Serum type and concentration both affect the protein-corona composition of PLGA nanoparticles

• Katrin Partikel,
• Robin Korte,
• Dennis Mulac,
• Hans-Ulrich Humpf and
• Klaus Langer

Beilstein J. Nanotechnol. 2019, 10, 1002–1015, doi:10.3762/bjnano.10.101

• the need to carefully evaluate the data acquired so far from in vitro studies in order to develop safe biomedical applications. Conclusion We investigated the importance of selecting a proper physiological medium used for in vitro protein corona analysis. Therefore, we employed several analytical

The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model

• Qura Tul Ain,
• Samina Hyder Haq,
• Abeer Alshammari,
• Moudhi Abdullah Al-Mutlaq and
• Muhammad Naeem Anjum

Beilstein J. Nanotechnol. 2019, 10, 901–911, doi:10.3762/bjnano.10.91

• restricts its use for biomedical applications. Scientists have overcome this challenge through the oxidation of graphene by an improved Hummer’s method [3]. Graphene oxide (GO), due to its hydrophilic nature, can host a large number of biocompatible polymers, such as chitosan [4], polyethylene glycol (PEG

Co-doped MnFe₂O₄ nanoparticles: magnetic anisotropy and interparticle interactions

• Bagher Aslibeiki,
• Parviz Kameli,
• Hadi Salamati,
• Giorgio Concas,
• Maria Salvador Fernandez,
• Alessandro Talone,
• Giuseppe Muscas and
• Davide Peddis

Beilstein J. Nanotechnol. 2019, 10, 856–865, doi:10.3762/bjnano.10.86

• implemented for large-scale nanoparticle applications, such as for permanent magnets and biomedical applications. Given their good particle size distribution (≈10 nm diameter) and almost the same saturation magnetization per particle, these samples represent a good model system to study the systematic effect

Tungsten disulfide-based nanocomposites for photothermal therapy

• Tzuriel Levin,
• Hagit Sade,
• Rina Ben-Shabbat Binyamini,
• Maayan Pour,
• Iftach Nachman and
• Jean-Paul Lellouche

Beilstein J. Nanotechnol. 2019, 10, 811–822, doi:10.3762/bjnano.10.81

• effect, other ligands on the cerium ion can be replaced by different polymers and linkers. The resulting nanocomposites can be used for biomedical applications, such as gene silencing [52], magnetic imaging, and drug delivery. Here we present a new and simple-to-fabricate WS2-NT-CAN-mag (WS2-NT-CM

Polydopamine-coated Au nanorods for targeted fluorescent cell imaging and photothermal therapy

• Boris N. Khlebtsov,
• Andrey M. Burov,
• Timofey E. Pylaev and
• Nikolai G. Khlebtsov

Beilstein J. Nanotechnol. 2019, 10, 794–803, doi:10.3762/bjnano.10.79

• taken together give the opportunity to use AuNR/PDA composites as promising agents for theranostics. The published examples of fabrication and biomedical applications of PDA-coated nanorods include the following nanoconstructs: (1) AuNR-PDA-Ab for targeted PPT of cells in vitro [28]; AuNR-CuPDA for non

Ceria/polymer nanocontainers for high-performance encapsulation of fluorophores

• Kartheek Katta,
• Dmitry Busko,
• Yuri Avlasevich,
• Katharina Landfester,
• Stanislav Baluschev and
• Rafael Muñoz-Espí

Beilstein J. Nanotechnol. 2019, 10, 522–530, doi:10.3762/bjnano.10.53

• free-radical scavengers in biomedical applications as a potent therapeutic option for the treatment of disorders generated by reactive oxygen species, such as neurodegenerative disorders, retinal disorders and cancer [43][44][45]. In this work, we report the process of armoring anionically

