4 article(s) from Mei, Haibo
Graphical Abstract
Figure 1: Anti-HIV compound containing a trifluoromethylpropargylamine moiety.
Scheme 1: Literature-known methods (a and b) and the here reported (c) approach for the synthesis of α-triflu...
Scheme 2: Substrate scope study. Reaction conditions: arylethyne 2 (0.39 mmol), imine 1 (0.3 mmol), LiHMDS (0...
Figure 2: ORTEP diagram showing of the minor product of 3a.
Figure 3: Mode of nucleophilic attacks A and B.
Scheme 3: Large-scale application of the reaction.
Scheme 4: Removal of the chiral auxiliary.
Graphical Abstract
Scheme 1: Cascade 1,2-difunctionalization and cyclization to construct heterocycles.
Scheme 2: Cyclization of cyclohexane (2a) with substituted N-(2-methylallyl)benzamide (reaction conditions: 4...
Scheme 3: Cyclization of cycloalkanes with N-methyl-N-(2-methylallyl)benzamide (reaction conditions: 4a (0.2 ...
Scheme 4: Cyclization reaction of 6 with cyclohexane 2a (reaction conditions: 6 (0.2 mmol), cyclohexane 2a (2...
Scheme 5: Control experiments for the mechanism studies. a) Reaction with N-unprotected substrate 8a; b) reac...
Scheme 6: Proposed mechanism.
Graphical Abstract
Scheme 1: An anomalous outcome with benzylamine as organic base.
Scheme 2: Transformation of vicinal haloamines by the use of organic amines.
Figure 1: ORTEP diagram of compound 5o.
Scheme 3: Ring-opening of aziridine 6.
Scheme 4: Proposed mechanism.
Graphical Abstract
Figure 1: Typical sulfinyl (a), phosphonyl aldimines (b) and phosphinyl imino esters (c).
Scheme 1: Synthesis of α-imino ester by rearrangement.
Scheme 2: Cleavage of the chiral auxiliary.