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Search for "bioimaging" in Full Text gives 38 result(s) in Beilstein Journal of Organic Chemistry.

Synthesis of photo- and ionochromic N-acylated 2-(aminomethylene)benzo[b]thiophene-3(2Н)-ones with a terminal phenanthroline group

  • Vladimir P. Rybalkin,
  • Sofiya Yu. Zmeeva,
  • Lidiya L. Popova,
  • Irina V. Dubonosova,
  • Olga Yu. Karlutova,
  • Oleg P. Demidov,
  • Alexander D. Dubonosov and
  • Vladimir A. Bren

Beilstein J. Org. Chem. 2024, 20, 552–560, doi:10.3762/bjoc.20.47

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  • , molecular logic gates, photopharmacology, bioimaging and chemosensorics [5][6][7][8][9][10][11]. For most photochromic compounds, irradiation of the solution or solid results in a deepening of the color (positive photochromism). Less studied are those characterized by photoinduced bleaching (negative or
  • catalysis and bioimaging [24][25][26]. In addition, such systems provide a convenient platform for creating chemo- and biosensors for rapid analysis of the ionic composition of the environment [27][28]. Results and Discussion The starting compound for the synthesis of N-acylated 2-(aminomethylene)benzo[b
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Published 11 Mar 2024

A deep-red fluorophore based on naphthothiadiazole as emitter with hybridized local and charge transfer and ambipolar transporting properties for electroluminescent devices

  • Suangsiri Arunlimsawat,
  • Patteera Funchien,
  • Pongsakorn Chasing,
  • Atthapon Saenubol,
  • Taweesak Sudyoadsuk and
  • Vinich Promarak

Beilstein J. Org. Chem. 2023, 19, 1664–1676, doi:10.3762/bjoc.19.122

Graphical Abstract
  • deep-red/near-infrared (DR/NIR) emission properties (λem = 650–900 nm) have received much attention due to their potential applications in several different fields such as chemosensing [1][2][3], bioimaging/biosensing [4][5][6][7][8], photodynamic therapy [9], optical communication [10], NLO materials
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Published 03 Nov 2023

Organic thermally activated delayed fluorescence material with strained benzoguanidine donor

  • Alexander C. Brannan,
  • Elvie F. P. Beaumont,
  • Nguyen Le Phuoc,
  • George F. S. Whitehead,
  • Mikko Linnolahti and
  • Alexander S. Romanov

Beilstein J. Org. Chem. 2023, 19, 1289–1298, doi:10.3762/bjoc.19.95

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  • fluorescence [1][2][3]. Organic TADF emitters have gained substantial attention in recent years for their prospective application in organic light-emitting diodes (OLEDs), photocatalysis, bioimaging, and sensors [4][5][6]. The ability to harvest both singlet and triplet excitons enable organic TADF emitters to
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Published 07 Sep 2023

Thermally activated delayed fluorescence (TADF) emitters: sensing and boosting spin-flipping by aggregation

  • Ashish Kumar Mazumdar,
  • Gyana Prakash Nanda,
  • Nisha Yadav,
  • Upasana Deori,
  • Upasha Acharyya,
  • Bahadur Sk and
  • Pachaiyappan Rajamalli

Beilstein J. Org. Chem. 2022, 18, 1177–1187, doi:10.3762/bjoc.18.122

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  • the potential applications in optoelectronic devices [1][2][3][4], solid-phase sensing [5], bioimaging [6][7], security [8], and storage devices [9]. The optical and electrochemical properties of the organic emitters can be tuned by external stimuli, such as mechanical force, heat, solvent, acid and
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Published 08 Sep 2022

Synthesis, optical and electrochemical properties of (D–π)2-type and (D–π)2Ph-type fluorescent dyes

  • Kosuke Takemura,
  • Kazuki Ohira,
  • Taiki Higashino,
  • Keiichi Imato and
  • Yousuke Ooyama

