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Search for "piperazine" in Full Text gives 64 result(s) in Beilstein Journal of Organic Chemistry.

Design, synthesis and structure of novel G-2 melamine-based dendrimers incorporating 4-(n-octyloxy)aniline as a peripheral unit

  • Cristina Morar,
  • Pedro Lameiras,
  • Attila Bende,
  • Gabriel Katona,
  • Emese Gál and
  • Mircea Darabantu

Beilstein J. Org. Chem. 2018, 14, 1704–1722, doi:10.3762/bjoc.14.145

Graphical Abstract
  • block A [1,3,5-tris(piperazinomethyl)benzene] consisted of the amination of 1,3,5-tris(bromomethyl)benzene with commercially available N-Boc-piperazine followed by deprotection, and was achieved according to the literature [39] (97% overall yield in our hands). Similarly, 2,4,6-tris[(4-hydroxy
  • (in B) and rigid 1,4-phenylene with adjustable alkoxy-spacers (n = 1, 3, in C1 and C3, respectively). G-1 chloro- and piperazine-dendrons, D-Cl and D-N

    NH, as well as central building blocks B, C1 and C3, had s-triazine rings linked by C(s-triazine)–N(exocyclic) partial double bonds, which exist due

  • installation of the piperazine linkers on 2a (Table 1, entry 3) and on D-Cl (Table 1, entry 5) was ensured by the use of a 300% molar excess of this inexpensive reagent. We note the long-reaction time and large temperature domains (Table 1) required in order to obtain the quantitative results shown in Scheme 2
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Published 09 Jul 2018

An overview of recent advances in duplex DNA recognition by small molecules

  • Sayantan Bhaduri,
  • Nihar Ranjan and
  • Dev P. Arya

Beilstein J. Org. Chem. 2018, 14, 1051–1086, doi:10.3762/bjoc.14.93

Graphical Abstract
  • Hoechst 33258. These conjugates are fluorescent dimeric bisbenzimidazoles [(DB)n and (DBP)n] tethered by oligomethylene linkers of varied lengths with or without a central 1,4-piperazine residue [117]. The low solubility of (DB)n in aqueous solution due to aggregation has forced the authors to introduce a
  • 1,4-piperazine residue in the oligomethylene linkers (DBP)n, making them tetracations instead of dications for (DB)n at neutral pH. By the virtue of their higher solubility in aqueous media, (DBP)n could easily penetrate cell and nuclear membranes of living cells and inhibit in vitro eukaryotic DNA
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Published 16 May 2018

Mechanochemistry of nucleosides, nucleotides and related materials

  • Olga Eguaogie,
  • Joseph S. Vyle,
  • Patrick F. Conlon,
  • Manuela A. Gîlea and
  • Yipei Liang

Beilstein J. Org. Chem. 2018, 14, 955–970, doi:10.3762/bjoc.14.81

Graphical Abstract
  • exhibited enhanced membrane permeability compared with the pure API [85]. The preparation of co-crystals of 5FU with other API’s (imatinib [86] and piperazine [87]) using LAG has also been reported. Solid dispersions of acyclovir (20%) in neutral carriers (chitosan, hydroxypropylmethyl cellulose K100M® or
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Published 27 Apr 2018

Carbohydrate inhibitors of cholera toxin

  • Vajinder Kumar and
  • W. Bruce Turnbull

Beilstein J. Org. Chem. 2018, 14, 484–498, doi:10.3762/bjoc.14.34

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  • chelating mechanism. Hughes and co-workers synthesised and evaluated bivalent 1,2,3 triazole-linked galactopyranosides 14 and 15 as shown in Figure 7 [48]. They used a piperazine core as central divalent core on to which the galactose units were attached via flexible linkers. They found that these compounds
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Published 21 Feb 2018

5-Aminopyrazole as precursor in design and synthesis of fused pyrazoloazines

  • Ranjana Aggarwal and
  • Suresh Kumar

Beilstein J. Org. Chem. 2018, 14, 203–242, doi:10.3762/bjoc.14.15

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Published 25 Jan 2018

Dialkyl dicyanofumarates and dicyanomaleates as versatile building blocks for synthetic organic chemistry and mechanistic studies

