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Search for "structural features" in Full Text gives 216 result(s) in Beilstein Journal of Organic Chemistry. Showing first 200.

Synthesis of chiral cyclohexane-linked bisimidazolines

  • Changmeng Xi,
  • Qingshan Sun and
  • Jiaxi Xu

Beilstein J. Org. Chem. 2025, 21, 1786–1790, doi:10.3762/bjoc.21.140

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  • vicinal amino alcohols as starting materials in their synthesis. However, it is difficult to tune the electronic effects of cHBOX ligands. Chiral cyclohexane-1,2-linked bisimidazolines possess similar structural features as cHBOX ligands and their electronic effect can be tuned by the introduction of
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Published 04 Sep 2025

Research progress on calixarene/pillararene-based controlled drug release systems

  • Liu-Huan Yi,
  • Jian Qin,
  • Si-Ran Lu,
  • Liu-Pan Yang,
  • Li-Li Wang and
  • Huan Yao

Beilstein J. Org. Chem. 2025, 21, 1757–1785, doi:10.3762/bjoc.21.139

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  • applications. This section will focus on the structural features and applications of CAs and PAs. 1.1 CAs: structure and properties CAs are the third generation of supramolecular hosts [40], succeeding cyclodextrins and crown ethers. They are macrocycles composed of phenolic units condensed with formaldehyde
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Published 03 Sep 2025

Structural analysis of stereoselective galactose pyruvylation toward the synthesis of bacterial capsular polysaccharides

  • Tsun-Yi Chiang,
  • Mei-Huei Lin,
  • Chun-Wei Chang,
  • Jinq-Chyi Lee and
  • Cheng-Chung Wang

Beilstein J. Org. Chem. 2025, 21, 1671–1677, doi:10.3762/bjoc.21.131

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  • immunological cross-reactivity. Moreover, pyruvate ketals are recognized as immunodominant structural features of polysaccharides, which are important in cell–cell recognition processes [13][14][15][16][17][18]. The pyruvate ketal is an important portion of immunological determinant in bacterial polysaccharides
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Published 21 Aug 2025

Transition-state aromaticity and its relationship with reactivity in pericyclic reactions

  • Israel Fernández

Beilstein J. Org. Chem. 2025, 21, 1613–1626, doi:10.3762/bjoc.21.125

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  • [1][2][3]. Initially introduced to account for the remarkable stability, low reactivity, and unique structural features of benzene and related aromatic hydrocarbons, the concept has undergone a significant evolution [4]. Since the introduction of the famous Hückel’s (4n + 2) rule [5], first clearly
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Published 12 Aug 2025

Thermodynamic equilibrium between locally excited and charge transfer states in perylene–phenothiazine dyads

  • Issei Fukunaga,
  • Shunsuke Kobashi,
  • Yuki Nagai,
  • Hiroki Horita,
  • Hiromitsu Maeda and
  • Yoichi Kobayashi

Beilstein J. Org. Chem. 2025, 21, 1577–1586, doi:10.3762/bjoc.21.121

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  • structural characterization A series of π-orthogonal D–A molecules based on the Pe–PTZ framework were synthesized to systematically modulate the electronic properties and spatial arrangement between the donor and acceptor units. Structural features were designed to ensure orthogonality between the Pe and PTZ
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Published 05 Aug 2025

pH-Controlled isomerization kinetics of ortho-disubstituted benzamidines: E/Z isomerism and axial chirality

  • Ryota Kimura,
  • Satoshi Ichikawa and
  • Akira Katsuyama

Beilstein J. Org. Chem. 2025, 21, 1568–1576, doi:10.3762/bjoc.21.120

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  • various fields, such as functional materials, biological probes, and drugs. a) Structural features of DiBA. b) Resonance structure of the amide moiety of DiBA. c) Molecular form and protonated structure of ortho-disubstituted benzamidine. Rotational barriers of 2-bromo-N,N,6-trimethylbenzimidamide and its
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Published 04 Aug 2025

Photoredox-catalyzed arylation of isonitriles by diaryliodonium salts towards benzamides

  • Nadezhda M. Metalnikova,
  • Nikita S. Antonkin,
  • Tuan K. Nguyen,
  • Natalia S. Soldatova,
  • Alexander V. Nyuchev,
  • Mikhail A. Kinzhalov and
  • Pavel S. Postnikov

