Multicomponent reactions

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Editor: Prof. Thomas J. J. Müller
Heinrich-Heine-Universität Düsseldorf
 
Chemistry as a central science is facing a steadily increasing demand for new chemical entities. Innovative solutions, in all kinds of disciplines that depend on chemistry, require new molecules with specific properties, and their societal consequences are fundamental and pioneering. However, these molecules not only demand a realistic structural space but also their feasibility poses challenges to synthetic chemists. Nowadays the question of how to perform a synthesis has become most crucial. In particular multicomponent reactions are masterpieces of synthetic efficiency and reaction design. These one-pot processes consist of concatenations of elementary organic reactions under similar conditions.

See also the Thematic Series:
Multicomponent reactions II

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Multicomponent reactions

  • Thomas J. J. Müller

Beilstein J. Org. Chem. 2011, 7, 960–961, doi:10.3762/bjoc.7.107

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Editorial
Published 13 Jul 2011

A practical two-step procedure for the preparation of enantiopure pyridines: Multicomponent reactions of alkoxyallenes, nitriles and carboxylic acids followed by a cyclocondensation reaction

  • Christian Eidamshaus,
  • Roopender Kumar,
  • Mrinal K. Bera and
  • Hans-Ulrich Reissig

Beilstein J. Org. Chem. 2011, 7, 962–975, doi:10.3762/bjoc.7.108

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Published 13 Jul 2011

Long-range diastereoselectivity in Ugi reactions of 2-substituted dihydrobenzoxazepines

  • Luca Banfi,
  • Andrea Basso,
  • Valentina Cerulli,
  • Valeria Rocca and
  • Renata Riva

Beilstein J. Org. Chem. 2011, 7, 976–979, doi:10.3762/bjoc.7.109

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Letter
Published 13 Jul 2011

Multicomponent reaction access to complex quinolines via oxidation of the Povarov adducts

  • Esther Vicente-García,
  • Rosario Ramón,
  • Sara Preciado and
  • Rodolfo Lavilla

Beilstein J. Org. Chem. 2011, 7, 980–987, doi:10.3762/bjoc.7.110

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Published 13 Jul 2011

A practical route to tertiary diarylmethylamides or -carbamates from imines, organozinc reagents and acyl chlorides or chloroformates

  • Erwan Le Gall,
  • Antoine Pignon and
  • Thierry Martens

Beilstein J. Org. Chem. 2011, 7, 997–1002, doi:10.3762/bjoc.7.112

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Published 20 Jul 2011

Novel synthesis of pseudopeptides bearing a difluoromethyl group by Ugi reaction and desulfanylation

  • Jingjing Wu,
  • Hui Li and
  • Song Cao

Beilstein J. Org. Chem. 2011, 7, 1070–1074, doi:10.3762/bjoc.7.123

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Published 08 Aug 2011

Multicomponent synthesis of artificial nucleases and their RNase and DNase activity

  • Anton V. Gulevich,
  • Lyudmila S. Koroleva,
  • Olga V. Morozova,
  • Valentina N. Bakhvalova,
  • Vladimir N. Silnikov and
  • Valentine G. Nenajdenko

Beilstein J. Org. Chem. 2011, 7, 1135–1140, doi:10.3762/bjoc.7.131

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Published 19 Aug 2011

One-pot four-component synthesis of pyrimidyl and pyrazolyl substituted azulenes by glyoxylation–decarbonylative alkynylation–cyclocondensation sequences

  • Charlotte F. Gers,
  • Julia Rosellen,
  • Eugen Merkul and
  • Thomas J. J. Müller

Beilstein J. Org. Chem. 2011, 7, 1173–1181, doi:10.3762/bjoc.7.136

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Published 26 Aug 2011

Synthesis of diverse dihydropyrimidine-related scaffolds by fluorous benzaldehyde-based Biginelli reaction and post-condensation modifications

  • Bruno Piqani and
  • Wei Zhang

Beilstein J. Org. Chem. 2011, 7, 1294–1298, doi:10.3762/bjoc.7.150

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Published 16 Sep 2011

A straightforward approach towards combined α-amino and α-hydroxy acids based on Passerini reactions

  • Ameer F. Zahoor,
  • Sarah Thies and
  • Uli Kazmaier

Beilstein J. Org. Chem. 2011, 7, 1299–1303, doi:10.3762/bjoc.7.151

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Published 19 Sep 2011

Ugi post-condensation copper-triggered oxidative cascade towards pyrazoles

  • Aurélie Dos Santos,
  • Laurent El Kaim,
  • Laurence Grimaud and
  • Caroline Ronsseray

Beilstein J. Org. Chem. 2011, 7, 1310–1314, doi:10.3762/bjoc.7.153

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Published 21 Sep 2011

Amines as key building blocks in Pd-assisted multicomponent processes

  • Didier Bouyssi,
  • Nuno Monteiro and
  • Geneviève Balme

Beilstein J. Org. Chem. 2011, 7, 1387–1406, doi:10.3762/bjoc.7.163

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Published 10 Oct 2011

Pseudo five-component synthesis of 2,5-di(hetero)arylthiophenes via a one-pot Sonogashira–Glaser cyclization sequence

  • Dominik Urselmann,
  • Dragutin Antovic and
  • Thomas J. J. Müller

Beilstein J. Org. Chem. 2011, 7, 1499–1503, doi:10.3762/bjoc.7.174

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Published 04 Nov 2011

Synthesis of (−)-julocrotine and a diversity oriented Ugi-approach to analogues and probes

  • Ricardo A. W. Neves Filho,
  • Bernhard Westermann and
  • Ludger A. Wessjohann

Beilstein J. Org. Chem. 2011, 7, 1504–1507, doi:10.3762/bjoc.7.175

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Published 07 Nov 2011

Regioselectivity in the multicomponent reaction of 5-aminopyrazoles, cyclic 1,3-diketones and dimethylformamide dimethylacetal under controlled microwave heating

  • Kamal Usef Sadek,
  • Ramadan Ahmed Mekheimer,
  • Tahany Mahmoud Mohamed,
  • Moustafa Sherief Moustafa and
  • Mohamed Hilmy Elnagdi

Beilstein J. Org. Chem. 2012, 8, 18–24, doi:10.3762/bjoc.8.3

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Published 04 Jan 2012
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