Synthesis of Xenia diterpenoids and related metabolites isolated from marine organisms

• Tatjana Huber,
• Lara Weisheit and
• Thomas Magauer

Beilstein J. Org. Chem. 2015, 11, 2521–2539, doi:10.3762/bjoc.11.273

• affecting the sensitive caryophyllene-like subunit, the methoxy group was replaced with a phenylseleno moiety, which was converted to the alcohol and finally oxidized to lactone 73. In three further steps, lactone 73 was converted to aldehyde ester 74, which upon treatment with piperidine gave a β-enamino

Continuous formation of N-chloro-N,N-dialkylamine solutions in well-mixed meso-scale flow reactors

• A. John Blacker and
• Katherine E. Jolley

Beilstein J. Org. Chem. 2015, 11, 2408–2417, doi:10.3762/bjoc.11.262

• piperidine in toluene at 0.5 mL/min. Due to the high volatility of N-chloropiperidine the product was not isolated and was instead obtained as a solution in toluene (0.94 M, 94%) by separation of the organic phase from the aqueous phase of the reaction solution. The yield of product was determined by NMR

Recent applications of ring-rearrangement metathesis in organic synthesis

• Sambasivarao Kotha,
• Milind Meshram,
• Priti Khedkar,
• Shaibal Banerjee and
• Deepak Deodhar

Beilstein J. Org. Chem. 2015, 11, 1833–1864, doi:10.3762/bjoc.11.199

• this method by isolating the RCM product of the ROM–CM byproduct 290, which was recovered in the ROM–RCM–CM cascade (Scheme 62). Kouklovsky and co-workers [62] have described a stereoselective synthesis of 2-(2-hydroxyalkyl)piperidine alkaloids by employing a RRM of NDA adduct 293. The required

An efficient synthesis of N-substituted 3-nitrothiophen-2-amines

• Sundaravel Vivek Kumar,
• Shanmugam Muthusubramanian,
• J. Carlos Menéndez and
• Subbu Perumal

Beilstein J. Org. Chem. 2015, 11, 1707–1712, doi:10.3762/bjoc.11.185

• , entry 5), pyridine (Table 1, entry 6), N,N-dimethylaminopyridine (DMAP, Table 1, entry 7), piperidine (Table 1, entry 8), L-proline (Table 1, entry 9), potassium carbonate (Table 1, entry 10), sodium carbonate (Table 1, entry 11) and caesium carbonate (Table 1, entry 12). After identifying potassium

Pyridinoacridine alkaloids of marine origin: NMR and MS spectral data, synthesis, biosynthesis and biological activity

• Louis P. Sandjo,
• Victor Kuete and
• Maique W. Biavatti

Beilstein J. Org. Chem. 2015, 11, 1667–1699, doi:10.3762/bjoc.11.183

• effect [89]. Piperidinic phosphonates derivatives also showed the same enzyme inhibition (Figure 18) [90] and the only chemical resemblance with pyridoacridines is the piperidine ring. Since piperidine is related to pyridine, the dihydropyridone (C) and the pyridine (E) rings in the structure of 99 could

Preparative semiconductor photoredox catalysis: An emerging theme in organic synthesis

• David W. Manley and
• John C. Walton

Beilstein J. Org. Chem. 2015, 11, 1570–1582, doi:10.3762/bjoc.11.173

• case of benzylic amines and piperidine, but aliphatic amines and aniline exhibited poor reactivity. Carboxylic acids are available in great variety from natural and industrial sources. Green synthetic methods based around them as starting materials are undoubtedly worthy of development. That simple

Synthesis of alpha-tetrasubstituted triazoles by copper-catalyzed silyl deprotection/azide cycloaddition

• Zachary L. Palchak,
• Paula T. Nguyen and
• Catharine H. Larsen

Beilstein J. Org. Chem. 2015, 11, 1425–1433, doi:10.3762/bjoc.11.154

• ), [27] and this motif is also critical to the activity of drugs like ketamine and phencyclidine (1-(1-phenylcyclohexyl)piperidine, PCP) [28]. Tetrasubstituted carbons bearing amines can provide much higher levels of activity than the corresponding trisubstituted center. For example, fentanyl is an

Synthesis and evaluation of the biostability and cell compatibility of novel conjugates of nucleobase, peptidic epitope, and saccharide

• Dan Yuan,
• Xuewen Du,
• Junfeng Shi,
• Ning Zhou,
• Abdulgader Ahmed Baoum,
• Khalid Omar Al Footy,
• Khadija Omar Badahdah and
• Bing Xu

