Magnetic properties of biofunctionalized iron oxide nanoparticles as magnetic resonance imaging contrast agents

• Natalia E. Gervits,
• Andrey A. Gippius,
• Alexey V. Tkachev,
• Evgeniy I. Demikhov,
• Sergey S. Starchikov,
• Igor S. Lyubutin,
• Alexander L. Vasiliev,
• Vladimir P. Chekhonin,
• Maxim A. Abakumov,
• Alevtina S. Semkina and
• Alexander G. Mazhuga

Beilstein J. Nanotechnol. 2019, 10, 1964–1972, doi:10.3762/bjnano.10.193

• Background: One of the future applications of magnetic nanoparticles is the development of new iron-oxide-based magnetic resonance imaging (MRI) negative contrast agents, which are intended to improve the results of diagnostics and complement existing Gd-based contrast media. Results: Iron oxide

• nanoparticles designed for use as MRI contrast media are precisely examined by a variety of methods: powder X-ray diffraction (XRD), transmission electron microscopy (TEM), Raman spectroscopy, Mössbauer spectroscopy and zero-field nuclear magnetic resonance (ZF-NMR) spectroscopy. TEM and XRD measurements reveal

• allowed us to determine the relative amount of iron located in the core and the surface layer of the nanoparticles. The obtained results are important for understanding the structural and magnetic properties of iron oxide nanoparticles used as T2 contrast agents for MRI. Keywords: iron oxides; Mössbauer

Engineered superparamagnetic iron oxide nanoparticles (SPIONs) for dual-modality imaging of intracranial glioblastoma via EGFRvIII targeting

• Xianping Liu,
• Chengjuan Du,
• Haichun Li,
• Ting Jiang,
• Zimiao Luo,
• Zhiqing Pang,
• Daoying Geng and
• Jun Zhang

Beilstein J. Nanotechnol. 2019, 10, 1860–1872, doi:10.3762/bjnano.10.181

• imaging (MRI); molecular imaging; superparamagnetic iron oxide nanoparticles (SPIONs); nanomedicine; tumor resection; Introduction Tumor resection is one of the most promising clinical treatments of glioblastoma, which is commonly associated with high mortality and inevitable tumor recurrence. To achieve

• imaging [32][33][34]. There are many targeted probes for the diagnosis and treatment of GBM that have been constructed with high expression of EGFRvIII in the literature. Hadjipanayis and co-workers showed the specific EGFRvIII targeting and MRI contrast enhancement by means of EGFRvIII antibody

• -functionalized iron oxide nanoparticles after convection-enhanced delivery (CED) [35]. Lee and co-workers also showed that combining MRI with fluorescent imaging by using fluorescent silica-coated iron oxide nanoparticles has potential application in GBM treatment for improved intraoperative staging and enhanced

The effect of magneto-crystalline anisotropy on the properties of hard and soft magnetic ferrite nanoparticles

• Hajar Jalili,
• Bagher Aslibeiki,
• Ali Ghotbi Varzaneh and
• Volodymyr A. Chernenko

Beilstein J. Nanotechnol. 2019, 10, 1348–1359, doi:10.3762/bjnano.10.133

• magnetocrystalline anisotropy at room temperature [10]. The anisotropy constant of CoFe2O4 (K = 2 × 105 J·m−3) is nearly one order of magnitude larger than that of Fe3O4 [11][12][13]. Fe3O4 NPs have been studied extensively for bio-medical applications, such as drug delivery [14], magnetic resonance imaging (MRI

Scavenging of reactive oxygen species by phenolic compound-modified maghemite nanoparticles

• Małgorzata Świętek,
• Yi-Chin Lu,
• Rafał Konefał,
• Liliana P. Ferreira,
• M. Margarida Cruz,
• Yunn-Hwa Ma and
• Daniel Horák

Beilstein J. Nanotechnol. 2019, 10, 1073–1088, doi:10.3762/bjnano.10.108

• , targeting tumor sites using an external magnetic field, MRI contrast agents, or magnetic hyperthermia. Under physiological conditions, the nanoparticle surface is exposed to the action of biomolecules, oxygen, peroxides, and radicals, which changes particle properties and behavior. Moreover, Fe2+ ions can

Co-doped MnFe₂O₄ nanoparticles: magnetic anisotropy and interparticle interactions

