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Search for "gels" in Full Text gives 88 result(s) in Beilstein Journal of Organic Chemistry.
Novel analogues of a nonnucleoside SARS-CoV-2 RdRp inhibitor as potential antivirotics
Beilstein J. Org. Chem. 2024, 20, 1029–1036, doi:10.3762/bjoc.20.91
- ) Graphical representation of the inhibitory activity of selected compounds evaluated from the gels obtained in the primer extension assay. The percentage of inhibition (against control) was plotted against the logarithm of the concentration of compounds. The results were fitted to sigmoidal dose–response
Elucidating the glycan-binding specificity and structure of Cucumis melo agglutinin, a new R-type lectin
Beilstein J. Org. Chem. 2024, 20, 306–320, doi:10.3762/bjoc.20.31
- from the expression of CMA1 protein in CHO-S cells. Note the smeared band indicating the presence of glycosylation. (d) Recombinant expression of CMA1 in bacteria. SDS-PAGE gels of the His-tag affinity chromatography and cation exchange chromatography from the expression of CMA1 protein in E. coli BL21
Long oligodeoxynucleotides: chemical synthesis, isolation via catching-by-polymerization, verification via sequencing, and gene expression demonstration
Beilstein J. Org. Chem. 2023, 19, 1957–1965, doi:10.3762/bjoc.19.146
- . The gels were stained with GelGreen®. The M13 primers covered an additional 240 bp, and therefore the PCR products containing the full-length 399 bp and 401 bp dsODNs have about 640 bp, and those without incorporated dsODNs have about 240 bp. For the case of 399 bp dsODN, colonies corresponding to
Light-responsive rotaxane-based materials: inducing motion in the solid state
Beilstein J. Org. Chem. 2023, 19, 873–880, doi:10.3762/bjoc.19.64
- supramolecular gels (Figure 2a) [52]. Upon irradiation using a UV-light-emitting diode (LED) and a visible LED as sources, the reversible cleavage of the trithiocarbonate stoppers was accomplished, thus allowing the dethreading [53] of the wheels to take place by the shuttling of the macrocycles along the thread
- (Figure 2b). Interestingly, the viscosity of the gels was progressively reduced due to the decrease of the physical entanglement of the polymeric chains via photodegradation. Thus, the viscoelasticity of the rotaxane-based gels could be fine-tuned by modifying the irradiation time. This visible-light
- photodegradation of intertwined gels could lead to advanced functional materials avoiding the UV phototoxicity for biocompatible implementations, such as protein patterning and tissue engineering. Light-responsive metal-organic rotaxane frameworks The integration of the mechanical bond into metal-organic
Preparation of β-cyclodextrin/polysaccharide foams using saponin
Beilstein J. Org. Chem. 2023, 19, 78–88, doi:10.3762/bjoc.19.7
- carbon has been developed by Ma et al. [26], by the production of chitosan–saponin gels thanks to glutaraldehyde crosslinking. After adding potassium hydroxide, they freeze-dried the material and pyrolyzed the product. The resulting material possess a high absorption capacity of methylene blue, thanks to
Cryogels: recent applications in 3D-bioprinting, injectable cryogels, drug delivery, and wound healing
Beilstein J. Org. Chem. 2021, 17, 2553–2569, doi:10.3762/bjoc.17.171
- ; Introduction Gels can be defined as polymer networks that are expanded throughout their whole volume by a fluid. In the case of hydrogels, the network component is a hydrophilic polymer, and the swelling agent is water [1]. However, their lack of interconnected macropores and elasticity, required properties
- achieved in the field of injectable cryogels we can identify that the use of cryogel is not only novel but also extremely effective and easily achievable. Potential risks arise in the use of injectable gels which occur in the presence of not fully polymerised gels being injected into patients. The non
- tasks due to their adaptability and physical-chemical properties [18]. Macroporous polymeric gels with their unique heterogeneous open-porous structure open new perspectives for the development of innovative systems for biomedical and pharmaceutical applications. Cryotropic gelation is an efficient
Progress and challenges in the synthesis of sequence controlled polysaccharides
Beilstein J. Org. Chem. 2021, 17, 1981–2025, doi:10.3762/bjoc.17.129
- industrial applications in coating materials, cosmetics and pharmaceuticals [211]. Owing to their superior biological and mechanical properties, chitin and chitosan are used in fibers, gels, sponges, films, beads, and nanoparticles [212]. Tunable stiffness, solubility, and transparency can be obtained by
Biochemistry of fluoroprolines: the prospect of making fluorine a bioelement
Beilstein J. Org. Chem. 2021, 17, 439–460, doi:10.3762/bjoc.17.40
Circularly polarized luminescent systems fabricated by Tröger's base derivatives through two different strategies
Beilstein J. Org. Chem. 2021, 17, 52–57, doi:10.3762/bjoc.17.6
- DGG. In the CPL-active co-gels, noncovalent weak interactions might be formed between achiral fluorophores and a chiral gelator. So, the CPL emission of co-gels could be adjusted easily by external stimuli. The ᴅ-glutamic acid gelator DGG and its enantiomer LGG possess three hydrogen-bond sites, two
