Photothermal ablation of murine melanomas by Fe₃O₄ nanoparticle clusters

• Xue Wang,
• Lili Xuan and
• Ying Pan

Beilstein J. Nanotechnol. 2022, 13, 255–264, doi:10.3762/bjnano.13.20

• synthesized Fe3O4 NPCs was confirmed by the conserved DLS pattern of size distribution after five heating/cooling cycles with a NIR laser (Figure 1e). Altogether, our data confirmed the successful fabrication of superparamagnetic Fe3O4 NPCs that are spherical, uniformly sized and highly absorptive in the NIR

• region, validating their potential use as PTT agents. Photothermal effect of Fe3O4 NPCs To assess their photothermal effect, we measured the increments of temperature at different concentrations of Fe3O4 NPCs during 10 min of irradiation with an 808 nm laser in vitro. In general, the Fe3O4 NPC-induced

• Fe3O4 nanoparticle-containing up-conversion nanoprobes [15]. To check whether HSP70 was involved in Fe3O4 NPC-mediated PTT, we treated A375 cells for 24 h with NPCs at concentrations of 0.125 or 0.25 mg/mL, followed by 808 nm laser irradiation. Naïve cells were incubated with saline and served as normal

Engineered titania nanomaterials in advanced clinical applications

• Padmavati Sahare,
• Paulina Govea Alvarez,
• Juan Manual Sanchez Yanez,
• Gabriel Luna-Bárcenas,
• Samik Chakraborty,
• Sujay Paul and
• Miriam Estevez

Beilstein J. Nanotechnol. 2022, 13, 201–218, doi:10.3762/bjnano.13.15

• -bearing mouse xenograft demonstrated that upon laser irradiation in the NIR-II window (1064 nm), the tumor temperature reached up to 53.4 °C, inducing complete photothermal eradication of tumor tissue. This study proves the high synergistic efficacy of combined SDT and PTT of B-TiO2−x nps for the complete

• are the cell key energy centers and are extremely sensitive to heat shock, they contribute to apoptotic cell death by generating ROS. As a result, by lowering the intensity of laser power and dosage, mitochondria-targeted PDT and PTT would provide better results. In the study of Mou and co-workers, a

• NIR laser irradiation at a far lower power density and low intravenous dosage. Phototoxicity essays of G-TiO2−x on HeLa cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) showed 85% cell viability, confirming that G-TiO2−x itself is non-toxic even at higher concentrations

Bacterial safety study of the production process of hemoglobin-based oxygen carriers

• Axel Steffen,
• Yu Xiong,
• Radostina Georgieva,
• Ulrich Kalus and
• Hans Bäumler

Beilstein J. Nanotechnol. 2022, 13, 114–126, doi:10.3762/bjnano.13.8

• CCD method produces nearly uniform, peanut-shaped particles. The size distribution determined by dynamic light scattering (DLS) was 759 ± 25 nm. Confocal laser scanning microscopy (CLSM) images confirmed this size range (Figure 1C). Scanning electron microscopy (SEM) images of particles produced with

Influence of magnetic domain walls on all-optical magnetic toggle switching in a ferrimagnetic GdFe film

• Rahil Hosseinifar,
• Evangelos Golias,
• Ivar Kumberg,
• Quentin Guillet,
• Karl Frischmuth,
• Sangeeta Thakur,
• Mario Fix,
• Manfred Albrecht,
• Florian Kronast and
• Wolfgang Kuch

Beilstein J. Nanotechnol. 2022, 13, 74–81, doi:10.3762/bjnano.13.5

• film with out-of-plane easy axis of magnetization by X-ray magnetic circular dichroism photoelectron emission microscopy. Individual linearly polarized laser pulses of 800 nm wavelength and 100 fs duration above a certain threshold fluence reverse the sample magnetization, independent of the

• magnetization direction, the so-called toggle switching. Local deviations from this deterministic behavior close to magnetic domain walls are studied in detail. Reasons for nondeterministic toggle switching are related to extrinsic effects, caused by pulse-to-pulse variations of the exciting laser system, and

• where the line of constant threshold fluence in the Gaussian footprint of the laser pulse comes close to an already existing domain wall. On the other hand, we identify the presence of laser-induced domain-wall motion in the toggle-switching event as a further cause for local deviations from purely

