3][18]. Surface modification of printed scaffolds can allow for the tuning of surface functionalization to promote vascularization and tissue regeneration while maintaining control over the mechanical robustness of the bulk structure

• engineering applications [18]. In another example of surface functionalization, Wang et al. reported a method for modifying the surfaces of 3DP structures fabricated via SLA by using a UV-curable resin with an embedded alkyl bromide initiator from which atom transfer radical polymerization was initiated [19

Deposition of exchange-coupled dinickel complexes on gold substrates utilizing ambidentate mercapto-carboxylato ligands

• Martin Börner,
• Laura Blömer,
• Marcus Kischel,
• Peter Richter,
• Georgeta Salvan,
• Dietrich R. T. Zahn,
• Pablo F. Siles,
• Maria E. N. Fuentes,
• Carlos C. B. Bufon,
• Daniel Grimm,
• Oliver G. Schmidt,
• Daniel Breite,
• Bernd Abel and
• Berthold Kersting

Beilstein J. Nanotechnol. 2017, 8, 1375–1387, doi:10.3762/bjnano.8.139

• to deposit these materials as rows [15], thin films [16][17][18][19], or multilayers [20][21][22][23][24][25][26]. However, the limited thermal and kinetic stability of most SMMs prevents their thermal evaporation [27] and has initiated the search for milder, solution-based methods for surface

• functionalization. Of these, the formation of self-assembled monolayers of SMMs appears to be an attractive and suitable method [28][29][30][31][32][33][34][35][36]. Our work involves the deposition of exchange-coupled complexes of the type [MII2L(μ-L’)](ClO4), where L represents a hexaazadithiophenolate macrocycle

Characterization of ferrite nanoparticles for preparation of biocomposites

• Urszula Klekotka,
• Magdalena Rogowska,
• Dariusz Satuła and
• Beata Kalska-Szostko

Beilstein J. Nanotechnol. 2017, 8, 1257–1265, doi:10.3762/bjnano.8.127

• ; magnetic nanoparticles; surface immobilization; trypsin; X-ray diffraction; Introduction Nanoparticles are important ingredients in the fabrication of biocomposites, and therefore, the surface functionalization of nanoparticles attracts great interest among scientists [1][2]. Tests that aim at the

• fabrication procedure, additional characteristics can be supplemented (e.g., ferrite core differentiation or surface modification). The improvement of the surface functionalization by introduction of active linkers is, in some cases, a crucial issue as it was presented in the case of albumin. This paper is a

The integration of graphene into microelectronic devices

• Guenther Ruhl,
• Sebastian Wittmann,
• Matthias Koenig and
• Daniel Neumaier

Beilstein J. Nanotechnol. 2017, 8, 1056–1064, doi:10.3762/bjnano.8.107

• 25,000–140,000 cm2·V−1·s−1 for h-BN [44]. Besides the formation of chemical bonds, mainly two mechanisms describe the graphene–substrate interactions, charge-transfer doping and the introduction of strain on the nanoscale. Also, the surface functionalization, e.g., of SiO2 with hexamethyldisilazane (HMDS

Silicon microgrooves for contact guidance of human aortic endothelial cells

• Sara Fernández-Castillejo,
• Pilar Formentín,
• Úrsula Catalán,
• Josep Pallarès,
• Lluís F. Marsal and
• Rosa Solà

Beilstein J. Nanotechnol. 2017, 8, 675–681, doi:10.3762/bjnano.8.72

• environmental scanning electron microscope (Hillsboro, OR, USA) operating at accelerating voltages between 15 and 25 keV. Surface functionalization Surface functionalization was carried out in a similar manner as described before [38]. The grooved silicon substrates were oxidized at 600 °C for 15 min. Then, the

Methods for preparing polymer-decorated single exchange-biased magnetic nanoparticles for application in flexible polymer-based films

• Laurence Ourry,
• Delphine Toulemon,
• Souad Ammar and
• Fayna Mammeri

Beilstein J. Nanotechnol. 2017, 8, 408–417, doi:10.3762/bjnano.8.43

• . Dipolar interactions between NPs too close to each other favour a collective magnetic glass state with lower magnetization and coercivity because of inhomogeneous and frustrated macrospin cluster freezing. Consequently, tailoring chemically (through surface functionalization) and magnetically stable NPs

