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Search for "steroids" in Full Text gives 57 result(s) in Beilstein Journal of Organic Chemistry.
Recyclable fluorous cinchona alkaloid ester as a chiral promoter for asymmetric fluorination of β-ketoesters
Beilstein J. Org. Chem. 2012, 8, 1233–1240, doi:10.3762/bjoc.8.138
- . Introducing one or a few fluorine atoms to biologically interesting molecules can significantly change the physical, chemical and biological properties [1][2]. The significant amount of publications on fluorinated small molecules, amino acids, carbohydrates, steroids and nucleosides indicates that
Carbamate derivatives and sesquiterpenoids from the South China Sea gorgonian Melitodes squamata
Beilstein J. Org. Chem. 2012, 8, 170–176, doi:10.3762/bjoc.8.18
- , diterpenoids, prostanoids, and steroids [1][2]. However, nitrogen-containing compounds were relatively few obtained from gorgonians. Gorgonian Melitodes squamata Nutting belonging to Melithaea family is a kind of pharmaceutical coral that has the efficacy of relieving cough, bleeding, and diarrhea, soothing
- nerves, and calming scare, etc [3]. A previous study on the chemical constituents of Melithaea family gorgonians led to the isolation of four new steroids melithasterols A–D from Melithaea ocracea [4]. Results and Discussion In order to further obtain new bioactive compounds from gorgonians, we studied
Tertiary alcohol preferred: Hydroxylation of trans-3-methyl-L-proline with proline hydroxylases
Beilstein J. Org. Chem. 2011, 7, 1643–1647, doi:10.3762/bjoc.7.193
- approach whose potential has not yet been fully exploited is the stereospecific hydroxylation of tertiary alkyl moieties with oxygenases. Most oxidations to tertiary alcohols described so far were observed during degradation of steroids and other terpenoid bioactive compounds by microbial whole cells [10
Development of the titanium–TADDOLate-catalyzed asymmetric fluorination of β-ketoesters
Beilstein J. Org. Chem. 2011, 7, 1421–1435, doi:10.3762/bjoc.7.166
- (Figure 1a) is highly toxic [14]. Modulation of drug action by inclusion of fluorine, described already in 1954 for steroids (Figure 1b) [15], is now regularly explored in medicinal chemistry. An example of interest for the present work is the modification of the antibiotic erythromycine by α-fluorination
Continuous gas/liquid–liquid/liquid flow synthesis of 4-fluoropyrazole derivatives by selective direct fluorination
Beilstein J. Org. Chem. 2011, 7, 1048–1054, doi:10.3762/bjoc.7.120
- complex systems such as fluorinated terpenoids, steroids and a range of heterocyclic systems, upon appropriate synthetic elaboration [7], and, consequently, there is much interest in the development of a synthetic methodology for the preparation of such useful fluorinated intermediates. It has been
Asymmetric synthesis of tertiary thiols and thioethers
Beilstein J. Org. Chem. 2011, 7, 582–595, doi:10.3762/bjoc.7.68
- opening of epoxides in hindered systems [18][19][20][21][22][23], with most examples of the latter occurring at quaternary carbon atoms which are part of ring systems [18][19][20][21][22], and in particular in steroids [18][19][20]. For example, the thiol-containing androgen 19 is prepared in 71% yield by
High stereoselectivity on low temperature Diels- Alder reactions
Beilstein J. Org. Chem. 2005, 1, No. 14, doi:10.1186/1860-5397-1-14
- sesquiterpenes, labdanic and hydrophenanthroid diterpenes, steroids, and tetracyclic and pentacyclic triterpenes) [5][6]. The role of the Lewis acid is to produce an extra lowering of the LUMO energy of the carbonyl substrate, through complexation with the carbonyl oxygen thus reducing the electron density of
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