Small protein sequences can induce cellular uptake of complex nanohybrids

• Jan-Philip Merkl,
• Malak Safi,
• Christian Schmidtke,
• Fadi Aldeek,
• Johannes Ostermann,
• Tatiana Domitrovic,
• Sebastian Gärtner,
• John E. Johnson,
• Horst Weller and
• Hedi Mattoussi

Beilstein J. Nanotechnol. 2019, 10, 2477–2482, doi:10.3762/bjnano.10.238

• nanostructures made of more than one component nanomaterial, combined with biomolecules is a highly sought goal in biomedical science, and can find applications in multimodal imaging and therapeutics [1][2]. Although interest in developing such hybrid nanostructures by, for example, combining plasmonic and

Coating of upconversion nanoparticles with silica nanoshells of 5–250 nm thickness

• Cynthia Kembuan,
• Maysoon Saleh,
• Bastian Rühle,
• Ute Resch-Genger and
• Christina Graf

Beilstein J. Nanotechnol. 2019, 10, 2410–2421, doi:10.3762/bjnano.10.231

• be similarly necessary for applications in plasmonics or chemical sensing [20][21]. One of the most versatile ways to protect the surface of NP, making hydrophobic particle surfaces hydrophilic and simultaneously providing functional groups for subsequent covalent attachment of, e.g., biomolecules

• the UCL emission spectra. This stepwise shell growth can most likely be also utilized for the coating of other NPs with similar hydrophobic surface chemistries of the initial particles such as iron oxide NPs or semiconductor NPs. Further applications can include the covalent attachment of biomolecules

Use of data processing for rapid detection of the prostate-specific antigen biomarker using immunomagnetic sandwich-type sensors

• Camila A. Proença,
• Tayane A. Freitas,
• Thaísa A. Baldo,
• Elsa M. Materón,
• Flávio M. Shimizu,
• Gabriella R. Ferreira,
• Frederico L. F. Soares,
• Ronaldo C. Faria and
• Osvaldo N. Oliveira Jr.

Beilstein J. Nanotechnol. 2019, 10, 2171–2181, doi:10.3762/bjnano.10.210

• magnetism than other iron oxide nanoparticles [17]. These MNPs can be synthesized through various techniques, such as ultrasound irradiation, sol–gel methods, thermal decomposition, and co-precipitation [18][19][20][21]. In addition, they can be modified with biomolecules and other compounds to improve the

• polymer-based immunosensor [34][55]. This rather low value is expected for biosensors where the index n is characteristic of heterogeneous adsorption with polyclonal biomolecules that have many active sites with different degrees of affinity and selectivity. Application of the immunosensor in real samples

Nitrogen-vacancy centers in diamond for nanoscale magnetic resonance imaging applications

• Alberto Boretti,
• Lorenzo Rosa,
• Jonathan Blackledge and
• Stefania Castelletto

Beilstein J. Nanotechnol. 2019, 10, 2128–2151, doi:10.3762/bjnano.10.207

• ultrashort 10 ms acquisition times in sub-nanomolar amounts of Gd spins. The photobleaching and blinking issues of NV are addressed in [27] by use of fluorescent ND (FND), which has an extremely high NV center concentration. Their lifetimes are longer than fluorescent biomolecules, and the emission can be

Review of advanced sensor devices employing nanoarchitectonics concepts

• Katsuhiko Ariga,
• Tatsuyuki Makita,
• Masato Ito,
• Taizo Mori,
• Shun Watanabe and
• Jun Takeya

Beilstein J. Nanotechnol. 2019, 10, 2014–2030, doi:10.3762/bjnano.10.198

• . Placing such water-insoluble receptor molecules at a water-contacting interface is crucial to sense water-soluble substances such as important biomolecules. Not limited to this technical requirement, interfacial media have the benefit to greatly enhance molecular recognition capability [146][147

• biomolecules including amino acids [156], peptides [157][158][159], sugars [160][161], nucleic acid bases [162][163], and nucleotides [164][165][166] at well-designed interfacial environments. In order to design and fabricate sensors with better performance, interfacial nanoarchitectonics should be crucial

Toxicity and safety study of silver and gold nanoparticles functionalized with cysteine and glutathione

• Barbara Pem,
• Igor M. Pongrac,
• Lea Ulm,
• Ivan Pavičić,
• Valerije Vrček,
• Darija Domazet Jurašin,
• Marija Ljubojević,
• Adela Krivohlavek and
• Ivana Vinković Vrček

Beilstein J. Nanotechnol. 2019, 10, 1802–1817, doi:10.3762/bjnano.10.175

• circulation via different routes [40][41][42][43]. Absorbed or intravenously applied NPs will accumulate in different body compartments [44][45][46]. AgNPs are prone to oxidative dissolution in biological media and the released Ag+ reacts with thiolate groups of sulfur-containing biomolecules [47], which may

