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Search for "ADP" in Full Text gives 33 result(s) in Beilstein Journal of Organic Chemistry.

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  • been used in artificial photosynthesis research to model different key photosynthesis processes. In plants, photosynthesis is a complex process where light-harvesting reactions are carried out in two photosystems to split water and recycle NADH and ADP. NADPH and ATP are then consumed in the Calvin
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Published 08 Aug 2023

Recommendations for performing measurements of apparent equilibrium constants of enzyme-catalyzed reactions and for reporting the results of these measurements

  • Robert N. Goldberg,
  • Robert T. Giessmann,
  • Peter J. Halling,
  • Carsten Kettner and
  • Hans V. Westerhoff

Beilstein J. Org. Chem. 2023, 19, 303–316, doi:10.3762/bjoc.19.26

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  • biochemical reaction and the many chemical reactions that accompany it is the hydrolysis reaction of ATP (adenosine 5’-triphosphate) to {ADP (adenosine 5’-diphosphate) + phosphate}: The apparent reaction quotient for this reaction is And the apparent equilibrium constant is Here, (aq) denotes that the
  • reaction is taking place in aqueous media and c denotes the respective concentrations (units of mol∙dm−3) of total amounts of ATP, ADP, and phosphate. Note that Q′ and K′ have the same form but they differ critically in that a measured value of K′ refers to Equation 1 having been established to be at
  • be written for total ADP and total phosphate. The word “total” is sometimes used to specify total concentrations and, while useful, it seems cumbersome and unnecessary if the context is clear. A substantial number of chemical reference reactions can be selected for the biochemical Equation 1 – a few
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Perspective
Published 15 Mar 2023

Synthesis of the biologically important dideuterium-labelled adenosine triphosphate analogue ApppI(d2)

  • Petri A. Turhanen

Beilstein J. Org. Chem. 2022, 18, 1466–1470, doi:10.3762/bjoc.18.153

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  • the formation of ApppI, i.e., the isopentenyl ester of ATP (Figure 2), which may also isomerize to ApppD (Figure 2). The authors have also concluded that these compounds can act in two different ways: inhibition of the mevalonate pathway and blockade of mitochondrial ADP/ATP translocase, which is
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Letter
Published 14 Oct 2022

Make or break: the thermodynamic equilibrium of polyphosphate kinase-catalysed reactions

  • Michael Keppler,
  • Sandra Moser,
  • Henning J. Jessen,
  • Christoph Held and
  • Jennifer N. Andexer

Beilstein J. Org. Chem. 2022, 18, 1278–1288, doi:10.3762/bjoc.18.134

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  • phosphate transfer potentials that are characterised by reaction yields close to full conversion, the PPK-catalysed reaction reaches an equilibrium in which about 30% ADP is left. These results were obtained for PPK1 and PPK2 enzymes, and are supported by theoretical data on the basic reaction. At high
  • fractions [5][10][15][16]. Based on the crystal structures of three PPK2-III, the coordination of polyP and ADP by positively charged amino acids (lysine and arginine) has been suggested [16][17]. Two magnesium ions are held in place by two conserved aspartate residues that further coordinate the polyP and
  • ADP for an in-line reaction of these two substrates. Out of this arrangement two reaction pathways have been discussed, an associative and a dissociative one. The associative one is an SN2-like attack of ADP on the terminal phosphate of the polyP chain, while the dissociative one is an SN1-like
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Published 20 Sep 2022

The PIFA-initiated oxidative cyclization of 2-(3-butenyl)quinazolin-4(3H)-ones – an efficient approach to 1-(hydroxymethyl)-2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-ones

  • Alla I. Vaskevych,
  • Nataliia O. Savinchuk,
  • Ruslan I. Vaskevych,
  • Eduard B. Rusanov,
  • Oleksandr O. Grygorenko and
  • Mykhailo V. Vovk

Beilstein J. Org. Chem. 2021, 17, 2787–2794, doi:10.3762/bjoc.17.189

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  • anti-inflammatory [9], antibacterial [10], antiarrythmic [11] activity; some representatives are CNS suppressors and poly-ADP ribose polymerase (PARP) inhibitors [12] (see Figure 1). Several approaches to obtain 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one derivatives of type 1 are known in the
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Letter
Published 25 Nov 2021