- , Scheme S2) [26]. When rac-TBPP was mixed with DGG at molar ratios from 1:100 to 1:16 (rac-TBPP/DGG), transparent yellow co-gels were successfully formed by being heated to dissolve in chloroform, and then cooled to ambient temperature (Supporting Information File 1, Figure S6). Owing to the AIE effect of
- the TB unit the fluorescence intensity of these co-assembly co-gels enhanced sharply (Figure 2a). More interestingly, at the molar ratio of rac-TBPP/DGG = 1:16, the CPL spectra of the co-gel shows a negative signal, while at the molar ratio of rac-TBPP/DGG = 1:32 or higher, positive signals exhibiting
Using multiple self-sorting for switching functions in discrete multicomponent systems
Beilstein J. Org. Chem. 2020, 16, 2831–2853, doi:10.3762/bjoc.16.233
- ‐stacking [15][16], dipole–dipole interactions [17] or hydrophobic interactions [18], have proven their significance as key players [19] in the creation of self-sorted supramolecular assemblies, such as 1D, 2D [20], and 3D architectures [21], polymers [22], gels [23], and most recently, of stand-alone
Dirhamnolipid ester – formation of reverse wormlike micelles in a binary (primerless) system
Beilstein J. Org. Chem. 2020, 16, 2820–2830, doi:10.3762/bjoc.16.232
- anisotropic at an elevated temperature. Differential scanning calorimetry analysis yielded a transition enthalpy of about ΔHSG/GS = ±7.2 kJ/mol. This value corresponds to a strong dispersion energy and explains the formation of the highly viscous gels by the entanglement of wormlike micelles through the
- dirhamnolipid esters, the ability to gel toluene vanishes. Rheological data Temperature sweep With this interesting observation we went on and performed rheological measurements to determine the viscoelastic properties of the dirhamnolipid ester/toluene gels. First, we performed temperature sweep measurements
pH- and concentration-dependent supramolecular self-assembly of a naturally occurring octapeptide
Beilstein J. Org. Chem. 2020, 16, 2017–2025, doi:10.3762/bjoc.16.168
- -responsiveness of self-assembled peptides has been extensively exploited for potential applications, with particular focus on drug delivery systems (DDS) [40], as injectable gels for tissue engineering [41][42], and biosensing applications [43]. pH-responsive DDS can deliver the drug to a specific tissue or
Heterogeneous photocatalysis in flow chemical reactors
Beilstein J. Org. Chem. 2020, 16, 1495–1549, doi:10.3762/bjoc.16.125
The use of isoxazoline and isoxazole scaffolding in the design of novel thiourea and amide liquid-crystalline compounds
Beilstein J. Org. Chem. 2020, 16, 175–184, doi:10.3762/bjoc.16.20
- study of gels derived from low molecular mass gelators [15][16], and consequently the investigation of gelators of low molar mass with liquid crystal proprieties remains active [17][18]. In addition, isoxazolines and isoxazoles have been identified as promising templates in liquid crystal development
Influence of the cis/trans configuration on the supramolecular aggregation of aryltriazoles
Beilstein J. Org. Chem. 2019, 15, 2881–2888, doi:10.3762/bjoc.15.282
- - and cis-1,2-glucopyranosyl and cyclohexyl ditriazoles, synthesized by CuAAC "click" chemistry, to form gels was studied, their physical properties determined, and the self-aggregation behavior investigated by SEM, X-ray, and EDC studies. The results revealed that self-assembly was driven mainly by π–π
- stabilization of the supramolecular aggregation of bis(4-bromophenyl)triazoles. The trans or cis spatial disposition of the triazole rings is highly important for gelation, with the cis configuration having higher propensity. Keywords: circular dichroism; cis/trans configuration; gels; triazole; X-ray
- diffraction; Introduction Structures self-assembled by noncovalent interactions give rise to supramolecular architectures with specific physical and/or chemical properties. Gels are colloid systems in which the dispersed phase has combined with the dispersion medium to yield a semisolid material. Gels from
Morphology-tunable and pH-responsive supramolecular self-assemblies based on AB2-type host–guest-conjugated amphiphilic molecules for controlled drug delivery
Beilstein J. Org. Chem. 2019, 15, 1925–1932, doi:10.3762/bjoc.15.188
- HGCMs containing one host and other guest moieties have been used to construct intramolecular complexes [36], cyclic oligomers [37], supramolecular polymers [23][38][39][40], gels [41][42], etc. However, AB-type HGCMs were still limited to obtain non-spherical stimuli-responsive supramolecular self
Cyclopropene derivatives of aminosugars for metabolic glycoengineering
Beilstein J. Org. Chem. 2019, 15, 584–601, doi:10.3762/bjoc.15.54
Non-metal-templated approaches to bis(borane) derivatives of macrocyclic dibridgehead diphosphines via alkene metathesis
Beilstein J. Org. Chem. 2018, 14, 2354–2365, doi:10.3762/bjoc.14.211
- substoichiometric amounts of H3B·SMe2 are added to THF solutions of purified 1·BH3, gels immediately form. A ca. 0.01 M CH2Cl2 solution of 1·BH3 and a ca. 0.002 M CH2Cl2 solution of Grubbs' first generation catalyst (3 mol %) were combined at 0 °C. The mixture was warmed to room temperature, and a second charge of
