Frequency-dependent nanomechanical profiling for medical diagnosis

• Santiago D. Solares and
• Alexander X. Cartagena-Rivera

Beilstein J. Nanotechnol. 2022, 13, 1483–1489, doi:10.3762/bjnano.13.122

• as an elastic modulus or qualitative measures [6][7][8][9][10][11][12][13], which cannot always be unambiguously interpreted for biological specimens. There also exist a few methods based on linear viscoelasticity, which can be used to estimate frequency-dependent quantities, such as the storage and

• ][16][17] could be applied at different length scales, ranging from the nano- to the macroscale. One can envision various applications at larger scales, such as the characterization of muscular viscoelasticity in orthopedic rehabilitation or in athletics, where the mechanical properties of muscles

• are based on linear viscoelasticity. Since biological materials are known to be highly nonlinear, extension of existing methods into the nonlinear regime is highly encouraged. Additionally, application-specific AFM sensors still remain to be developed, although here also the required technologies are

Effects of substrate stiffness on the viscoelasticity and migration of prostate cancer cells examined by atomic force microscopy

• Xiaoqiong Tang,
• Yan Zhang,
• Jiangbing Mao,
• Yuhua Wang,
• Zhenghong Zhang,
• Zhengchao Wang and
• Hongqin Yang

Beilstein J. Nanotechnol. 2022, 13, 560–569, doi:10.3762/bjnano.13.47

• ; viscoelasticity; Introduction Prostate cancer is a common malignancy of the male urinary tract and has become the second most threatening type of cancer in male patients after lung cancer [1][2]. Clinical data indicate that 90% of patients have a survival rate of more than 10 years if the prostate tumour is

Self-assembly of amino acids toward functional biomaterials

• Huan Ren,
• Lifang Wu,
• Lina Tan,
• Yanni Bao,
• Yuchen Ma,
• Yong Jin and
• Qianli Zou

Beilstein J. Nanotechnol. 2021, 12, 1140–1150, doi:10.3762/bjnano.12.85

• phenylalanine to produce hydrogels driven by hydrogen bonds and π–π interactions and to form microfiber three-dimensional networks at 1 wt % and pH 7.4. The microfibers have AIE properties and strong blue emission under an ultraviolet lamp. Ni-terminated hydrogels of NI-Phe exhibit viscoelasticity with a

A new method for obtaining model-free viscoelastic material properties from atomic force microscopy experiments using discrete integral transform techniques

• Berkin Uluutku,
• Enrique A. López-Guerra and
• Santiago D. Solares

Beilstein J. Nanotechnol. 2021, 12, 1063–1077, doi:10.3762/bjnano.12.79

• unbounded inputs traditionally used to acquire force–distance relationships in AFM, such as ramp functions, in which the cantilever position is displaced linearly with time for a finite period of time. Keywords: atomic force microscopy; force spectroscopy; material properties; viscoelasticity

• ][9][10][11]. With regards to viscoelasticity, efforts that incorporate classical viscoelastic theory [12][13][14][15][16] rely on force–distance curves [17][18][19][20][21][22][23][24][25][26], which describe the dependence of the probe–sample interaction force with respect to the probe–surface

• appropriate for the analysis of viscoelasticity. Guided by the same motivation that has led the classical rheology field to rely on the more general Laplace transform technique for analytical treatments, we rely on the Z-transform to accomplish viscoelastic extraction for finite discrete experimental data

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

Physical constraints lead to parallel evolution of micro- and nanostructures of animal adhesive pads: a review

• Thies H. Büscher and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2021, 12, 725–743, doi:10.3762/bjnano.12.57

• principles of attachment pads with a special focus on insects, describe micro- and nanostructures, surface patterns, origin of different pads and their evolution, discuss the material properties (elasticity, viscoelasticity, adhesion, friction) and basic physical forces contributing to adhesion, show the

Correction: Extracting viscoelastic material parameters using an atomic force microscope and static force spectroscopy

• Cameron H. Parvini,
• M. A. S. R. Saadi and
• Santiago D. Solares

Beilstein J. Nanotechnol. 2021, 12, 137–138, doi:10.3762/bjnano.12.10

• microscopy (AFM); creep; force mapping; indentation; Kelvin–Voigt; static force spectroscopy (SFS); viscoelasticity; In the “Useful Viscoelastic Quantities” section of the original publication, it is stated that the storage modulus (E′) and storage compliance (J′) are inverses of one another (Equation 10