  • Grzegorz Mlostoń and
  • Heinz Heimgartner

Beilstein J. Org. Chem. 2017, 13, 2235–2251, doi:10.3762/bjoc.13.221

Graphical Abstract
  • bicyclic piperazine (quinoxaline) derivative 73 in 61% yield [68] (Scheme 23). The analogous reaction with [(S)-pyrrolidin-2-yl]methylamine ((S)-prolinamine) with E-1a–c occurred smoothly in CH2Cl2 at room temperature yielding optically active (4-oxohexahydropyrrolo[1,2-a]pyrazin-3-ylidene)-2-cyanoacetates
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Published 24 Oct 2017

High-speed vibration-milling-promoted synthesis of symmetrical frameworks containing two or three pyrrole units

  • Marco Leonardi,
  • Mercedes Villacampa and
  • J. Carlos Menéndez

Beilstein J. Org. Chem. 2017, 13, 1957–1962, doi:10.3762/bjoc.13.190

Graphical Abstract
  • ), piperazine (1i,j) or tetramethyldisiloxane (1k–o) fragments, was also feasible. Interestingly, the use of N1-(2-aminoethyl)ethane-1,2-diamine as the starting material was also possible, without interference from the secondary amino group in spite of its nucleophilicity, to give compound 1h. This kind of
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Published 15 Sep 2017

Synthesis of oligonucleotides on a soluble support

  • Harri Lönnberg

Beilstein J. Org. Chem. 2017, 13, 1368–1387, doi:10.3762/bjoc.13.134

Graphical Abstract
  • to 98% yield per coupling cycle. Evidently the lack of amide hydrogens on the support is essential for the desired solubility properties, since replacement of the piperazine fragment within the linker structure with ethylene diamine 8 gave considerably less satisfactory results. When the succinyl
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Published 12 Jul 2017

Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic

  • Chinmay A. Shukla and
  • Amol A. Kulkarni

Beilstein J. Org. Chem. 2017, 13, 960–987, doi:10.3762/bjoc.13.97

Graphical Abstract
  • over 250 h. The reaction mixture is further mixed with HCl in MeOH/AcOEt and subjected to acid-catalyzed cyclization in a 0.3 mL coiled reactor at 140 °C (inductive heating, 800 kHz). This resulted in 88% overall yield. The isolated product is then mixed with piperazine and passed through the PEEK
  • on the entire system. The process stream can be mixed with piperazine (in MeOH/NMP) and subjected to evaporation to remove ethyl acetate solvent. The outlet flow rate of the evaporator can be controlled by maintaining the liquid level inside the evaporator. The process stream can further be passed
  • through the membrane separator. The outlet pressure of the aqueous stream was maintained at 2 psi pressure resulting in a perfect separation. The aryl chloride is further reacted with piperazine (1.5 equiv) to obtain 1-(diphenylmethyl)piperazine in 92% yield. The optimum conditions were 150 °C, 45 min
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Published 19 May 2017

Brønsted acid-mediated cyclization–dehydrosulfonylation/reduction sequences: An easy access to pyrazinoisoquinolines and pyridopyrazines

  • Ramana Sreenivasa Rao and
  • Chinnasamy Ramaraj Ramanathan

Beilstein J. Org. Chem. 2017, 13, 428–440, doi:10.3762/bjoc.13.46

Graphical Abstract
  • Ramana Sreenivasa Rao Chinnasamy Ramaraj Ramanathan Department of Chemistry, Pondicherry University, Puducherry – 605 014, India 10.3762/bjoc.13.46 Abstract An efficient and alternative synthetic approach has been developed to prepare various N-(arylethyl)piperazine-2,6-diones from 4
  • -benzenesulfonyliminodiacetic acid and primary amines using carbonyldiimidazole in the presence of a catalytic amount of DMAP at ambient temperature. Piperazine-2,6-diones are successfully transformed to pharmaceutically useful pyridopyrazines or pyrazinoisoquinolines and ene-diamides via an imide carbonyl group activation
  • strategy using a Brønsted acid. Subsequent dehydrosulfonylation reactions of the ene-diamides, in a one pot manner, smoothly transformed them to substituted pyrazinones. A concise synthesis of praziquantel (1) has also been achieved through this method. Keywords: Brønsted acid; piperazine-2,6-diones
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Published 07 Mar 2017

