Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

• Douglas Dourado,
• Thayse Silva Medeiros,
• Éverton do Nascimento Alencar,
• Edijane Matos Sales and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4

• higher. In vivo studies demonstrated that the nanoformulations were more effective in reducing parasitemia in the spleen, with results equivalent to the group treated with amphotericin B. Das and collaborators, on the other hand, addressed the development of nanostructured lipid carriers (NLC) with

• impact specific drug release kinetics and increase biocompatibility [60]. Different biodegradable polymers have been used for the development of targeted PNPs for the treatment of leishmaniasis [102]. In this scenario, chitosan is an interesting polymer for NP synthesis due to its positive charge, which

• system and consequently the intracellular leishmanicidal activity [50][105]. Poly(lactic-co-glycolic) acid (PLGA) is another polymer used for the development of nanoparticles for the treatment of leishmaniasis [107][108]. PLGA is an FDA-approved polymer that is commonly used in the synthesis of

Measurements of dichroic bow-tie antenna arrays with integrated cold-electron bolometers using YBCO oscillators

• Leonid S. Revin,
• Dmitry A. Pimanov,
• Alexander V. Chiginev,
• Anton V. Blagodatkin,
• Viktor O. Zbrozhek,
• Andrey V. Samartsev,
• Anastasia N. Orlova,
• Dmitry V. Masterov,
• Alexey E. Parafin,
• Victoria Yu. Safonova,
• Anna V. Gordeeva,
• Andrey L. Pankratov,
• Leonid S. Kuzmin,
• Anatolie S. Sidorenko,
• Silvia Masi and
• Paolo de Bernardis

Beilstein J. Nanotechnol. 2024, 15, 26–36, doi:10.3762/bjnano.15.3

• have resulted in jagged edges or a raised edge of the plating after lift-off, which in turn would have prevented thin electron beam resist from being deposited in the next operation. Therefore, LOR3A and S1805 photoresists were used. After the development, a layer of Ti/Au/Pd with thicknesses of 10/100

Nanotechnological approaches in the treatment of schistosomiasis: an overview

• Lucas Carvalho,
• Michelle Sarcinelli and
• Beatriz Patrício

Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2

• an encouraging prognosis for the development of future products [56]. Curcumin is a naturally yellow pigment obtained from the rhizomes of Curcuma longa. In the literature, many articles explore anti-inflammatory, antioxidant, antiviral, anti-infectious, and antitumoral properties of curcumin [58

TEM sample preparation of lithographically patterned permalloy nanostructures on silicon nitride membranes

• Joshua Williams,
• Michael I. Faley,
• Joseph Vimal Vas,
• Peng-Han Lu and
• Rafal E. Dunin-Borkowski

Beilstein J. Nanotechnol. 2024, 15, 1–12, doi:10.3762/bjnano.15.1

• layer to prevent the top layer from dissolving the lower one. Next, the top resist layer was deposited and exposed to the nominal size. The structure was developed from top to bottom including removal of the Al spacer. The development of the bottom layer, in other words the size of the undercut, is

• controlled only by the development time. In a more recent study, the Al spacer was omitted, and the development was done with one solution since the bilayer resist is made from PMMA and its copolymer [28]. The process is quite time-consuming since the exposures are done layer by layer. Considering the two

• small, then the undercut will not develop; if it is too high, then PMMA will dissolve in a larger area than the nominal diameter. It takes approximately 15 min development time to get 2 µm undercut that is shown in Figure 3b. Once the resist was developed, we deposited a 50 nm thick layer of Py using

unDrift: A versatile software for fast offline SPM image drift correction

• Tobias Dickbreder,
• Franziska Sabath,
• Lukas Höltkemeier,
• Ralf Bechstein and
• Angelika Kühnle

Beilstein J. Nanotechnol. 2023, 14, 1225–1237, doi:10.3762/bjnano.14.101

• for non-commercial purposes but the development of new features requires a Kontrast license. Input data The import of SPM data into unDrift is designed to read files in the Gwyddion Native Format (gwy format) as created with the open source SPM data analysis software Gwyddion [48]. Gwyddion contains

A combined gas-phase dissociative ionization, dissociative electron attachment and deposition study on the potential FEBID precursor [Au(CH₃)₂Cl]₂

• Elif Bilgilisoy,
• Ali Kamali,
• Thomas Xaver Gentner,
• Gerd Ballmann,
• Sjoerd Harder,
• Hans-Peter Steinrück,
• Hubertus Marbach and
• Oddur Ingólfsson