On the frequency dependence of viscoelastic material characterization with intermittent-contact dynamic atomic force microscopy: avoiding mischaracterization across large frequency ranges

• Enrique A. López-Guerra and
• Santiago D. Solares

Beilstein J. Nanotechnol. 2020, 11, 1409–1418, doi:10.3762/bjnano.11.125

• help inform dynamic AFM characterization. Keywords: dynamic atomic force microscopy; Generalized Maxwell model; loss modulus; storage modulus; viscoelasticity; Introduction There have been significant methodology developments since the introduction of atomic force microscopy (AFM) in the mid-1980s [1

• methods have found niches of application and have provided physical insight into a wide variety of materials. In keeping with the above trajectory in the development of new AFM methods for viscoelastic materials, in recent years we have focused on the application of linear viscoelasticity within quasi

• ) moduli, in order to follow the convention often used in linear viscoelasticity theory, which is related to the fact that the moduli directly measured in many classical experiments (e.g., using rheometers) are shear moduli. However, the relationship between the viscoelastic shear modulus (G) and the

Extracting viscoelastic material parameters using an atomic force microscope and static force spectroscopy

• Cameron H. Parvini,
• M. A. S. R. Saadi and
• Santiago D. Solares

Beilstein J. Nanotechnol. 2020, 11, 922–937, doi:10.3762/bjnano.11.77

• microscopy (AFM); creep; force mapping; indentation; Kelvin–Voigt; static force spectroscopy (SFS); viscoelasticity; Introduction Modern AFM applications commonly involve testing samples that are soft, biological, or polymeric in nature. Understanding the dissipative nature of these materials at the

• viscoelasticity involves connecting different combinations of springs and dashpots in series and/or parallel to mimic the action of a material. These physical systems are then described algebraically, transformed into Laplace space, and rearranged to create transfer functions that describe the material response

Examination of the relationship between viscoelastic properties and the invasion of ovarian cancer cells by atomic force microscopy

• Mengdan Chen,
• Jinshu Zeng,
• Weiwei Ruan,
• Zhenghong Zhang,
• Yuhua Wang,
• Shusen Xie,
• Zhengchao Wang and
• Hongqin Yang

Beilstein J. Nanotechnol. 2020, 11, 568–582, doi:10.3762/bjnano.11.45

• light on the biomechanical changes for early diagnosis of tumor transformation and progression at single-cell level. Keywords: atomic force microscopy (AFM); cancer invasion; cancer migration; ovarian cancer cells; viscoelasticity; Introduction Ovarian cancer is a lethal gynecological malignancy with

• SKOV-3. Therefore, the three cell lines OVCAR-3, HO-8910 and HOSEpiC were selected for the present work [34]. The viscoelastic properties of cells include elasticity and viscosity, which are prominent biomechanical properties of cells. This study, the cell viscoelasticity was derived from the force

• the reduction of viscoelasticity was related with an increase of the migratory potential of cancer cells, providing a new understanding of the mechanisms in cancer development [8]. The process of invasion and metastasis is based on the movement and deformation of cancer cells [8], and this process is

Current measurements in the intermittent-contact mode of atomic force microscopy using the Fourier method: a feasibility analysis

• Berkin Uluutku and
• Santiago D. Solares

Beilstein J. Nanotechnol. 2020, 11, 453–465, doi:10.3762/bjnano.11.37

• surface properties, such as topography, viscoelasticity, electrical potential and conductivity. Some of these properties are measured using contact methods (static contact or intermittent contact), while others are measured using noncontact methods. Some properties can be measured using different

Design of a nanostructured mucoadhesive system containing curcumin for buccal application: from physicochemical to biological aspects

• Sabrina Barbosa de Souza Ferreira,
• Gustavo Braga,
• Évelin Lemos Oliveira,
• Jéssica Bassi da Silva,
• Hélen Cássia Rosseto,
• Lidiane Vizioli de Castro Hoshino,
• Mauro Luciano Baesso,
• Wilker Caetano,
• Craig Murdoch,
• Helen Elizabeth Colley and
• Marcos Luciano Bruschi

