Linear-g-hyperbranched and cyclodextrin-based amphiphilic block copolymer as a multifunctional nanocarrier

• Yamei Zhao,
• Wei Tian,
• Guang Yang and
• Xiaodong Fan

Beilstein J. Org. Chem. 2014, 10, 2696–2703, doi:10.3762/bjoc.10.284

• ), further indicating that the pseudo-one-step method was effective in this reaction. Although the structure of P2 is relatively complicated, 1H nuclear magnetic resonance (NMR), 13C NMR, and Fourier transform infrared spectroscopy (FTIR) spectra can still be used to confirm the existence of characteristic

Synthesis of a resin monomer-soluble polyrotaxane crosslinker containing cleavable end groups

• Ji-Hun Seo,
• Shino Nakagawa,
• Koichiro Hirata and
• Nobuhiko Yui

Beilstein J. Org. Chem. 2014, 10, 2623–2629, doi:10.3762/bjoc.10.274

• degradable nature of prepared photosetting plastic. Characterization 1H nuclear magnetic resonance (NMR) measurement was conducted with a Bruker Avance III 500 MHz spectrometer (Bruker Biospin, Rheinstetten, Germany) in DMSO-d6 (Sigma-Aldrich). Size-exclusion chromatography (SEC) analysis was conducted by

Oxidative phenylamination of 5-substituted 1-hydroxynaphthalenes to N-phenyl-1,4-naphthoquinone monoimines by air and light “on water”

• Julio Benites,
• Juan Meléndez,
• Cynthia Estela,
• David Ríos,
• Luis Espinoza,
• Iván Brito and
• Jaime A. Valderrama

Beilstein J. Org. Chem. 2014, 10, 2448–2452, doi:10.3762/bjoc.10.255

• hand, the reaction of juglone (2) with 4-hydroxyphenylamine, performed in water suspension at room temperature, gives rise compounds 4a and 4b in 45% and 16% yields, respectively. The structures of compounds 4a and 4b were fully established on the basis of their nuclear magnetic resonance (1H NMR, 13C

Expanding the scope of cyclopropene reporters for the detection of metabolically engineered glycoproteins by Diels–Alder reactions

• Anne-Katrin Späte,
• Verena F. Schart,
• Julia Häfner,
• Andrea Niederwieser,
• Thomas U. Mayer and
• Valentin Wittmann

Beilstein J. Org. Chem. 2014, 10, 2235–2242, doi:10.3762/bjoc.10.232

• -Reveleris system from Grace. Nuclear magnetic resonance (NMR) spectra were recorded at room temperature on Avance III 400 and Avance III 600 instruments from Bruker. Chemical shifts are reported relative to solvent signals (CDCl3: δH = 7.26 ppm, δC = 77.16 ppm). Signals were assigned by first-order analysis

Expedient synthesis of 1,6-anhydro-α-D-galactofuranose, a useful intermediate for glycobiological tools

• Luciana Baldoni and
• Carla Marino

Beilstein J. Org. Chem. 2014, 10, 1651–1656, doi:10.3762/bjoc.10.172

• ). Optical rotations were measured with a Perkin-Elmer 343 digital polarimeter. Nuclear magnetic resonance (NMR) spectra were recorded with a Bruker AMX 500 spectrometer. Assignments of 1H and 13C were assisted by 2D 1H COSY and HSQC experiments. High resolution mass spectra (HRMS–ESI+) were recorded in a

Dimerisation, rhodium complex formation and rearrangements of N-heterocyclic carbenes of indazoles

• Zong Guan,
• Jan C. Namyslo,
• Martin H. H. Drafz,
• Martin Nieger and
• Andreas Schmidt

Beilstein J. Org. Chem. 2014, 10, 832–840, doi:10.3762/bjoc.10.79

• 60 (0.040–0.063 mm). Nuclear magnetic resonance (NMR) spectra were obtained with a Bruker Avance 400 and Bruker Avance III 600 MHz. 1H NMR spectra were recorded at 400 MHz or 600 MHz. 13C NMR spectra were recorded at 100 MHz or 150 MHz, with the solvent peak or tetramethylsilane used as the internal