Beilstein J. Nanotechnol. 2023, 14, 1178–1199, doi:10.3762/bjnano.14.98

• and through reductive halogen removal using atomic hydrogen [58]. In an early study by Spencer et al. [57], 0.7 nm layers of Pt(CO)2Cl2 were exposed to 500 eV electrons and desorbing ligands were monitored by mass spectrometry, while the development of the deposit was monitored using XPS. It was found

Hierarchically patterned polyurethane microgrooves featuring nanopillars or nanoholes for neurite elongation and alignment

• Lester Uy Vinzons,
• Guo-Chung Dong and
• Shu-Ping Lin

Beilstein J. Nanotechnol. 2023, 14, 1157–1168, doi:10.3762/bjnano.14.96

• doses, maybe because of UV oxidation of the films or changes in the shape of the PS-NS caused by residual GBL in the SU-8.) The SU-8 was subjected to a post-exposure bake at 95 °C for 2 min, followed by development in the SU-8 developer for 1 min, rinsing with isopropyl alcohol, and N2 drying (Figure 1A

• -exposure bake at 95 °C for 2.5 min, and development for 60 s and 70 s for microgroove and pillar–groove, respectively. A less dilute SU-8 solution with SU-8 50/GBL volume ratio of 1:0.33 was used for the hole–groove sample to create microgrooves of similar depth with the following adjusted parameters: soft

• bake at 95 °C for 190 s, UV dose of 210 mJ·cm−2, post-exposure bake at 95 °C for 160 s, and development for 80 s. The SU-8 pillar–groove sample was also subjected to a hard-baking “reinforcement” step similar to that of the SU-8 nanopillars, as described above (Figure 3A(iii) and (iv)). All photoresist

Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systems

• Agnes-Valencia Weiss and
• Marc Schneider

Beilstein J. Nanotechnol. 2023, 14, 1149–1156, doi:10.3762/bjnano.14.95

• drug delivery can be achieved, are mechanical properties of nanoparticles. Even though this is often not even considered during formulation development, and it is not requested for approval, an increasing number of studies show that it is important to have knowledge about these characteristics. In this

• properties are well investigated regarding their effect on cellular uptake and the influence on in vivo performance [3][10]. Only since the first decade of the 2000s, mechanical properties have been investigated in the development of nanoparticulate drug delivery systems. A well-known example in biology

• , one can appreciate the relevant role of mechanical properties of biological systems. However, it is surprising that mechanical properties still play a minor role in the development of drug delivery systems. Even though there is an increasing number of studies focusing on the influence of mechanical

A multi-resistance wide-range calibration sample for conductive probe atomic force microscopy measurements

• François Piquemal,
• Khaled Kaja,
• Pascal Chrétien,
• José Morán-Meza,
• Frédéric Houzé,
• Christian Ulysse and
• Abdelmounaim Harouri

Beilstein J. Nanotechnol. 2023, 14, 1141–1148, doi:10.3762/bjnano.14.94

• work, we demonstrate the development of a multi-resistance reference sample for calibrating resistance measurements in conductive probe atomic force microscopy (C-AFM) covering the range from 100 Ω to 100 GΩ. We present a comprehensive protocol for in situ calibration of the whole measurement circuit

• than 1% for a reduced range from 1 MΩ to 50 GΩ. Our findings break through the long-standing bottleneck in C-AFM measurements, providing a universal means for adopting calibrated resistance measurements at the nanoscale in the industrial and academic research and development sectors. Keywords

• standard photolithography, using a mask aligner (MA6, Karl Suss, Germany), and conventional deposition techniques. Following a resist (about 1 µm thick) development process, a 2 inch diameter wafer was placed in a vacuum chamber for electron beam deposition of a 200 nm thick titanium/gold layer

Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study

• Nittiya Suwannasom,
• Netsai Sriaksorn,
• Chutamas Thepmalee,
• Krissana Khoothiam,
• Ausanai Prapan,
• Hans Bäumler and
• Chonthida Thephinlap

Beilstein J. Nanotechnol. 2023, 14, 1127–1140, doi:10.3762/bjnano.14.93

• cells [34]. Thus, submicron particles offer potential in the development of CUR delivery systems. The photophysical properties of CUR, HSA-MPs, and CUR-HSA-MPs in ethanol solution were evaluated. CUR exhibited the maximum emission at 545 nm, while CUR-HSA-MPs exhibited the maximum emission at 540 nm

A bifunctional superconducting cell as flux qubit and neuron

• Dmitrii S. Pashin,
• Pavel V. Pikunov,
• Marina V. Bastrakova,
• Andrey E. Schegolev,
• Nikolay V. Klenov and
• Igor I. Soloviev

Beilstein J. Nanotechnol. 2023, 14, 1116–1126, doi:10.3762/bjnano.14.92

• , EJ = 2Ec, and t1 = 3t2. Funding The development of the method of analysing the evolution of observables for the adiabatic logic cells in quantum mode was carried out with the support of the Grant of the Russian Science Foundation No. 22-72-10075. The development of the main concept was carried out