Beilstein J. Org. Chem. 2025, 21, 1480–1488, doi:10.3762/bjoc.21.110

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  • evaluated and their reactivity was systematically analyzed in relation to the structural features of the iodonium salts and isonitriles. The study revealed that EWG-substituted diaryliodonium salts exhibited superior performance compared to EDG-substituted ones. Furthermore, the potential for selective
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Published 21 Jul 2025

Advances in nitrogen-containing helicenes: synthesis, chiroptical properties, and optoelectronic applications

  • Meng Qiu,
  • Jing Du,
  • Nai-Te Yao,
  • Xin-Yue Wang and
  • Han-Yuan Gong

Beilstein J. Org. Chem. 2025, 21, 1422–1453, doi:10.3762/bjoc.21.106

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  • electronic structures and enhance properties such as fluorescence efficiency, charge transport, and chiroptical responses. In this section, we begin by summarizing representative imide-functionalized helicenes, highlighting their structural features and photophysical performances. In 2020, Ravat’s group
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Published 11 Jul 2025

Oxetanes: formation, reactivity and total syntheses of natural products

  • Peter Gabko,
  • Martin Kalník and
  • Maroš Bella

Beilstein J. Org. Chem. 2025, 21, 1324–1373, doi:10.3762/bjoc.21.101

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  • vitro [19]. As for natural occurrence of oxetanes, they are relatively uncommon, and an extensive review has recently been published by Dembitsky which explored the structural features and biological activities of oxetane-containing natural products [20]. Some of the most famous examples are taxol [21
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Published 27 Jun 2025

Regioselective formal hydrocyanation of allenes: synthesis of β,γ-unsaturated nitriles with α-all-carbon quaternary centers

  • Seeun Lim,
  • Teresa Kim and
  • Yunmi Lee

Beilstein J. Org. Chem. 2025, 21, 800–806, doi:10.3762/bjoc.21.63

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  • bonds is one of the most efficient and atom-economical approaches for synthesizing alkyl nitriles [15][16]. Among the potential substrates, allenes have attracted significant attention because of their unique structural features, which consist of two orthogonal and contiguous C=C bonds. This dual π
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Published 17 Apr 2025

Acyclic cucurbit[n]uril bearing alkyl sulfate ionic groups

  • Christian Akakpo,
  • Peter Y. Zavalij and
  • Lyle Isaacs

Beilstein J. Org. Chem. 2025, 21, 717–726, doi:10.3762/bjoc.21.55

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  • , two aromatic o-xylylene walls, and four sulfonates as solubilizing ionic groups. In accord with these structural features, M1 binds a variety of hydrophobic and cationic guest molecules by the hydrophobic effect, π–π interactions, and electrostatic (ion–dipole and ion–ion) interactions. Although
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Published 03 Apr 2025

Recent advances in allylation of chiral secondary alkylcopper species

  • Minjae Kim,
  • Gwanggyun Kim,
  • Doyoon Kim,
  • Jun Hee Lee and
  • Seung Hwan Cho

Beilstein J. Org. Chem. 2025, 21, 639–658, doi:10.3762/bjoc.21.51

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  • transfer (TS2). The structural features of the tert-butyl group allow more efficient pyramidalization compared to the rigid adamantyl framework, suggesting that the flexibility of the transferring group plays a crucial role in facilitating transmetalation. Copper hydride chemistry for enantioselective
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Published 20 Mar 2025

Deep-blue emitting 9,10-bis(perfluorobenzyl)anthracene

  • Long K. San,
  • Sebastian Balser,
  • Brian J. Reeves,
  • Tyler T. Clikeman,
  • Yu-Sheng Chen,
  • Steven H. Strauss and
  • Olga V. Boltalina

Beilstein J. Org. Chem. 2025, 21, 515–525, doi:10.3762/bjoc.21.39

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  • for material scientists [12][13][14]. One of the structural features favorable for an efficient anthracene-based blue emitter is the introduction of bulky substituents in the 9 and 10 positions, which results in a solid-state packing with limited π–π intermolecular interactions, which, in turn, tends
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Published 07 Mar 2025

Synthesis, characterization, antimicrobial, cytotoxic and carbonic anhydrase inhibition activities of multifunctional pyrazolo-1,2-benzothiazine acetamides

