Synthesis and acaricidal activity against Varroa destructor of α- and γ-costic acid dimers

• Alessandro Santarsiere,
• Ernesto Santoro,
• Maria Letizia Ciavatta,
• Marianna Carbone,
• Sonia Ganassi,
• Cosimo Tedino,
• Antonio De Cristofaro,
• Antonio Evidente and
• Stefano Superchi

Beilstein J. Org. Chem. 2026, 22, 1088–1096, doi:10.3762/bjoc.22.87

• interest to investigate whether ethylene glycol ester dimers of α-costic acid (1) or γ-costic acid (3) would enhance their bioactivity as well. Accordingly, we herein report the synthesis, chemical characterization, and acaricidal activity against V. destructor of α,α- and γ,γ-costic acid homodimers and α

Synthesis of functionalized, 13-alkyl-substituted coralyne derivatives and investigation of their interactions with duplex and abasic site-containing DNA

• Laurin Beckmann,
• Jason Lennard Kunze,
• Hannah Karola Strunk,
• Maurice Michel and
• Heiko Ihmels

Beilstein J. Org. Chem. 2026, 22, 1057–1066, doi:10.3762/bjoc.22.84

• description of synthesis and compound characterization with complete set of NMR spectra (Figures S1–S65). Acknowledgements We thank Jennifer Hermann and Sandra Uebach (University of Siegen) for technical assistance. Funding We thank the University of Siegen for financial support.

One-pot four-component sequential synthesis of S-alkyl dithiocarbamates using lipase as a biocatalyst

• Mansour Shahedi,
• Pargol Tahmasebi pour and
• Zohreh Habibi

Beilstein J. Org. Chem. 2026, 22, 1048–1056, doi:10.3762/bjoc.22.83

• ), Novozyme 435 (30 mg), aniline (0.05 mmol), CH3CN (1 mL), 30 °C, 12 h; then, CS2 (4, 0.4 mmol), amine 5c,d (0.2 mmol), 25 °C, 12 h. Control reactions. Proposed mechanism. Optimization of model reaction.a Supporting Information Supporting Information File 8: Product characterization data and copies of NMR

Synthesis of novel 1,2,4-oxadiazole-isoxazoline hybrids and their in silico potential with adenosine receptors

• Pshtiwan S. Mohammed,
• Mohammed K. S. Dalo,
• Onur C. Yazıcı,
• Muhammet Yildirim and
• Akın Sağırlı

Beilstein J. Org. Chem. 2026, 22, 1033–1047, doi:10.3762/bjoc.22.82

• structural data for benzaldoximes (2a–k) and aryl vinyl 1,2,4-oxadiazoles (6a–j) are consistent with those reported in the literature [80][81][82][83][84][85][86][87][88][89][90][91]. Following the characterization of the precursors (2a–k and 6a–j), we proceeded to the synthesis of 1,2,4-oxadiazole

Z-Selective semihydrogenation of alkynes via Ni/Lewis acid synergistic catalyzed system using DMF as hydrogen source and solvent

• Lei Kang,
• Haifeng Gao and
• Luo Yang

Beilstein J. Org. Chem. 2026, 22, 1004–1012, doi:10.3762/bjoc.22.79

• , compound characterization data, and copies of spectra. Acknowledgements The authors sincerely appreciate Professor Weiyu Li at Guangxi University for his kind help on performing revision experiments addressing the referees’ suggestions, with his research team finishing all required supplementary

The role of spacer length and flexibility in peptide self-assembly

• Julian Link,
• Albin Lahu,
• Manfred Wagner,
• Tanja Weil and
• David Y. W. Ng

Beilstein J. Org. Chem. 2026, 22, 986–996, doi:10.3762/bjoc.22.77

• of the pro-assembling tripeptide Ile-Cys-Ala (ICA), which forms fibrous networks upon functionalization with aromatic groups at the N-terminus [35]. To enable both, π–π interactions and fluorescence-based characterization, we chose a naphthalene imide fluorophore as the hydrophobic segment (Nap). The

