7 article(s) from Opatz, Till
- Full Research Paper
- Published 20 Jul 2017
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Figure 1: Structure of fusaricidins E (1) and F (2).
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Figure 2: NOESY /COSY and HMBC correlations of compound 1.
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Figure 3: Fragmentation pattern of compounds 1 and 2.
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Scheme 1: Retrosynthetic plan for the depsipeptide and GHPD side chain.
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Scheme 2: a) LiAlH4, THF, reflux, 12 h, quant.; b) Fmoc-OSu, NaHCO3, 1,4-dioxane, H2O, 0 °C to rt, 87%; c) 1:...
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Scheme 3: Ester bond formation with 2,2-dimethylated pseudoproline including peptide 16.
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Scheme 4: Cyclization with 2,2-dimethylated pseudoproline including peptide 16.
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Scheme 5: Depsipeptide cyclization and coupling with GHPD side chain.
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Figure 4: Byproducts from removal of Cbz group in THF and DMF.
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- Full Research Paper
- Published 21 Dec 2016
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Figure 1: Synthetic cannabinoids JWH-018 (1), MDMB-CHMICA (2), MDMB-CHMCZCA (3), and EG-018 (4).
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Figure 2: Molecular structure of (S)-MDMB-CHMCZCA (3) with numbering scheme.
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Figure 3: ESI-MSn pattern of 3 (m/z values) with probable fragment ion structures.
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Figure 4: Observed (top) and calculated (bottom) ECD spectra for (S)-3 in acetonitrile, theory level: TD-B3LY...
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Figure 5: Observed (top) and calculated (bottom) VCD spectra for (S)-3 in chloroform, theory level: B3PW91/6-...
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Figure 6: Molecular structure of (S)-3 in the solid state at 110 K (ORTEP-ellipsoids drawn at 30% probability...
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Figure 7: UV traces (254 nm) of the chiral HPLC for commercial (S)-3 (top) and the (R/S)-3 (bottom). tR = 6.8...
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- Full Research Paper
- Published 21 Mar 2014
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Scheme 1: Synthesis of formamide 4. Reagents and conditions: a) KHMDS, THF, −78 °C; then: NaBH4, MeOH, 63%. b...
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Figure 1: Equilibration of the Z-rotamer of 4 at 293 K.
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Figure 2: Equilibration of the E-rotamer of 4 at 293 K.
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Figure 3: Elution profiles obtained by temperature-dependent DHPLC measurements of 4.
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Figure 4: Eyring plot obtained by temperature dependent DHPLC measurements of 4.
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Figure 5: Potential energy surface scan graph for the dihedral angle O–C–N–C1 (
![[Graphic 2]](/bjoc/content/inline/1860-5397-10-63-i3.png?max-width=637&scale=1.18182)
) in 4 (BP-D3/def2-SVP).
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Figure 6: Energy differences and geometries for E- and Z-4 and both transition states (TS1 and TS2) in hexane...
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- Full Research Paper
- Published 24 Feb 2014
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Scheme 1: Synthesis and conversion of 3,4-dihydro-2H-pyrrole-2-carbonitriles 6.
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- Full Research Paper
- Published 22 Jan 2014
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Figure 1: HMBC, COSY and NOESY correlations of compound 1.
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Figure 2: HMBC, COSY and NOESY correlations of compound 2.
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Figure 3: HMBC, COSY and NOESY correlations of compound 3.
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Figure 4: HMBC, COSY and NOESY correlations of compound 4.
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Figure 5: Structures of the isolated compounds.
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Figure 6: Crystal structures (ORTEP plot) of arohynapene A (5, left) and tanzawaic acid E (8, right). Thermal...
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- Full Research Paper
- Published 13 Dec 2013
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Figure 1: Structure of SF002-96-1.
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Figure 2: COSY (bold) and HMBC (arrow) correlations of SF002-96-1.
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Figure 3: NOESY correlations of SF002-96-1.
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Figure 4: Effect of SF002-96-1 on survivin promoter activity, survivin mRNA levels and expression. (A) Colo 3...
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Figure 5: Effect of SF002-96-1 on Sat3 and NF-κB binding to the survivin promoter in Colo 320 cells analyzed ...
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Figure 6: SF002-96-1 induces apoptosis of Colo 320 cells. (A) Colo 320 cells were treated without (control) o...
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Figure 7: Single-quadrupole mass spectrumof SF002-96-1 obtained using an atmospheric pressure chemical ioniza...
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- Full Research Paper
- Published 17 Jul 2012
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Figure 1: Selected examples of bioactive natural diaryl ethers.
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Figure 2: Ligands that were subjected to the ligand screening.
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Figure 3: Conversions of the model reaction versus the ligand numbers. For structures of the ligands refer to ...
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