  • Ayesha Saeed,
  • Shahana Ehsan,
  • Muhammad Zia-ur-Rehman,
  • Erin M. Marshall,
  • Sandra Loesgen,
  • Abdus Saleem,
  • Simone Giovannuzzi and
  • Claudiu T. Supuran

Beilstein J. Org. Chem. 2025, 21, 348–357, doi:10.3762/bjoc.21.25

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  • moiety was beneficial to optimize therapeutic activity of different analogs with lesser adverse effects [32]. Amide linkages are a common drug feature that comprises about 25% of the most prescribed and vended medication [33]. Mimicking biologically relevant structural features of proteins and enzymes
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Published 12 Feb 2025

Antibiofilm and cytotoxic metabolites from the entomopathogenic fungus Samsoniella aurantia

  • Rita Toshe,
  • Syeda J. Khalid,
  • Blondelle Matio Kemkuignou,
  • Esteban Charria-Girón,
  • Paul Eckhardt,
  • Birthe Sandargo,
  • Kunlapat Nuchthien,
  • J. Jennifer Luangsa-ard,
  • Till Opatz,
  • Hedda Schrey,
  • Sherif S. Ebada and
  • Marc Stadler

Beilstein J. Org. Chem. 2025, 21, 327–339, doi:10.3762/bjoc.21.23

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  • characteristic spin system between two pairs of electromagnetically equivalent aromatic protons at δH 6.60 (d, J = 8.4 Hz, H-6'/8') and δH 7.01 (d, J = 8.4 Hz, H-5'/9') suggesting the presence of a 1,4-disubstituted aromatic ring in 1. A literature search of 1 based on the deduced structural features revealed
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Published 11 Feb 2025

Synthesis of acenaphthylene-fused heteroarenes and polyoxygenated benzo[j]fluoranthenes via a Pd-catalyzed Suzuki–Miyaura/C–H arylation cascade

  • Merve Yence,
  • Dilgam Ahmadli,
  • Damla Surmeli,
  • Umut Mert Karacaoğlu,
  • Sujit Pal and
  • Yunus Emre Türkmen

Beilstein J. Org. Chem. 2024, 20, 3290–3298, doi:10.3762/bjoc.20.273

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  • focus of extensive research within the past two decades due to their interesting structural features, attractive photophysical properties, and diverse applications [2]. Indeed, fluoranthenes are particularly useful in supramolecular chemistry, organic electronics, and materials science [3] as
  • ). Finally, due to our interest in the structural features and chemistry of 1,8-dihydroxynaphthalene (1,8-DHN) [48][49], we were curious to check the reactivity of the previously unknown boronic ester 17d, which was prepared in one step from thiophene-3-ylboronic acid (17a) and 1,8-DHN [50]. Note that
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Published 23 Dec 2024

Chemical structure metagenomics of microbial natural products: surveying nonribosomal peptides and beyond

  • Thomas Ma and
  • John Chu

Beilstein J. Org. Chem. 2024, 20, 3050–3060, doi:10.3762/bjoc.20.253

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  • to fully understand the determinant(s) of NRP topology. There are many ways to classify NRPs when topology and chemical structural features are considered simultaneously. For example, a macrocycle may be a lactam or a lactone depending on whether the internal nucleophile is an amine or an alcohol
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Published 20 Nov 2024

Tunable full-color dual-state (solution and solid) emission of push–pull molecules containing the 1-pyrindane moiety

  • Anastasia I. Ershova,
  • Sergey V. Fedoseev,
  • Konstantin V. Lipin,
  • Mikhail Yu. Ievlev,
  • Oleg E. Nasakin and
  • Oleg V. Ershov

Beilstein J. Org. Chem. 2024, 20, 3016–3025, doi:10.3762/bjoc.20.251

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  • able to emit in two different states (solution and solid state). This makes them more versatile and allows them to be used for the creation of fluorescent materials with different characteristics. Molecules exhibiting DSE are required to have certain structural features. First, they often contain donor
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Published 19 Nov 2024

Structure and thermal stability of phosphorus-iodonium ylids

  • Andrew Greener,
  • Stephen P. Argent,
  • Coby J. Clarke and
  • Miriam L. O’Duill

