Controlled synthesis of poly(3-hexylthiophene) in continuous flow

• Helga Seyler,
• Jegadesan Subbiah,
• David J. Jones,
• Andrew B. Holmes and
• Wallace W. H. Wong

Beilstein J. Org. Chem. 2013, 9, 1492–1500, doi:10.3762/bjoc.9.170

• following device geometry: ITO/PEDOT:PSS/P3HT:PC61BM (1:1)/ZnO nanoparticle/Al, where ITO = indium tin oxide, PEDOT:PSS = poly(3,4-ethylenedioxy-thiophene):poly(styrenesulfonate) and PC61BM = [6,6]-phenyl-C61-butyric acid methyl ester (Figure 5a). The P3HT:PC61BM active layer was deposited by spin coating

A³-Coupling catalyzed by robust Au nanoparticles covalently bonded to HS-functionalized cellulose nanocrystalline films

• Jian-Lin Huang,
• Derek G. Gray and
• Chao-Jun Li

Beilstein J. Org. Chem. 2013, 9, 1388–1396, doi:10.3762/bjoc.9.155

• coupled plasma (ICP) analytical techniques. Both the HS-CNC and the Au sponge were inactive, implying that the Au is the active site and that the controlling of Au nanoparticle size is essential for the present reactions. The catalytic activity first increased with the increase of the Au loading up to 4.4

• diminish the environmental impact of such reactions. Other immobilized metallic nanoparticle catalysts could also be designed based on the present method, which offered more opportunities for greener organic synthesis. Au4f and S2p XPS spectra of the Au@HS-CNC (4.4 mol %) catalyst. TEM pictures of the HS

C–C Bond formation catalyzed by natural gelatin and collagen proteins

• Dennis Kühbeck,
• Basab Bijayi Dhar,
• Eva-Maria Schön,
• Carlos Cativiela,
• Vicente Gotor-Fernández and
• David Díaz Díaz

Beilstein J. Org. Chem. 2013, 9, 1111–1118, doi:10.3762/bjoc.9.123

• degree of deamidation of glutamine and asparagine. Besides traditional applications in the food industry, gelatin has also gained attention in the scientific community as a reducing ligand and supporting media for the preparation of uniform metal nanoparticle catalysts [2][3][4]. In addition, the average

Self-assembled organic–inorganic magnetic hybrid adsorbent ferrite based on cyclodextrin nanoparticles

• Ângelo M. L. Denadai,
• Frederico B. De Sousa,
• Joel J. Passos,
• Fernando C. Guatimosim,
• Kirla D. Barbosa,
• Ana E. Burgos,
• Fernando Castro de Oliveira,
• Jeann C. da Silva,
• Bernardo R. A. Neves,
• Nelcy D. S. Mohallem and
• Rubén D. Sinisterra

Beilstein J. Org. Chem. 2012, 8, 1867–1876, doi:10.3762/bjoc.8.215

• level up to the aggregate particles, are shown in Figure 2a and Figure 2b. In addition, the TEM image for the Fe-Ni/Zn/βCD showed aligned structures in the nanoparticle matrix, which can correspond to the assembled βCD structures in the MHM. These lamellar self-assembled structures are similar to the

Cyclodextrin nanosponge-sensitized enantiodifferentiating photoisomerization of cyclooctene and 1,3-cyclooctadiene

• Wenting Liang,
• Cheng Yang,
• Masaki Nishijima,
• Gaku Fukuhara,
• Tadashi Mori,
• Andrea Mele,
• Franca Castiglione,
• Fabrizio Caldera,
• Francesco Trotta and
• Yoshihisa Inoue

Beilstein J. Org. Chem. 2012, 8, 1305–1311, doi:10.3762/bjoc.8.149

• the steric hindrance in the network polymer and/or the less efficient complexation inside the nanoparticle of CDNS would be responsible. The circular dichroism spectral changes observed for the more cross-linked CDNSs 4 and 5 upon binding 1Z or 2ZZ were too small to allow quantitative evaluation of

Control over molecular motion using the cis–trans photoisomerization of the azo group

• Estíbaliz Merino and
• María Ribagorda

Beilstein J. Org. Chem. 2012, 8, 1071–1090, doi:10.3762/bjoc.8.119

• devices. The idea is to anchor a functionalized azobenzene inside the silica nanoparticle, thereby forming light-activated mesostructured silica nanoparticles. The azobenzene 16 is anchored to the particle wall while the other extreme is free (Figure 16) [125][126][127]. These nanoparticles have pores

• incubated again in the dark for 48 hours. This experiment shows that the azobenzene units located within the LAMs (CPT) act as promoters (Figure 16), releasing the drug (CPT) only after irradiation of the nanoparticle with a light at a certain wavelength, hence resulting in cell death. The number of

Cyanoethylation of the glucans dextran and pullulan: Substitution pattern and formation of nanostructures and entrapment of magnetic nanoparticles

• Kathrin Fiege,
• Heinrich Lünsdorf,
• Sevil Atarijabarzadeh and
• Petra Mischnick