Characterization and influence of hydroxyapatite nanopowders on living cells

• Przemyslaw Oberbek,
• Tomasz Bolek,
• Adrian Chlanda,
• Seishiro Hirano,
• Sylwia Kusnieruk,
• Julia Rogowska-Tylman,
• Ganna Nechyporenko,
• Viktor Zinchenko,
• Wojciech Swieszkowski and
• Tomasz Puzyn

Beilstein J. Nanotechnol. 2018, 9, 3079–3094, doi:10.3762/bjnano.9.286

• 100 nm can exhibit properties (including toxicological) different from those of non-nanoscale (bulk) materials [4]. Interest in the use of nanomaterials for biomedical applications is constantly growing due to their unique physical, chemical, biological and mechanical properties [5][6]. However

• regenerative medicine. The use of nanosized hydroxyapatites in biomedical applications is constantly growing due to their good mechanical properties and enhanced efficiency of gene transfection in drug delivery. Calcium phosphates are sensitive to the preparation conditions [11][12][13][14][15]. They can be

Magnetic and luminescent coordination networks based on imidazolium salts and lanthanides for sensitive ratiometric thermometry

• Pierre Farger,
• Cédric Leuvrey,
• Mathieu Gallart,
• Pierre Gilliot,
• Guillaume Rogez,
• João Rocha,
• Duarte Ananias,
• Pierre Rabu and
• Emilie Delahaye

Beilstein J. Nanotechnol. 2018, 9, 2775–2787, doi:10.3762/bjnano.9.259

• elaboration of light-emitting devices or for biomedical applications [15]. Moreover, due to the narrowness and the hypersensitivity of their transitions, lanthanide-based networks can also find utility for the sensing of gases, vapors or small molecules [9][16]. In the case of mixed lanthanide coordination

Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified γ-Fe₂O₃ nanoparticles towards human tumor cells

• Zdeněk Plichta,
• Yulia Kozak,
• Rostyslav Panchuk,
• Viktoria Sokolova,
• Matthias Epple,
• Lesya Kobylinska,
• Pavla Jendelová and
• Daniel Horák

Beilstein J. Nanotechnol. 2018, 9, 2533–2545, doi:10.3762/bjnano.9.236

• a minimally invasive method that increases the exposure of affected tissues to drug-loaded magnetic nanoparticles [5]. Colloidal stability, high drug-loading capacity, and relatively long circulation time are of primary importance for diverse biomedical applications of magnetic nanoparticles ranging

• , biocompatibility, absence of toxicity, minimal immunogenicity, and enhanced permeability and retention to cancer cells [18]. Moreover, PHPMA, which has a long history of biomedical applications as a drug-delivery vehicle, enables the control of biodistribution and accumulation via molecular weight limitations [19

• kDa according to HPLC) were obtained, which was unacceptable from the point of in vivo biomedical applications. Therefore, RAFT copolymerization was selected, which enables the preparation of well-defined telechelic P(HPMA-MMAA) molecules of medium or low molecular weight [21]. With this technique the

Enhanced antineoplastic/therapeutic efficacy using 5-fluorouracil-loaded calcium phosphate nanoparticles

• Shanid Mohiyuddin,
• Saba Naqvi and
• Gopinath Packirisamy

Beilstein J. Nanotechnol. 2018, 9, 2499–2515, doi:10.3762/bjnano.9.233

• the bulk. Thus metal-based NPs applied to biomedical applications could contradict the success of disease prognosis and treatment. Upon synthesis via solvent-extraction or calcination procedures, mesoporous silica nanoparticles (MSNs) were found to inhibit cellular respiration [10] in the in vivo

• nanoparticles in biomedical applications is extended to tissue engineering, gene/siRNA delivery, anticancer drug delivery, protein and antigen delivery, vaccine delivery, insulin as well as imaging probe or contrasting agent delivery for bio-imaging. 5-Fluorouracil (5-FU), a well-known anticancer agent

• . Characteristic features such as high biocompatibility, bioavailability and pH-triggered behaviour, highlight the great potential of calcium phosphate nanoparticles as carriers for biomedical applications. Moreover, the low cost, highly reproducible microemulsion synthetic procedure further enhances the