Beilstein J. Org. Chem. 2024, 20, 2931–2939, doi:10.3762/bjoc.20.245

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  •  2) and two highly unstable compounds (1d: 88 °C, 671 J/g; 1k: 74 °C, 70.2 J/g; Table 2). We were interested to investigate whether we could identify structural features that could explain these outliers. We observed a quantifiable anion (X) effect, with acyclic tetrafluoroborate 1a showing greater
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Published 14 Nov 2024

The charge transport properties of dicyanomethylene-functionalised violanthrone derivatives

  • Sondos A. J. Almahmoud,
  • Joseph Cameron,
  • Dylan Wilkinson,
  • Michele Cariello,
  • Claire Wilson,
  • Alan A. Wiles,
  • Peter J. Skabara and
  • Graeme Cooke

Beilstein J. Org. Chem. 2024, 20, 2921–2930, doi:10.3762/bjoc.20.244

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  • structural features of violanthrones suggest that these materials may possess similar charge transport, optical and electrochemical properties to those of PDIs. However, the larger π-conjugated system of violanthrone, along with the two carbonyl groups, increases the possibility of stronger π–π
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Published 13 Nov 2024

Applications of microscopy and small angle scattering techniques for the characterisation of supramolecular gels

  • Connor R. M. MacDonald and
  • Emily R. Draper

Beilstein J. Org. Chem. 2024, 20, 2608–2634, doi:10.3762/bjoc.20.220

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  • number of structural features, but the sample preparation required can lead to significant changes in the materials morphology. EM requires many preparative steps to allow structures to be imaged including the application of an ultrathin coating of carbon, gold, or platinum. These are applied to conduct
  • the quantification of structural features of the larger network by changing the morphology resulting in statistics which are not representative of the structures in situ [31]. Mears et al. have shown that when the fibres are hydrophobic and not heavily charged, microscopy techniques which require
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Published 16 Oct 2024

Natural resorcylic lactones derived from alternariol

  • Joachim Podlech

Beilstein J. Org. Chem. 2024, 20, 2171–2207, doi:10.3762/bjoc.20.187

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Published 30 Aug 2024

Computational toolbox for the analysis of protein–glycan interactions

  • Ferran Nieto-Fabregat,
  • Maria Pia Lenza,
  • Angela Marseglia,
  • Cristina Di Carluccio,
  • Antonio Molinaro,
  • Alba Silipo and
  • Roberta Marchetti

Beilstein J. Org. Chem. 2024, 20, 2084–2107, doi:10.3762/bjoc.20.180

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  • crucial for comprehending their roles and biological activities and for correlating their structural features with their activity [3][13]. Given the plethora of remarkable biological roles played by complex glycans, this knowledge is essential for their potential applications in promoting health benefits
  • docking algorithms. Unlike other docking programs such as AutoDock, AutoDock Vina, DOCK, FlexX, Glide, and GOLD, which are primarily designed for small, rigid ligands, GlycanDock is specifically optimized to address the flexibility and complex structural features of glycans. The carbohydrate chains are
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Published 22 Aug 2024

Cage-like microstructures via sequential Ugi reactions in aqueous emulsions

  • Rita S. Alqubelat,
  • Yaroslava A. Menzorova and
  • Maxim A. Mironov

Beilstein J. Org. Chem. 2024, 20, 2078–2083, doi:10.3762/bjoc.20.179

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  • approached low-molecular-weight substances. We used AFM to identify the structural features of the original colloidal particles. For this, colloidal particles were adsorbed on the substrate surface and then analyzed without complete drying, which made it possible to reveal the initial microgel structure
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Published 22 Aug 2024

2-Heteroarylethylamines in medicinal chemistry: a review of 2-phenethylamine satellite chemical space

  • Carlos Nieto,
  • Alejandro Manchado,
  • Ángel García-González,
  • David Díez and
  • Narciso M. Garrido

Beilstein J. Org. Chem. 2024, 20, 1880–1893, doi:10.3762/bjoc.20.163

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  • from furanyl derivatives to thienyl-substituted compounds 17–23 in the search to elucidate structural features for accessing this receptor (Scheme 4). The chloride- and bromide-substituted thienyl derivatives encompassed micromolar to submicromolar activities in radioligand binding assays based on (R
  • envisaged by Heffernan et al. [40], including human TAAR1 agonist activity and structural evaluation via homology model development followed by molecular docking and molecular dynamics studies (Scheme 6). Structural features like sulfur location and ring opening of the aminoethyl section were investigated
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Published 02 Aug 2024
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