Functionalized TiO₂ nanoparticles by single-step hydrothermal synthesis: the role of the silane coupling agents

• Antoine R. M. Dalod,
• Lars Henriksen,
• Tor Grande and
• Mari-Ann Einarsrud

Beilstein J. Nanotechnol. 2017, 8, 304–312, doi:10.3762/bjnano.8.33

• surface functionalization of commercial TiO2 nanoparticles in ethanol using n-(6-aminohexyl)aminopropyltrimethoxysilane [18]. Nanoparticle synthesis with in situ surface functionalization has the advantage to reduce the number of reaction steps and is thus of greater interest for potential industrial

• Synthesis The synthesis of the non-functionalized TiO2 nanoparticles was based on a hydrothermal route previously described by Hayashi and Torii, using titanium(IV) isopropoxide (TIP) as precursor [28]. The synthesis method was further developed for in situ surface functionalization using selected silane

Colorimetric gas detection by the varying thickness of a thin film of ultrasmall PTSA-coated TiO₂ nanoparticles on a Si substrate

• Urmas Joost,
• Andris Šutka,
• Meeri Visnapuu,
• Aile Tamm,
• Meeri Lembinen,
• Mikk Antsov,
• Kathriin Utt,
• Krisjanis Smits,
• Ergo Nõmmiste and
• Vambola Kisand

Beilstein J. Nanotechnol. 2017, 8, 229–236, doi:10.3762/bjnano.8.25

• from 1.87 to 1.81, i.e., also 3% measured at 633 nm. A decrease of the refractive index during swelling is understandable, taking into account the refractive index of ethanol (1.36 at 633 nm). The selectivity to different gases can be achieved by surface functionalization of the nanoparticles, which

Sensitive detection of hydrocarbon gases using electrochemically Pd-modified ZnO chemiresistors

• Elena Dilonardo,
• Michele Penza,
• Marco Alvisi,
• Gennaro Cassano,
• Cinzia Di Franco,
• Francesco Palmisano,
• Luisa Torsi and
• Nicola Cioffi

Beilstein J. Nanotechnol. 2017, 8, 82–90, doi:10.3762/bjnano.8.9

• components of the O 1s spectrum, O–Zn and O–C, remains unchanged after the surface functionalization. Therefore, the atomic ratio O–Zn/Zn (the percentage of oxygen bound to metal divided by the total metal percentage) remained stoichiometric, i.e. equal to 1, also after the metal decoration, as reported in

Streptavidin-coated gold nanoparticles: critical role of oligonucleotides on stability and fractal aggregation

• Roberta D'Agata,
• Pasquale Palladino and
• Giuseppe Spoto

Beilstein J. Nanotechnol. 2017, 8, 1–11, doi:10.3762/bjnano.8.1

• Andrea Doria 6, I-95125, Catania, Italy 10.3762/bjnano.8.1 Abstract Gold nanoparticles (AuNPs) exhibit unique properties that can be modulated through a tailored surface functionalization, enabling their targeted use in biochemical sensing and medical diagnostics. In particular, streptavidin-modified

Functionalized platinum nanoparticles with surface charge trigged by pH: synthesis, characterization and stability studies

• Giovanna Testa,
• Laura Fontana,
• Iole Venditti and
• Ilaria Fratoddi

Beilstein J. Nanotechnol. 2016, 7, 1822–1828, doi:10.3762/bjnano.7.175

• solvothermal techniques are well favored for the synthesis of PtNPs, together with sol–gel methods [17]. They give rise to colloidal suspensions although a fine control of the size, dispersity and the surface functionalization is quite difficult to reach. Poly(N-vinyl-2-pyrrolidone) (PVP) has been used as a

Monolayer graphene/SiC Schottky barrier diodes with improved barrier height uniformity as a sensing platform for the detection of heavy metals

• Ivan Shtepliuk,
• Jens Eriksson,
• Volodymyr Khranovskyy,
• Tihomir Iakimov,
• Anita Lloyd Spetz and
• Rositsa Yakimova