Electrospun one-dimensional nanostructures: a new horizon for gas sensing materials

• Muhammad Imran,
• Nunzio Motta and
• Mahnaz Shafiei

Beilstein J. Nanotechnol. 2018, 9, 2128–2170, doi:10.3762/bjnano.9.202

Nanocomposites comprised of homogeneously dispersed magnetic iron-oxide nanoparticles and poly(methyl methacrylate)

• Sašo Gyergyek,
• David Pahovnik,
• Ema Žagar,
• Alenka Mertelj,
• Rok Kostanjšek,
• Miloš Beković,
• Marko Jagodič,
• Heinrich Hofmann and
• Darko Makovec

Beilstein J. Nanotechnol. 2018, 9, 1613–1622, doi:10.3762/bjnano.9.153

• coercivity in the absence of an external magnetic field [1][2]. Their colloidal suspensions are vital in a variety of technological [3] and biomedical applications [4], such as contrast agents in magnetic resonance imaging (MRI) [5][6], targeted drug delivery [6] and magnetic hyperthermia based on the

Surface characterization of nanoparticles using near-field light scattering

• Eunsoo Yoo,
• Yizhong Liu,
• Chukwuazam A. Nwasike,
• Sebastian R. Freeman,
• Brian C. DiPaolo,
• Bernardo Cordovez and
• Amber L. Doiron

Beilstein J. Nanotechnol. 2018, 9, 1228–1238, doi:10.3762/bjnano.9.114

• studies of reaction kinetics at the particle surface that result in changes in particle size, dielectric constant, or surface chemistry, which is of particular interest in protein adsorption to nanoparticles for biomedical applications. Results and Discussion Size, morphology, and elemental analysis of

• interest in protein or biomolecule binding to nanoparticles for biomedical applications. Experimental Materials for nanoparticle synthesis The metallic precursors iron(II) chloride (FeCl2), iron(III) chloride (FeCl3), N,N’-diisopropylcarbodiimide (DIC), 4-dimethylaminopyridine (DMAP), dimethyl sulfoxide

Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations

• Jaison Jeevanandam,
• Ahmed Barhoum,
• Yen S. Chan,
• Alain Dufresne and
• Michael K. Danquah

Beilstein J. Nanotechnol. 2018, 9, 1050–1074, doi:10.3762/bjnano.9.98

• on the nanoscale dimension by using scientific knowledge of various industrial and biomedical applications. Nanomaterial: Material with any internal or external structures on the nanoscale dimension. Nano-object: Material that possesses one or more peripheral nanoscale dimensions. Nanoparticle: Nano

• beneficial biomedical applications. Insects have nanostructures that are formed via an evolutionary process which helps them to survive in harsh living conditions. Plants also utilize the nutrients available in soil and water for their growth which leads to the accumulation of these biominerals in nano-form

Green synthesis of fluorescent carbon dots from spices for in vitro imaging and tumour cell growth inhibition

• Nagamalai Vasimalai,
• Vânia Vilas-Boas,
• Juan Gallo,
• María de Fátima Cerqueira,
• Mario Menéndez-Miranda,
• José Manuel Costa-Fernández,
• Lorena Diéguez,
• Begoña Espiña and
• María Teresa Fernández-Argüelles

Beilstein J. Nanotechnol. 2018, 9, 530–544, doi:10.3762/bjnano.9.51

• compatibility and water solubility without the need of performing surface chemistry after their synthesis make them the perfect candidates for optical bioimaging and other biomedical applications [5][6][7]. The fluorescence mechanism of C-dots is not fully understood and there is an ongoing debate on the origin

• source selected for the synthesis the C-dots exhibit different toxicological behaviour. In fact, tumour cell growth inhibition can be achieved by incubating the tumour cells with these C-dots. Such fundamental finding, not reported before, opens an exciting venue to explore future biomedical applications