True and masked three-coordinate T-shaped platinum(II) intermediates

• Manuel A. Ortuño,
• Salvador Conejero and
• Agustí Lledós

Beilstein J. Org. Chem. 2013, 9, 1352–1382, doi:10.3762/bjoc.9.153

• complexes were prepared by using phosphine ligands (Figure 5). In the 80s, Goel et al. proposed, from nuclear magnetic resonance (NMR) data, a T-shaped structure for the cationic hydride trans-[(t-Bu3P)2Pt(H)]+ T1 containing bulky phosphine ligands [19]. However, it was not until 2005 when Braunschweig et

Diastereoselective synthesis of nitroso acetals from (S,E)-γ-aminated nitroalkenes via multicomponent [4 + 2]/[3 + 2] cycloadditions promoted by LiCl or LiClO₄

• Leandro Lara de Carvalho,
• Robert Alan Burrow and
• Vera Lúcia Patrocinio Pereira

Beilstein J. Org. Chem. 2013, 9, 838–845, doi:10.3762/bjoc.9.96

• and extended ORTEP drawing of 11b. Acknowledgements We acknowledge the CAPES, FAPERJ and the CNPq for financial support. We also thank professor N. P. Lopes and C. B. Barreto, Jr. and the National Center of Nuclear Magnetic Resonance (CNRMN) IBqM/UFRJ.

Thermotropic and lyotropic behaviour of new liquid-crystalline materials with different hydrophilic groups: synthesis and mesomorphic properties

• Alexej Bubnov,
• Miroslav Kašpar,
• Věra Hamplová,
• Ute Dawin and
• Frank Giesselmann

Beilstein J. Org. Chem. 2013, 9, 425–436, doi:10.3762/bjoc.9.45

• compounds is presented in this section. Structures of the intermediate and final products were confirmed by 1H nuclear magnetic resonance spectroscopy by using a 300 MHz Varian spectrometer in solutions with CDCl3 or dimethylsulfoxide (DMSO) with tetramethylsilane as an internal standard. The chemical

A new family of four-ring bent-core nematic liquid crystals with highly polar transverse and end groups

• Kalpana Upadhyaya,
• Venkatesh Gude,
• Golam Mohiuddin and
• Rao V. S. Nandiraju

Beilstein J. Org. Chem. 2013, 9, 26–35, doi:10.3762/bjoc.9.4

• distilled and dried before use. Micro analysis of C and H elements were determined on Carlo-Erba 1106 elemental analyzer. IR spectra were recorded on Shimadzu IR Prestige-21, FTIR-8400S (νmax in cm−1) as KBr disks. The 1H nuclear magnetic resonance spectra were recorded on NMR spectrometers (Bruker DPX-400

Synthesis of a derivative of α-D-Glcp(1->2)-D-Galf suitable for further glycosylation and of α-D-Glcp(1->2)-D-Gal, a disaccharide fragment obtained from varianose

• Carla Marino,
• Carlos Lima,
• Karina Mariño and
• Rosa M. de Lederkremer

Beilstein J. Org. Chem. 2012, 8, 2142–2148, doi:10.3762/bjoc.8.241

• . Nuclear magnetic resonance (NMR) spectra were recorded with a Bruker AMX 500 spectrometer. Assignments of 1H and 13C were assisted by 2D 1H COSY and HSQC experiments. High-resolution mass spectra (HRMS–ESI+) were recorded on a Bruker micrOTOF-Q II spectrometer. Synthesis 2-O-(2,3,4,6-Tetra-O-benzyl-α-D

Automated three-component synthesis of a library of γ-lactams

• Erik Fenster,
• David Hill,
• Oliver Reiser and
• Jeffrey Aubé

Beilstein J. Org. Chem. 2012, 8, 1804–1813, doi:10.3762/bjoc.8.206

• performed on a Shimadzu SCL-10A system with a SPD-10AV UV–vis detector and hexane/isopropanol as the solvent mobile phase. Proton nuclear magnetic resonance (1H NMR) and carbon nuclear magnetic resonance (13C NMR) spectra were recorded in deuterochloroform by using a Bruker AV-400 or a Bruker DRX-500

Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations

• Bo Leng,
• Stephanie Chichetti,
• Shun Su,
• Aaron B. Beeler and
• John A. Porco Jr.

