Multi-step domino (cascade) and one-pot reactions are powerful tools to economically and sustainably build up pharmaceutically relevant compounds, natural products, ligand systems and building blocks for materials science.

In particular, catalytic domino reactions and one-pot processes with excellent selectivity and functional group tolerance are of significant interest for industrial and academic research alike. Such processes, using conventional reagents and also visible light, can simplify the synthesis of pharmaceutical ingredients and drugs. In these so-called domino reactions, all of the required reagents, the catalyst and a solvent are simply mixed in one flask, in which multiple reaction steps take place autonomously without the addition of further reactants. This strategy is in contrast to the conventional "stop-and-go" synthetic approach. These efficient and straightforward synthetic methods make the isolation and purification of intermediate products after each reaction step superfluous, thereby drastically reducing the number of work-up and purification steps, which is superior to conventional organic synthesis.

For this thematic issue, contributions on all types of catalytic multi-step domino and one-pot reactions are welcome.

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