Biocatalytic oligomerization-induced self-assembly of crystalline cellulose oligomers into nanoribbon networks assisted by organic solvents

• Yuuki Hata,
• Yuka Fukaya,
• Toshiki Sawada,
• Masahito Nishiura and
• Takeshi Serizawa

Beilstein J. Nanotechnol. 2019, 10, 1778–1788, doi:10.3762/bjnano.10.173

• harmonization of mutual interactions [1][2][3][4][5][6][7][8][9][10][11]. Such harmonized mechanisms are found ubiquitously in biological systems consisting of a huge number of components; biomolecules, such as DNAs and peptides, and even living cells have therefore attracted considerable attention in

Materials nanoarchitectonics at two-dimensional liquid interfaces

• Katsuhiko Ariga,
• Michio Matsumoto,
• Taizo Mori and
• Lok Kumar Shrestha

Beilstein J. Nanotechnol. 2019, 10, 1559–1587, doi:10.3762/bjnano.10.153

• bottom-up approaches are self-assembly and self-organization based on supramolecular chemistry [69]. These supramolecular mechanisms can be widely observed in various species including small molecules, nanomaterials, and biomolecules [70][71][72][73][74][75]. Despite this generality, there are still many

A silver-nanoparticle/cellulose-nanofiber composite as a highly effective substrate for surface-enhanced Raman spectroscopy

• Yongxin Lu,
• Yan Luo,
• Zehao Lin and
• Jianguo Huang

Beilstein J. Nanotechnol. 2019, 10, 1270–1279, doi:10.3762/bjnano.10.126

• ][58][59]. The SERS substrate was also applied to monitor the molecular recognition through multiple hydrogen bonds between adenosine and thymidine. This paper-based SERS substrate could hold potential in the detection of trace amounts of analytes and for the spectroscopic study of biomolecules

• hydrogen bonds between nucleosides to test its potential in monitoring biomolecules. Figure 6 shows the Raman spectra obtained from adenosine and thymidine, measured before and after the molecular recognition between the two nucleosides on the substrate. Compared to the Raman spectra of the powder samples

Scavenging of reactive oxygen species by phenolic compound-modified maghemite nanoparticles

• Małgorzata Świętek,
• Yi-Chin Lu,
• Rafał Konefał,
• Liliana P. Ferreira,
• M. Margarida Cruz,
• Yunn-Hwa Ma and
• Daniel Horák

Beilstein J. Nanotechnol. 2019, 10, 1073–1088, doi:10.3762/bjnano.10.108

• , targeting tumor sites using an external magnetic field, MRI contrast agents, or magnetic hyperthermia. Under physiological conditions, the nanoparticle surface is exposed to the action of biomolecules, oxygen, peroxides, and radicals, which changes particle properties and behavior. Moreover, Fe2+ ions can

Enhanced inhibition of influenza virus infection by peptide–noble-metal nanoparticle conjugates

• Zaid K. Alghrair,
• David G. Fernig and
• Bahram Ebrahimi

Beilstein J. Nanotechnol. 2019, 10, 1038–1047, doi:10.3762/bjnano.10.104

• allows for the detection at very low levels, using a range of approaches, from absorbance [17][18] to photothermal microscopy [19] and various extensions of the latter [20][21]. Noble-metal nanoparticles can be passivated and functionalised with biomolecules such that they possess the biological

Serum type and concentration both affect the protein-corona composition of PLGA nanoparticles

• Katrin Partikel,
• Robin Korte,
• Dennis Mulac,
• Hans-Ulrich Humpf and
• Klaus Langer

Beilstein J. Nanotechnol. 2019, 10, 1002–1015, doi:10.3762/bjnano.10.101

• ]. Nevertheless, FBS is still widely used as protein source for the investigation of the reaction at the interface between NPs and biomolecules [14][18]. Consequently, we propose to examine the protein corona formation in the respective medium of the desired species (e.g., murine or human) for a better prediction

Polydopamine-coated Au nanorods for targeted fluorescent cell imaging and photothermal therapy

• Boris N. Khlebtsov,
• Andrey M. Burov,
• Timofey E. Pylaev and
• Nikolai G. Khlebtsov

Beilstein J. Nanotechnol. 2019, 10, 794–803, doi:10.3762/bjnano.10.79

• ], Fe3O4 [35], graphene [36], and many others [37][38]. The PDA shell surface contains numerous catechol and quinone groups suitable for click conjugation with various biomolecules through Michael addition and Schiff-base reaction [39][40]. The high loading capacity and biocompatibility of the PDA layer