Continuous N-alkylation reactions of amino alcohols using γ-Al2O3 and supercritical CO2: unexpected formation of cyclic ureas and urethanes by reaction with CO2

  • Emilia S. Streng,
  • Darren S. Lee,
  • Michael W. George and
  • Martyn Poliakoff

Beilstein J. Org. Chem. 2017, 13, 329–337, doi:10.3762/bjoc.13.36

Graphical Abstract
  • CO2 (entries 4–6).a Cyclisation and N-alkylation of 1 with different alcohols.a Reactions of ethanolamine.a Showing the effect of conditions on the reaction of diethanolamine 12 to form carbamate 13 and piperazine 14.a Supporting Information Supporting Information File 62: Experimental data
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Published 21 Feb 2017

Synthesis, dynamic NMR characterization and XRD studies of novel N,N’-substituted piperazines for bioorthogonal labeling

  • Constantin Mamat,
  • Marc Pretze,
  • Matthew Gott and
  • Martin Köckerling

Beilstein J. Org. Chem. 2016, 12, 2478–2489, doi:10.3762/bjoc.12.242

Graphical Abstract
  • Novel, functionalized piperazine derivatives were successfully synthesized and fully characterized by 1H/13C/19F NMR, MS, elemental analysis and lipophilicity. All piperazine compounds occur as conformers resulting from the partial amide double bond. Furthermore, a second conformational shape was
  • observed for all nitro derivatives due to the limited change of the piperazine chair conformation. Therefore, two coalescence points were determined and their resulting activation energy barriers were calculated using 1H NMR. To support this result, single crystals of 1-(4-nitrobenzoyl)piperazine (3a
  • , monoclinic, space group C2/c, a = 24.587(2), b = 7.0726(6), c = 14.171(1) Å, β = 119.257(8)°, V = 2149.9(4) Å3, Z = 4, Dobs = 1.454 g/cm3) and the alkyne derivative 4-(but-3-yn-1-yl)-1-(4-fluorobenzoyl)piperazine (4b, monoclinic, space group P21/n, a = 10.5982(2), b = 8.4705(1), c = 14.8929(3) Å, β = 97.430
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Published 21 Nov 2016

Opportunities and challenges for direct C–H functionalization of piperazines

  • Zhishi Ye,
  • Kristen E. Gettys and
  • Mingji Dai

Beilstein J. Org. Chem. 2016, 12, 702–715, doi:10.3762/bjoc.12.70

Graphical Abstract
  • Zhishi Ye Kristen E. Gettys Mingji Dai Department of Chemistry and Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States 10.3762/bjoc.12.70 Abstract Piperazine ranks within the top three most utilized N-heterocyclic moieties in FDA-approved small-molecule
  • functionalizations, and photoredox catalysis are discussed. We also highlight the difficulties experienced when successful methods for α-C–H functionalization of acyclic amines and saturated mono-nitrogen heterocyclic compounds (such as piperidines and pyrrolidines) were applied to piperazine substrates. Keywords
  • : α-lithiation; C–H functionalization; heterocycle; photoredox catalysis; piperazine; Introduction Piperazine is one of the most important saturated N-heterocycles frequently found in life-saving small-molecule pharmaceuticals [1]. In a recent statistical study done by Njardarson and co-workers
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Published 13 Apr 2016

(Thio)urea-mediated synthesis of functionalized six-membered rings with multiple chiral centers

  • Giorgos Koutoulogenis,
  • Nikolaos Kaplaneris and
  • Christoforos G. Kokotos

Beilstein J. Org. Chem. 2016, 12, 462–495, doi:10.3762/bjoc.12.48

Graphical Abstract
  • -workers disclosed the first enantioselective reaction of α-cyanoketones 118 to α,β-unsaturated trifluoromethyl ketones 119, utilizing a novel organocatalyst that they developed containing a piperazine moiety (S)-120 (Scheme 38) [58]. The reaction proceeded through a Michael addition to the unsaturated
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Published 10 Mar 2016

Bifunctional phase-transfer catalysis in the asymmetric synthesis of biologically active isoindolinones