• Bagher Aslibeiki,
• Parviz Kameli,
• Hadi Salamati,
• Giorgio Concas,
• Maria Salvador Fernandez,
• Alessandro Talone,
• Giuseppe Muscas and
• Davide Peddis

Beilstein J. Nanotechnol. 2019, 10, 856–865, doi:10.3762/bjnano.10.86

• of potential applications, e.g., from catalysis [5] and microwaves applications [6] to biomedicine, such as MRI [7], hyperthermia [8], and drug delivery [7][9] applications. Nanometer-sized magnetic materials exhibit different properties compared their bulk counterparts [10][11]. Below a critical

• different magnetic anisotropy opens interesting perspectives for applications in biomedical fields (e.g., MRI, drug delivery, hyperthermia) [20][21] and energy harvesting. Experimental Synthesis Several samples consisting of manganese ferrite nanoparticles with different cobalt doping, i.e., Mn1−xCoxFe2O4

Polydopamine-coated Au nanorods for targeted fluorescent cell imaging and photothermal therapy

• Boris N. Khlebtsov,
• Andrey M. Burov,
• Timofey E. Pylaev and
• Nikolai G. Khlebtsov

Beilstein J. Nanotechnol. 2019, 10, 794–803, doi:10.3762/bjnano.10.79

• . Meanwhile different imaging and therapeutic agents can be loaded into the shell of multifunctional nanocomposites. Various AuNR-based nanocomposites loaded with anticancer drugs [17][18][19], photodynamic dyes [20][21], MRI contrast agents [22] and many others ligands [23][24] have already been reported for

• -targeted PPT and chemotherapy (via Cu(II) release) [34]; AuNR-PDA-pMBA-Ab for targeted SERS cell imaging [31]; AuNR-PDA-MB/DOX for notargeted combined photodynamic and chemotherapy in vivo [32]; AuNR-PDA-Cisplatin-Iodine125-RGDpeptide for targeted MRI imaging and chemotherapy in vivo [33]. However, AuNR

Size-selected Fe₃O₄–Au hybrid nanoparticles for improved magnetism-based theranostics

• Maria V. Efremova,
• Yulia A. Nalench,
• Eirini Myrovali,
• Anastasiia S. Garanina,
• Ivan S. Grebennikov,
• Polina K. Gifer,
• Maxim A. Abakumov,
• Marina Spasova,
• Makis Angelakeris,
• Alexander G. Savchenko,
• Michael Farle,
• Natalia L. Klyachko,
• Alexander G. Majouga and
• Ulf Wiedwald

Beilstein J. Nanotechnol. 2018, 9, 2684–2699, doi:10.3762/bjnano.9.251

• properties of Fe3O4 NPs give rise to novel therapeutic approaches such as magneto-mechanical cancer treatment [4] and magnetic particle hyperthermia (MPH) [5][6][7] as well as to improvements in diagnostic techniques like magnetic resonance imaging (MRI) [8][9][10] and magnetic particle imaging (MPI) [11][12

• properties in biocompatible Fe3O4 NPs is of utmost importance for improved performance in MPH, MRI, or MPI [16][17]. It is essential to obtain Fe3O4 NPs of high crystallinity with bulk-like magnetic properties, which change with the NP size, shape and iron oxidation state [18][19][20]. These parameters can

• -dependent study of hybrid Fe3O4–Au NPs with Janus structure for application in theranostics where improvements in MRI and MPH were demonstrated. Increasing the magnetic NP diameter from 6 to 44 nm, we show the gradual transition of their lattice parameters from an intermediate value between maghemite γ

Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified γ-Fe₂O₃ nanoparticles towards human tumor cells

• Zdeněk Plichta,
• Yulia Kozak,
• Rostyslav Panchuk,
• Viktoria Sokolova,
• Matthias Epple,
• Lesya Kobylinska,
• Pavla Jendelová and
• Daniel Horák

Beilstein J. Nanotechnol. 2018, 9, 2533–2545, doi:10.3762/bjnano.9.236

• therapeutic performance of the anticancer agents and reduced non-specific toxicity to normal cells. Moreover, the strong magnetic susceptibility of the nanoparticles enables magnetic targeting, and the accumulation of these particles can be monitored by magnetic resonance imaging (MRI). Magnetic targeting is

• from MRI contrast agents to drug-delivery systems, local heat sources in magnetic hyperthermia therapy of tumors, magnetically assisted transfection of cells, and magnetic field-assisted separation techniques. Let us to note that MRI is already widely used in human medicine and several iron-oxide-based