Sputtering onto liquids: a critical review

• Anastasiya Sergievskaya,
• Adrien Chauvin and
• Stephanos Konstantinidis

Beilstein J. Nanotechnol. 2022, 13, 10–53, doi:10.3762/bjnano.13.2

• in the synthesis procedures. The most common physical methods used to generate NPs are high-energy ball milling, laser ablation, electrospraying, inert gas condensation, PVD, laser pyrolysis, flash spray pyrolysis, and melt mixing [16]. Chemical methods are the traditional and most widely used

• chapter, we introduce the basic physical mechanisms involved in the sputter deposition of materials and related processes. Low-pressure plasma-based sputter deposition, along with evaporation, cathodic arc, or laser-based deposition, belongs to the family of PVD techniques, which have been originally

Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy

• Xiaoteng Liang,
• Shuai Liu,
• Xiuchao Wang,
• Dan Xia and
• Qiang Li

Beilstein J. Nanotechnol. 2021, 12, 1372–1379, doi:10.3762/bjnano.12.101

• into MIA PaCa-2, which was pre-grown for two days. The DOX solution was removed after 4 h and the cells were then washed with PBS for three times. Afterwards, the cells were cultured in normal medium for another 12 h. Laser confocal microscopy The cells (3 × 104 cells/well) were grown in 500 µL culture

• membranes were stained with Hoechst 33342 (1 µg/mL) or AF488-WGA (1 µg/mL) for 10 min. Then, the cells were rinsed three times with PBS before imaging with laser confocal microscopy. To investigate the effect of DOX on the nanostructure of MIA-PaCa-2, cell nuclei and the cytoskeleton were stained with DAPI

• (10 µg/mL) and FITC-Phalloidin (100 nM), respectively, for 30 min and 5 min. The cytoskeleton and cell nuclei were investigated by laser confocal microscopy. AFM measurement The slides with grown cells were transferred to the sample table. Then, culture medium was added both to the cell slide surface

Polarity in cuticular ridge development and insect attachment on leaf surfaces of Schismatoglottis calyptrata (Araceae)

• Venkata A. Surapaneni,
• Tobias Aust,
• Thomas Speck and
• Marc Thielen

Beilstein J. Nanotechnol. 2021, 12, 1326–1338, doi:10.3762/bjnano.12.98

• of adaxial leaf surfaces at various ontogenetic stages to study the morphological changes occurring on the leaf surfaces. We characterized the replica surfaces by using confocal laser scanning microscopy and commercial surface analysis software. The development of cuticular ridges is polar and the

• changes Figure 1 shows S. calyptrata leaves at their different ontogenetic stages (Figure 1a) and the corresponding confocal laser scanning microscopy (CLSM) observations (Figure 1b–f) on leaf microstructures. A schematic representation of the leaves and the corresponding locations of smooth and ridged

• 22.6 ± 2.6 °C and 73.5 ± 11.0%, respectively. Voucher specimens (FB 15013) of the leaves are deposited in the herbarium of Freiburg, University of Freiburg, Germany. The leaf growth was monitored from bud to adult stages. Initial trial experiments by using a confocal laser scanning microscope helped in

Cantilever signature of tip detachment during contact resonance AFM

• Devin Kalafut,
• Ryan Wagner,
• Maria Jose Cadena,
• Anil Bajaj and
• Arvind Raman

Beilstein J. Nanotechnol. 2021, 12, 1286–1296, doi:10.3762/bjnano.12.96

• Asylum Research’s blueDrive photothermal excitation module for laser-based excitation of the cantilever. The optical lever sensitivity (OLS) corresponding to the static cantilever beam shape with a point load at the tip was calculated from a force displacement curve [32] on the silicon sample. The

• position was recorded with an optical lever system consisting of a detection laser and a quadrant photodiode. The photodiode signal was converted into amplitude and phase at the drive frequency using a lock-in amplifier. The OLS resulting from the above calibration procedure is only valid for quasistatic

• indentation coefficient, and P is the parameter controlling the probe tip geometry. Photothermal excitation of the AFM cantilever is approximated as a pair of opposing bending moments centered at the laser spot location LbD, measured from the base of the cantilever, and separated from each other by the laser

Morphology-driven gas sensing by fabricated fractals: A review

• Vishal Kamathe and
• Rupali Nagar

Beilstein J. Nanotechnol. 2021, 12, 1187–1208, doi:10.3762/bjnano.12.88

• a lower value of fractal dimension is more effective in sensing NO2 gas and lowers the optimum operating temperature. Chen et al. used pulsed laser deposition for growing different SnO2 thin films by varying the substrate temperature. The obtained films exhibited fractal features [43]. In another