Beilstein J. Org. Chem. 2012, 8, 1338–1343, doi:10.3762/bjoc.8.153

• novel polycyclic cyclopropanes as well as additional studies employing reaction screening for metal-mediated processes is ongoing and will be reported in future publications. Experimental General Information: All nuclear magnetic resonance spectra were recorded on either a Varian or Bruker spectrometer

Design of a novel tryptophan-rich membrane-active antimicrobial peptide from the membrane-proximal region of the HIV glycoprotein, gp41

• Evan F. Haney,
• Leonard T. Nguyen,
• David J. Schibli and
• Hans J. Vogel

Beilstein J. Org. Chem. 2012, 8, 1172–1184, doi:10.3762/bjoc.8.130

• to the formation of insoluble peptide–lipid complexes. Unfortunately, due to the loss of CD signal in these samples, it is impossible to determine what type of secondary structure is present in these aggregates. NMR solution structure All the gp41w derivatives were examined by nuclear magnetic

• resonance (NMR) spectroscopy to determine the high-resolution structure in a membrane mimetic environment. The structure of gp41w was previously determined in the presence of DPC micelles [12]. However, when the three derivatives were tested with SDS and DPC micelles, the resulting NMR spectra were poorly

Partial thioamide scan on the lipopeptaibiotic trichogin GA IV. Effects on folding and bioactivity

• Marta De Zotti,
• Barbara Biondi,
• Cristina Peggion,
• Matteo De Poli,
• Haleh Fathi,
• Simona Oancea,
• Claudio Toniolo and
• Fernando Formaggio

Beilstein J. Org. Chem. 2012, 8, 1161–1171, doi:10.3762/bjoc.8.129

• , MA) was employed. Cells with path lengths of 1.0 and 10 mm (with CaF2 windows) were used. Spectrograde deuterated chloroform (99.8%, d) was purchased from Merck (Darmstadt, Germany). Nuclear magnetic resonance All 1H NMR experiments were performed on a Bruker AVANCE DMX-600, DRX-400 or AC200

Control over molecular motion using the cis–trans photoisomerization of the azo group

• Estíbaliz Merino and
• María Ribagorda

Beilstein J. Org. Chem. 2012, 8, 1071–1090, doi:10.3762/bjoc.8.119

• other [9]. The arrangement of the aromatic rings is also reflected in the proton nuclear magnetic resonance spectrum (1H NMR). The signals of the cis isomer appear at higher field than the signals corresponding to the trans isomer, due to the anisotropic effect of the π cloud of the aromatic ring. The

The use of glycoinformatics in glycochemistry

• Thomas Lütteke

Beilstein J. Org. Chem. 2012, 8, 915–929, doi:10.3762/bjoc.8.104

• of nuclear magnetic resonance (NMR) experiments that had been performed to elucidate the structures. Other sources of NMR data are SugaBase [36], which similar to CarbBank is no longer maintained, GlycoBase (Lille), Escherichia coli O-antigen Database (ECODAB) [22], and Glycosciences.DB [31], the

Synthesis, solid-state fluorescence properties, and computational analysis of novel 2-aminobenzo[4,5]thieno[3,2-d]pyrimidine 5,5-dioxides

• Kenichirou Yokota,
• Masayori Hagimori,
• Naoko Mizuyama,
• Yasuhisa Nishimura,
• Hiroshi Fujito,
• Yasuhiro Shigemitsu and
• Yoshinori Tominaga

Beilstein J. Org. Chem. 2012, 8, 266–274, doi:10.3762/bjoc.8.28

• JASCO 810 or Shimazu IR-460 spectrometer. Ultraviolet (UV) absorption spectra were determined in 95% ethanol on a Hitachi 323 spectrometer. Fluorescence spectra were determined on a Shimazu RF-1500. Nuclear-magnetic-resonance (NMR) spectra were obtained on Gemini 300NMR (300 MHz) and 500NMR (500 MHz

