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Search for "three-dimensional" in Full Text gives 173 result(s) in Beilstein Journal of Organic Chemistry.
Calixazulenes: azulene-based calixarene analogues – an overview and recent supramolecular complexation studies
Beilstein J. Org. Chem. 2018, 14, 2488–2494, doi:10.3762/bjoc.14.225
- relatively facile and reproducible syntheses of the classical calix[n]arenes 1 in which n = 4, 6 or 8, with phenolic groups linked or bridged via methylene groups to form defined three-dimensional basket-like cavities with “upper” or “lower” rims, were developed by Gutsche and co-workers [4][5][6]. As a
Nucleoside macrocycles formed by intramolecular click reaction: efficient cyclization of pyrimidine nucleosides decorated with 5'-azido residues and 5-octadiynyl side chains
Beilstein J. Org. Chem. 2018, 14, 2404–2410, doi:10.3762/bjoc.14.217
- = 173°) [48] adopt an anti-conformation [49]. The conformation of the 2’-deoxyribofuranosyl moiety of 8 shows an C3’-endo envelope pucker (4E, N-type) in the solid state with a pseudorotational phase angle P = 50.2(2)° and a maximum amplitude of τm = 38.7(1)°. The extended structure forms a three
- -dimensional network consisting of a linear unit connected by hydrogen bonds between N3–H and the triazole N3’’ of a second molecule (Figure 3, Supporting Information File 1, Figures S3 and S4). Additionally, the molecules are bridged by water molecules connecting O2 of the base moiety and N2’’ of the triazole
Synthesis and post-functionalization of alternate-linked-meta-para-[2n.1n]thiacyclophanes
Beilstein J. Org. Chem. 2018, 14, 2190–2197, doi:10.3762/bjoc.14.192
- ; Introduction The ability of cyclophanes to form three-dimensional cavities is interesting for various potential applications, e.g., as supramolecular hosts. Synthetic procedures towards novel cyclophanes have attracted much interest in the scientific community [1][2][3][4]. An interesting subclass of
Evaluation of dispersion type metal···π arene interaction in arylbismuth compounds – an experimental and theoretical study
Beilstein J. Org. Chem. 2018, 14, 2125–2145, doi:10.3762/bjoc.14.187
- of a neighboring molecule in a way that each bismuth atom interacts with three oxygen atoms of different neighbors. In the resulting three-dimensional structure, one molecule of 3 interacts with six other molecules (Figure 6b). Similar Bi···O interactions are also found in tris(2-methoxyphenyl)- and
A self-assembled photoresponsive gel consisting of chiral nanofibers
Beilstein J. Org. Chem. 2018, 14, 1994–2001, doi:10.3762/bjoc.14.174
- by three-dimensional networks through self-assembly have drawn significant attention in the past decades. They are normally fabricated by means of noncovalent intermolecular interactions [3], such as π–π stacking, hydrogen bonding, van der Waals forces, hydrophobic, electrostatic, host–guest and
Recent applications of chiral calixarenes in asymmetric catalysis
Beilstein J. Org. Chem. 2018, 14, 1389–1412, doi:10.3762/bjoc.14.117
- Analysis Technological Application and Research Center (UBATAM), Usak University, Usak, Turkey Vocational School of Health Services, Usak University, 64200 Usak, Turkey 10.3762/bjoc.14.117 Abstract The use of calixarenes in asymmetric catalysis is receiving increasing attention due to their tunable three
- -dimensional molecular platforms along with their easy syntheses and versatile modification at the upper and lower rims. This review summarizes the recent progress of synthesis and use of chiral calixarenes in asymmetric syntheses which emerged later than 2010. Keywords: asymmetric catalysis; chiral
Nanoreactors for green catalysis
Beilstein J. Org. Chem. 2018, 14, 716–733, doi:10.3762/bjoc.14.61
- tuned by varying their initial molecular components or the number of generations they possess [91][92]. They can assemble in a spherical shape, and within the three-dimensional structure, an interior void is present wherein to accommodate other molecules [93]. Catalysis in dendrimers: The controlled
Solvent-free copper-catalyzed click chemistry for the synthesis of N-heterocyclic hybrids based on quinoline and 1,2,3-triazole
Beilstein J. Org. Chem. 2017, 13, 2352–2363, doi:10.3762/bjoc.13.232
- notation as R22(18) [54]. Although the same motif formed by the analogous hydrogen bond is observed in other three structures (Table S3, Supporting Information File 1), the final supramolecular structures of 5–8 differ, from one-dimensional chains to three-dimensional network. It should be mentioned that
Synthesis and application of trifluoroethoxy-substituted phthalocyanines and subphthalocyanines
Beilstein J. Org. Chem. 2017, 13, 2273–2296, doi:10.3762/bjoc.13.224
- composed of three isoindoline units. The only central element of subphthalocyanine is boron, and it has a ligand in the axial direction on the boron. Since subphthalocyanines have excellent spectroscopic properties and a unique three-dimensional structure, it is expected that they will be applied to