Beilstein J. Org. Chem. 2012, 8, 551–566, doi:10.3762/bjoc.8.63

• were fixed with strong magnets and washed with distilled water. Monodisperse and regularly shaped iron oxide nanoparticles were obtained as shown by TEM (Figure 9). The iron concentration of the nanoparticle dispersion, as analyzed with inductively coupled plasma optical emission spectroscopy (ICP–OES

• . According to the micrographs, the morphology of the cyanoethyl nanoparticles can be considered as spherical. Representative SEM pictures of CEP-3 + Fe-np (Table 3, entry 2) are shown in Figure 10. The influence of different amounts of ferromagnetic nanoparticle dispersion was investigated (10–200 μL or

• , pump speed 20 rps). Atom emission lines: ion emission lines: 234.350/238.204/239.563/259.940/260.709/261.187 nm, and internal reference line: Ar, 470.067 nm. Sample preparation: 0.408 g iron nanoparticle dispersion was dissolved by adding 5 mL HCl (37%) and subsequently diluted to 100 mL with

Liquid-crystalline nanoparticles: Hybrid design and mesophase structures

• Gareth L. Nealon,
• Romain Greget,
• Cristina Dominguez,
• Zsuzsanna T. Nagy,
• Daniel Guillon,
• Jean-Louis Gallani and
• Bertrand Donnio

Beilstein J. Org. Chem. 2012, 8, 349–370, doi:10.3762/bjoc.8.39

• addressable 2-D and 3-D arrangements exhibiting high processability and self-healing properties. Herein, we review the developments in the field of discrete thermotropic liquid-crystalline nanoparticle hybrids, with special emphasis on the relationship between the nanoparticle morphology and the nature of the

• organic ligand coating and their resulting phase behaviour. Mechanisms proposed to explain the supramolecular organisation of the mesogens within the liquid-crystalline phases are discussed. Keywords: hybrid; liquid crystal; mesogen; mesomorphism; mesophase; nanoparticle; self-organisation; supramolecule

• molecular machines and devices, with dimensions on the order of atoms and molecules, capable of performing specific predetermined tasks [2]. At the core of this nanotechnology revolution lies the nanoparticle (NP), the most common of which being metallic particles (including alloys and oxides) with at least

Sexithiophenes as efficient luminescence quenchers of quantum dots

• Christopher R. Mason,
• Yang Li,
• Paul O’Brien,
• Neil J. Findlay and
• Peter J. Skabara

Beilstein J. Org. Chem. 2011, 7, 1722–1731, doi:10.3762/bjoc.7.202

• represents molecules with (1a,b) and without (2a,b) a Lewis base functionality for quantum-dot surface coordination, with a view to determining whether structural complexity is required to achieve nanoparticle–sexithiophene electronic interactions. Results and Discussion Synthesis The preparation of

Continuous preparation of carbon-nanotube-supported platinum catalysts in a flow reactor directly heated by electric current

• Alicja Schlange,
• Antonio Rodolfo dos Santos,
• Ulrich Kunz and
• Thomas Turek

Beilstein J. Org. Chem. 2011, 7, 1412–1420, doi:10.3762/bjoc.7.165

• average cluster size resulting in lower electrocatalytic activity, as reported by [21]. The microemulsion method allows for better control of the nanoparticle size and distribution in comparison to the impregnation method. Disadvantages of this method are the high cost of the used surfactants and their

Scaling up of continuous-flow, microwave-assisted, organic reactions by varying the size of Pd-functionalized catalytic monoliths

• Ping He,
• Stephen J. Haswell,
• Paul D. I. Fletcher,
• Stephen M. Kelly and
• Andrew Mansfield

Beilstein J. Org. Chem. 2011, 7, 1150–1157, doi:10.3762/bjoc.7.133

• interactions and substitution of Cl by silanol groups present on the monolith surface, resulting in highly stable nanoparticle fixation [26][27]. The presence of a strong specific metal/support interaction is also supported by observations made during the impregnation process, where PdCl42− uptake in the

Nano copper oxide catalyzed synthesis of symmetrical diaryl sulfides under ligand free conditions

• K. Harsha Vardhan Reddy,
• V. Prakash Reddy,
• A. Ashwan Kumar,
• G. Kranthi and
• Y.V.D. Nageswar

Beilstein J. Org. Chem. 2011, 7, 886–891, doi:10.3762/bjoc.7.101

• recyclable copper oxide nanoparticle-catalyzed cross-coupling of aryl halides with potassium thiocyanate [46][47][48][49][50][51]. Initially, the reaction between potassium thiocyanate and iodobenzene was selected as the model reaction for optimizing the reaction conditions involving various copper sources

Olefin metathesis in nano-sized systems

• Didier Astruc,
• Abdou K. Diallo,
• Sylvain Gatard,
• Liyuan Liang,
• Cátia Ornelas,
• Victor Martinez,
• Denise Méry and
• Jaime Ruiz

Beilstein J. Org. Chem. 2011, 7, 94–103, doi:10.3762/bjoc.7.13

• performing RCM of branches and then to remove the core has also been applied by the Peng group to produce nanoparticle-cored dendrimers [48][49][50][51]. Dendrimers have been synthesized by reaction sequences involving hydrosilylation of olefin-terminated dendrimer cores followed by Williamson reactions with