Self-assembly of amino acids toward functional biomaterials

• Huan Ren,
• Lifang Wu,
• Lina Tan,
• Yanni Bao,
• Yuchen Ma,
• Yong Jin and
• Qianli Zou

Beilstein J. Nanotechnol. 2021, 12, 1140–1150, doi:10.3762/bjnano.12.85

• exhibited high accumulation and ultra-long tumor retention effects. Importantly, animal experiments demonstrated complete eradication of tumor in mice after injection of PWG NPs and laser irradiation, demonstrating the efficacy of PWG nanoparticles in vivo. Indocyanine green (ICG) is widely used in

• maintain the photothermal conversion efficiency up to 32.0%. After entering the tumor cells, the nanoparticles convert light into heat under a laser irradiation of 808 nm and effectively kill the tumor cells. Inspired by natural photosynthesis, artificial light systems consisting of photosensitizers and

A new method for obtaining model-free viscoelastic material properties from atomic force microscopy experiments using discrete integral transform techniques

• Berkin Uluutku,
• Enrique A. López-Guerra and
• Santiago D. Solares

Beilstein J. Nanotechnol. 2021, 12, 1063–1077, doi:10.3762/bjnano.12.79

• indentation are calculated with respect to time with the aid of the probe position detection system (e.g., a laser beam detector). The most important assumptions in our linear viscoelastic analysis, which is described in subsequent sections, are that the sample is homogeneous and isotropic, and that the

Use of nanosystems to improve the anticancer effects of curcumin

• Andrea M. Araya-Sibaja,
• Norma J. Salazar-López,
• Krissia Wilhelm Romero,
• José R. Vega-Baudrit,
• J. Abraham Domínguez-Avila,
• Carlos A. Velázquez Contreras,
• Ramón E. Robles-Zepeda,
• Mirtha Navarro-Hoyos and
• Gustavo A. González-Aguilar

Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78

• factors that determine the effectiveness of phototherapy against cancer cells [142]. For example, Rahimi-Moghaddam et al. [140] reported a higher cytotoxic effect of a gold–CUR nanosystem used as photothermal therapy against breast cancer cells when exposed to an 808 nm laser (1.5 W/cm2), as compared to a

• 650 nm laser (1.5 W/cm2). The advantages of incorporating CUR into nanostructures used as photodynamic anticancer therapy are diverse. They include making nasal delivery a possibility, thereby minimizing patient discomfort [145], subcellular internalization of the molecule (enhancing sensitization and

An overview of microneedle applications, materials, and fabrication methods

• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2021, 12, 1034–1046, doi:10.3762/bjnano.12.77

• injection moulding [61], wet chemical etching [75], reactive ion etching [2][76], hot embossing [4][5], laser drilling [77], lithography plus electroforming [78][79], drawing lithography [80][81], two-photon polymerization [5][82], and 3D printing [83][84]. To date, DRIE of silicon; micromoulding

• manufacturing compared to silicon, notwithstanding some issues of toxicity. Photochemical etching, electroplating, and laser cutting are common techniques in the fabrication of solid and hollow metallic microneedles. Studies have demonstrated the fabrication of hollow nickel microneedles by electroplating, with

• combination of drawing lithography and nickel electroplating (Figure 5a, Figure 5b). The bevelled tip of the structure was achieved through laser cutting. A negative pressure of 13.45 kPa was applied to extract 20 µL of blood from the tail of a mouse [104]. In another study, nickel microneedles were

Self-assembly of Eucalyptus gunnii wax tubules and pure ß-diketone on HOPG and glass

• Miriam Anna Huth,
• Axel Huth and
• Kerstin Koch

Beilstein J. Nanotechnol. 2021, 12, 939–949, doi:10.3762/bjnano.12.70

• tubules in nature. On E. gunnii leaves, wax regeneration can be observed by AFM, but the measurement is limited to small areas and short times due to the roughness of the leaf surface [30]. In addition, fresh plant leaves containing water are heated by the laser beam during scanning, which can cause a

Modification of a SERS-active Ag surface to promote adsorption of charged analytes: effect of Cu²⁺ ions

• Bahdan V. Ranishenka,
• Andrei Yu. Panarin,
• Irina A. Chelnokova,
• Sergei N. Terekhov,
• Peter Mojzes and
• Vadim V. Shmanai

