Multivalency as a chemical organization and action principle

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Editor: Prof. Rainer Haag
Freie Universität Berlin
 
Multivalency is a key principle in nature to establish strong, but also reversible chemical interactions between two units, e.g., a receptor and a ligand, viruses and host cells, or between two cell surfaces. Multivalent binding is based on multiple simultaneous molecular recognition processes and plays an important role in the self-organization of matter, in biological recognition processes as well as in signal transduction in biological systems. The targeted development of multivalent molecules is not only used for the strong inhibition of proteins and prevention of pathogen infections, but also allows for the selective production of functional molecular architectures and surface structures as well as the controlled interaction of multivalent surfaces. In the future a deeper understanding of multivalent interactions at all length scales from the nanometer to the micrometer range is crucial for solving important problems and for the development of new systems in the fields of life and materials science.

See also the Thematic Series:
Multivalent glycosystems for nanoscience

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Multivalency as a chemical organization and action principle

  • Rainer Haag

Beilstein J. Org. Chem. 2015, 11, 848–849, doi:10.3762/bjoc.11.94

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Published 19 May 2015

Potential of acylated peptides to target the influenza A virus

  • Daniel Lauster,
  • Damian Pawolski,
  • Julian Storm,
  • Kai Ludwig,
  • Rudolf Volkmer,
  • Henry Memczak,
  • Andreas Herrmann and
  • Sumati Bhatia

Beilstein J. Org. Chem. 2015, 11, 589–595, doi:10.3762/bjoc.11.65

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Published 29 Apr 2015

Synthesis of a hexasaccharide partial sequence of hyaluronan for click chemistry and more

  • Marina Bantzi,
  • Stephan Rigol and
  • Athanassios Giannis

Beilstein J. Org. Chem. 2015, 11, 604–607, doi:10.3762/bjoc.11.67

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Published 30 Apr 2015

Automated solid-phase synthesis of oligosaccharides containing sialic acids

  • Chian-Hui Lai,
  • Heung Sik Hahm,
  • Chien-Fu Liang and
  • Peter H. Seeberger

Beilstein J. Org. Chem. 2015, 11, 617–621, doi:10.3762/bjoc.11.69

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Published 04 May 2015

Synthesis of multivalent carbohydrate mimetics with aminopolyol end groups and their evaluation as L-selectin inhibitors

  • Joana Salta,
  • Jens Dernedde and
  • Hans-Ulrich Reissig

Beilstein J. Org. Chem. 2015, 11, 638–646, doi:10.3762/bjoc.11.72

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Published 05 May 2015

Design, synthesis and photochemical properties of the first examples of iminosugar clusters based on fluorescent cores

  • Mathieu L. Lepage,
  • Antoine Mirloup,
  • Manon Ripoll,
  • Fabien Stauffert,
  • Anne Bodlenner,
  • Raymond Ziessel and
  • Philippe Compain

Beilstein J. Org. Chem. 2015, 11, 659–667, doi:10.3762/bjoc.11.74

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Published 06 May 2015

Synthesis of carbohydrate-scaffolded thymine glycoconjugates to organize multivalency

  • Anna K. Ciuk and
  • Thisbe K. Lindhorst

Beilstein J. Org. Chem. 2015, 11, 668–674, doi:10.3762/bjoc.11.75

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Published 07 May 2015

Synthesis of tripodal catecholates and their immobilization on zinc oxide nanoparticles

  • Franziska Klitsche,
  • Julian Ramcke,
  • Julia Migenda,
  • Andreas Hensel,
  • Tobias Vossmeyer,
  • Horst Weller,
  • Silvia Gross and
  • Wolfgang Maison

Beilstein J. Org. Chem. 2015, 11, 678–686, doi:10.3762/bjoc.11.77

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Published 07 May 2015

First principle investigation of the linker length effects on the thermodynamics of divalent pseudorotaxanes

  • Andreas J. Achazi,
  • Doreen Mollenhauer and
  • Beate Paulus

Beilstein J. Org. Chem. 2015, 11, 687–692, doi:10.3762/bjoc.11.78

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Published 08 May 2015

Self-assembly of heteroleptic dinuclear metallosupramolecular kites from multivalent ligands via social self-sorting

  • Christian Benkhäuser and
  • Arne Lützen

Beilstein J. Org. Chem. 2015, 11, 693–700, doi:10.3762/bjoc.11.79

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Published 08 May 2015

Exploring monovalent and multivalent peptides for the inhibition of FBP21-tWW

  • Lisa Maria Henning,
  • Sumati Bhatia,
  • Miriam Bertazzon,
  • Michaela Marczynke,
  • Oliver Seitz,
  • Rudolf Volkmer,
  • Rainer Haag and
  • Christian Freund