Isolation and characterization of new phenolic siderophores with antimicrobial properties from Pseudomonas sp. UIAU-6B

  • Emmanuel T. Oluwabusola,
  • Olusoji O. Adebisi,
  • Fernando Reyes,
  • Kojo S. Acquah,
  • Mercedes De La Cruz,
  • Larry L. Mweetwa,
  • Joy E. Rajakulendran,
  • Digby F. Warner,
  • Deng Hai,
  • Rainer Ebel and
  • Marcel Jaspars

Beilstein J. Org. Chem. 2021, 17, 2390–2398, doi:10.3762/bjoc.17.156

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  • hypotheses not previously reported in natural product biosynthesis. Experimental General experimental procedures IR spectra were acquired on a Perkin Elmer Spectrum Two FT-IR spectrometer equipped with an ATR diamond cell. Optical rotations were measured on an ADP 410 digital Polarimeter (Bellingham
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Published 13 Sep 2021

On the application of 3d metals for C–H activation toward bioactive compounds: The key step for the synthesis of silver bullets

  • Renato L. Carvalho,
  • Amanda S. de Miranda,
  • Mateus P. Nunes,
  • Roberto S. Gomes,
  • Guilherme A. M. Jardim and
  • Eufrânio N. da Silva Júnior

Beilstein J. Org. Chem. 2021, 17, 1849–1938, doi:10.3762/bjoc.17.126

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Published 30 Jul 2021

Selected peptide-based fluorescent probes for biological applications

  • Debabrata Maity

Beilstein J. Org. Chem. 2020, 16, 2971–2982, doi:10.3762/bjoc.16.247

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  • >> ADP > UDP. Nucleobases undergo differential interactions with the tryptophan residues and naphthimide which varies the hydrophobic microenvironment around the fluorophore and results in dissimilar fluorescence enhancement. The addition of monophosphorylated species such as HPO42−, c-AMP, AMP, CMP, GMP
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Published 03 Dec 2020

Selective recognition of ATP by multivalent nano-assemblies of bisimidazolium amphiphiles through “turn-on” fluorescence response

  • Rakesh Biswas,
  • Surya Ghosh,
  • Shubhra Kanti Bhaumik and
  • Supratim Banerjee

Beilstein J. Org. Chem. 2020, 16, 2728–2738, doi:10.3762/bjoc.16.223

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  • buffer and also in buffer containing 150 mM NaCl at physiological pH value. Furthermore, the multivalent aggregates demonstrated a significant selectivity in ATP detection over ADP, AMP and pyrophosphate. Keywords: amphiphile; ATP; excimer; multivalency; self-assembly; Introduction Supramolecular anion
  • level of selectivity as the response observed in the presence of other adenosine phosphates, ADP and AMP and even pyrophosphate (PPi) was comparatively much lower than that observed for ATP in a wide concentration range (1–100 µM). Results and Discussion Synthesis The synthesis of PBImNs (N = 4, 10, 12
  • issues of a sensor design is the selectivity for an analyte in comparison to other interfering analytes. Therefore, we carried out selectivity studies with the multivalent sensors for ATP over the other adenosine phosphates ADP and AMP, PPi and inorganic phosphate (Pi). We employed PBIm12 (75 µM) for
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Published 10 Nov 2020

NMR Spectroscopy of supramolecular chemistry on protein surfaces

  • Peter Bayer,
  • Anja Matena and
  • Christine Beuck

Beilstein J. Org. Chem. 2020, 16, 2505–2522, doi:10.3762/bjoc.16.203

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  • [122][123], extend the possibility to monitor binding events to very large protein assemblies by NMR. It has mostly been used to investigate protein–protein interactions within large multi-protein assemblies [120][121] and the effect of small natural ligands like ATP or ADP on the dynamics of
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Published 09 Oct 2020

Palladium-catalyzed synthesis and nucleotide pyrophosphatase inhibition of benzo[4,5]furo[3,2-b]indoles

  • Hoang Huy Do,
  • Saif Ullah,
  • Alexander Villinger,
  • Joanna Lecka,
  • Jean Sévigny,
  • Peter Ehlers,
  • Jamshed Iqbal and
  • Peter Langer