Beilstein J. Nanotechnol. 2021, 12, 902–912, doi:10.3762/bjnano.12.67

• possible in the case of luminescent dyes. As BHQ1 has a wide band that overlaps the excitation laser frequency, we can speak about surface-enhanced Raman resonance scattering (SERRS) in this case. The unmodified SERS substrate did not show any SERS signal of the oligonucleotide (Figure 8). Based on our

• microscope in PeakForceQNM mode with recording the adhesion force maps and topographic images. SERS measurements were carried out by using a scanning probe Raman microscope “NanoFlex” (Solar LS, Belarus). The source of excitation at 488.0 nm was an argon ion laser (Melles Griot, USA). Excitation and

• detector (Princeton Instruments). Spectra were excited by a 441.6 nm of a He–Cd laser. Synthesis of silver NPs The synthetic procedure was analogous to that described in [36]. 50 mL of deionized water, 42 mg of sodium bicarbonate, 15 mg sodium citrate, and 450 mg of water-free glucose were added into a

The role of convolutional neural networks in scanning probe microscopy: a review

• Ido Azuri,
• Irit Rosenhek-Goldian,
• Neta Regev-Rudzki,
• Georg Fantner and
• Sidney R. Cohen

Beilstein J. Nanotechnol. 2021, 12, 878–901, doi:10.3762/bjnano.12.66

• the exposure and laser power of the confocal microscopy images [97]. Pairs of healthy and diseased leaf photographs from different plants were collected in order to develop a deep learning model for disease detection [97][98]. Acquiring sets of images can be a complicated and prolonged task

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

• Medical Sciences, Tehran, Iran Department of Science, University of Kurdistan, Kurdistan, Sanandaj, Iran Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein 2028, South Africa Physiology Research Center, Faculty of medicine, Iran University of Medical Sciences

9.1% efficient zinc oxide/silicon solar cells on a 50 μm thick Si absorber

• Rafal Pietruszka,
• Bartlomiej S. Witkowski,
• Monika Ozga,
• Katarzyna Gwozdz,
• Ewa Placzek-Popko and
• Marek Godlewski

Beilstein J. Nanotechnol. 2021, 12, 766–774, doi:10.3762/bjnano.12.60

• environmentally friendly solar cells are cells based on zinc oxide (ZnO). ZnO thin films can be obtained using many technologies, including molecular beam epitaxy, RF magnetron sputtering, pulsed laser deposition, chemical vapor deposition, and atomic layer deposition (ALD) [3]. ALD attracts the attention of many

Recent progress in actuation technologies of micro/nanorobots

• Ke Xu and
• Bing Liu

Beilstein J. Nanotechnol. 2021, 12, 756–765, doi:10.3762/bjnano.12.59

• actuation Wang et al. [31] designed a needle-shaped liquid metal gallium nanoswimmer with controllable movement under near-infrared laser irradiation. Its propulsion force is mainly derived from the thermophoresis force generated by the temperature gradient along the longitudinal axis. Experiments show that

• the speed of the nanoswimmer can be adjusted by the light intensity. Under a laser intensity of 5 W·cm−2, the nanoswimmer can reach a speed of 31.22 μm/s. The potential of this nanoswimmer in biomedical applications and active soft materials provides support for future research. Sato et al. [32

• standard photolithography process. When the actuator is stimulated by laser pulses, it will bend and make the robot walk. The research of this technology provides an extremely powerful theoretical basis for the manufacture of actuators in the future. Acoustic field actuation Ultrasound is sound with a

Fate and transformation of silver nanoparticles in different biological conditions

• Barbara Pem,
• Marija Ćurlin,
• Darija Domazet Jurašin,
• Valerije Vrček,
• Rinea Barbir,
• Vedran Micek,
• Raluca M. Fratila,
• Jesus M. de la Fuente and
• Ivana Vinković Vrček

Beilstein J. Nanotechnol. 2021, 12, 665–679, doi:10.3762/bjnano.12.53

• ) equipped with a green laser (532 nm) at an angle of 173°. The values of dH were obtained as the value of the maximum peak of the size distribution by volume and reported as an average of ten measurements. The ζ potential values were determined by ELS using the same Zetasizer Nano ZS instrument. The values

A review of defect engineering, ion implantation, and nanofabrication using the helium ion microscope