Liquid-crystalline nanoarchitectures for tissue engineering

• Baeckkyoung Sung and
• Min-Ho Kim

Beilstein J. Nanotechnol. 2018, 9, 205–215, doi:10.3762/bjnano.9.22

• striving for decades to invent biocompatible LC nanostructures for biomedical applications [6][7]. These works cover medical imaging and spectroscopy instruments [8][9], diagnostic biosensors [10], microlens devices [11], soft actuators [12][13], and drug delivery systems [14][15]. On the other hand, LCs

• an additional benefit for inventing sensor devices for biomedical applications. In spite of these advantages and functionalities, the application of LC nanoarchitectures in the field of tissue engineering still remains in its infancy, when compared to the advance in the applications to LC display

Comparative study of post-growth annealing of Cu(hfac)₂, Co₂(CO)₈ and Me₂Au(acac) metal precursors deposited by FEBID

• Marcos V. Puydinger dos Santos,
• Aleksandra Szkudlarek,
• Artur Rydosz,
• Carlos Guerra-Nuñez,
• Fanny Béron,
• Kleber R. Pirota,
• Stanislav Moshkalev,
• José Alexandre Diniz and
• Ivo Utke

Beilstein J. Nanotechnol. 2018, 9, 91–101, doi:10.3762/bjnano.9.11

• metals, makes its localised direct-write deposition attractive for applications in high-performance integrated circuits and nanoelectronics [13][27]. Similarly, Au nanostructures are promising materials in nanoplasmonics, biomedical applications, electrochemical sensing, as well as contacts for carbon

Advances and challenges in the field of plasma polymer nanoparticles

• Andrei Choukourov,
• Pavel Pleskunov,
• Daniil Nikitin,
• Valerii Titov,
• Artem Shelemin,
• Mykhailo Vaidulych,
• Anna Kuzminova,
• Pavel Solař,
• Jan Hanuš,
• Jaroslav Kousal,
• Ondřej Kylián,
• Danka Slavínská and
• Hynek Biederman

Beilstein J. Nanotechnol. 2017, 8, 2002–2014, doi:10.3762/bjnano.8.200

• to the investigation of the properties of plasma polymer particles themselves, regardless of the effects their presence produces on the plasma. It was recognized that polymeric nanoparticles (NPs) can be highly desired in various fields including photonics [37] and biomedical applications where they

• of plasma polymers has been considered to be of paramount importance, especially in terms of retention of primary amines which are attractive in biomedical applications as linkers for binding biomolecules. Yet, it has been recently argued that primary amines find it difficult to survive the influence

Optical techniques for cervical neoplasia detection

• Tatiana Novikova

Beilstein J. Nanotechnol. 2017, 8, 1844–1862, doi:10.3762/bjnano.8.186

• together with) intensity measurements. Apart from the intensity and wavelength of probing light its polarization can carry important information about the sample. Many research groups work in the field of biomedical applications of polarized light [94][95][96][97][98][99][100][101][102][103]. Even the

Synthesis and functionalization of NaGdF₄:Yb,Er@NaGdF₄ core–shell nanoparticles for possible application as multimodal contrast agents

• Dovile Baziulyte-Paulaviciene,
• Vitalijus Karabanovas,
• Marius Stasys,
• Greta Jarockyte,
• Vilius Poderys,
• Simas Sakirzanovas and
• Ricardas Rotomskis

Beilstein J. Nanotechnol. 2017, 8, 1815–1824, doi:10.3762/bjnano.8.183

• biologically active molecules, UCNPs could be multifunctional in both therapy and diagnostics (theranostics) [9]. However, biomedical applications require ultrasmall multifunctional nanoparticles to be hydrophilic, biocompatible and have intense upconversion emission and efficient paramagnetic properties

Laser processing of thin-film multilayer structures: comparison between a 3D thermal model and experimental results