Sulfur nanocomposites with insecticidal effect for the control of Bactericera cockerelli

• Lany S. Araujo-Yépez,
• Juan O. Tigrero-Salas,
• Vicente A. Delgado-Rodríguez,
• Vladimir A. Aguirre-Yela and
• Josué N. Villota-Méndez

Beilstein J. Nanotechnol. 2023, 14, 1106–1115, doi:10.3762/bjnano.14.91

• nanocomposites are more effective in controlling nymphs of paratrioza than the commercial insecticide thiamethoxam; thus, they could be used for the development of new insecticides. Keywords: eucalyptus; nanoinsecticide; nanotechnology; Paratrioza control; rosemary; Introduction Paratrioza (Bactericera

• bacterium Candidatus Liberibacter solanacearum causes abnormal plant development and early death, reducing the quality and yields of potato, tomato, and pepper crops [2]. Bactericella cockerelli tends to be difficult to manage with synthetic insecticides, such as organophosphates, organochlorines

• development of new nanoinsecticides to combat pests in a more productive, cost-effective, and eco-friendly way [8][12]. Nanoscale agricultural products are developed using nanotechnology, such as nanopesticides, nanoinsecticides, nanoemulsions, and nanoparticles, to reduce the use of toxic chemicals [14

Properties of tin oxide films grown by atomic layer deposition from tin tetraiodide and ozone

• Kristjan Kalam,
• Peeter Ritslaid,
• Tanel Käämbre,
• Aile Tamm and
• Kaupo Kukli

Beilstein J. Nanotechnol. 2023, 14, 1085–1092, doi:10.3762/bjnano.14.89

• File 10: Supplementary material. Funding The study was partially supported by the European Regional Development Fund projects Nos. TT20 and 2014-2020.4.01.20-0278 „Developing new research services and research infrastructures at MAX IV synchrotron radiation source“ (MAX-TEENUS), “Emerging orders in

Dual-heterodyne Kelvin probe force microscopy

• Benjamin Grévin,
• Fatima Husainy,
• Dmitry Aldakov and
• Cyril Aumaître

Beilstein J. Nanotechnol. 2023, 14, 1068–1084, doi:10.3762/bjnano.14.88

• development of KPFM-based approaches specifically designed to investigate photogeneration mechanisms and charge dynamics at the nanoscale in photovoltaic and optoelectronic materials is an active research area. In photoassisted KPFM, the idea is to probe the surface photovoltage (SPV), which is the

Spatial mapping of photovoltage and light-induced displacement of on-chip coupled piezo/photodiodes by Kelvin probe force microscopy under modulated illumination

• Zeinab Eftekhari,
• Nasim Rezaei,
• Hidde Stokkel,
• Jian-Yao Zheng,
• Andrea Cerreta,
• Ilka Hermes,
• Minh Nguyen,
• Guus Rijnders and
• Rebecca Saive

Beilstein J. Nanotechnol. 2023, 14, 1059–1067, doi:10.3762/bjnano.14.87

• characterization technique, we cannot fully conclude the reason for the deviation from the expected behavior, the results stress the importance of employing advanced, time-dependent spatial mapping characterization techniques for the development of novel nano/micro-actuators. Conclusion In this study, we

Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one

• Jonathan-Gabriel Nimz,
• Pichayut Rerkshanandana,
• Chiraphat Kloypan,
• Ulrich Kalus,
• Saranya Chaiwaree,
• Axel Pruß,
• Radostina Georgieva,
• Yu Xiong and
• Hans Bäumler

Beilstein J. Nanotechnol. 2023, 14, 1028–1040, doi:10.3762/bjnano.14.85

• during development, namely nitrogen monoxide scavenging and associated hypertensive crises, massive renal damage due to tubular reabsorption of hemoglobin (Hb), decay into dimers [8][9][10][11][12][13], and oxidative stress [14][15]. Various approaches of intra- as well as intermolecular modifications of

• our HbMPs into monocytes, while there might be additional other mechanisms at play. The aim of this work is to contribute a further step towards the development of HbMPs as a complete, safe blood substitute for volume expansion and oxygen distribution. Materials and Methods Chemicals 0.9% sodium

• the development of a suitable experimental setup, a strong influence of direct fluorescent labeling of HbMPs on the phagocytosis activity of monocytes was found. Consequently, we chose an indirect phagocytosis assay for our experiments, which did not require any labeling of the HbMPs potentially to be

A visible-light photodetector based on heterojunctions between CuO nanoparticles and ZnO nanorods