• Frances I. Allen

Beilstein J. Nanotechnol. 2021, 12, 633–664, doi:10.3762/bjnano.12.52

Properties of graphene deposited on GaN nanowires: influence of nanowire roughness, self-induced nanogating and defects

• Jakub Kierdaszuk,
• Piotr Kaźmierczak,
• Justyna Grzonka,
• Aleksandra Krajewska,
• Aleksandra Przewłoka,
• Wawrzyniec Kaszub,
• Zbigniew R. Zytkiewicz,
• Marta Sobanska,
• Maria Kamińska,
• Andrzej Wysmołek and
• Aneta Drabińska

Beilstein J. Nanotechnol. 2021, 12, 566–577, doi:10.3762/bjnano.12.47

• spectra were collected by using a T64000 Horiba Jobin-Yvon spectrometer with a Nd:YAG laser operating at 532 nm wavelength as the excitation source, and with an objective with a magnification of 100× that allowed to obtain a spatial resolution of approx. 300 nm. The laser power was reduced to 3 mW in

• our system the lowest mapping step is comparable with the average distance between NWs and three times smaller than the diameter of the laser spot. Therefore, a single measurement is averaged over a few NWs and local interactions between graphene and small groups of NWs are traced rather than

• zone. For the presence of D band, the resonant scattering on the iTO phonon near the K point of the Brillouin zone and the defect are necessary. Consequently, the intensity of the G band is proportional to the laser spot area while the intensity of the D band depends on the number of defects in the

On the stability of microwave-fabricated SERS substrates – chemical and morphological considerations

• Limin Wang,
• Aisha Adebola Womiloju,
• Christiane Höppener,
• Ulrich S. Schubert and
• Stephanie Hoeppener

Beilstein J. Nanotechnol. 2021, 12, 541–551, doi:10.3762/bjnano.12.44

• . Van Duyne and others elaborated the fundamental concept of the enhancement process, which was found to be mainly based on the amplification of the electric field component when the illuminating laser irradiation interacts with metal nanoparticles [6]. Suitable nanoparticles consist preferentially of

• laser excitation was set to 532 nm which overlaps with the plasmon resonance of the SERS substrates [24]. After an incubation time of eight minutes, the intensity of the characteristic peak of 4-ATP located at 1442 cm−1 reached a maximum intensity which did not further increase after longer incubation

• can be found in Supporting Information File 1, Table S1. The observed band structure clearly identifies bands at 1394, 1440, and 1580 cm−1 which are indicative of 4,4’-dimercaptoazobenzene (DMAB), which is formed by an oxidative transformation of 4-ATP on Ag nanoparticle surfaces at higher laser power

The preparation temperature influences the physicochemical nature and activity of nanoceria

• Robert A. Yokel,
• Wendel Wohlleben,
• Johannes Georg Keller,
• Matthew L. Hancock,
• Jason M. Unrine,
• D. Allan Butterfield and
• Eric A. Grulke

Beilstein J. Nanotechnol. 2021, 12, 525–540, doi:10.3762/bjnano.12.43

• hydroxide, was determined using an Anton Paar Litesizer 500 Particle Analyzer. The instrument was equipped with a 40 mW laser emitting at 658 nm. One hundred runs were completed in sequence with a 30 s equilibration time at 25 °C. Based on the bath cerium concentration after 75, 102, and 152 days the

Surface-enhanced Raman scattering of water in aqueous dispersions of silver nanoparticles

• Paulina Filipczak,
• Krzysztof Hałagan,
• Jacek Ulański and
• Marcin Kozanecki

Beilstein J. Nanotechnol. 2021, 12, 497–506, doi:10.3762/bjnano.12.40

• phenomenon is present only in the AgNPs blue sample, not in the AgNPs yellow sample. Also, changes in the structure of AgNPs induced by laser irradiation may be excluded, as an identical UV–vis absorption spectra of the investigated AgNPs dispersions (see Figure S1 in Supporting Information File 1) collected

• changes its shape. The intensity of the component at 3400 cm−1 becomes stronger than that at 3200 cm−1. In this form the enhanced Raman signal is very similar to other results reported for the resonance water spectrum [34]. Moreover, in the case of the AgNPs blue sample, the excitation laser light is

• absorbed much more strongly than in pure water or in the AgNPs yellow sample. The absorption of laser light in the AgNPs blue sample leads to the excitation of both plasmons in the AgNPs and vibrations of water molecules. Thus, one can conclude that the most probable hypothesis is that the enhancement of