• and 254 nm wavelengths. The softwares LabSolutions by Shimadzu and Origin Pro by OriginLab® were used to process the generated HPLC spectra. The samples were analyzed in triplicates (n = 3). Assembly characterization by NMR To investigate the self-assembly propensity of the three peptide conjugates

• , DMF, rt, overnight; x) TFA (95%), TIPS (2.5%), H2O (2.5%), rt, 2 h. Summary of the assembly characteristics of C6-Nap-ICA 6, C3-Nap-ICA 7, and C0-Nap-ICA 8 at 100 µM in PBS (50 mM, pH 7.4, 1% TFE). Supporting Information Supporting Information File 22: Experimental, characterization data and copies

Electrochemical reduction of unsaturated carbon–carbon bonds via 3d transition-metal catalysis

• Geon Kang,
• Minki Jeon,
• Pooja Kumari Jat,
• Cheoljae Kim and
• Isaac Choi

Beilstein J. Org. Chem. 2026, 22, 955–981, doi:10.3762/bjoc.22.75

• concentration, strongly supporting an intramolecular HAT event as the kinetically controlling step. In situ generation and characterization of (DHP)Ni intermediates are consistent with the involvement of a reduced, formal Ni(I) species as a key catalytic entry point (Scheme 11C, i). Moreover, radical-probe

Synthesis of sterically shielded piperidine nitroxides via acid-catalyzed heterocyclization of β-aminoketone derivatives with ketones

• Mark M. Gulman,
• Yurii I. Glazachev and
• Sergey A. Dobrynin

Beilstein J. Org. Chem. 2026, 22, 948–954, doi:10.3762/bjoc.22.74

• . Hydrogenation of carbon–carbon multiple bonds of nitroxides 7a–d. Sequential hydrogenation and dioxolane deprotection. EPR spectra parameters and reduction rate constants. Supporting Information Supporting Information File 16: Experimental section and characterization data of synthesized compounds

Recent advances in copper-catalyzed direct hydroamination of alkenes with (hetero)aromatic amines

• Hyejeong Lee and
• Yunmi Lee

Beilstein J. Org. Chem. 2026, 22, 925–947, doi:10.3762/bjoc.22.73

• characterization of well-defined copper–amido complexes I and II, supported by electron-donating ligands such as phosphines and N-heterocyclic carbenes (NHCs) (Scheme 2) [32][33][34]. Copper–amido complex I was prepared by treating the dtbpe-ligated Cu–Cl complex (dtbpe = 1,2-bis(di-tert-butylphosphino)ethane

A practical CO₂-mediated synthesis of 5,6-carboxylated silicon-rhodamines for targeted probe development

• Dongjie Hou,
• Shaowei Wu,
• Ning Xu,
• Pengjun Bao,
• Wenhao Jia,
• Qinglong Qiao and
• Zhaochao Xu

Beilstein J. Org. Chem. 2026, 22, 915–924, doi:10.3762/bjoc.22.72

• with 4c in live HeLa cells. Scale bars: 5.0 μm. Supporting Information Supporting Information File 8: Experimental details and characterization of compounds by NMR and ESIMS. Funding This work is supported by the National Natural Science Foundation of China (22541705, U25A20620, 22225806, 22522816

Cascade transformation of 2-(diazoacetyl)-2H-azirines to 2-aroyl-3-hydroxy-1H-pyrroles via condensation with aromatic aldehydes

• Timur O. Zanakhov,
• Ekaterina E. Galenko,
• Mikhail S. Novikov and
• Alexander F. Khlebnikov

Beilstein J. Org. Chem. 2026, 22, 897–904, doi:10.3762/bjoc.22.70

• Crystallographic Data Centre. Supporting Information File 3: Full experimental details, characterization data and copies of NMR spectra for all new compounds. Supporting Information File 4: Crystallographic information file for compound 5a. Acknowledgements This research was carried out using resources of the