  • Antonia Di Mola,
  • Maximilian Tiffner,
  • Francesco Scorzelli,
  • Laura Palombi,
  • Rosanna Filosa,
  • Paolo De Caprariis,
  • Mario Waser and
  • Antonio Massa

Beilstein J. Org. Chem. 2015, 11, 2591–2599, doi:10.3762/bjoc.11.279

Graphical Abstract
  • recovered methyl ester of 9 (60% ee), although high yields were observed (Table 3, entry 1). Then, in another attempt, the malonic acid 10 was subjected to the reaction with carbonyldiimidazole (CDI) under different conditions but also in combination with a piperazine. This method has been reported for a
  • efficiently obtained by condensation of the chiral acid (S)-9 with the commercially available piperazine 16. Since most of the bioactive isoindolinones have a heteroaromatic group on the lactam, we focused on the CuI arylation of amides developed by Buchwald [40], previously applied by us to racemic
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Published 15 Dec 2015

The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

  • Marcus Baumann and
  • Ian R. Baxendale

Beilstein J. Org. Chem. 2015, 11, 1194–1219, doi:10.3762/bjoc.11.134

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Published 17 Jul 2015

Domino reactions of 2H-azirines with acylketenes from furan-2,3-diones: Competition between the formation of ortho-fused and bridged heterocyclic systems

  • Alexander F. Khlebnikov,
  • Mikhail S. Novikov,
  • Viktoriia V. Pakalnis,
  • Roman O. Iakovenko and
  • Dmitry S. Yufit

Beilstein J. Org. Chem. 2014, 10, 784–793, doi:10.3762/bjoc.10.74

Graphical Abstract
  • give monoadduct 12a. Interaction of the latter with ketene 6a leads to unsymmetrical cis-isomer 4a' with the piperazine ring in a chair conformation. The isomer 4a' transforms through a low barrier to a much more stable isomer 4a of C2 symmetry with the piperazine ring in a boat conformation (see
  • Supporting Information File 1). No intermediate structure was located on the way to the most stable conformation of trans-isomer 5a with the piperazine ring in a boat conformation. The free energies of the highest transition states on the pathways from 12a to cis-isomer 4a and trans-isomer 5a are practically
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Published 04 Apr 2014

Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

  • Richard J. Ingham,
  • Claudio Battilocchio,
  • Joel M. Hawkins and
  • Steven V. Ley

Beilstein J. Org. Chem. 2014, 10, 641–652, doi:10.3762/bjoc.10.56

Graphical Abstract
  • treatment of tuberculosis – and its reduced derivative piperazine-2-carboxamide. Keywords: automation; flow chemistry; hydration; hydrogenation; sustainable processing; Introduction Enabling synthesis technologies such as flow chemistry are becoming commonplace in modern laboratories (for recent reviews
  • database for medicinal chemistry. For example, piperazine-2-carboxamide (1, Figure 2a) is an amino acid derivative with interesting biological properties [17]. At the time of writing, racemic 1 was identified as a notably expensive building block [18] and thus a good target for this transformation. We have
  • pyrazine 2 to piperazine 1 (Figure 2b). Both of these steps involve flowing through heterogeneous catalysts, a metal oxide for the hydration of the nitrile and a supported precious metal for the hydrogenation of the heteroaromatic ring. Furthermore, both steps involve the addition of a volatile small
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Published 12 Mar 2014

Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics

  • Gijs Koopmanschap,
  • Eelco Ruijter and
  • Romano V.A. Orru

Beilstein J. Org. Chem. 2014, 10, 544–598, doi:10.3762/bjoc.10.50

Graphical Abstract
  • in e.g. beer, cacao and coffee [138][139][140]. The DKPs occur in three different isomers, in which the position of one oxo-group is different at the piperazine-ring [26]. The 2,5-diketopiperazines are most relevant due to the structural similarity with peptides (Figure 1). The DKP core shows
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Published 04 Mar 2014

Secondary amine-initiated three-component synthesis of 3,4-dihydropyrimidinones and thiones involving alkynes, aldehydes and thiourea/urea