Beilstein J. Org. Chem. 2019, 15, 2830–2839, doi:10.3762/bjoc.15.276

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  • aryl substituent located on the nitrogen atom. Nucleotide pyrophosphatase activity Nucleotide pyrophosphatases belong to the family of ecto-nucleotidases [34][35]. They can hydrolyze nucleotides, dinucleotides, and nucleotide sugars, e.g., ATP, ADP, NAD+, ADP-ribose and diadenosine polyphosphates [36
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Published 22 Nov 2019

Design, synthesis and biological evaluation of immunostimulating mannosylated desmuramyl peptides

  • Rosana Ribić,
  • Ranko Stojković,
  • Lidija Milković,
  • Mariastefania Antica,
  • Marko Cigler and
  • Srđanka Tomić

Beilstein J. Org. Chem. 2019, 15, 1805–1814, doi:10.3762/bjoc.15.174

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  • innate immunity through macrophage response as well as to more distally affect adaptive immunity through the production of antigen-specific T cells [5]. MDP binding to NOD2 has been confirmed [6] as well as the crystal structure of NOD2 in the inactive ADP-bound state [7]. MDP is the structural fragment
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Published 29 Jul 2019

Syntheses and chemical properties of β-nicotinamide riboside and its analogues and derivatives

  • Mikhail V. Makarov and
  • Marie E. Migaud

Beilstein J. Org. Chem. 2019, 15, 401–430, doi:10.3762/bjoc.15.36

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Published 13 Feb 2019

Nucleoside macrocycles formed by intramolecular click reaction: efficient cyclization of pyrimidine nucleosides decorated with 5'-azido residues and 5-octadiynyl side chains

  • Jiang Liu,
  • Peter Leonard,
  • Sebastian L. Müller,
  • Constantin Daniliuc and
  • Frank Seela

Beilstein J. Org. Chem. 2018, 14, 2404–2410, doi:10.3762/bjoc.14.217

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  • macrocyclic systems [18][19][20][21][22][23][24][25]. DNA mimics with triazole linkages were constructed [26][27]. The click reaction was used to generate a cyclic ADP-ribose second messenger mimic [28]. Modelling studies using MM+ energy minimization showed that pyrimidine nucleosides are useful synthons for
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Published 13 Sep 2018

Hypervalent iodine compounds for anti-Markovnikov-type iodo-oxyimidation of vinylarenes

  • Igor B. Krylov,
  • Stanislav A. Paveliev,
  • Mikhail A. Syroeshkin,
  • Alexander A. Korlyukov,
  • Pavel V. Dorovatovskii,
  • Yan V. Zubavichus,
  • Gennady I. Nikishin and
  • Alexander O. Terent’ev

Beilstein J. Org. Chem. 2018, 14, 2146–2155, doi:10.3762/bjoc.14.188

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  • . bDMP (0.15 mmol) was used instead of PhI(OAc)2, reaction time 30 min. Molecular structure of 3ca. Atoms are presented as anisotropic displacement parameters (ADP) ellipsoids (50% probability). For clarity, only one set of positions of the disordered ethylene bridge and Ph groups is shown. CV curves of
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Published 16 Aug 2018

Synthesis of new p-tert-butylcalix[4]arene-based polyammonium triazolyl amphiphiles and their binding with nucleoside phosphates

  • Vladimir A. Burilov,
  • Guzaliya A. Fatikhova,
  • Mariya N. Dokuchaeva,
  • Ramil I. Nugmanov,
  • Diana A. Mironova,
  • Pavel V. Dorovatovskii,
  • Victor N. Khrustalev,
  • Svetlana E. Solovieva and
  • Igor S. Antipin

Beilstein J. Org. Chem. 2018, 14, 1980–1993, doi:10.3762/bjoc.14.173

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  • for nucleotides sensing through a dye replacement procedure. It is unusual that disubstituted macrocycles 10a,b bind more effectively a less charged adenosine 5'-diphosphate (ADP) than adenosine 5'-triphosphate (ATP). A simple colorimetric method based on polydiacetylene vesicles decorated with 10b
  • was elaborated for the naked-eye detection of ADP with a detection limit of 0.5 mM. Keywords: ADP; amphiphile; ATP; calix[4]arene; CuAAC; eosin Y probe; molecular recognition; polydiacetylene; self-assembly; triazole; Introduction During the last two decades many researcher groups have paid much
  • are very important as a universal energy source and as intracellular mediators in many biological processes [6]. In the cellular metabolism, adenosine 5'-triphosphate (ATP) is hydrolyzed to adenosine 5'-monophosphate (AMP) or adenosine 5'-diphosphate (ADP) by enzymes [7]. Thus, the receptors for
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Published 31 Jul 2018