Mechanical and thermodynamic properties of Aβ₄₂, Aβ₄₀, and α-synuclein fibrils: a coarse-grained method to complement experimental studies

• Adolfo B. Poma,
• Horacio V. Guzman,
• Mai Suan Li and
• Panagiotis E. Theodorakis

Beilstein J. Nanotechnol. 2019, 10, 500–513, doi:10.3762/bjnano.10.51

• experimental observations. Keywords: β-amyloid; atomic force microscopy, mechanical deformation; molecular simulation; proteins; α-synuclein; Introduction All-atom molecular dynamics (MD) simulations have been employed to study the physical and chemical behaviour of the fundamental biomolecules of life (e.g

• ], AFM base-force spectroscopy [51], or by the design of sophisticated microelectromechanical systems (MEMS) [52]. These techniques have been successfully used to predict the elastic properties of several biomolecules. However, OT are limited to applied loads below 0.1 nN and AFM has delicate calibration

• range of applications of AFM technique span from biomolecules to single cells [31][56][57]. The AFM nanoindentation force–distance curves typically depend on the correct determination of the cantilever stiffness and only measurements of biological fibrils located at the centre of the fibril are

Surface plasmon resonance enhancement of photoluminescence intensity and bioimaging application of gold nanorod@CdSe/ZnS quantum dots

• Siyi Hu,
• Yu Ren,
• Yue Wang,
• Jinhua Li,
• Junle Qu,
• Liwei Liu,
• Hanbin Ma and
• Yuguo Tang

Beilstein J. Nanotechnol. 2019, 10, 22–31, doi:10.3762/bjnano.10.3

• and they show excellent quantum confinement for charge carrier and lattice mismatch. In such cases, the energy range of the QDs depends on the relative conduction and valence band offsets for the two materials, and this characteristic can enable many chemical materials or biomolecules to conjugate

The nanoscaled metal-organic framework ICR-2 as a carrier of porphyrins for photodynamic therapy

• Jan Hynek,
• Sebastian Jurík,
• Martina Koncošová,
• Jaroslav Zelenka,
• Ivana Křížová,
• Tomáš Ruml,
• Kaplan Kirakci,
• Ivo Jakubec,
• František Kovanda,
• Kamil Lang and
• Jan Demel

Beilstein J. Nanotechnol. 2018, 9, 2960–2967, doi:10.3762/bjnano.9.275

• internalisation by cells [18]. Moreover, the downsizing of MOFs also facilitates the diffusion of O2(1∆g), and makes interactions with bulky biomolecules inside the cells more effective. This concept was successfully applied using the UiO-66 family of MOFs: nanoparticles made of Hf6-based SBUs with dicarboxylic

Charged particle single nanometre manufacturing

• Philip D. Prewett,
• Cornelis W. Hagen,
• Claudia Lenk,
• Steve Lenk,
• Marcus Kaestner,
• Tzvetan Ivanov,
• Ahmad Ahmad,
• Ivo W. Rangelow,
• Xiaoqing Shi,
• Stuart A. Boden,
• Alex P. G. Robinson,
• Dongxu Yang,
• Sangeetha Hari,
• Marijke Scotuzzi and
• Ejaz Huq

Beilstein J. Nanotechnol. 2018, 9, 2855–2882, doi:10.3762/bjnano.9.266

• example, is interesting for the localisation and analysis of biomolecules. Miyazoe [91] used a conventional SEM fitted with an external reservoir for precursor injection to etch holes as small as 18 nm in diameter in a thin carbon membrane using both H2O and XeF2. Yemini [92] fabricated a nanopore array

Accurate control of the covalent functionalization of single-walled carbon nanotubes for the electro-enzymatically controlled oxidation of biomolecules

• Naoual Allali,
• Veronika Urbanova,
• Mathieu Etienne,
• Xavier Devaux,
• Martine Mallet,
• Brigitte Vigolo,
• Jean-Joseph Adjizian,
• Chris P. Ewels,
• Sven Oberg,
• Alexander V. Soldatov,
• Edward McRae,
• Yves Fort,
• Manuel Dossot and
• Victor Mamane

Beilstein J. Nanotechnol. 2018, 9, 2750–2762, doi:10.3762/bjnano.9.257

• putting oxidative defects on their sidewalls and extremities to decrease their hydrophobicity, ii) to use non-covalent interaction with hydrophilic biomolecules or surfactants [15][16][17][18] or iii) to use covalently grafted polyethyleneglycol (PEG) linkers, as described by us [9][11][12]. Many studies

Low cost tips for tip-enhanced Raman spectroscopy fabricated by two-step electrochemical etching of 125 µm diameter gold wires

• Antonino Foti,
• Francesco Barreca,
• Enza Fazio,
• Cristiano D’Andrea,
• Paolo Matteini,
• Onofrio Maria Maragò and
• Pietro Giuseppe Gucciardi