Beilstein J. Org. Chem. 2022, 18, 1047–1054, doi:10.3762/bjoc.18.106

Graphical Abstract
  • ][16][17][18][19][20][21][22], as well as fluorescent probes [23][24][25][26][27][28] for bioimaging and fluorescent sensors for specific target species [29][30][31][32]. Among many kinds of organic fluorescent dyes, much efforts have been made on the development of donor–π–acceptor (D–π–A)-type
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Published 18 Aug 2022

Constrained thermoresponsive polymers – new insights into fundamentals and applications

  • Patricia Flemming,
  • Alexander S. Münch,
  • Andreas Fery and
  • Petra Uhlmann

Beilstein J. Org. Chem. 2021, 17, 2123–2163, doi:10.3762/bjoc.17.138

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Published 20 Aug 2021

Sustainable manganese catalysis for late-stage C–H functionalization of bioactive structural motifs

  • Jongwoo Son

Beilstein J. Org. Chem. 2021, 17, 1733–1751, doi:10.3762/bjoc.17.122

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  • powerful synthetic strategy for accessing advanced agrochemicals, bioimaging materials, and drug candidates, among other complex molecules. While traditional late-stage diversification relies on the use of precious transition metals, the utilization of 3d transition metals is an emerging approach in
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Published 26 Jul 2021

Free-radical cyclization approach to polyheterocycles containing pyrrole and pyridine rings

  • Ivan P. Mosiagin,
  • Olesya A. Tomashenko,
  • Dar’ya V. Spiridonova,
  • Mikhail S. Novikov,
  • Sergey P. Tunik and
  • Alexander F. Khlebnikov

Beilstein J. Org. Chem. 2021, 17, 1490–1498, doi:10.3762/bjoc.17.105

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  • heteroaromatics available for various applications. Fused polyheteroarenes, containing a pyrrole moiety, are widely present in natural products and pharmacologically important agents and have a significant importance in the development of new materials useful for bioimaging applications and chemosensor systems [3
  • metal-catalyzed arylation [17][18][19]. We have recently successfully applied this approach to synthesize the new luminescent heterocyclic system pyrido[2,1-a]pyrrolo[3,2-c]isoquinoline A [17], which turned out to be useful for bioimaging [13] and as a ligand for the preparation of luminescent metal
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Published 23 Jun 2021

Molecular basis for protein–protein interactions

  • Brandon Charles Seychell and
  • Tobias Beck

Beilstein J. Org. Chem. 2021, 17, 1–10, doi:10.3762/bjoc.17.1

Graphical Abstract
  • , these proteins can be employed as containers in delivery vehicles [100], reaction vessels [101], and bioimaging agents [102]. These containers can also be modified to produce interactions between one container to another, and thus creating building blocks for nanoparticle assembly. Künzle et al. showed
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Published 04 Jan 2021

Naphthalonitriles featuring efficient emission in solution and in the solid state

  • Sidharth Thulaseedharan Nair Sailaja,
  • Iván Maisuls,
  • Jutta Kösters,
  • Alexander Hepp,
  • Andreas Faust,
  • Jens Voskuhl and
  • Cristian A. Strassert

Beilstein J. Org. Chem. 2020, 16, 2960–2970, doi:10.3762/bjoc.16.246

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  • substitution and environment is reported with potential applications in sensing, bioimaging and optoelectronics. Keywords: aggregation caused quenching (ACQ); aggregation-induced emission enhancement (AIEE); naphthalonitriles (NCNs); solution and solid state emitters (SSSE); solvent quenching (SQ
  • decrease in the dielectric constant. In summary, our straightforward synthetic strategy enables the realization of molecules which can go from deep blue to red emission and highly luminescent materials in solution and in the solid state, which are potentially interesting for optoelectronic and bioimaging
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Published 02 Dec 2020

Automated high-content imaging for cellular uptake, from the Schmuck cation to the latest cyclic oligochalcogenides