Beilstein J. Org. Chem. 2015, 11, 1352–1359, doi:10.3762/bjoc.11.145

• ]. The conjugates NAS were produced by a combination of SPPS and liquid phase synthesis. Scheme 2 shows a representative synthesis route of a NAS conjugate (1). We loaded the first amino acid, Fmoc-Val-OH, on 2-chlorotrityl chloride resin, then removed the Fmoc group with 20% piperidine in

• solid-phase peptide synthesis and liquid-phase synthesis). i) Fmoc-Val-OH, DIPEA; ii) 20% piperidine; iii) Fmoc-Pro-OH, HBTU, DIPEA; iv) Fmoc-Thr(t-Bu)-OH, HBTU, DIPEA; v) thymine-1-acetic acid, HBTU, DIPEA; vi) TFE/DCM 2:8; vii) D-glucosamine hydrochloride, HBTU, DIPEA; viii) TFA/H2O 95:5

Reactions of nitroxides 15. Cinnamates bearing a nitroxyl moiety synthesized using a Mizoroki–Heck cross-coupling reaction

• Jerzy Zakrzewski and
• Bogumiła Huras

Beilstein J. Org. Chem. 2015, 11, 1155–1162, doi:10.3762/bjoc.11.130

• , 109 [53][54]. The signals at m/z 124, and 109 are abundant. The signal at m/z 154 was assigned to the structure, resulting from elimination of a XOH from the position 4 and 3 of the piperidine ring. The subsequent loss of a NO group (M = 30) and a CH3 group (M = 15), respectively, generates ions at m

An intramolecular C–N cross-coupling of β-enaminones: a simple and efficient way to precursors of some alkaloids of Galipea officinalis

• Hana Doušová,
• Radim Horák,
• Zdeňka Růžičková and
• Petr Šimůnek

Beilstein J. Org. Chem. 2015, 11, 884–892, doi:10.3762/bjoc.11.99

• . Conditions: (a) piperidine, PhCOOH, toluene, reflux 4 h; (b) NaBH4, MeOH/MeCN, rt, 3.5 h; (c) KOH, H2O, reflux, 8 h; (d) H2SO4, H2O, reflux, 20 h; (e) MeOH, SOCl2, reflux, 4 h; (f) Meldum’s acid, HCOOH, Et3N, 100 °C, 4 h. The synthesis of the starting β-enaminones. Conditions: (a) H2SO4, 65 °C, 46 h; (b) 1

Thiazole formation through a modified Gewald reaction

• Carl J. Mallia,
• Lukas Englert,
• Gary C. Walter and
• Ian R. Baxendale

Beilstein J. Org. Chem. 2015, 11, 875–883, doi:10.3762/bjoc.11.98

• , but generated complicated product mixtures allowing only a moderate isolated yield of 33% for the TMG and negligible recovery for the DBU (Table 1, entries 7 and 8). Interestingly, the use of piperidine led to no conversion under these reaction conditions (Table 1, entry 9), we believe this is due to

Self-assembly of heteroleptic dinuclear metallosupramolecular kites from multivalent ligands via social self-sorting

• Christian Benkhäuser and
• Arne Lützen

Beilstein J. Org. Chem. 2015, 11, 693–700, doi:10.3762/bjoc.11.79

• -bottomed flask was charged with 5-ethynyl-2,2’-bipyridine (11, 109 mg, 0.6 mmol, 2 equiv), 1,3-diiodobenzene (100 mg, 0.3 mmol), [Pd(PPh3)2Cl2] (5.32 mg, 2.5 mol %), and copper(I) iodide (1.44 mg, 2.5 mol %) and flushed with argon. Dry THF (15 mL) and dry piperidine (5 mL) were added and the resulting

Sequence-specific RNA cleavage by PNA conjugates of the metal-free artificial ribonuclease tris(2-aminobenzimidazole)

• Friederike Danneberg,
• Alice Ghidini,
• Plamena Dogandzhiyski,
• Elisabeth Kalden,
• Roger Strömberg and
• Michael W. Göbel

Beilstein J. Org. Chem. 2015, 11, 493–498, doi:10.3762/bjoc.11.55

• : 45 bar H2, Pd/C (10%), MeOH sat. with NH3, 60 °C, 5 h, rt, overnight, 37%; f: Mukaiyama’s reagent, NEt3, DMF, 22 h, rt, 56%. Boc-ON: 2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile. Synthesis of PNA conjugates. Conditions: a: 1) 9, HOBt, DIC, DMF, rt, 24 h; 2) piperidine, DMF, rt, 30 min; b: 1

Articulated rods – a novel class of molecular rods based on oligospiroketals (OSK)

• Pablo Wessig,
• Roswitha Merkel and
• Peter Müller

Beilstein J. Org. Chem. 2015, 11, 74–84, doi:10.3762/bjoc.11.11

• terminal or lateral positions of the rods. Building blocks with lateral SEGs are called sleeves. In Figure 1 a typical sleeve D (cyan) as well as other typical building blocks of OSK rods are depicted, such as pentaerythritol C (red), cyclohexane-1,4-dione E (green), and piperidine-4-ones B (blue). An OSK