Beilstein J. Nanotechnol. 2018, 9, 2718–2729, doi:10.3762/bjnano.9.254

• tested on dyes, pigments and biomolecules and enhancement factors higher than 105 are observed. TERS mapping with a spatial resolution of 5 nm is demonstrated. Keywords: amyloid; enhanced spectroscopy; gold tips; plasmonics; TERS; Introduction Tip-enhanced Raman spectroscopy (TERS) combines the

• times of approximately 2 min. The tips can be easily manipulated and safely mounted, by gluing or clamping them into STM- or ShF-based TERS setups. The good performance of the tips is highlighted by TERS spectra of dyes, pigments and biomolecules. The enhancement factor in the range of 104–105 was found

• on the shaft (red line). Typical laser powers are 1.0–2.5 mW and integration times are 0.5–1.0 s per pixel. TERS spectra of dyes, pigments and biomolecules The tips have been applied to evaluate the spectra of analyze standard dye molecules such as rhodamine 6G (R6G), crystal violet (CV), methylene

Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified γ-Fe₂O₃ nanoparticles towards human tumor cells

• Zdeněk Plichta,
• Yulia Kozak,
• Rostyslav Panchuk,
• Viktoria Sokolova,
• Matthias Epple,
• Lesya Kobylinska,
• Pavla Jendelová and
• Daniel Horák

Beilstein J. Nanotechnol. 2018, 9, 2533–2545, doi:10.3762/bjnano.9.236

• chemical attachment of target biomolecules, reduces cytotoxicity, and controls particle uptake by the cells [10]. Coatings can be either of low molecular weight, such are carbohydrates and organic acids (ethylenediaminetetraacetic acid, tartaric acid, citric acid, succinic acid, bisphosphonic acid), or of

Enhanced antineoplastic/therapeutic efficacy using 5-fluorouracil-loaded calcium phosphate nanoparticles

• Shanid Mohiyuddin,
• Saba Naqvi and
• Gopinath Packirisamy

Beilstein J. Nanotechnol. 2018, 9, 2499–2515, doi:10.3762/bjnano.9.233

• nanomaterial was found to be toxic in some metal-based NPs (e.g., gold, silver, iron, and copper), while the bulk counterparts showed less toxicity [9]. The metal ions present at the surface of the particles were found to interact with biomolecules at a comparatively higher rate in nanoformulations compared to

ZnO-nanostructure-based electrochemical sensor: Effect of nanostructure morphology on the sensing of heavy metal ions

• Marina Krasovska,
• Vjaceslavs Gerbreders,
• Irena Mihailova,
• Andrejs Ogurcovs,
• Eriks Sledevskis,
• Andrejs Gerbreders and
• Pavels Sarajevs

Beilstein J. Nanotechnol. 2018, 9, 2421–2431, doi:10.3762/bjnano.9.227

• molecular recognition device based on the nanostructures of metal oxides for biomolecules detection”.

Electrospun one-dimensional nanostructures: a new horizon for gas sensing materials

• Muhammad Imran,
• Nunzio Motta and
• Mahnaz Shafiei

Beilstein J. Nanotechnol. 2018, 9, 2128–2170, doi:10.3762/bjnano.9.202

Quantitative comparison of wideband low-latency phase-locked loop circuit designs for high-speed frequency modulation atomic force microscopy

• Kazuki Miyata and
• Takeshi Fukuma

Beilstein J. Nanotechnol. 2018, 9, 1844–1855, doi:10.3762/bjnano.9.176

• subnanometer-scale imaging of biomolecules [15][16][17]. Moreover, three-dimensional (3D) imaging techniques have been developed based on FM-AFM and used to visualize 3D distributions of hydration structures as well as flexible surface structures at solid–liquid interfaces [18][19][20][21][22]. Although FM-AFM

• enables atomic-scale measurements to be performed in vacuum and in liquids, its imaging speed is relatively slow (ca. 1 min/frame). High-speed amplitude modulation AFM has been developed [23] and employed to visualize the dynamic behavior of biomolecules in liquids at 10–100 ms/frame [24]. However, its

A visible-light-controlled platform for prolonged drug release based on Ag-doped TiO₂ nanotubes with a hydrophobic layer

• Caihong Liang,
• Jiang Wen and
• Xiaoming Liao

Beilstein J. Nanotechnol. 2018, 9, 1793–1801, doi:10.3762/bjnano.9.170

• comprised of UV light, which can cause the denaturation or decomposition of some biomolecules and organic matter. As a result, such a trigger mechanism may not be the ideal way in an environment with adequate solar or natural light. Xu et al. [25] found a solution for enhancing the utilization of natural