Chiral cyclopropenimine-catalyzed enantioselective Michael reactions of phenol and benzofuran-derived α,β-unsaturated pyrazolamides with benzophenone-imine of glycine esters

• Ya Bai,
• Xue-Ying Wang,
• Si-Kai Zhu,
• Yan-Ting Shen,
• Sheng-Yong Zhang and
• Ping-An Wang

Beilstein J. Org. Chem. 2026, 22, 888–896, doi:10.3762/bjoc.22.69

• Supporting Information File 42: Detailed experimental procedures, characterization data of all new compounds with NMR, HRMS, HPLC charts, and X-ray single crystal diffraction data. Funding The authors thank the National Science Foundation of China (no. 21372259) for providing financial support for this work.

Diastereodivergent electrophilic trapping of α-boryl lithium derivatives

• Tereza Pavlíčková,
• Noam Orbach and
• Ilan Marek

Beilstein J. Org. Chem. 2026, 22, 882–887, doi:10.3762/bjoc.22.68

• File 40: Experimental section, characterization data and copies of spectra. Funding This project has received funding from the European Union’s Horizon 2020 Research and Innovation Program, under Grant Agreement No. 101198411, from the Israel Science Foundation administered by the Israel Academy of

Unsymmetrical sulfoxides with sterically hindered catechol fragment: synthesis, structure, electrochemical properties, and antiradical activity

• Daria A. Burmistrova,
• Vasiliy A. Fokin,
• Oleg P. Demidov,
• Mikhail A. Kiskin,
• Maxim V. Arsenyev,
• Andrey I. Poddel’sky,
• Nadezhda T. Berberova and
• Ivan V. Smolyaninov

Beilstein J. Org. Chem. 2026, 22, 828–837, doi:10.3762/bjoc.22.65

• . Supporting Information Supporting Information File 37: Experimental procedures and characterization data. Supporting Information File 38: Crystallographic information files. Funding This work was supported by the Russian Science Foundation, grant 25-73-00164.

Synthetic study of vic-bromination of diarylacetylenes, easy purification and separation

• Akane Togo,
• Hiyono Suzuki,
• Yuto Akai,
• Makoto Matsumoto,
• Yoshinori Suzuma,
• Hidehiko Kodama and
• Kouichi Matsumoto

Beilstein J. Org. Chem. 2026, 22, 795–802, doi:10.3762/bjoc.22.61

• contribute to process chemistry for the synthesis of (E)-1,2-dibromo-1,2-diphenylethylene and their derivatives. Further synthetic investigations are currently underway in our laboratory. Experimental The experimental procedures and characterization data (Table 1, entry 1). The glass flask was dried and

• present reaction. Reaction optimization of bromination reaction of diphenylacetylene (1a). Scope and limitations for bromination of various diarylacetylenes 1. Supporting Information Supporting Information File 24: General remarks, preparation of substrates, experimental procedure, characterization data

Halogenated azobenzene acrylates: from efficient solution photoswitching to stable solid-state photochromic materials

• Martina Vachtlová,
• Michaela Fecková,
• Vítězslav Zima,
• Jan Podlesný,
• Milan Klikar,
• Oldřich Pytela,
• Patrik Pařík,
• Jakub Opršal,
• Eliška Juhaňáková,
• Veronika Chrtová and
• Filip Bureš

Beilstein J. Org. Chem. 2026, 22, 782–794, doi:10.3762/bjoc.22.60

• . Neumanna 1316, Pardubice, 53002, Czech Republic Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentská 573, Pardubice, 53210, Czech Republic 10.3762/bjoc.22.60 Abstract The design, synthesis, and comprehensive characterization of six novel

• Information Supporting Information File 22: Experimental section, characterization data and details on compound analyses. Funding The work was supported by the Technology Agency of the Czech Republic, Sigma (project No. TQ03000624 “Photoresponsive azo-polymeric materials applied as a thermal sensor”).