• defined a 1,2,3-triazole containing linkage between two piperidine rings as the flexible joint F, which should be easily accessible by copper-catalyzed cycloaddition between an azide G and a terminal alkyne H (CuAAC, “Click” reaction) [16]. Primary alcohols I serve as “protected” azides accessible by

• modified Appel reaction [17]. The alkynes H can be protected by silylation (J) because only primary alkynes react in the CuAAC (Figure 3). The synthesis commences with 4-hydroxypiperidine (1), which was converted to piperidine-4-one 3 bearing a protected alkyne moiety as well as to piperidin-4-one 5 with a

Enantioselective synthesis of polyhydroxyindolizidinone and quinolizidinone derivatives from a common precursor

• Nemai Saha and
• Shital K. Chattopadhyay

Beilstein J. Org. Chem. 2014, 10, 3104–3110, doi:10.3762/bjoc.10.327

• -piperidine derivative 7 (Scheme 1) in very good yield. The 4-OH group in compound 7 was then protected as its TBDMS ether (8) wherein the use of TBS triflate was essential as the more conventional TBSCl was found to be ineffective. Treatment of the free amino group in 8 with neat acrylic acid provided the

The Shono-type electroorganic oxidation of unfunctionalised amides. Carbon–carbon bond formation via electrogenerated N-acyliminium ions

• Alan M. Jones and
• Craig E. Banks

Beilstein J. Org. Chem. 2014, 10, 3056–3072, doi:10.3762/bjoc.10.323

• functionalise a pyrrolidine or piperidine carbamate [86][87]. A lithium perchlorate–nitromethane system was used to prepare electrochemically azanucleoside derivatives [88]. Unactivated prolinol derivatives underwent anodic oxidation to generate N-acyliminium ions that were intercepted by nucleophilic bases

Formal total syntheses of classic natural product target molecules via palladium-catalyzed enantioselective alkylation

• Yiyang Liu,
• Marc Liniger,
• Ryan M. McFadden,
• Jenny L. Roizen,
• Jacquie Malette,
• Corey M. Reeves,
• Douglas C. Behenna,
• Masaki Seto,
• Jimin Kim,
• Justin T. Mohr,
• Scott C. Virgil and
• Brian M. Stoltz

Beilstein J. Org. Chem. 2014, 10, 2501–2512, doi:10.3762/bjoc.10.261

• enantioselective total synthesis of quebrachamine (Scheme 12) [92]. In their planning, disconnection at the macrocycle led to amide 52, which was prepared from 3,3-disubstituted piperidine 53. The all-carbon quaternary stereocenter in 53 was installed by double alkylation of lactam 55, using an auxiliary to

• furnished N-boc piperidine-alcohol (+)-53 [84], thus intercepting an intermediate in Amat’s synthesis of quebrachamine. G) Vincadifformine Vincadifformine (59) was isolated in both enantioenriched and racemic forms from the leaves and roots of Rhazya stricta in 1963 [93]. Not only is it a representative

Synthesis of aromatic glycoconjugates. Building blocks for the construction of combinatorial glycopeptide libraries

• Markus Nörrlinger and
• Thomas Ziegler

Beilstein J. Org. Chem. 2014, 10, 2453–2460, doi:10.3762/bjoc.10.256

• % piperidine in DMF at room temperature for 3.5 h gave crude aminomethyl compounds 16 and 19 which were used for the next step without further purification. Final coupling of 15 with 16 and 18 with 19 using HBTU, 1-hydroxybenzotriazole (HOBt) and diisopropylethylamine (DIPEA) in DMF as the condenation agent

• gave non-glycosylated fully protected dipeptides 17 and 20 in 73% and 88% yield, respectively (Scheme 2). Likewise, the Fmoc protecting groups in glucosylated building blocks 13a and 14a were first removed with piperidine in DMF to give crude aminomethyl derivates 21 and 23. Next, the latter were

Synthesis of novel conjugates of a saccharide, amino acids, nucleobase and the evaluation of their cell compatibility

• Dan Yuan,
• Xuewen Du,
• Junfeng Shi,
• Ning Zhou,
• Abdulgader Ahmed Baoum and
• Bing Xu

Beilstein J. Org. Chem. 2014, 10, 2406–2413, doi:10.3762/bjoc.10.250

• -Asp (20). After loading the first amino acid (Fmoc-Asp(Ot-Bu)-OH) on the 2-chlorotrityl chloride resin, we blocked the resin by dichloromethane (DCM)/methanol (MeOH)/N,N-diisopropylethylamine (DIEA) (8:1.5:0.5), next removed the Fmoc protecting group by 20% piperidine in N,N-dimethylformamide (DMF