Droplet-based synthesis of homogeneous magnetic iron oxide nanoparticles

• Christian D. Ahrberg,
• Ji Wook Choi and
• Bong Geun Chung

Beilstein J. Nanotechnol. 2018, 9, 2413–2420, doi:10.3762/bjnano.9.226

• healthcare significantly [5]. For example, a composite nanomaterial has been developed as a photosensitizer in photothermal therapy (PTT), while also acting as a contrast agent for magnetic resonance imaging (MRI) [6]. Magnetic materials are of particular interest here, as they can be used for targeting [7

• ], as contrast agents for MRI [8][9], or for magnetically induced thermotherapy [10]. Furthermore, they can be used for a combination of these functions [11][12]. However, batch synthesis on small scales often suffers from batch-to-batch reproducibility issues, and inhomogeneities of the chemical and

Nanocomposites comprised of homogeneously dispersed magnetic iron-oxide nanoparticles and poly(methyl methacrylate)

• Sašo Gyergyek,
• David Pahovnik,
• Ema Žagar,
• Alenka Mertelj,
• Rok Kostanjšek,
• Miloš Beković,
• Marko Jagodič,
• Heinrich Hofmann and
• Darko Makovec

Beilstein J. Nanotechnol. 2018, 9, 1613–1622, doi:10.3762/bjnano.9.153

• coercivity in the absence of an external magnetic field [1][2]. Their colloidal suspensions are vital in a variety of technological [3] and biomedical applications [4], such as contrast agents in magnetic resonance imaging (MRI) [5][6], targeted drug delivery [6] and magnetic hyperthermia based on the

Excitation of nonradiating magnetic anapole states with azimuthally polarized vector beams

• Aristeidis G. Lamprianidis and
• Andrey E. Miroshnichenko

Beilstein J. Nanotechnol. 2018, 9, 1478–1490, doi:10.3762/bjnano.9.139

• useful applications in biosensing, i.e., in the detection of molecules that interact strongly once exposed to magnetic field hotspots, which nanoparticles in a magnetic anapole state can offer in their near field. Moreover, the signal-to-noise ratio of an MRI machine, that is defined as the ratio of the

Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations

• Jaison Jeevanandam,
• Ahmed Barhoum,
• Yen S. Chan,
• Alain Dufresne and
• Michael K. Danquah

Beilstein J. Nanotechnol. 2018, 9, 1050–1074, doi:10.3762/bjnano.9.98

• ]. Generally, biocompatible magnetite (Fe3O4), iron oxide, iron sulfides and maghemite (Fe2O3) are synthesized using magnetotactic bacteria [156][157] that helps in targeted cancer treatment via magnetic hyperthermia, magnetic resonance imaging (MRI), DNA analysis and gene therapy [158]. Moreover, surface

Heavy-metal detectors based on modified ferrite nanoparticles

• Urszula Klekotka,
• Ewelina Wińska,
• Elżbieta Zambrzycka-Szelewa,
• Dariusz Satuła and
• Beata Kalska-Szostko

Beilstein J. Nanotechnol. 2018, 9, 762–770, doi:10.3762/bjnano.9.69

• nanoparticles can be widely used in medicine for drug delivery, implants manufacture, as components of contrast agents in magnetic resonance imaging (MRI) as well as active centers in hyperthermia treatment [1]. The use of magnetic nanoparticles in drug delivery allows for a significant reduction of the amount

Tailoring the nanoscale morphology of HKUST-1 thin films via codeposition and seeded growth

• Landon J. Brower,
• Lauren K. Gentry,
• Amanda L. Napier and
• Mary E. Anderson

Beilstein J. Nanotechnol. 2017, 8, 2307–2314, doi:10.3762/bjnano.8.230

• . Acknowledgements This research was supported by the National Science Foundation (Chem RUI Grant #1508244, Chem REU Grant #1263097, and Chem MRI Grant #1126462) and the American Chemical Society (PRF-UNI5 Grant #54106). Additional funding was provided by the Towsley Foundation and Hope College. We thank Prof

Magnetic properties of optimized cobalt nanospheres grown by focused electron beam induced deposition (FEBID) on cantilever tips

• Soraya Sangiao,
• César Magén,
• Darius Mofakhami,
• Grégoire de Loubens and
• José María De Teresa