A switchable [2]rotaxane with two active alkenyl groups
Beilstein J. Org. Chem. 2018, 14, 2074–2081, doi:10.3762/bjoc.14.181
- station when the DBA site is deprotonated by external base. Besides, in the structure, one side of the chain is terminated by a bulky stopper bearing three long alkyl chains to prevent the macrocyclic moiety from slipping out the thread. Meanwhile, the long alkyl chains make it easy to form gels when the
- . The naked alkenyl groups could react with other functional groups such as alkenyl and thiol groups to prepare stimuli-responsive polymers. Besides, the introduction of long alkyl chains makes the polymers easier to form gels. This kind of functional rotaxane enriches the species of building blocks to
Synthesis and supramolecular self-assembly of glutamic acid-based squaramides
Beilstein J. Org. Chem. 2018, 14, 2065–2073, doi:10.3762/bjoc.14.180
- aliphatic chain and on the other side to a glutamic acid residue. The gelator bearing the free carboxylic groups showed a lower gelation capacity than its precursor diester derivative. Some selected gels were further studied by infrared spectroscopy, rheology and electron microscopy. Critical gelation
- crystal engineering [13][14][15][16][17]. Despite their isosteric relationship with ureas, which have become key synthons in supramolecular chemistry [18][19], there are only a few reports on the formation of self-assembled supramolecular gels using squaramide derivatives [20][21][22][23]. Along this line
- , supramolecular or physical gels have received great attention during the last decade [24][25] due to their unique architectures and potential applications in many areas such as biomedicine (mainly hydrogels), health care and catalysis, among others [26][27][28][29]. In contrast to chemical gels [30], physical
A self-assembled photoresponsive gel consisting of chiral nanofibers
Beilstein J. Org. Chem. 2018, 14, 1994–2001, doi:10.3762/bjoc.14.174
- absorption spectroscopy, circular dichroism, scanning electron microscopy and rheological techniques. This work provides a new method for facile synthesis of chiro-optical gels. Keywords: chirality; nanostructure; organogel; photoresponse; self-assembly; Introduction Supramolecular gels [1][2] immobilized
- ], and chemosensing [13][14]. Among the supramolecular gels, the low-molecular-weight gels (LMWGs) [15][16] are those that self-assemble into gels in organic solvents with molecular weights of <2000 Da. The weak noncovalent intermolecular interactions between LMWGs make them more sensitive to external
Nanoreactors for green catalysis
Beilstein J. Org. Chem. 2018, 14, 716–733, doi:10.3762/bjoc.14.61
- nanosystems suitable for many applications [113][114][115]. Catalysis in nanogels: Nanogels have intrinsic properties that make them well suited for green chemistry [116][117]. Water-compatible gels are usually based on poly(N-isopropylacrylamide) (PNIPAM), poly(N-vinylcaprolactam) (PVCL) or other water
Binding abilities of polyaminocyclodextrins: polarimetric investigations and biological assays
Beilstein J. Org. Chem. 2017, 13, 2751–2763, doi:10.3762/bjoc.13.271
- Tris Base, 2.75 g boric acid, 2 mL of EDTA, 0.5 M, pH 8) pH 7.5 along with the pUC19 DNA as reference. At the end of the electrophoresis, the gels were visualized under UV light using a Bio-Rad Trans illuminator. The illuminated gels were photographed by using a Polaroid camera. Heparin competitive
One-pot synthesis of block-copolyrotaxanes through controlled rotaxa-polymerization
Beilstein J. Org. Chem. 2017, 13, 1310–1315, doi:10.3762/bjoc.13.127
- polymers without chemical modification of the backbone. Through polyrotaxane formation solubility [2][3][4][5], as well as mechanical [1][2][3][6][7][8][9] and electrical properties [10], can be improved. Cross-linking of threaded macrocycles gives rise to so-called slide-ring gels with unique mechanical
- polyrotaxanes was already investigated in the fields of biomedicine, as drug [22] or gene [23] delivery vehicles, or in materials sciences, as slide ring gels [6]. Polyrotaxanes are mostly synthesized by a threading approach [2], a multistep method starting from pre-synthesized (co)polymers. Due to the
- monomers and CD derivatives. The resulting triblock-copolyrotaxanes might be good stocks for the synthesis of highly elastic slide-ring gels and hydrogels. Due to the biocompatibility of the constituents and the ability of the polyrotaxanes to self-assemble, these materials might also be applicable for
Glycoscience@Synchrotron: Synchrotron radiation applied to structural glycoscience
Beilstein J. Org. Chem. 2017, 13, 1145–1167, doi:10.3762/bjoc.13.114
- methods of choice to investigate the states of soft-condensed materials, which include solutions and gels. Differences in wavelengths and scatterers can be used for combined measurements yielding supplemental information. Following the instrumental developments of light sources, SAXS has become a common
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