- various fields [126][127][128], alongside phthalocyanines. However, the solubility of subphthalocyanines is not very high despite of the non-aggregation phenomenon due to their three-dimensional structure. On the other hand, since trifluoroethoxy-substituted subphthalocyanines (TFEO-subPcs) have high
Conformational impact of structural modifications in 2-fluorocyclohexanone
Beilstein J. Org. Chem. 2017, 13, 1781–1787, doi:10.3762/bjoc.13.172
- , while organic fluorine plays a fundamental role in the design of performance organic molecules. Since these features are dependent on the three-dimensional chemical structure of a molecule, simple structural modifications can affect its conformational stability and, consequently, the corresponding
2-Methyl-2,4-pentanediol (MPD) boosts as detergent-substitute the performance of ß-barrel hybrid catalyst for phenylacetylene polymerization
Beilstein J. Org. Chem. 2017, 13, 1498–1506, doi:10.3762/bjoc.13.148
- can destroy the three dimensional structure and cause protein precipitation [19][20][21]. To avoid precipitation when using nonpolar substrates, the protein concentration usually is decreased leading to a loss in activity. As an example, the polymerization of phenylacetylene was achieved in water by
A speedy route to sterically encumbered, benzene-fused derivatives of privileged, naturally occurring hexahydropyrrolo[1,2-b]isoquinoline
Beilstein J. Org. Chem. 2017, 13, 1413–1424, doi:10.3762/bjoc.13.138
- hexahydropyrrolo[1,2-b]isoquinolone derivatives fused with benzene 10 that have pronounced three-dimensional features and potentially contain several quaternary carbon centers (Figure 2). The first aspect has been recently recognized [29] as a central principle in drug design ensuring effective interaction of
Detection of therapeutic radiation in three-dimensions
Beilstein J. Org. Chem. 2017, 13, 1325–1331, doi:10.3762/bjoc.13.129
- John A. Adamovics Department of Chemistry, Biochemistry and Physics, Rider University, 2083 Lawrenceville Road, Lawrenceville, NJ 08648-3099, USA 10.3762/bjoc.13.129 Abstract For over the last twenty years there has been a multitude of sophisticated three-dimensional radiation delivery procedures
- developed which requires a corresponding verification of the impact on patients. This article reviews the state of the art in the development of chemical detectors used to characterize the three-dimensional shape of therapeutic radiation. These detectors are composed of polyurethane, radical initiator and a
- made in developing chemical-based three-dimensional radiation detection systems but as of this review these dosimeters are primarily used in clinical research settings. This is partially due to the lack of a viable commercially available OCT scanner and availability of alternative semi-3D radiation
Glycoscience@Synchrotron: Synchrotron radiation applied to structural glycoscience
Beilstein J. Org. Chem. 2017, 13, 1145–1167, doi:10.3762/bjoc.13.114
- the wavelength to reach the values that are optimum for a given experiment provides the most powerful way to determine the three-dimensional features of macromolecular structures. Diffraction performed at an energy close to a heavy element absorption edge produces a resonant effect for which scattered
- 1930, the first crystal structures of organic compounds to be investigated were carbohydrates of low molecular weight. Over the following years, only eight additional crystal structures were reported. The determination of the three dimensional structure of the dehydrated form of sucrose, in 1947, was
- technique’s high resolution, new possibilities exist, such as the investigations of the occurrence of phase transitions in large macromolecules as a function of temperature. Macromolecular structures X-ray diffraction with synchrotron radiation is the most powerful method for revealing the three-dimensional
From chemical metabolism to life: the origin of the genetic coding process
Beilstein J. Org. Chem. 2017, 13, 1119–1135, doi:10.3762/bjoc.13.111
- atomic composition of matter: N for nitrogen, Fe, for iron, C for carbon). Thus a chemical molecule is information-rich. sn-Glycerol-3-phosphate can be described, including an outline of its three-dimensional configuration, by a limited alphabet of symbols (e.g., the Simplified Molecular Input Line Entry
Total syntheses of the archazolids: an emerging class of novel anticancer drugs
Beilstein J. Org. Chem. 2017, 13, 1085–1098, doi:10.3762/bjoc.13.108
- three dimensional conformation of the archazolids by NMR methods, molecular modelling and chemical derivatizations [59][60]. During these studies, they became aware that C2–C5 diene of acyclic analogs would be very labile towards isomerization. However, such processes would be suppressed in the
Expression, purification and structural analysis of functional GABA transporter 1 using the baculovirus expression system
Beilstein J. Org. Chem. 2017, 13, 874–882, doi:10.3762/bjoc.13.88
- protein, GAT1, is a potential drug target. The exact three-dimensional structure of GAT1 protein could provide more information for pharmaceutical research. The structural analysis of most membrane proteins is challenging since significant protein yields are required and because eukaryotic membrane
