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Search for "biocompatibility" in Full Text gives 56 result(s) in Beilstein Journal of Organic Chemistry.
New bio-nanocomposites based on iron oxides and polysaccharides applied to oxidation and alkylation reactions
Beilstein J. Org. Chem. 2017, 13, 1982–1993, doi:10.3762/bjoc.13.194
- have been widely reported for the preparation of nanocomposites with a great range of applications, due to their low cytotoxicity and notable biocompatibility and stability [33][34][35][36][37], their catalytic application is still lacking. In addition, these natural products are easily and
An efficient Pd–NHC catalyst system in situ generated from Na2PdCl4 and PEG-functionalized imidazolium salts for Mizoroki–Heck reactions in water
Beilstein J. Org. Chem. 2017, 13, 1735–1744, doi:10.3762/bjoc.13.168
- polymers from the polymerization of ethylene oxide [67]. Owing to their significant advantages, including widely commercial availability, biocompatibility, chemical and thermal stability and ease to be derived, PEGs have been widely used as phase-transfer catalysts (PTC) or in the preparation of water
One-pot synthesis of block-copolyrotaxanes through controlled rotaxa-polymerization
Beilstein J. Org. Chem. 2017, 13, 1310–1315, doi:10.3762/bjoc.13.127
- because of its high biocompatibility and biodegradability [31][32][33]. Here should be noted that polyisoprene was already subjected to pseudopolyrotaxane formation, with limited success, i.e., with β-CD only oligoisoprenes (degree of polymerization < 9) could form complexes with low coverage (3.0%) [34
- monomers and CD derivatives. The resulting triblock-copolyrotaxanes might be good stocks for the synthesis of highly elastic slide-ring gels and hydrogels. Due to the biocompatibility of the constituents and the ability of the polyrotaxanes to self-assemble, these materials might also be applicable for
Glyco-gold nanoparticles: synthesis and applications
Beilstein J. Org. Chem. 2017, 13, 1008–1021, doi:10.3762/bjoc.13.100
- comparison to spherical and star-shaped AuNPs. Saccharidic functionalization: the coating density Besides the inorganic core, the surrounding organic shell plays a crucial role in GAuNP chemical-physical properties. The organic functionalization, in fact, impart the stealth ability and biocompatibility of
- inspired by the availability of novel nanomaterials with specific capabilities [95]. AuNPs have attracted great attention in this field due to their unique characteristics of biocompatibility and easy fabrication, already outlined previously. In the last five years, significant examples on the use of
Mutagenic activity of quaternary ammonium salt derivatives of carbohydrates
Beilstein J. Org. Chem. 2016, 12, 1434–1439, doi:10.3762/bjoc.12.138
- [22][23][24]. To overcome many problems associated with QASs, they were combined with sugars. We intended to obtain biologically active compounds – especially antibacterial and antifungal – with high biocompatibility and good biodegradation properties. Some examples of fused molecules containing QASs
Towards potential nanoparticle contrast agents: Synthesis of new functionalized PEG bisphosphonates
Beilstein J. Org. Chem. 2016, 12, 1366–1371, doi:10.3762/bjoc.12.130
- the development of superparamagnetic iron oxide nanoparticles (SPIONPs) because of their biocompatibility which allows there in vivo use both for diagnosis in magnetic resonance imaging and in therapy [1][2]. Most often, it is necessary to modify the surface of SPIONPs to increase the metabolic
Supramolecular polymer assembly in aqueous solution arising from cyclodextrin host–guest complexation
Beilstein J. Org. Chem. 2016, 12, 50–72, doi:10.3762/bjoc.12.7
- form hydrogels [84][85]. In particular, hydrogels formed by PEG and cyclodextrins have been investigated intensively because of the biocompatibility of their components. Interestingly, local crystallization of the polyrotaxane threaded cyclodextrins, sometimes called molecular necklaces [86], may form
Synthesis of D-fructose-derived spirocyclic 2-substituted-2-oxazoline ribosides
Beilstein J. Org. Chem. 2015, 11, 2289–2296, doi:10.3762/bjoc.11.249
- ) [4][5][6]. The strong affinity of the nitrogen in oxazoline towards metal makes the chiral derivatives excellent catalysts for asymmetrical transformations [7][8][9][10]. The amphiphilicity and biocompatibility of poly-2-substituted-2-oxazolines gained them recognition as biomaterials for polymer
Cholesterol lowering effects of mono-lactose-appended β-cyclodextrin in Niemann–Pick type C disease-like HepG2 cells
Beilstein J. Org. Chem. 2015, 11, 2079–2086, doi:10.3762/bjoc.11.224