Synthesis of pyrimido[1,6-a]quinoxalines via intermolecular trapping of thermally generated acyl(quinoxalin-2-yl)ketenes by Schiff bases

  • Svetlana O. Kasatkina,
  • Ekaterina E. Stepanova,
  • Maksim V. Dmitriev,
  • Ivan G. Mokrushin and
  • Andrey N. Maslivets

Beilstein J. Org. Chem. 2018, 14, 1734–1742, doi:10.3762/bjoc.14.147

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  • (quinoxaline fused by a six-membered heterocycle at the [a]-side) are promising biologically active compounds. Recent research studies revealed that they can act as inhibitors of poly(ADP-ribose) polymerase (PARP) [3], inhibitors of hepatitis C virus [4], 5-HT2C agonists [5][6][7], substances for controlling
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Published 11 Jul 2018

An uracil-linked hydroxyflavone probe for the recognition of ATP

  • Márton Bojtár,
  • Péter Zoltán Janzsó-Berend,
  • Dávid Mester,
  • Dóra Hessz,
  • Mihály Kállay,
  • Miklós Kubinyi and
  • István Bitter

Beilstein J. Org. Chem. 2018, 14, 747–755, doi:10.3762/bjoc.14.63

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  • experiment; the results are summarized in Figure 5. As can be seen in Figure 5, among the different nucleotides, only ADP generated a slight fluorescence enhancement at 540 nm. According to [34], GTP and AMP caused a slight fluorescence enhancement in the case of DMHF; this was not detected in the case of
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Published 03 Apr 2018

Carbohydrate inhibitors of cholera toxin

  • Vajinder Kumar and
  • W. Bruce Turnbull

Beilstein J. Org. Chem. 2018, 14, 484–498, doi:10.3762/bjoc.14.34

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  • into cells and direct the toxin to the endoplasmic reticulum, from where it can escape into the cytosol. The A1 chain has ADP-ribosyltransferase activity that allows the toxin to covalently modify the α-subunit of the stimulatory G protein Gsα so that it remains in its active GTP-bound state. The
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Published 21 Feb 2018

Chemical systems, chemical contiguity and the emergence of life

  • Terrence P. Kee and
  • Pierre-Alain Monnard

Beilstein J. Org. Chem. 2017, 13, 1551–1563, doi:10.3762/bjoc.13.155

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  • ATP from inorganic phosphate and ADP. In these systems, the “artificial” photosynthesis attained transduction levels that were comparable to those observed in cells, but in a completely artificial compartment. That such a complex dynamic system can be realized in artificial membranes is remarkable
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Published 07 Aug 2017

Contribution of microreactor technology and flow chemistry to the development of green and sustainable synthesis

  • Flavio Fanelli,
  • Giovanna Parisi,
  • Leonardo Degennaro and
  • Renzo Luisi

Beilstein J. Org. Chem. 2017, 13, 520–542, doi:10.3762/bjoc.13.51

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  • reagents” chemistry with the continuous-flow photosynthesis of 6(5H)-phenanthridinones, poly(ADP-ribose) polymerase (PARP) inhibitors [69]. The relevance of the work resides in the use of green solvents, the absence of heavy metals, the use of convenient temperatures, and the increased safety by
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Published 14 Mar 2017

Investigation of the action of poly(ADP-ribose)-synthesising enzymes on NAD+ analogues

  • Sarah Wallrodt,
  • Edward L. Simpson and
  • Andreas Marx

Beilstein J. Org. Chem. 2017, 13, 495–501, doi:10.3762/bjoc.13.49

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  • Sarah Wallrodt Edward L. Simpson Andreas Marx Department of Chemistry, University of Konstanz, Universitätsstraße 10, 78457 Konstanz, Germany 10.3762/bjoc.13.49 Abstract ADP-ribosyl transferases with diphtheria toxin homology (ARTDs) catalyse the covalent addition of ADP-ribose onto different
  • acceptors forming mono- or poly(ADP-ribos)ylated proteins. Out of the 18 members identified, only four are known to synthesise the complex poly(ADP-ribose) biopolymer. The investigation of this posttranslational modification is important due to its involvement in cancer and other diseases. Lately, metabolic
  • labelling approaches comprising different reporter-modified NAD+ building blocks have stimulated and enriched proteomic studies and imaging applications of ADP-ribosylation processes. Herein, we compare the substrate scope and applicability of different NAD+ analogues for the investigation of the polymer
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Published 10 Mar 2017