Beilstein J. Nanotechnol. 2019, 10, 2304–2328, doi:10.3762/bjnano.10.222

• nanometer-sized assembly into three-dimensional micelles with a hydrophobic core of PPO and a hydrophilic shell of PEO that can interact by hydrogen bonds with the hydrophilic acrylic-acid derivative polymer. This results in a binary polymeric system with good viscoelasticity, mucoadhesion, softness and

• G’ values exceeded G” and the loss tangent was smaller than 1 for the viscoelastic preparations. Thus, the viscoelasticity is favorable to oscillatory movements performed at 25 °C, occurring during transport and storage of formulations [9]. The gelation temperature, Tsol–gel, of the formulations

Review of advanced sensor devices employing nanoarchitectonics concepts

• Katsuhiko Ariga,
• Tatsuyuki Makita,
• Masato Ito,
• Taizo Mori,
• Shun Watanabe and
• Jun Takeya

Beilstein J. Nanotechnol. 2019, 10, 2014–2030, doi:10.3762/bjnano.10.198

• nanostructured materials with exotic properties [198] undoubtedly have important contributions. In addition, mass-sensitive sensors, quartz and crystal microbalance [199] are are useful for many substances because mass changes and alteration of viscoelasticity such as phase transition [200] are common over all

Nanoscale spatial mapping of mechanical properties through dynamic atomic force microscopy

• Zahra Abooalizadeh,
• Leszek Josef Sudak and
• Philip Egberts

Beilstein J. Nanotechnol. 2019, 10, 1332–1347, doi:10.3762/bjnano.10.132

• uncovered and covered HOPG step edges. The calibration sample was a polycrystalline Nb glass, which also has very little viscoelasticity, similar to the HOPG sample. As indicated in Figure 10, the calculated elastic modulus using the Kelvin–Voigt model resulted in an elastic modulus of about 2 GPa for the

Graphene–graphite hybrid epoxy composites with controllable workability for thermal management

• Idan Levy,
• Eyal Merary Wormser,
• Maxim Varenik,
• Matat Buzaglo,
• Roey Nadiv and
• Oren Regev

Beilstein J. Nanotechnol. 2019, 10, 95–104, doi:10.3762/bjnano.10.9

• graphite-containing composites to higher volume fractions of the filler compared to those of GNP-loaded composites [41][48][49][50], in line with previously studied silicone rubber systems [41]. The viscoelasticity of a composite may be described by the dynamic moduli, G' (storage modulus) and G'' (loss

Electrospun one-dimensional nanostructures: a new horizon for gas sensing materials

• Muhammad Imran,
• Nunzio Motta and
• Mahnaz Shafiei

Beilstein J. Nanotechnol. 2018, 9, 2128–2170, doi:10.3762/bjnano.9.202

Imaging of viscoelastic soft matter with small indentation using higher eigenmodes in single-eigenmode amplitude-modulation atomic force microscopy

• Miead Nikfarjam,
• Enrique A. López-Guerra,
• Santiago D. Solares and
• Babak Eslami

Beilstein J. Nanotechnol. 2018, 9, 1116–1122, doi:10.3762/bjnano.9.103

• short theoretical discussion of the key underlying concepts, along with numerical simulations and experiments to illustrate a simple recipe for imaging soft viscoelastic matter with reduced indentation. Keywords: higher eigenmodes; multifrequency AFM; soft matter; viscoelasticity; Introduction Since

Liquid-crystalline nanoarchitectures for tissue engineering

• Baeckkyoung Sung and
• Min-Ho Kim

Beilstein J. Nanotechnol. 2018, 9, 205–215, doi:10.3762/bjnano.9.22

• preferred in this phase. The columnar phase is fundamentally different from the crystalline phase in the sense that the rod suspensions exhibit fluidity and viscoelasticity. The crystalline phase is a complete solid state where the rods are fully ordered and tightly bound to each other in a 3D hexagonal

Material property analytical relations for the case of an AFM probe tapping a viscoelastic surface containing multiple characteristic times

• Enrique A. López-Guerra and
• Santiago D. Solares

Beilstein J. Nanotechnol. 2017, 8, 2230–2244, doi:10.3762/bjnano.8.223

• imaging method. Keywords: atomic force microscopy; harmonic functions; tapping-mode AFM; viscoelasticity; Introduction Several current applications demand physical understanding of soft dissipative materials at the nanoscale [1][2][3][4][5]. This type of materials, such as polymers, biological cells and