- mice through a reduction in cholesterol levels [7][8][9]. Most recently, it was reported that HP-γ-CyD, which has great advantages in biocompatibility compared to HP-β-CyD, can also reduce the cholesterol accumulation in NPC-like cells [10]. However, a high dose of HP-β-CyD or HP-γ-CyD was necessary to
Synthesis and evaluation of the biostability and cell compatibility of novel conjugates of nucleobase, peptidic epitope, and saccharide
Beilstein J. Org. Chem. 2015, 11, 1352–1359, doi:10.3762/bjoc.11.145
- proteolytic stabilities of the conjugates depend on the functional peptidic epitopes. We found that TTPV is proteolytic resistant and LGFNI is susceptible to proteolysis. In addition, all the conjugates are compatible to the mammalian cells tested. Keywords: biocompatibility; biostability; nucleobase
Multivalent dendritic polyglycerolamine with arginine and histidine end groups for efficient siRNA transfection
Beilstein J. Org. Chem. 2015, 11, 763–772, doi:10.3762/bjoc.11.86
- and degrees of branching [5]. Additionally, dPG has multiple groups for further functionalization, high chemical stability, and good biocompatibility in vitro and in vivo [6][7][8]. All these characteristics make dPG an ideal scaffold for a broad range of applications from anti fouling [9] to
Synthesis of tripodal catecholates and their immobilization on zinc oxide nanoparticles
Beilstein J. Org. Chem. 2015, 11, 678–686, doi:10.3762/bjoc.11.77
- derivatives bearing an additional effector moiety may be used to generate stable particles with tailored properties, good solubility and biocompatibility. Suitable effectors in this context are PEG [31][32][33], zwitterions [34][35] or polyglycerols [36][37] which, when immobilized on NPs, may be used to tune
Conjugates of methylated cyclodextrin derivatives and hydroxyethyl starch (HES): Synthesis, cytotoxicity and inclusion of anaesthetic actives
Beilstein J. Org. Chem. 2014, 10, 3087–3096, doi:10.3762/bjoc.10.325
- al. [28]. We intended to conjugate the corresponding methylated mono-azido-β-CD derivatives to propargylated hydroxyethyl starch (HES). Advantages of HES are its very high aqueous solubility paired with good biocompatibility and its very low allergenic potential [33]. HES is in use for a long time
Detonation nanodiamonds biofunctionalization and immobilization to titanium alloy surfaces as first steps towards medical application
Beilstein J. Org. Chem. 2014, 10, 2765–2773, doi:10.3762/bjoc.10.293
- -existent toxicity and improved biocompatibility, in comparison to the unmodified DND, extends the applications of this carbon material from microelectronics, polishing and optical monitoring to biomedicine. Titanium and titanium-based alloys have been used as bone implant material for a long time, because
- achieve improved surface properties with enhanced wear behavior, corrosion resistance, and biocompatibility. Scharnweber et al. worked on biofunctionalization of titanium implant materials by immobilizing collagen type I and studied conformational changes caused by adsorptive immobilization [17][18
- oxide layer. Stability and biocompatibility investigations of the achieved coatings will then follow. Experimental Chemicals DND were purchased from Plasmachem GmbH (purity degree: 95%). All buffers where made from p.a. grade chemicals supplied by Merck KGaA and autoclaved before use. All other
A promising cellulose-based polyzwitterion with pH-sensitive charges
Beilstein J. Org. Chem. 2014, 10, 1549–1556, doi:10.3762/bjoc.10.159
- with trimethylsilyl methacrylate [8][9]. Polybetaines, for example sulfobetaines, could be prepared from the reaction of a tertiary amine (monomer or polymer) and a sultone [10]. Due to their biocompatibility and hemocompatibility polybetaines are attributed to be materials with biomimetic properties
- repeating unit, but not in the same side chain. Moreover, regioselective functionalization is possible [13]. In contrast to synthetic polybetaines an increased solubility could be expected for polysaccharide derivatives and, furthermore, biopolymers possess an inherent biocompatibility and biodegradability
An economical and safe procedure to synthesize 2-hydroxy-4-pentynoic acid: A precursor towards ‘clickable’ biodegradable polylactide
Beilstein J. Org. Chem. 2014, 10, 1365–1371, doi:10.3762/bjoc.10.139
- Aliphatic polyesters, in particular polylactide (PLA), are now widely used for biomedical applications, such as surgery sutures [1], implants for bone fixation [2], drug delivery vehicles [3][4] and tissue engineering scaffolds [5] because of their excellent biocompatibility, biodegradability and mechanical
Synthesis of a sucrose dimer with enone tether; a study on its functionalization
Beilstein J. Org. Chem. 2014, 10, 1246–1254, doi:10.3762/bjoc.10.124