  • Rémi Martinent,
  • Javier López-Andarias,
  • Dimitri Moreau,
  • Yangyang Cheng,
  • Naomi Sakai and
  • Stefan Matile

Beilstein J. Org. Chem. 2020, 16, 2007–2016, doi:10.3762/bjoc.16.167

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  • for help with the high-content microscopy and analysis, J. A. Kritzer (Tufts University) and M. Hensel (Osnabrück University) for providing materials, and the Bioimaging and ACCESS platforms for services. Funding We thank the University of Geneva, the NCCR Chemical Biology, the NCCR Molecular Systems
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Published 14 Aug 2020

Synthesis of new fluorescent molecules having an aggregation-induced emission property derived from 4-fluoroisoxazoles

  • Kazuyuki Sato,
  • Akira Kawasaki,
  • Yukiko Karuo,
  • Atsushi Tarui,
  • Kentaro Kawai and
  • Masaaki Omote

Beilstein J. Org. Chem. 2020, 16, 1411–1417, doi:10.3762/bjoc.16.117

Graphical Abstract
  • ; Introduction Fluorescence bioprobes based on conventional organic dyes are used for enzyme activity measurements and in bioimaging systems with promising applications in the field of clinical diagnostics [1][2][3][4][5][6][7]. Most of the fluorescence bioprobes are mainly excited with near-ultraviolet or blue
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Published 22 Jun 2020

Regioselectively α- and β-alkynylated BODIPY dyes via gold(I)-catalyzed direct C–H functionalization and their photophysical properties

  • Takahide Shimada,
  • Shigeki Mori,
  • Masatoshi Ishida and
  • Hiroyuki Furuta

Beilstein J. Org. Chem. 2020, 16, 587–595, doi:10.3762/bjoc.16.53

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  • -materials. Keywords: alkynylation; BODIPY; direct C–H functionalization; gold(I); Introduction Boron-dipyrromethene (BODIPY, 1) and its derivatives are representative families of fluorophores that have been widely used in applications for bioimaging [1][2][3][4][5][6], photodynamic therapy [7][8][9][10
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Published 01 Apr 2020

A systematic review on silica-, carbon-, and magnetic materials-supported copper species as efficient heterogeneous nanocatalysts in “click” reactions

  • Pezhman Shiri and
  • Jasem Aboonajmi

Beilstein J. Org. Chem. 2020, 16, 551–586, doi:10.3762/bjoc.16.52

Graphical Abstract
  • , superparamagnetic behavior, ease of separation, and high safety. Indeed, materials including silica, carbon, etc. were combined with MNPs to produce new compositions that illustrated unique efficiency in the areas of catalysis [89], sensors [90], water purification [91], bioimaging [92], energy storage [92], drug
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Published 01 Apr 2020

Synthesis of triphenylene-fused phosphole oxides via C–H functionalizations

  • Md. Shafiqur Rahman and
  • Naohiko Yoshikai

Beilstein J. Org. Chem. 2020, 16, 524–529, doi:10.3762/bjoc.16.48

Graphical Abstract
  • extended π-system. These included, in particular, those fused with polycyclic aromatic hydrocarbons (PAHs) for possible applications in organic electronics, bioimaging and sensing, and asymmetric catalysis (Figure 1). To name a few examples, Yamaguchi et al. described synthetic routes to novel phosphorus
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Published 27 Mar 2020

Plasma membrane imaging with a fluorescent benzothiadiazole derivative

  • Pedro H. P. R. Carvalho,
  • Jose R. Correa,
  • Karen L. R. Paiva,
  • Daniel F. S. Machado,
  • Jackson D. Scholten and
  • Brenno A. D. Neto