Beilstein J. Nanotechnol. 2016, 7, 1800–1814, doi:10.3762/bjnano.7.173

• need to chemically modify the surface of the electrodes (surface functionalization) [8][13], which will complicate the fabrication of the sensors and reduces the reproducibility. Taking the above discussion into account, one can conclude that the need to create accurate and real-time analytical

Hydrophilic silver nanoparticles with tunable optical properties: application for the detection of heavy metals in water

• Paolo Prosposito,
• Federico Mochi,
• Erica Ciotta,
• Mauro Casalboni,
• Fabio De Matteis,
• Iole Venditti,
• Laura Fontana,
• Giovanna Testa and
• Ilaria Fratoddi

Beilstein J. Nanotechnol. 2016, 7, 1654–1661, doi:10.3762/bjnano.7.157

• agent (not reported) was about 60 nm. The broadening of about 30 nm can be ascribed to the surface functionalization of the AgNPs with 3MPS. We characterized the AgNP-3MPS nanoparticles via STM spectroscopy. Figure 3a,b shows the morphology and the profile of the nanoparticles, respectively. We

Nano- and microstructured materials for in vitro studies of the physiology of vascular cells

• Alexandra M. Greiner,
• Adria Sales,
• Hao Chen,
• Sarah A. Biela,
• Dieter Kaufmann and
• Ralf Kemkemer

Beilstein J. Nanotechnol. 2016, 7, 1620–1641, doi:10.3762/bjnano.7.155

• ] to a few megapascals [166]. All these three artificial polymeric materials are by themselves non-adhesive for cells. Therefore, surface functionalization with cell adhesive molecules is essential prior to cell culture studies. In summary, the engineering of defined micro- and nanostructured cell

• desired to have a predictable influence on cell behavior. Moreover, some synthetic materials are not promoting cell adhesion; a functionalization of the surface prior of cell contact becomes necessary to render it cell-adhesive. There are numerous methods and strategies for chemical surface

• functionalization. It will be beyond the scope of this review to give a detailed account; only a few examples can be depicted. One simple and often used way to functionalize a surface non-specifically with molecules is by simple physisorption, often after enhancing the surface charge of hardly adhesive surfaces

Viability and proliferation of endothelial cells upon exposure to GaN nanoparticles

• Tudor Braniste,
• Ion Tiginyanu,
• Tibor Horvath,
• Simion Raevschi,
• Serghei Cebotari,
• Marco Lux,
• Axel Haverich and
• Andres Hilfiker

Beilstein J. Nanotechnol. 2016, 7, 1330–1337, doi:10.3762/bjnano.7.124

• cells grown on surfaces functionalized with GaN nanoparticles demonstrated excellent adhesion and proliferation, suggesting good biocompatibility of the nanostructured GaN. Keywords: endothelial cells; GaN nanoparticles; proliferation; surface functionalization; Introduction The development of new

• . Values are expressed as mean ± standard deviation of 3 independent experiments with 2 replicates. Supporting Information Supporting Information File 202: Details regarding nanoparticle characterization, chemical analysis measurements and schematics of the surface functionalization process with

• . Since each cell division reduces the number of the incorporated GaN nanoparticles by 50%, the load of GaN nanoparticles in a single cell diminishes with time. The growth of endothelial cells on top of fixed nanoparticles avoids the internalization process of nanoparticles by cells. Surface

Straightforward and robust synthesis of monodisperse surface-functionalized gold nanoclusters

• Silvia Varela-Aramburu,
• Richard Wirth,
• Chian-Hui Lai,
• Guillermo Orts-Gil and
• Peter H. Seeberger

Beilstein J. Nanotechnol. 2016, 7, 1278–1283, doi:10.3762/bjnano.7.118

• groups. To illustrate the surface functionalization of Glc-NCs, pentylthiol mannoside (Scheme S1, Supporting Information File 1) was incubated with Glc-NCs overnight to yield Glc-NC@Man (Figure 2A). After dialysis, the IR spectrum revealed two new peaks corresponding to the C–H bonds of the linker at