  • Jie-Ping Wan,
  • Yunfang Lin,
  • Kaikai Hu and
  • Yunyun Liu

Beilstein J. Org. Chem. 2014, 10, 287–292, doi:10.3762/bjoc.10.25

Graphical Abstract
  • demonstrated that 0.5 equiv of piperazine was favorable (Table 1, entries 4–6). Reducing the amount of TMSCl led to a decrease in product yield (Table 1, entry 7). Other Lewis acid or Brønsted acids such as FeCl3 and p-TSA gave no better result for the same reaction (Table 1, entries 8 and 9). In addition, the
  • 2 (0.4 mmol) and alkyl propionate 3 (0.3 mmol) piperazine (0.15 mmol), and p-tolylsulfonic acid (0.15 mmol, 0.3 mmol for the reaction of urea) were charged in a 25 mL round bottom flask equipped with a stirring bar. DMF (THF for the reaction of urea) (4 mL) and TMSCl (0.6 mmol, 0.9 mmol for the
  • and removing of the solvent under reduced pressure, the residue was subjected to flash column chromatography to provide pure products. Synthesis of intermediate 6a. Into a 25 mL round bottom flask was added ethyl propiolate (0.6 mmol) and piperazine (0.3 mmol). 1.5 mL DMF was added and the mixture was
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Published 29 Jan 2014

An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles

  • Marcus Baumann and
  • Ian R. Baxendale

Beilstein J. Org. Chem. 2013, 9, 2265–2319, doi:10.3762/bjoc.9.265

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Published 30 Oct 2013

α-Bromodiazoacetamides – a new class of diazo compounds for catalyst-free, ambient temperature intramolecular C–H insertion reactions

  • Åsmund Kaupang and
  • Tore Bonge-Hansen

Beilstein J. Org. Chem. 2013, 9, 1407–1413, doi:10.3762/bjoc.9.157

Graphical Abstract
  • N-methylene groups of the amide [44]. With the exception of the piperazine derivative 5d, the observed diastereomeric ratio in the β-lactam products was approximately 6:1, favouring the diastereomer in which the bromine atom and the ring fragment are in a trans relationship (hereafter referred to as
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Published 11 Jul 2013

Facile synthesis of benzothiadiazine 1,1-dioxides, a precursor of RSV inhibitors, by tandem amidation/intramolecular aza-Wittig reaction

  • Krishna C. Majumdar and
  • Sintu Ganai

Beilstein J. Org. Chem. 2013, 9, 503–509, doi:10.3762/bjoc.9.54

Graphical Abstract
  • double bonds in various heterocycles and heterocycle-containing natural products [33][34][35][36][37][38][39][40][41][42][43]. Recently, we have synthesized asymmetrically substituted piperazine-2,5-dione derivatives using the intramolecular aza-Wittig reaction [44]. In continuation of our earlier work
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Published 08 Mar 2013

Synthesis of meso-substituted dihydro-1,3-oxazinoporphyrins

  • Satyasheel Sharma and
  • Mahendra Nath

Beilstein J. Org. Chem. 2013, 9, 496–502, doi:10.3762/bjoc.9.53

Graphical Abstract
  • [25], pyrrolidinone [26], pyrrolidine [27] and piperazine [28], to the porphyrin periphery. In addition, many porphyrin dimers and trimers have displayed significant biological efficacy [29] and some of these are used as photosensitizers in PDT applications for the treatment of various types of
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Published 07 Mar 2013

Chemical–biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target

  • Jonathan W. Choy,
  • Clifford Bryant,
  • Claudia M. Calvet,
  • Patricia S. Doyle,
  • Shamila S. Gunatilleke,
  • Siegfried S. F. Leung,
  • Kenny K. H. Ang,
  • Steven Chen,
  • Jiri Gut,
  • Juan A. Oses-Prieto,
  • Jonathan B. Johnston,
  • Michelle R. Arkin,
  • Alma L. Burlingame,
  • Jack Taunton,
  • Matthew P. Jacobson,
  • James M. McKerrow,
  • Larissa M. Podust and
  • Adam R. Renslo

Beilstein J. Org. Chem. 2013, 9, 15–25, doi:10.3762/bjoc.9.3

Graphical Abstract
  • potential for lysosomotropic behavior [31][32]. We sought to address the question of lysosomotropism by preparing analogues of 1 in which the basic piperazine substituent at “P3” (which binds the S3 subsite of cruzain) was replaced with nonbasic or weakly basic heterocycles. In our initial structure
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Published 04 Jan 2013
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