• highlighted the challenges involved in characterizing viscoelastic materials with dynamic intermittent-contact methods [19][20][21][22], but further work remains, both in accurately pinpointing the issues involved and in finding robust solutions for them. Typically, viscoelasticity in AFM has been

• oversimplified in an effort to maintain the analytics tractable, but this has been done at the expense of implementing models that do not properly represent the behavior of real materials, at least with regards to the well-established classical viscoelasticity, which predicts complex time behaviors for samples

High-stress study of bioinspired multifunctional PEDOT:PSS/nanoclay nanocomposites using AFM, SEM and numerical simulation

• Alfredo J. Diaz,
• Hanaul Noh,
• Tobias Meier and
• Santiago D. Solares

Beilstein J. Nanotechnol. 2017, 8, 2069–2082, doi:10.3762/bjnano.8.207

• ]. Additionally, polymer mechanical properties are very sensitive to the frequency of the measurement due to their viscoelasticity (rate-dependent behavior) [52]. In CRFM, an additional challenge is the inability to probe at frequencies lower than the kilohertz to megahertz range because of the resonance

Impact of surface wettability on S-layer recrystallization: a real-time characterization by QCM-D

• Jagoba Iturri,
• Ana C. Vianna,
• Alberto Moreno-Cencerrado,
• Dietmar Pum,
• Uwe B. Sleytr and
• José Luis Toca-Herrera

Beilstein J. Nanotechnol. 2017, 8, 91–98, doi:10.3762/bjnano.8.10

• in terms of bound mass and viscoelasticity of the film is by means of the so-called Df plots, as seen in Figure 3. It must be noted that the starting coordinates (0,0) were adapted to exactly refer to the moment at which SbpA is injected into the chamber while the red-to-blue color variation reflects

Structural and tribometric characterization of biomimetically inspired synthetic "insect adhesives"

• Matthias W. Speidel,
• Malte Kleemeier,
• Andreas Hartwig,
• Klaus Rischka,
• Angelika Ellermann,
• Rolf Daniels and
• Oliver Betz

Beilstein J. Nanotechnol. 2017, 8, 45–63, doi:10.3762/bjnano.8.6

• of possible synergisms between the structural component of the carrier (e.g., its viscoelasticity or the geometry of its surface) and the physico-chemical properties of the adhesive. The combination of emulsion-based adhesives and porous carrier materials should make possible the fine-tuning of

Nanoscale effects in the characterization of viscoelastic materials with atomic force microscopy: coupling of a quasi-three-dimensional standard linear solid model with in-plane surface interactions

• Santiago D. Solares

Beilstein J. Nanotechnol. 2016, 7, 554–571, doi:10.3762/bjnano.7.49

• AFM simulation. A multifrequency AFM simulation tool based on the above sample model is provided as supporting information. Keywords: atomic force microscopy; modeling; polymers; simulation; spectroscopy; standard linear solid; surface elasticity; surface energy; viscoelasticity; Introduction The

• method and instrumentation, almost arriving at the conclusion that it is nearly impossible to carry out quantitatively accurate measurements of viscoelasticity with AFM, unless one assumes that the sample follows the simplest continuum behaviors. For the most part, the development of new AFM imaging and

• , which can cause the material properties to vary with time and location within the sample. This paper, therefore, offers only a glimpse into the research gaps that exist in the treatment of sample material properties within AFM simulation. Viscoelasticity and the standard linear solid The standard linear

Molecular machines operating on the nanoscale: from classical to quantum

• Igor Goychuk

Beilstein J. Nanotechnol. 2016, 7, 328–350, doi:10.3762/bjnano.7.31

Nanoscale rippling on polymer surfaces induced by AFM manipulation

• Mario D’Acunto,
• Franco Dinelli and
• Pasqualantonio Pingue

Beilstein J. Nanotechnol. 2015, 6, 2278–2289, doi:10.3762/bjnano.6.234

• . Typically the samples are heated rather than the tip, as these setups are easier to build and to control. For instance, Schmidt et al. investigated the ripple patterns, as they were concerned with the dependence of the viscoelasticity on T [45]. Similarly, Rice et al. have investigated the T dependence of