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Search for "direct functionalization" in Full Text gives 37 result(s) in Beilstein Journal of Organic Chemistry.
Recent advances in C(sp3)–H bond functionalization via metal–carbene insertions
Beilstein J. Org. Chem. 2016, 12, 796–804, doi:10.3762/bjoc.12.78
- –carbene; site-selectivity; Introduction Direct functionalization of inactivated C–H bonds, especially C(sp3)–H bonds, have attracted significant attentions in recent years. The C(sp3)–H bond activation strategies based on radical reactions and transition metal catalysis have been explored, alongside the
Iridium/N-heterocyclic carbene-catalyzed C–H borylation of arenes by diisopropylaminoborane
Beilstein J. Org. Chem. 2016, 12, 654–661, doi:10.3762/bjoc.12.65
- borylation; iridium; N-heterocyclic carbene; Introduction Catalytic C–H borylation of arenes has become an essential tool in organic synthesis [1]. The eminent features of this methodology include 1) no directing group is needed, allowing the direct functionalization of simple arenes; 2) the
Recent advances in copper-catalyzed C–H bond amidation
Beilstein J. Org. Chem. 2015, 11, 2209–2222, doi:10.3762/bjoc.11.240
- ideal model of modern organic synthesis, the direct functionalization of inactivated C–H bonds has been proved to be a promising tool to enable atom and step economical synthesis. Inspired by the splendid advances that have taken place in the chemistry of C–H activation, the synthesis of amides has
Lewis acid-catalyzed redox-neutral amination of 2-(3-pyrroline-1-yl)benzaldehydes via intramolecular [1,5]-hydride shift/isomerization reaction
Beilstein J. Org. Chem. 2014, 10, 2892–2896, doi:10.3762/bjoc.10.306
- used for the activation of C–H bonds [11][12][13][14][15][16][17][18]. Among the reported transformations, intramolecular redox processes based on direct functionalization of C(sp3)–H bonds linking with α heteroatoms are useful for the synthesis of structurally diverse amines and ether derivatives [19
Exploration of C–H and N–H-bond functionalization towards 1-(1,2-diarylindol-3-yl)tetrahydroisoquinolines
Beilstein J. Org. Chem. 2014, 10, 2186–2199, doi:10.3762/bjoc.10.226
- wanted to use direct functionalization either via C–H activation or cross dehydrogenative coupling for C–C-bond-forming reactions avoiding the use of two prefunctionalized building blocks. Naturally, C–N-bond formation should proceed via Buchwald–Hartwig coupling. The target molecules can be considered
Zinc–gold cooperative catalysis for the direct alkynylation of benzofurans
Beilstein J. Org. Chem. 2013, 9, 1763–1767, doi:10.3762/bjoc.9.204
- successful in the case of the more complex drug 8-methoxypsoralen (8-MOP). Keywords: alkynylation; benzofurans; cooperative catalysis; direct functionalization; gold catalysis; hypervalent iodine; Introduction Benzofurans are important heterocycles frequently encountered in both bioactive compounds and
Aerobic radical multifunctionalization of alkenes using tert-butyl nitrite and water
Beilstein J. Org. Chem. 2013, 9, 1713–1717, doi:10.3762/bjoc.9.196
- useful methods because they can provide a shortcut to desired products. Various methods used widely, such as organometallic reactions, cycloaddition reactions and multicomponent reactions, are utilized for multifunctionalization [1][2][3][4][5]. If direct functionalization reactions of inactivated bonds
Arylglycine-derivative synthesis via oxidative sp3 C–H functionalization of α-amino esters
Beilstein J. Org. Chem. 2012, 8, 1564–1568, doi:10.3762/bjoc.8.178
- reported the copper-catalyzed oxidative coupling reaction of alkynes with tertiary amine N-oxides [15]. This new strategy for the direct functionalization of sp3 C–H bonds adjacent to a nitrogen atom, via tertiary amine N-oxide intermediates, was successfully applied to the coupling reaction of ethyl 2
- -(disubstituted amino)acetates with indoles to achieve indolylglycine derivatives (Scheme 2, reaction 1) [16]. In the course of our continuous research on the direct functionalization of sp3 C–H bonds, we found that this new strategy could also be applied to the coupling reaction of naphthols and phenols with
C2-Alkylation of N-pyrimidylindole with vinylsilane via cobalt-catalyzed C–H bond activation
Beilstein J. Org. Chem. 2012, 8, 1536–1542, doi:10.3762/bjoc.8.174
- efficient and regioselective functionalization of indole derivatives [4][5][6]. Over the past decade, transition-metal-catalyzed direct functionalization has emerged as a powerful strategy for the direct introduction of aryl and alkenyl groups to the C2 and C3 positions of indole [7][8][9]. The situation is
Directed ortho,ortho'-dimetalation of hydrobenzoin: Rapid access to hydrobenzoin derivatives useful for asymmetric synthesis
Beilstein J. Org. Chem. 2011, 7, 1315–1322, doi:10.3762/bjoc.7.154
- associated with their optical enrichment [6], and the necessary determination of optical purity for each derivative, all complicate the rapid preparation of congeneric libraries. To address these issues, we recently reported a new process for the direct functionalization of (R,R)-hydrobenzoin (3) [23
- with the reported synthesis and should be effective for the rapid production of new ligands for asymmetric synthesis. Conclusion In conclusion, an efficient and economical process was developed for the direct functionalization of hydrobenzoin that relies on a directed ortho,ortho'-dimetalation strategy
Recent advances in the gold-catalyzed additions to C–C multiple bonds
Beilstein J. Org. Chem. 2011, 7, 897–936, doi:10.3762/bjoc.7.103
One-pot gold-catalyzed synthesis of 3-silylethynyl indoles from unprotected o-alkynylanilines
Beilstein J. Org. Chem. 2011, 7, 565–569, doi:10.3762/bjoc.7.65
- to carry out (RT, and requires neither an inert atmosphere nor special solvents). Keywords: alkynylation; direct functionalization; gold; hypervalent iodine; indoles; Introduction Indoles are widespread in both natural products and synthetic drugs [1][2] and as a result, their synthesis and
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