• Babak B. Naghshine and
• Amirkianoosh Kiani

Beilstein J. Nanotechnol. 2017, 8, 1749–1759, doi:10.3762/bjnano.8.176

• can have many potential applications including patterning the cell growth for biomedical applications and controlling the grain size in fabrication of polycrystalline silicon (poly-Si) thin-film transistors (TFTs). Keywords: 3D transient modelling; heat transfer; laser materials processing

Near-infrared-responsive, superparamagnetic Au@Co nanochains

• Varadee Vittur,
• Arati G. Kolhatkar,
• Shreya Shah,
• Irene Rusakova,
• Dmitri Litvinov and
• T. Randall Lee

Beilstein J. Nanotechnol. 2017, 8, 1680–1687, doi:10.3762/bjnano.8.168

• external magnetic field. Furthermore, the NIR-responsive capability (optical extinction maximum at ca. 900 nm) combined with their magnetic properties can plausibly be harnessed in nanotechnology-based biomedical applications, such as photo-thermally modulated drug delivery, photonic devices, and photo

• unique new choice for biomedical applications in which such dual functional properties can be utilized. Experimental Materials Cobalt chloride (Baker), polyvinylpyrrolidone (MW ≈ 50000, Aldrich), sodium borohydride (Aldrich), potassium carbonate (Aldrich), hydrogen tetrachloroaurate(III) hydrate (Strem

Uptake and intracellular accumulation of diamond nanoparticles – a metabolic and cytotoxic study

• Antonín Brož,
• Lucie Bačáková,
• Pavla Štenclová,
• Alexander Kromka and
• Štěpán Potocký

Beilstein J. Nanotechnol. 2017, 8, 1649–1657, doi:10.3762/bjnano.8.165

• are tailorable on demand [2]. This work investigates the use of diamond nanomaterials, or nanodiamonds (NDs), especially in life sciences, tissue engineering and regenerative medicine [3][4][5][6]. Diamond is biocompatible [7][8], and for advanced biomedical applications, it is particularly promising

Surface functionalization of 3D-printed plastics via initiated chemical vapor deposition

• Christine Cheng and
• Malancha Gupta

Beilstein J. Nanotechnol. 2017, 8, 1629–1636, doi:10.3762/bjnano.8.162

• , and prior use in biomedical applications [33]. A silicon wafer piece was placed under the substrate to visually observe the penetration of polymer through the lattice. To measure the change in hydrophobicity of the 7.5 mm PLA lattice after the deposition of PPFDA, contact angle changes were monitored

• biomedical applications [35][36]. However, because PHEMA is water soluble, the cross-linker EGDA was incorporated during the deposition to ensure that the hydrophilic polymer coating would not dissolve in water. As shown in Figure 4, an uncoated PLA lattice did not sink in water, despite PLA having a density

Calcium fluoride based multifunctional nanoparticles for multimodal imaging

• Marion Straßer,
• Joachim H. X. Schrauth,
• Sofia Dembski,
• Daniel Haddad,
• Bernd Ahrens,
• Stefan Schweizer,
• Bastian Christ,
• Alevtina Cubukova,
• Marco Metzger,
• Heike Walles,
• Peter M. Jakob and
• Gerhard Sextl

Beilstein J. Nanotechnol. 2017, 8, 1484–1493, doi:10.3762/bjnano.8.148

• materials [15][16]. Other than fluoride NP systems doped with rare earth elements, such as LaF3:Ln3+, CeF3:Tb3+, NaYF4:(Yb3+,Er3+), NaGdF4:(Yb3+,Er3+), which were actively investigated during last decades for biomedical applications [17][18][19][20][21][22], alkaline earth metal fluorides such as CaF2

• fluorolytic sol–gel process [33]. The stability and biocompatibility of CaF2 makes it an attractive material for biomedical applications [28][29]. In addition, due to the high capacity to accept lanthanide ions, CaF2 is suitable for the preparation of CAs for multimodal imaging [24]. In this study, we report