Design, synthesis, and biological evaluation of FXR/ASK1 dual-target modulators

• Xi Zhang,
• Jingyan Wang,
• Ziqiang Zhao,
• Caiyi Wang,
• Zenghui Ye,
• Wei-Yuan Ma,
• Jian-Xing Xu and
• Fengzhi Zhang

Beilstein J. Org. Chem. 2026, 22, 771–781, doi:10.3762/bjoc.22.59

• study, we present the rational design and characterization of a balanced dual modulator targeting the nuclear receptors FXR and ASK1 [32], with the objective of advancing this experimental therapeutic concept (Scheme 3) [33][34]. The conception of this class of dual ligands was achieved by the merging

• Supporting Information File 20: Experimental, characterization data and copies of spectra. Funding We thank Hangzhou Medical College for financial support.

Synthesis and biological evaluation of new brassinosteroid analogs with C-22 benzoate function

• María Núñez,
• Camila Escobar,
• Mario Párraga,
• Mauricio Soto,
• Luis Espinoza-Catalán,
• Katy Díaz and
• Andrés F. Olea

Beilstein J. Org. Chem. 2026, 22, 753–762, doi:10.3762/bjoc.22.57

• characterization of new brassinosteroid (BR) analogs, in which substituents with different electronegativities and molecular sizes have been attached to a C-22 benzoate function, are described. The biological activities of all new compounds were evaluated by using the rice lamina inclination test (RLIT) and

• dihydroxylation of double bond on C-2 of compounds 23–28, following a described procedure [29], leads to BR analogs 17–22 with good reaction yields (63.4–84.9%) (Scheme 1). Structural characterization of BR analogs 17–22 was accomplished by using 13C NMR data, combined with 2D NMR techniques (HSQC and HMBC). For

Rongalite addition to dienones: diastereoselectivity in cyclic sulfone synthesis; stereochemical rationalization and prospects as a general conjugate nucleophile

• Melina Goga,
• Hao Zong,
• James Franco,
• Jazmine Prana,
• Rudolph Michel,
• Antonia Muro,
• Elana Rubin,
• Janet Brenya,
• Henk Eshuis and
• Magnus W. P. Bebbington

Beilstein J. Org. Chem. 2026, 22, 742–752, doi:10.3762/bjoc.22.56

• unknown products. Typical signals for the trans-product could be seen in the crude 1H NMR spectrum, but we were not able to isolate this compound in sufficient purity for characterization. We were intrigued to study the cyclooctanone-derived substrate 17 [41], as it would give an interesting bicyclic

Anti-invasive and cytotoxic evaluation of a (+)-pinoresinol-based semisynthetic library against glioblastoma

• Chen Zhang,
• Kah Yean Lum,
• Jonathan M. White,
• Paul I. Forster,
• Nicholas Booth,
• Sunita A. Ramesh and
• Rohan A. Davis

Beilstein J. Org. Chem. 2026, 22, 691–704, doi:10.3762/bjoc.22.54

• reported. In this study, we chemically investigated the seeds of Eremophila maculata for the first time, which led to the isolation and characterization of two known plant metabolites, (+)-salicifoliol and (+)-pinoresinol. Due to the reported biological properties of the lignan natural product

• reaction using N-bromosuccinimide (NBS) in CH2Cl2 at room temperature (1 h), we produced 5 as a single enantiomer (i.e., (+)-5,5'-dibromopinoresinol). Herein, we report the full spectroscopic and spectrometric characterization of this molecule. Furthermore, analogues 6 and 7 are new semisynthetic molecules

• ), which enabled the absolute configuration of 3 to be assigned as 7S,8R,7'S,8'R. Moreover, this is the first report of a crystal structure of (+)-eudesmin (3). In 2015, Lu et al. reported the purification and full characterization of both enantiomers of eudesmin from Acorus tatarinowii, along with the X

Regioselective approach to 5-arylsulfonylisoxazoles and their antimicrobial activity