Chiral phosphines in nucleophilic organocatalysis

• Yumei Xiao,
• Zhanhu Sun,
• Hongchao Guo and
• Ohyun Kwon

Beilstein J. Org. Chem. 2014, 10, 2089–2121, doi:10.3762/bjoc.10.218

• chiral cyclic phosphine B1 (Scheme 43) [84]. In the presence of 5 mol % of B1, asymmetric [4 + 2] annulations of allenoates with a broad range of aromatic N-tosylimines worked efficiently in dichloromethane at room temperature to give an array of chiral piperidine derivatives in good to excellent

• stereoselectivities (up to 99% ee, up to 99:1 dr) and moderate to excellent yields (42–99%). The piperidine products could be transformed conveniently into biologically important heterocyclic compounds. For example, with this asymmetric [4 + 2] annulation as the key step, using indole-2-carboxaldehyde as the starting

• , both aryl and alkyl. The addition of a Brønsted acid to the reaction system slightly improved the yields and diastereocontrol. In addition, the resulting tetrahydropyridines could be transformed to more complex dihydroxylated piperidine derivatives. At almost the same time, an intramolecular variant of

Multicomponent reactions in nucleoside chemistry

• Mariola Koszytkowska-Stawińska and
• Włodzimierz Buchowicz

Beilstein J. Org. Chem. 2014, 10, 1706–1732, doi:10.3762/bjoc.10.179

• a secondary amine (i.e., dimethylamine [49][50], diethylamine [51][52], N-methylbenzylamine [49], pyrrolidine [53][54], or piperidine [55][56]) at temperatures ranging from 60 °C to 100 °C afforded the corresponding 5-(alkylaminomethyl)pyrimidine nucleosides 2 (Scheme 2). Compounds 2 served as

Photoswitchable precision glycooligomers and their lectin binding

• Daniela Ponader,
• Sinaida Igde,
• Marko Wehle,
• Katharina Märker,
• Mark Santer,
• David Bléger and
• Laura Hartmann

Beilstein J. Org. Chem. 2014, 10, 1603–1612, doi:10.3762/bjoc.10.166

• Fmoc protecting group was cleaved by treatment with 25% piperidine in DMF three times for 5, 10 and 15 minutes. After complete removal of the Fmoc protecting group, the second building block (AZO or EDS) was coupled following the same reaction conditions. After repetition of the coupling/deprotection

• hours. After that, the resin was washed with a 23 mM solution of sodium diethyl dithiocarbamate in DMF, water, DMF and DCM. Fmoc cleavage: The Fmoc protecting group was cleaved by the addition of a solution of 25% piperidine in DMF three times for 5, 10 and 15 minutes, respectively. This was followed by

C–H-Functionalization logic guides the synthesis of a carbacyclopamine analog

• Sebastian Rabe,
• Johann Moschner,
• Marina Bantzi,
• Philipp Heretsch and
• Athanassios Giannis

Beilstein J. Org. Chem. 2014, 10, 1564–1569, doi:10.3762/bjoc.10.161

• application in the rational design of new hedgehog inhibitors based on lead structure 2. Future work will focus on the synthesis of carbacyclopamine analogs with a piperidine F-ring and their biological investigation. Structures of cyclopamine (1) and carbacyclopamine analog 2. Retrosynthetic analysis of

Orthogonal dual thiol–chloroacetyl and thiol–ene couplings for the sequential one-pot assembly of heteroglycoclusters

• Michele Fiore,
• Gour Chand Daskhan,
• Baptiste Thomas and
• Olivier Renaudet

Beilstein J. Org. Chem. 2014, 10, 1557–1563, doi:10.3762/bjoc.10.160

• resin loading, 3 equiv of Fmoc-protected amino acid activated in situ with 3 equiv of PyBOP and 6 equiv of DIPEA in DMF (10 mL/g resin) for 30 min. Fmoc protecting groups were removed by treatment with a piperidine/DMF solution 1:4 (10 mL/g resin) for 10 min. Synthetic linear peptides were recovered

Efficient routes toward the synthesis of the D-rhamno-trisaccharide related to the A-band polysaccharide of Pseudomonas aeruginosa

• Aritra Chaudhury,
• Sajal K. Maity and
• Rina Ghosh

Beilstein J. Org. Chem. 2014, 10, 1488–1494, doi:10.3762/bjoc.10.153

• would have similar reactivity towards glycosylative activation. Hence, a preactivation-based glycosylation protocol was devised for the first step leading to the disaccharide 11 using 1-benzenesulfinyl piperidine–triflic anhydride (BSP–Tf2O) [46]. The subsequent step was carried out using NIS–TMSOTf to