Beilstein J. Org. Chem. 2019, 15, 2644–2654, doi:10.3762/bjoc.15.257

Graphical Abstract
  • fluorescence imaging probes, many contributions [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] appeared successfully applying fluorescent BTDs in bioimaging experiments (see examples in Figure 1). Based on our interest in the development of new bioimaging agents [38][39][40], we disclose herein
  • the design, synthesis, properties and application of a new fluorogenic BTD derivative as a water-soluble selective plasma membrane probe for bioimaging experiments. Results and Discussion The new water-soluble fluorescent BTD derivative (named BTD-4APTEG) was planned and synthesized as shown in Scheme
  • bioimaging experiments and proved to be stable under constant light irradiation for more than 4 hours (see Figure S4 in Supporting Information File 1). Theoretical calculations were then performed for a better comprehension of the photophysical data obtained for BTD-4APTEG by means of the time-dependent
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Published 06 Nov 2019

Arylisoquinoline-derived organoboron dyes with a triaryl skeleton show dual fluorescence

  • Vânia F. Pais,
  • Tristan Neumann,
  • Ignacio Vayá,
  • M. Consuelo Jiménez,
  • Abel Ros and
  • Uwe Pischel

Beilstein J. Org. Chem. 2019, 15, 2612–2622, doi:10.3762/bjoc.15.254

Graphical Abstract
  • ], BASHY dyes [10][11] or Boranils [12][13]) often feature quite rigid structures which contribute to high fluorescence quantum yields. These dyes have been applied for example in optoelectronics [14][15][16], sensing [17][18][19][20], and bioimaging [6][20][21][22][23][24][25][26]. On the other hand
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Published 04 Nov 2019

Synthesis of a dihalogenated pyridinyl silicon rhodamine for mitochondrial imaging by a halogen dance rearrangement

  • Jessica Matthias,
  • Thines Kanagasundaram,
  • Klaus Kopka and
  • Carsten S. Kramer

Beilstein J. Org. Chem. 2019, 15, 2333–2343, doi:10.3762/bjoc.15.226

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  • optical properties for medical and bioimaging. As a compound with intrinsic mitochondria targeting ability, the radiolabelled analogue can be applied in multimodal (PET/OI) imaging of mitochondria for diagnostic and therapeutic use in, e.g., cancer patients. Keywords: halogen-dance reaction
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Published 01 Oct 2019

Fluorescent phosphorus dendrimers excited by two photons: synthesis, two-photon absorption properties and biological uses

  • Anne-Marie Caminade,
  • Artem Zibarov,
  • Eduardo Cueto Diaz,
  • Aurélien Hameau,
  • Maxime Klausen,
  • Kathleen Moineau-Chane Ching,
  • Jean-Pierre Majoral,
  • Jean-Baptiste Verlhac,
  • Olivier Mongin and
  • Mireille Blanchard-Desce

Beilstein J. Org. Chem. 2019, 15, 2287–2303, doi:10.3762/bjoc.15.221

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  • the mechanism of action of anticancer compounds, and for safer photodynamic therapy. Keywords: bioimaging; dendrimer; fluorescence; phosphorus; two-photon absorption; Introduction Natural luminescence phenomena such as the bioluminescence of fireflies or of certain marine microorganisms, or the
  • ). This dendrimer retains some fluorescence as well as very high TPA cross-sections in a broad range of the NIR (near infra-red) biological spectral window. Furthermore, it displays significant singlet oxygen production, thus this dendrimer combines unique properties for bioimaging and anticancer therapy
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Published 24 Sep 2019

Complexation of a guanidinium-modified calixarene with diverse dyes and investigation of the corresponding photophysical response

  • Yu-Ying Wang,
  • Yong Kong,
  • Zhe Zheng,
  • Wen-Chao Geng,
  • Zi-Yi Zhao,
  • Hongwei Sun and
  • Dong-Sheng Guo