• Artem S. Sazonov,
• Dmitry A. Vasilenko,
• Denis V. Porfiriev,
• Yuri K. Grishin,
• Rimma A. Gazzaeva,
• Alisa P. Chernyshova,
• Maxim A. Kryakvin,
• Anna A. Baranova,
• Vera A. Alferova and
• Elena B. Averina

Beilstein J. Org. Chem. 2026, 22, 592–602, doi:10.3762/bjoc.22.45

• conditions. MIC (μg/mL) against bacterial and fungal lines. Supporting Information Supporting Information File 8: General synthetic and biological procedures, characterization data and copies of 1H, 13C{1H}, 19F, 31P, 1H-13C HSQC, 1H-13C HMBC NMR spectra, HRMS spectra and the results of the elemental

Molecular tweezer–peptide conjugates disrupt the protein–protein interaction between survivin and histone H3 essential in mitosis

• Catherine Gsell,
• Philipp Rebmann,
• Karina Opara,
• Christine Beuck,
• Peter Bayer,
• David Bier,
• Ingrid R. Vetter and
• Thomas Schrader

Beilstein J. Org. Chem. 2026, 22, 557–567, doi:10.3762/bjoc.22.41

• lyophilization, the product 2a was obtained as fully protonated TFA salt (43%); deprotonation with equimolar aq. NaOH produced the sodium salt of 2a quantitatively. The analytical characterization of 2a turned out to be difficult, because even in DMSO-d6, most NMR signals remained very broad, and in part

Experimental and DFT studies on the regioselective methanolysis of 5-azido-9-oxabicyclo[6.1.0]nonan-4-yl 4-nitrobenzoate isomers

• İlknur Polat,
• Selçuk Eşsiz and
• Emine Salamci

Beilstein J. Org. Chem. 2026, 22, 547–556, doi:10.3762/bjoc.22.40

• regioselective methanolysis of new azido-4-nitrobenzoate epoxycyclooctane isomers and the characterization of the resulting products are described herein. Firstly, treatment of key compound 8-azidocyclooct-4-en-1-ol with 4-nitrobenzoyl chloride followed by an epoxidation reaction and then methanolysis of the

• ring-opening reaction of the epoxides 9 with HCl(g) in MeOH resulted in the formation of chlorohydrin-azidobenzoate isomers 10 and 11 in a total yield of 96% (Scheme 2). Then, for full characterization of the structures of the obtained products, the mixture of chlorohydrins was converted into the

Synthesis and uranyl(VI) extraction performance of a calix[4]pyrrole–tetrahydroxamic acid receptor

• Sara Karnib,
• Rana Baydoun,
• Wissam Zaidan,
• Nancy AlHaddad,
• Omar El Samad,
• Bilal Nsouli,
• Francine Cazier-Dennin and
• Pierre-Edouard Danjou

Beilstein J. Org. Chem. 2026, 22, 486–494, doi:10.3762/bjoc.22.36

• capable of remediating uranium from aqueous environments [38][39]. Results and Discussion PCP HA synthesis and characterization Various strategies have been developed for the synthesis of hydroxamic acid derivatives over the years [40]. Classical and most popular routes involve the direct reaction of

• industrial effluent remediation or for the challenging task of uranium extraction from seawater [79]. Experimental Detailed synthetic procedures, compound characterization (1H and 13C NMR, HRMS), and uranyl extraction protocols, including pH and ligand-to-metal ratio studies, are described in Supporting

Synthesis of a HDAC inhibitor–nanogold probe for cryo-EM visualization in class I HDAC co-repressor complexes

• Wiktoria A. Pytel,
• John W. R. Schwabe and
• James T. Hodgkinson

Beilstein J. Org. Chem. 2026, 22, 480–485, doi:10.3762/bjoc.22.35

• to rt, 18 h, 92%; l) Au–NH2, DMSO, rt, 20 h. Supporting Information Supporting Information File 4: Chemical protocols and characterization data for compounds, biological protocols including cryo-EM grid prep, data collection, and images of micrographs. Acknowledgements We thank Dr. Christos Savva