Beilstein J. Nanotechnol. 2017, 8, 2106–2115, doi:10.3762/bjnano.8.210

• investigation of spin dynamics at the nanoscale [41]. This near field scanning probe technique allows magnetic resonance imaging (MRI) with nanometer spatial resolution and extreme spin sensitivity [42] and the investigation of spin waves at the sub-micrometer scale [43][44][45]. In these applications, very

Spin-dependent transport and functional design in organic ferromagnetic devices

• Guichao Hu,
• Shijie Xie,
• Chuankui Wang and
• Carsten Timm

Beilstein J. Nanotechnol. 2017, 8, 1919–1931, doi:10.3762/bjnano.8.192

• the bias-dependent multi-state MR as MRi(V) = [RCi(V) − RC1(V)]/RCi(V). Threshold voltage, maximum current, and multi-state MR for each case are summarized in Table 1. Obviously, four values of MR are realized with the change of the magnetization configuration. A maximum MR of 98% is obtained at a

Synthesis and functionalization of NaGdF₄:Yb,Er@NaGdF₄ core–shell nanoparticles for possible application as multimodal contrast agents

• Dovile Baziulyte-Paulaviciene,
• Vitalijus Karabanovas,
• Marius Stasys,
• Greta Jarockyte,
• Vilius Poderys,
• Simas Sakirzanovas and
• Ricardas Rotomskis

Beilstein J. Nanotechnol. 2017, 8, 1815–1824, doi:10.3762/bjnano.8.183

• still no information has been presented about uptake of these nanoparticles into different types of cancer cells [22]. Although different gadolinium chelates are widely used in clinics as contrast agents for magnetic resonance imaging (MRI), the literature for the last two years shows increased

• demonstrate the effective surface modification method that uses a surfactant polysorbate 80 (Tween 80, polyoxyethylene sorbitan laurate). Hexagonal phase β-NaGdF4 was chosen as host lattice for its ability to combine optical and MRI. Tween 80 was used to make the UCNPs colloidally stable and dispersible in

• ) signal was observed for all the UCNPs samples when compared to water. Moreover, with the increase of the concentration of UCNPs, the T1-weighted MRI signal intensity (SI) continuously increased, resulting in brighter images for both types of UCNPs. The MR SI values of UCNPs are presented in Figure 5. The

Near-infrared-responsive, superparamagnetic Au@Co nanochains

• Varadee Vittur,
• Arati G. Kolhatkar,
• Shreya Shah,
• Irene Rusakova,
• Dmitri Litvinov and
• T. Randall Lee

Beilstein J. Nanotechnol. 2017, 8, 1680–1687, doi:10.3762/bjnano.8.168

• shift from that of a single particle because of near-field coupling. This shift in wavelength is proportional to the number of nanoparticles in the chain [31][32]. These new types of magnetic nanostructures find use in several applications, such as combined MRI imaging and photothermal treatment and bio

Calcium fluoride based multifunctional nanoparticles for multimodal imaging

• Marion Straßer,
• Joachim H. X. Schrauth,
• Sofia Dembski,
• Daniel Haddad,
• Bernd Ahrens,
• Stefan Schweizer,
• Bastian Christ,
• Alevtina Cubukova,
• Marco Metzger,
• Heike Walles,
• Peter M. Jakob and
• Gerhard Sextl

Beilstein J. Nanotechnol. 2017, 8, 1484–1493, doi:10.3762/bjnano.8.148

• different imaging techniques, such as photoluminescence (PL) microscopy and magnetic resonance imaging (MRI), open new possibilities for medical imaging, e.g., in the fields of diagnostics or tissue characterization in regenerative medicine. The focus of this study is on the synthesis and characterization

• Gd3+ ions on the surface, the NPs reduce the MR T1 relaxation time constant as a function of their concentration. Thus, the NPs can be used as a MRI CA with a mean relaxivity of about r = 0.471 mL·mg−1·s−1. Repeated MRI examinations of four different batches prove the reproducibility of the NP

• nanoparticles; magnetic resonance imaging (MRI); multifunctional nanoparticles; multimodal imaging; photoluminescence; Introduction In recent years, medical imaging has become an important approach in the fields of diagnostics, therapy and regenerative medicine. Besides the classical technology of X-ray