- crystallography, thereby improving our understanding of the three-dimensional structure of the GAT1 protein. Experimental Immunoprecipitation and Western blotting The immunoprecipitation and Western blotting procedures were similar to those described previously [12]. Briefly, the GAT1/GFP protein was solubilized
The effect of cyclodextrin complexation on the solubility and photostability of nerolidol as pure compound and as main constituent of cabreuva essential oil
Beilstein J. Org. Chem. 2017, 13, 835–844, doi:10.3762/bjoc.13.84
- narrow side of CD. Molecular modelling The theoretical molecular modelling is useful to illustrate the most energetically favorable three-dimensional structure of the inclusion complex in solution. The inclusion complex conformer that presents the weakest relative binding energies (ΔE) (i.e., the most
Continuous-flow processes for the catalytic partial hydrogenation reaction of alkynes
Beilstein J. Org. Chem. 2017, 13, 734–754, doi:10.3762/bjoc.13.73
- substrate hindrance affects catalyst activity, even if not directly related to continuous flow operation conditions. It was proposed that ligand-modified surfaces, such as Pd(HHDMA)@C, are three-dimensional catalytic ensembles whose organic capping layer cannot be penetrated with ease by larger alkynes
A new class of organogelators based on triphenylmethyl derivatives of primary alcohols: hydrophobic interactions alone can mediate gelation
Beilstein J. Org. Chem. 2017, 13, 138–149, doi:10.3762/bjoc.13.17
- two adjacent linear arrays will be approximately equal to (or less than) the width of the TPM-G12 molecule (8.50 Å). Subsequently, different layers of these two-dimensional planar structures can aggregate together to give the three-dimensional microstructure of the gel. The distance between any two
A postsynthetically 2’-“clickable” uridine with arabino configuration and its application for fluorescent labeling and imaging of DNA
Beilstein J. Org. Chem. 2017, 13, 127–137, doi:10.3762/bjoc.13.16
- DNA polymerases in primer extension experiments and PCR [4][16]. To develop fluorescently labelled oligonucleotides that undergo energy transfer reactions [17] we recently applied 2’-propargyl-modified uridine 1 as DNA building block (Scheme 1) [15][18][19]. A simple look on the three-dimensional
3D printed fluidics with embedded analytic functionality for automated reaction optimisation
Beilstein J. Org. Chem. 2017, 13, 111–119, doi:10.3762/bjoc.13.14
- reaction analysis; reaction optimisation; selective laser melting; stereolithography; Introduction Additive manufacturing (AM), or as it is widely known ‘3D printing’, is the internationally recognised term used to describe a wide range of manufacturing processes that can generate complex three
- -dimensional parts, often with geometries which would be extremely complex, or in some cases impossible to manufacture using more conventional subtractive manufacturing processes [1]. In AM, parts are built layer-by-layer, using processes such as material extrusion [2], material jetting [3], vat
Supramolecular frameworks based on [60]fullerene hexakisadducts
Beilstein J. Org. Chem. 2017, 13, 1–9, doi:10.3762/bjoc.13.1
- retaining permanent porosity in the solvent-free state have been reported so far. Here, we report on the crystallization of three-dimensional hydrogen-bonding frameworks based on [60]fullerene hexakisadducts bearing twelve carboxylic acid groups icosahedrally arranged on the fullerene surface. By varying
- investigations, the implementation of fullerene derivatives possessing long but rigid spacer units might be beneficial for retaining porosity of such supramolecular crystals. Conclusion We have presented the crystallization of two [60]fullerene dodecaacids possessing three-dimensional hydrogen bonding networks
Biochemical and structural characterisation of the second oxidative crosslinking step during the biosynthesis of the glycopeptide antibiotic A47934
Beilstein J. Org. Chem. 2016, 12, 2849–2864, doi:10.3762/bjoc.12.284
- products and are highly effective antibiotics against Gram-positive bacteria, where they affect their function by preventing the correct crosslinking of the peptidoglycan cell wall [1]. Produced by bacteria, these compounds derive their efficacy from their unique three-dimensional structure, which in turn
- enables them to bind to the dipeptide terminus of the peptidoglycan precursor lipid II [1][2]. This three-dimensional structure is generated by the high degree of crosslinking exhibited by the glycopeptide antibiotics: in the case of the two most widely known natural examples (vancomycin and teicoplanin
Synthesis of spiro[isoindole-1,5’-isoxazolidin]-3(2H)-ones as potential inhibitors of the MDM2-p53 interaction
Beilstein J. Org. Chem. 2016, 12, 2793–2807, doi:10.3762/bjoc.12.278
- ’, respectively). Crystal packing is a racemate due to the centrosymmetric symmetry and in the picture the choice of the enantiomer is arbitrary. C: light blue, H: white, O: red, N: magenta. Probability of the ORTEP ellipsoids is set to 50%, whereas H size is arbitrary. Three-dimensional plots of TSs of reaction
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