• L929 cells. Surface functionalization of Glc-NCs with biomolecules opens opportunities for drug delivery applications. A) One-pot synthesis of Glc-NCs at room temperature; B) UV–vis spectra of freshly synthesized Glc-NCs and after three days are indicative of stable particles; C) high-resolution TEM

Rigid multipodal platforms for metal surfaces

• Michal Valášek,
• Marcin Lindner and
• Marcel Mayor

Beilstein J. Nanotechnol. 2016, 7, 374–405, doi:10.3762/bjnano.7.34

• with oxygen and can be handled even under ambient conditions in the laboratory before its surface functionalization with organosulfur compounds. The covalent bond between sulfur and gold gives rise to robust and reasonably conductive single-molecular junctions of adsorbed molecules on gold substrates

Self-organization of gold nanoparticles on silanated surfaces

• Htet H. Kyaw,
• Salim H. Al-Harthi,
• Azzouz Sellai and
• Joydeep Dutta

Beilstein J. Nanotechnol. 2015, 6, 2345–2353, doi:10.3762/bjnano.6.242

• substrates through their terminal groups [1][2][3][4]. Among them, aminopropyltriethoxysilane (APTES; NH2(CH2)3Si(OCH2CH3)3) is probably the best-known coupling agent used for surface functionalization. APTES has three hydrolysable ethoxy groups that attach to the metal nanoparticle surface (known as

Orthogonal chemical functionalization of patterned gold on silica surfaces

• Francisco Palazon,
• Didier Léonard,
• Thierry Le Mogne,
• Francesca Zuttion,
• Céline Chevalier,
• Magali Phaner-Goutorbe,
• Éliane Souteyrand,
• Yann Chevolot and
• Jean-Pierre Cloarec

Beilstein J. Nanotechnol. 2015, 6, 2272–2277, doi:10.3762/bjnano.6.233

• biosensors) is a major challenge. Keywords: characterization; self-assembled monolayer; surface functionalization; ToF–SIMS; XPS; Introduction The orthogonal self-assembly of different molecules onto a patterned substrate was first demonstrated in 1989 by Whitesides and co-workers [1]. Recently, especially

• forward power (10 W reflected), 90 Pa, for 5 min to ensure that no residual resist remained on the surface. Surface functionalization HS-(CH2)11-NH-C(O)-Biotin 95% (MU-Biot) was purchased from ProChimia. 1H,1H,2H,2H-Perfluorodecanethiol (F-thiol) 97% was purchased from Sigma-Aldrich. Trichloro(1H,1H,2H,2H

Selective porous gates made from colloidal silica nanoparticles

• Roberto Nisticò,
• Paola Avetta,
• Paola Calza,
• Debora Fabbri,
• Giuliana Magnacca and
• Dominique Scalarone

Beilstein J. Nanotechnol. 2015, 6, 2105–2112, doi:10.3762/bjnano.6.215

• in the preparation of microfiltration devices was realized by the surface functionalization of macroporous supports or membranes by nanoporous functional coatings [17][18][19][20]: the macroporous, permeable supports, in fact, can provide mechanical strength to the thinner functional coatings on top

• separation processes and dosing of chemicals. In this study, the surface functionalization of silicon nitride commercial microsieves by means of colloidal silica nanoparticles has been proposed as a novel strategy to fabricate composite membranes for microfluidic devices. The permeability and size

Continuum models of focused electron beam induced processing

• Milos Toth,
• Charlene Lobo,
• Vinzenz Friedli,
• Aleksandra Szkudlarek and
• Ivo Utke

Beilstein J. Nanotechnol. 2015, 6, 1518–1540, doi:10.3762/bjnano.6.157

• beam induced etching (FEBIE), deposition (FEBID) [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] and surface functionalization [17] techniques. They are typically used to simulate growth rates and nanostructure geometries as a function of experimental parameters, and to help elucidate the

• , and cause the etch rate to increase with electron beam irradiation time. Electron beam induced surface functionalization and spontaneous decomposition of precursor molecules at the substrate surface: These two processes have been modeled for the case of XeF2 [17] which can fragment through a