- designed for such receptors, sugars are the most promising due to their availability and biocompatibility. Up to date only monosaccharides have found a wide application in the synthesis of crown ether analogs [5][6]. The disaccharide scaffold is much less pronounced [7]. During the past decade we have
Charge-transfer interaction mediated organogels from 18β-glycyrrhetinic acid appended pyrene
Beilstein J. Org. Chem. 2013, 9, 2877–2885, doi:10.3762/bjoc.9.324
- the form of free acids or aglycones, has been noted by its low toxicity, biocompatibility and bioactivity [31][32]. A wide array of papers has been published to report its anti-inflammatory, antiviral, and antitumor effects [33][34]. In recent years, it has been found that triterpenoids can serve as
Advancements in the mechanistic understanding of the copper-catalyzed azide–alkyne cycloaddition
Beilstein J. Org. Chem. 2013, 9, 2715–2750, doi:10.3762/bjoc.9.308
- tris(hydroxypropyltriazolylmethyl)amine (THPTA, Figure 1) was present [64]. In bioorganic chemistry, research efforts have focused on developing ligands that can prevent the copper ions from causing biological damage [68][69][70]. Apart from TBTA that had been shown to increase the biocompatibility of
3D-printed devices for continuous-flow organic chemistry
Beilstein J. Org. Chem. 2013, 9, 951–959, doi:10.3762/bjoc.9.109
- chemistry because of its biocompatibility; however, from a chemical point of view its use is limited to a few solvents and organic compounds, and to preserve its integrity it can only be used up to temperatures of 60–66 °C [19]. Polyacrylates consist of a vast group of polymers with different physical and
The conjugation of nonsteroidal anti-inflammatory drugs (NSAID) to small peptides for generating multifunctional supramolecular nanofibers/hydrogels
Beilstein J. Org. Chem. 2013, 9, 908–917, doi:10.3762/bjoc.9.104
- inherently easily biodegradable. To meet the prerequisites for self-delivery systems, besides biodegradability, the hydrogelators should preserve the pharmacological efficacy of the therapeutic building blocks, any side effects should be minimized and the biocompatibility maximized. Therefore, a convenient
- biocompatibility of these NSAID hydrogelators, we select 1a, 1c, and 1d to test their cytotoxicity by incubating them with HeLa cells for 72 h at 37 °C. As shown in Figure 4, 1a, 1c, and 1d exhibit IC50 values of 206 µM, 321 µM, and 294 µM, respectively. Among these three hydrogels, 1a lacks the tyrosine residue
Polymerization of novel methacrylated anthraquinone dyes
Beilstein J. Org. Chem. 2013, 9, 453–459, doi:10.3762/bjoc.9.48
- /cm2 2500 h) for 100 days. As an example, Figure 4 shows the transmission spectrum for the polymer containing cross-linker 6. After 100 days, no changes in the transmission spectra could be observed, which proves the monomer dye stability and is also a hint toward its biocompatibility. Mixture of
Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide
Beilstein J. Org. Chem. 2013, 9, 270–277, doi:10.3762/bjoc.9.33
- ]. Finally, TPX surfaces 8a and 8b functionalized with cRGD behaved differently regarding their cell-adhesion properties (Figure 5e and 5g). These tests strongly indicate that copper-catalyzed attachment of cRGD pentapeptides only provides a minor increase of biocompatibility, despite the fact that the
- copper-free “click” protocols on TPX surfaces. Finally, cRGD-functionalized TPX membrane surfaces showed excellent biocompatibility regarding the adhesion of endothelial cells. These studies pave the way for the development of improved, extracorporeal oxygenators. We believe that the combination of
Cyclodextrin-based nanosponges as drug carriers
Beilstein J. Org. Chem. 2012, 8, 2091–2099, doi:10.3762/bjoc.8.235
- cyclodextrin nanosponges in drug delivery By virtue of their biocompatibility and versatility, nanosponges have many potential applications in the pharmaceutical field. One recent EU commission report focused on the use of cyclodextrin nanosponges as a promising innovative system for drug delivery. They can be
- are a new type of biocompatible cross-linked polymer, whose production is flexible and cost-effective. Cyclodextrin nanosponges possess particular properties in terms of their encapsulation ability, biocompatibility and solubilisation capacity with regard to different types of molecules. Nanosponges
Control over molecular motion using the cis–trans photoisomerization of the azo group
Beilstein J. Org. Chem. 2012, 8, 1071–1090, doi:10.3762/bjoc.8.119
- does not affect cell survival, and similarly irradiation of incubated cells with LAMs not containing CPT, did not lead to cell death, thus confirming the biocompatibility of the LAMs with the cells. Molecular lift The individual molecular motion of azobenzene in the cis–trans isomerization process can
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