Beilstein J. Org. Chem. 2015, 11, 701–706, doi:10.3762/bjoc.11.80

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Published 11 May 2015

DNA display of glycoconjugates to emulate oligomeric interactions of glycans

  • Alexandre Novoa and
  • Nicolas Winssinger

Beilstein J. Org. Chem. 2015, 11, 707–719, doi:10.3762/bjoc.11.81

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Published 11 May 2015

Probing multivalency in ligand–receptor-mediated adhesion of soft, biomimetic interfaces

  • Stephan Schmidt,
  • Hanqing Wang,
  • Daniel Pussak,
  • Simone Mosca and
  • Laura Hartmann

Beilstein J. Org. Chem. 2015, 11, 720–729, doi:10.3762/bjoc.11.82

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Published 12 May 2015

Multivalent polyglycerol supported imidazolidin-4-one organocatalysts for enantioselective Friedel–Crafts alkylations

  • Tommaso Pecchioli,
  • Manoj Kumar Muthyala,
  • Rainer Haag and
  • Mathias Christmann

Beilstein J. Org. Chem. 2015, 11, 730–738, doi:10.3762/bjoc.11.83

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Published 12 May 2015

Glycodendrimers: tools to explore multivalent galectin-1 interactions

  • Jonathan M. Cousin and
  • Mary J. Cloninger

Beilstein J. Org. Chem. 2015, 11, 739–747, doi:10.3762/bjoc.11.84

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Published 12 May 2015

Discrete multiporphyrin pseudorotaxane assemblies from di- and tetravalent porphyrin building blocks

  • Mirko Lohse,
  • Larissa K. S. von Krbek,
  • Sebastian Radunz,
  • Suresh Moorthy,
  • Christoph A. Schalley and
  • Stefan Hecht

Beilstein J. Org. Chem. 2015, 11, 748–762, doi:10.3762/bjoc.11.85

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Published 12 May 2015

Multivalent dendritic polyglycerolamine with arginine and histidine end groups for efficient siRNA transfection

  • Fatemeh Sheikhi Mehrabadi,
  • Hanxiang Zeng,
  • Mark Johnson,
  • Cathleen Schlesener,
  • Zhibin Guan and
  • Rainer Haag

Beilstein J. Org. Chem. 2015, 11, 763–772, doi:10.3762/bjoc.11.86

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Published 13 May 2015

Regulation of integrin and growth factor signaling in biomaterials for osteodifferentiation

  • Qiang Wei,
  • Theresa L. M. Pohl,
  • Anja Seckinger,
  • Joachim P. Spatz and
  • Elisabetta A. Cavalcanti-Adam

Beilstein J. Org. Chem. 2015, 11, 773–783, doi:10.3762/bjoc.11.87

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Published 13 May 2015

Orthogonal dual-modification of proteins for the engineering of multivalent protein scaffolds

  • Michaela Mühlberg,
  • Michael G. Hoesl,
  • Christian Kuehne,
  • Jens Dernedde,
  • Nediljko Budisa and
  • Christian P. R. Hackenberger

Beilstein J. Org. Chem. 2015, 11, 784–791, doi:10.3762/bjoc.11.88

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Published 13 May 2015

Impact of multivalent charge presentation on peptide–nanoparticle aggregation

  • Daniel Schöne,
  • Boris Schade,
  • Christoph Böttcher and
  • Beate Koksch

Beilstein J. Org. Chem. 2015, 11, 792–803, doi:10.3762/bjoc.11.89

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Published 15 May 2015

Influence of length and flexibility of spacers on the binding affinity of divalent ligands

  • Susanne Liese and
  • Roland R. Netz

Beilstein J. Org. Chem. 2015, 11, 804–816, doi:10.3762/bjoc.11.90

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Published 15 May 2015

Mechanical stability of bivalent transition metal complexes analyzed by single-molecule force spectroscopy

  • Manuel Gensler,
  • Christian Eidamshaus,
  • Maurice Taszarek,
  • Hans-Ulrich Reissig and
  • Jürgen P. Rabe

Beilstein J. Org. Chem. 2015, 11, 817–827, doi:10.3762/bjoc.11.91

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Published 15 May 2015

Adsorption mechanism and valency of catechol-functionalized hyperbranched polyglycerols

  • Stefanie Krysiak,
  • Qiang Wei,
  • Klaus Rischka,
  • Andreas Hartwig,
  • Rainer Haag and
  • Thorsten Hugel

Beilstein J. Org. Chem. 2015, 11, 828–836, doi:10.3762/bjoc.11.92

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Published 18 May 2015

Peptide–polymer ligands for a tandem WW-domain, an adaptive multivalent protein–protein interaction: lessons on the thermodynamic fitness of flexible ligands

  • Katharina Koschek,
  • Vedat Durmaz,
  • Oxana Krylova,
  • Marek Wieczorek,
  • Shilpi Gupta,
  • Martin Richter,
  • Alexander Bujotzek,
  • Christina Fischer,
  • Rainer Haag,
  • Christian Freund,
  • Marcus Weber and
  • Jörg Rademann

Beilstein J. Org. Chem. 2015, 11, 837–847, doi:10.3762/bjoc.11.93

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Published 18 May 2015
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