From iron coordination compounds to metal oxide nanoparticles

• Mihail Iacob,
• Carmen Racles,
• Codrin Tugui,
• George Stiubianu,
• Adrian Bele,
• Liviu Sacarescu,
• Daniel Timpu and
• Maria Cazacu

Beilstein J. Nanotechnol. 2016, 7, 2074–2087, doi:10.3762/bjnano.7.198

• surfaces are often used for biomedical applications (e.g., biosensing, hyperthermia and MRI) [10]. In biomedical applications, the morphology of the nanoparticle significantly influences both pharmacokinetics and cell uptake [11]. Nanoparticles are also preferred as fillers for polymers to induce certain

Multiwalled carbon nanotube hybrids as MRI contrast agents

• Nikodem Kuźnik and
• Mateusz M. Tomczyk

Beilstein J. Nanotechnol. 2016, 7, 1086–1103, doi:10.3762/bjnano.7.102

• Nikodem Kuznik Mateusz M. Tomczyk Silesian University of Technology, Faculty of Chemistry, M. Strzody 9, 44-100 Gliwice, Poland 10.3762/bjnano.7.102 Abstract Magnetic resonance imaging (MRI) is one of the most commonly used tomography techniques in medical diagnosis due to the non-invasive

• functionalization and the potential to penetrate cell membranes result in a unique and very attractive candidate for a new MRI contrast agent. In this review we describe the different issues connected with MWCNT hybrids designed for MRI contrast agents, i.e., their synthesis and magnetic and dispersion properties

• , as well as both in vitro and in vivo behavior, which is important for diagnostic purposes. An introduction to MRI contrast agent theory is elaborated here in order to point to the specific expectations regarding nanomaterials. Finally, we propose a promising, general model of MWCNTs as MRI contrast

Improved biocompatibility and efficient labeling of neural stem cells with poly(L-lysine)-coated maghemite nanoparticles

• Igor M. Pongrac,
• Marina Dobrivojević,
• Lada Brkić Ahmed,
• Michal Babič,
• Miroslav Šlouf,
• Daniel Horák and
• Srećko Gajović

Beilstein J. Nanotechnol. 2016, 7, 926–936, doi:10.3762/bjnano.7.84

• track stem cells by magnetic resonance imaging (MRI) [11], and superparamagnetic iron oxide nanoparticles are particularly used for this purpose [12][13][14][15]. The efficient cellular uptake of nanoparticles, which would not interfere with the labeled cell activities is crucial for reliable cell

Simultaneous cancer control and diagnosis with magnetic nanohybrid materials

• Reza Saadat and
• Franz Renz

Beilstein J. Nanotechnol. 2016, 7, 121–125, doi:10.3762/bjnano.7.14

• nanotechnology have been recently gaining more and more importance [1][2]. In the last 30 years the positron emission tomography (PET) has acquired relevance among the current conventional imaging methods such as X-ray, computed tomography (CT) or magnetic resonance imaging (MRI) [3]. PET gives insights in the

Synthesis, characterization and in vitro biocompatibility study of Au/TMC/Fe₃O₄ nanocomposites as a promising, nontoxic system for biomedical applications

• Hanieh Shirazi,
• Maryam Daneshpour,
• Soheila Kashanian and
• Kobra Omidfar

Beilstein J. Nanotechnol. 2015, 6, 1677–1689, doi:10.3762/bjnano.6.170

• paramagnetism, super saturation, and having free electrons, magnetic nanoparticles have emerged as promising candidates for various medical and biological applications including magnetic resonance imaging (MRI) (as a contrast agent), smart drug delivery (as drug carriers), gene therapy, hyperthermia and tissue

Structural and magnetic properties of iron nanowires and iron nanoparticles fabricated through a reduction reaction

• Marcin Krajewski,
• Wei Syuan Lin,
• Hong Ming Lin,
• Katarzyna Brzozka,
• Sabina Lewinska,
• Natalia Nedelko,
• Anna Slawska-Waniewska,
• Jolanta Borysiuk and
• Dariusz Wasik

Beilstein J. Nanotechnol. 2015, 6, 1652–1660, doi:10.3762/bjnano.6.167

• inexpensive, a lot of them are biocompatible and low-toxic, it makes them very interesting from an application point of view. So far, they have been applied in many biomedical applications including magnetic resonance imaging (MRI) contrast enhancements [1], direct drug delivery systems [2], hyperthermia