Synthesis and characterization of fluorinated azadipyrromethene complexes as acceptors for organic photovoltaics

  • Forrest S. Etheridge,
  • Roshan J. Fernando,
  • Sandra Pejić,
  • Matthias Zeller and
  • Geneviève Sauvé

Beilstein J. Org. Chem. 2016, 12, 1925–1938, doi:10.3762/bjoc.12.182

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  • chelation [1][2][3][4]. BF2+-chelated ADP derivatives (Figure 1b) in particular have drawn interest for photodynamic therapy, bio-imaging and light harvesting applications [5][6][7][8]. We have shown that derivatives of Zn(ADP)2 are promising electron acceptors for organic photovoltaics (OPVs) [9][10]. A
  • showed negligible power conversion efficiencies, and Zn(ADP)2 gave a maximum efficiency of 1.4% [11]. Free ligands and BF2+ chelates tend to self-aggregate too much, leading to large scale phase separation with P3HT and low PCEs. Chelation with zinc(II) lowers the tendency to self-aggregate, but Zn(ADP)2
  • fluorinated derivatives allow access to triplet state blue light-emitters [13]. This work further investigates the effects of fluorination in n-type materials for OPVs. A series of selectively fluorinated ADP derivatives based on WS3 were synthesized (Figure 2). To understand the effect of the fluorination
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Published 29 Aug 2016

Cyclisation mechanisms in the biosynthesis of ribosomally synthesised and post-translationally modified peptides

  • Andrew W. Truman

Beilstein J. Org. Chem. 2016, 12, 1250–1268, doi:10.3762/bjoc.12.120

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  • hemiorthoamide is first formed by side-chain S- or O-attack onto the amide carbonyl [35] (Figure 3B, pathway a), which is analogous to a step proposed for protein autoproteolysis [36] (Figure 3, inset). The exocyclic oxygen in this intermediate then attacks the α-phosphate of ATP to displace ADP and generate a
  • was proposed by the Naismith group for the cyanobactin heterocyclase TruD, which contains fused C- and D-proteins [38]. Interestingly, this revealed a notable difference with the microcin pathway, as cyclisation was accompanied by the generation of AMP and pyrophosphate (PPi), instead of ADP and
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Published 20 Jun 2016

Synthesis of cyclic N1-pentylinosine phosphate, a new structurally reduced cADPR analogue with calcium-mobilizing activity on PC12 cells

  • Ahmed Mahal,
  • Stefano D’Errico,
  • Nicola Borbone,
  • Brunella Pinto,
  • Agnese Secondo,
  • Valeria Costantino,
  • Valentina Tedeschi,
  • Giorgia Oliviero,
  • Vincenzo Piccialli and
  • Gennaro Piccialli

Beilstein J. Org. Chem. 2015, 11, 2689–2695, doi:10.3762/bjoc.11.289

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  • Pietro Castellino 111, 80131 Napoli, Italy 10.3762/bjoc.11.289 Abstract Cyclic N1-pentylinosine monophosphate (cpIMP), a novel simplified inosine derivative of cyclic ADP-ribose (cADPR) in which the N1-pentyl chain and the monophosphate group replace the northern ribose and the pyrophosphate moieties
  • neuronal cells. Keywords: calcium mobilization; cIDPR analogues; cyclic ADP-ribose (cADPR); cyclization; Introduction Nucleosides and nucleotides (NNs) are widely used as key intermediates and important core structures in the field of synthetic medicinal chemistry [1][2]. They represent versatile
  • ]. Among these NNs there is the cyclic ADP-ribose (cADPR 1, Figure 1), a metabolite strictly involved in the homeostasis of cellular calcium ions. cADPR is a second messenger that activates the ryanodine receptors of the sarcoplasmic reticulum and mobilizes Ca2+ ions in many cell types of protozoa, plants
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Published 22 Dec 2015
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