Beilstein J. Org. Chem. 2019, 15, 1394–1406, doi:10.3762/bjoc.15.139

Graphical Abstract
  • fluorophores through supramolecular encapsulation using artificial macrocyclic hosts has always been an active research area [10][11][12]. The complexes of macrocycles with luminescent dyes not only act as reporter pairs for sensing [13][14][15], but also offer various applications in bioimaging [16][17
  • azocalix[4]arene with rhodamine 123 as the reporter pair [16]. Consequently, with regard to bioimaging, the study of the complexation between macrocycles and two-photon probes is meaningful as two-photon excitation microscopy exhibits several distinct advantages including a deeper tissue penetration
  • economy, sensitivity and interference. When expanding these supramolecular assay strategies to bioimaging in cells and in vivo, two-photon reporter dyes exhibit advantages of deeper tissue penetration, higher spacial resolution and reduced photodamage of tissue. In the field of photodynamic therapy
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Published 25 Jun 2019

Cyclopropene derivatives of aminosugars for metabolic glycoengineering

  • Jessica Hassenrück and
  • Valentin Wittmann

Beilstein J. Org. Chem. 2019, 15, 584–601, doi:10.3762/bjoc.15.54

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Published 04 Mar 2019

Olefin metathesis in multiblock copolymer synthesis

  • Maria L. Gringolts,
  • Yulia I. Denisova,
  • Eugene Sh. Finkelshtein and
  • Yaroslav V. Kudryavtsev

Beilstein J. Org. Chem. 2019, 15, 218–235, doi:10.3762/bjoc.15.21

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  • , IBI, and SIBIS multiblock copolymers, which include glassy, rubbery, and semicrystalline polymer segments and demonstrate peculiar mechanical behavior [57][58]. References [59] and [60] report on the preparation of fluorescent polymer nanoparticles for bioimaging and in vivo targeting of tumors and
  • bioimaging and in vivo tumor targeting [60]. The multiblock copolymer capable of post-functionalization [76]. Multiblock copolymers synthesized by macromolecular cross metathesis. Changes in the DSC thermograms during MCM of PBD and polyesters (left) [84] and PNB–PCOE (right) mediated by Gr1 catalyst [89
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Published 24 Jan 2019

Fabrication of supramolecular cyclodextrin–fullerene nonwovens by electrospinning

  • Hiroaki Yoshida,
  • Ken Kikuta and
  • Toshiyuki Kida

Beilstein J. Org. Chem. 2019, 15, 89–95, doi:10.3762/bjoc.15.10

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  • ). Because the red photoluminescence of C60 is useful for a bioimaging applications [30][31], the electrospun fibers were measured with confocal laser scanning microscopy (CLSM). Interestingly, a uniform red color distribution is observed (Figure S9, in Supporting Information File 1), indicating the presence
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Published 09 Jan 2019

Novel solid-phase strategy for the synthesis of ligand-targeted fluorescent-labelled chelating peptide conjugates as a theranostic tool for cancer

  • Sagnik Sengupta,
  • Mena Asha Krishnan,
  • Premansh Dudhe,
  • Ramesh B. Reddy,
  • Bishnubasu Giri,
  • Sudeshna Chattopadhyay and
  • Venkatesh Chelvam

Beilstein J. Org. Chem. 2018, 14, 2665–2679, doi:10.3762/bjoc.14.244

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  • tracking molecule to understand the destination of delivered cargos or biologics. For bioimaging of cancer and inflammatory diseases through specific biomarkers [2], several methods including single positron emission computed tomography (SPECT), positron emission tomography (PET) and magnetic resonance
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Published 18 Oct 2018

Synthesis of a water-soluble 2,2′-biphen[4]arene and its efficient complexation and sensitive fluorescence enhancement towards palmatine and berberine

  • Xiayang Huang,
  • Xinghua Zhang,
  • Tianxin Qian,
  • Junwei Ma,
  • Lei Cui and
  • Chunju Li

Beilstein J. Org. Chem. 2018, 14, 2236–2241, doi:10.3762/bjoc.14.198

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  • as bioimaging and self-assembled drug delivery systems [33][34][35][36][37][38][39][40]. For example, our group demonstrated a direct host–guest complexation-based drug delivery system for oxaliplatin by carboxylatopillar[6]arene [36]. The encapsulation could not only improve the drug‘s stability in
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Published 27 Aug 2018
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