ROMP-Derived cyclooctene-based monolithic polymeric materials reinforced with inorganic nanoparticles for applications in tissue engineering

• Franziska Weichelt,
• Solvig Lenz,
• Stefanie Tiede,
• Ingrid Reinhardt,
• Bernhard Frerich and
• Michael R. Buchmeiser

Beilstein J. Org. Chem. 2010, 6, 1199–1205, doi:10.3762/bjoc.6.137

• the nanoparticle type and content. Moreover, the reinforced monoliths were tested for the possible use as scaffold materials in tissue engineering, by carrying out cell cultivation experiments with human adipose tissue-derived stromal cells. Keywords: hybrid materials; monoliths; nanoparticles; ring

• be biocompatible [7]. SEM images of the nanoparticle-reinforced monolithic materials revealed an increase of the pore sizes with increasing nanoparticle content. An increase of the pore size from 10–30 µm (for monoliths without any inorganic component) up to 25–70 µm was observed with the addition of

• the nanoparticle content and type is advantageous and may allow for an alleviated cell attachment as well as ingrowth of living cells on the scaffold materials. Due to the OH groups present at its surface, HAp is more polar than CaCO3 and thus affects the pore formation process more strongly

Hybrid biofunctional nanostructures as stimuli-responsive catalytic systems

• Gernot U. Marten,
• Thorsten Gelbrich and
• Annette M. Schmidt

Beilstein J. Org. Chem. 2010, 6, 922–931, doi:10.3762/bjoc.6.98

• nanoparticle cores with a thermoresponsive poly[oligo(ethylene glycol) methyl ether methacrylate] copolymer shell [17][18][33][34] and covalently attached protease trypsin as the biocatalytically active species. A reversible shell collapse at elevated temperatures is made responsible for significantly enhanced

• is observed over time for different substrate concentrations cBAPNA. A410 is directly correlated to the p-nitroaniline concentration, thus the reaction rate v = d[P]/dt can be obtained from the initial slopes [2]. As a control experiment the primarily FeOx@P(O8M´84S8) nanoparticle dispersion without

• desired temperature. The respective BAPNA solution was added to a cuvette and mixed with 100 μL of FeOx@POEGMA-trypsin nanoparticle dispersion or with 50 μL trypsin solution. The cuvette was placed into the spectrophotometer and tempered. Starting with the addition of the enzyme, the change in absorption

Symmetry breaking and structure of a mixture of nematic liquid crystals and anisotropic nanoparticles

• Marjan Krasna,
• Matej Cvetko and
• Milan Ambrožič

Beilstein J. Org. Chem. 2010, 6, No. 74, doi:10.3762/bjoc.6.74

• past decade has witnessed an increased interest in the study of two-component mixtures consisting of nanoparticles (NPs) in a host material [1][2][3][4][5]. A characteristic feature of a nanoparticle is that at least one of its dimensions is of the order of nanometers. Such systems are expected to play

• by low binding energies and high temperatures. In order to discern the influence of geometrical details of NPs we consider dilute mixtures, where holds, where φ is the volume fraction of NPs and vNP (i.e., vLC) is the volume of an average nanoparticle (i.e., LC molecule). Therefore, the upper volume

• anchoring at the NP–LC interface of elongated NPs providing that Wd/K > 1. Here W is the anchoring strength, K is the characteristic nematic elastic constant and d is the length of a nanoparticle. We typically consider ensembles of N = 80 × 80 × 80 elements (i.e., LC molecules and NPs). In simulations we

New amphiphilic glycopolymers by click functionalization of random copolymers – application to the colloidal stabilisation of polymer nanoparticles and their interaction with concanavalin A lectin

• Otman Otman,
• Paul Boullanger,
• Eric Drockenmuller and
• Thierry Hamaide

Beilstein J. Org. Chem. 2010, 6, No. 58, doi:10.3762/bjoc.6.58

• -22), 66.93 (C-14), 62.05 (C-24), 58.07 (C-10), 50.65 (C-13), 48.40 (C-1), 40.04 (C-7), 35.00 (C-2), 31.48 (C-4), 26.00–26.50 (C-6, C-8), 18.27 (C-3). Nanoparticle formation Ethyl acetate and water were contacted for 2 h in order to obtain mutually saturated solutions. Polycaprolactone (80000 g/mol

• emulsified by sonication (ultrasonic processor Vibra Cell VCX-750) for 2 min at 525 W. De-ionized water (175 mL) was then added while stirring the solution at 700–800 rpm. The nanoparticle suspension was then concentrated at atmospheric pressure to 30–35 mL by stirring and heating to 70–80 °C. The sizes of

• containing D-mannose with con A In a 20 mL flask, 8.7 mg of concanavalin A was dissolved without stirring in 10 mL of phosphate-buffered saline (PBS, pH = 6.8, 0.1 M) over 16 hours. The flask was then stored at 4 °C. The nanoparticle stock solution (200 mg of dry matter in 3.5 mL H2O) was diluted in PBS and