Translation of microwave methodology to continuous flow for the efficient synthesis of diaryl ethers via a base-mediated S_NAr reaction

• Charlotte Wiles and
• Paul Watts

Beilstein J. Org. Chem. 2011, 7, 1360–1371, doi:10.3762/bjoc.7.160

• solvents purchased for use in aqueous extractions. Instrumentation. Unless otherwise stated, nuclear magnetic resonance (NMR) spectra were obtained at room temperature from solutions in deuterated chloroform (CDCl3 0.01% TMS) by means of a Jeol GX400 spectrometer; in the case of known compounds, all

The cross-metathesis of methyl oleate with cis-2-butene-1,4-diyl diacetate and the influence of protecting groups

• Arno Behr and
• Jessica Pérez Gomes

Beilstein J. Org. Chem. 2011, 7, 1–8, doi:10.3762/bjoc.7.1

• thickness 0.20 μm, VWR International). Substrates were visualised with p-anisaldehyde reagent. Flash chromatography was conducted on silica gel 60 (40–60 μm, Acros Organics). Nuclear magnetic resonance (NMR) spectra were recorded in deuterated chloroform on a Bruker AVANCE DRX spectrometer operating at 400

Expanding the gelation properties of valine-based 3,5-diaminobenzoate organogelators with N-alkylurea functionalities

• Hak-Fun Chow and
• Chin-Ho Cheng

Beilstein J. Org. Chem. 2010, 6, 1015–1021, doi:10.3762/bjoc.6.114

• a literature procedure [16], in the presence of N-diisopropylethylamine. Structural characterization All synthesized compounds were characterized by 1H and 13C nuclear magnetic resonance spectroscopy, mass spectrometry, elemental analysis, and optical polarimetry. Due to the poor solubilities of the

Novel multi-responsive P2VP-block-PNIPAAm block copolymers via nitroxide-mediated radical polymerization

• Cathrin Corten,
• Katja Kretschmer and
• Dirk Kuckling

Beilstein J. Org. Chem. 2010, 6, 756–765, doi:10.3762/bjoc.6.89

• nitroxide terminated polymers were characterized by nuclear magnetic resonance (NMR) spectroscopy, size exclusion chromatography (SEC) and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). Thermal properties were investigated by the differential scanning

Synthesis and crossover reaction of TEMPO containing block copolymer via ROMP

• Olubummo Adekunle,
• Susanne Tanner and
• Wolfgang H. Binder

Beilstein J. Org. Chem. 2010, 6, No. 59, doi:10.3762/bjoc.6.59

• using matrix assisted laser desorption ionization mass spectroscopy (MALDI-TOF) and nuclear magnetic resonance (NMR), respectively. MALDI showed that there was a complete crossover reaction after the addition of 25 equivalents of the second monomer. NMR investigation showed that U3 gave a faster rate of

Synthesis of phosphonate and phostone analogues of ribose-1-phosphates

• Pitak Nasomjai,
• David O'Hagan and
• Alexandra M. Z. Slawin

Beilstein J. Org. Chem. 2009, 5, No. 37, doi:10.3762/bjoc.5.37

• isomerase, the next enzyme on the pathway, and in order to probe the molecular mechanism of this enzyme, these phosphonates and the phostones 10 and 11 are being used in co-crystallisation trials with each of the over-expressed enzymes (PNP and isomerase). Experimental Nuclear magnetic resonance (NMR

The development and evaluation of a continuous flow process for the lipase- mediated oxidation of alkenes

• Charlotte Wiles,
• Marcus J. Hammond and
• Paul Watts

Beilstein J. Org. Chem. 2009, 5, No. 27, doi:10.3762/bjoc.5.27

• , Fisher Scientific). In all cases, materials were used as received. Instrumentation Unless otherwise stated, nuclear magnetic resonance (NMR) spectra were obtained at room temperature as solutions in deuterated chloroform (CDCl3) using a Jeol GX400 spectrometer; in the case of known compounds, all spectra