• Doan Nhat Giang,
• Nhat Minh Nguyen,
• Duc Anh Ngo,
• Thanh Trang Tran,
• Le Thai Duy,
• Cong Khanh Tran,
• Thi Thanh Van Tran,
• Phan Phuong Ha La and
• Vinh Quang Dang

Beilstein J. Nanotechnol. 2023, 14, 1018–1027, doi:10.3762/bjnano.14.84

• development of many technologies in the future, such as solar cells [1][2], light-emitting diodes (LEDs) [3][4], laser diodes [5], and optical fibers [6]. Optoelectronics devices contribute to meeting requirements in telecommunications, medical equipment, sensors, and military services. Among those

Exploring internal structures and properties of terpolymer fibers via real-space characterizations

• Michael R. Roenbeck and
• Kenneth E. Strawhecker

Beilstein J. Nanotechnol. 2023, 14, 1004–1017, doi:10.3762/bjnano.14.83

• forerunners in the field, such as Kevlar® and ultrahigh molecular weight polyethylene (UHMWPE), have driven tremendous interest in new fiber chemistries and processing techniques. The development of Technora® in 1987 marked a new approach to polymer fiber design, with an emphasis on aligning extended

• development of future classes of high-performance fibers. Results AFM characterizations of Technora® AFM maps enable direct characterization of both fiber nano- and microstructures in real space. Large-scale maps span across the fiber diameter to highlight prominent microstructural features. For Technora

Nanoarchitectonics of photothermal materials to enhance the sensitivity of lateral flow assays

• Elangovan Sarathkumar,
• Rajasekharan S. Anjana and
• Ramapurath S. Jayasree

Beilstein J. Nanotechnol. 2023, 14, 988–1003, doi:10.3762/bjnano.14.82

• maintained. Further, the development of a laser readout system to measure the signal intensity of the test line could potentially bring out the characteristic feature of POCT [10]. To establish a correlation between the nanoscale architecture and the optical properties of materials in order to enhance the

• nanomaterials; it also influences the capillary movement of nanoparticles inside the nitrocellulose membrane pores. Herein, we discuss the current development of photothermal nanomaterials regarding the application in LFAs. As an introduction, we discuss the classification of different photothermal

• systems and their development in POCT techniques. We also try to highlight the importance of photothermal nanomaterials in signal amplification techniques, which might allow for the sensitive and quantitative detection of analytes in LFAs and other POCT devices. A graphical outline of the content of this

Isolation of cubic Si₃P₄ in the form of nanocrystals

• Polina K. Nikiforova,
• Sergei S. Bubenov,
• Vadim B. Platonov,
• Andrey S. Kumskov,
• Nikolay N. Kononov,
• Tatyana A. Kuznetsova and
• Sergey G. Dorofeev

Beilstein J. Nanotechnol. 2023, 14, 971–979, doi:10.3762/bjnano.14.80

• number of potential benefits to both science and industry. These methods often employ new strategies for the synthesis of specific classes of substances. For example, the widely known development of perovskite synthesis through ion exchange reactions has attracted attention in scientific as well as

• 42: Additional experimental data. Acknowledgements The image of the unit cell of cubic Si3P4 was created using a VESTA-JP-Minerals program [50]. The authors acknowledge (partial) support from M. V. Lomonosov Moscow State University Program of Development in the form of access to a S2 Picofox TXRF

Metal-organic framework-based nanomaterials for CO₂ storage: A review

• Ha Huu Do,
• Iqra Rabani and
• Hai Bang Truong

Beilstein J. Nanotechnol. 2023, 14, 964–970, doi:10.3762/bjnano.14.79

• , including pore size manipulation, post-synthetic modifications, and composite formation. Finally, the extant challenges and anticipated prospects pertaining to the development of MOF-based nanomaterials for CO2 storage are described. Keywords: CO2 storage; metal-organic frameworks; nanomaterials; open

• problem involves increased government funding for the maintenance of existing renewable energy sources and the development of new green energies [2][3]. However, the widespread implementation of these solutions is hindered by the challenges posed by nascent technology [4][5]. Another feasible approach to

• ]. Therefore, identification and development of durable and efficient adsorbents are critical to the successful implementation of CCS. Until now, various classes of materials have been investigated for CO2 adsorption, such as covalent organic frameworks, molecular sieves, activated carbon, and metal-organic

Low temperature atomic layer deposition of cobalt using dicobalt hexacarbonyl-1-heptyne as precursor

• Mathias Franz,
• Mahnaz Safian Jouzdani,
• Lysann Kaßner,
• Marcus Daniel,
• Frank Stahr and
• Stefan E. Schulz

Beilstein J. Nanotechnol. 2023, 14, 951–963, doi:10.3762/bjnano.14.78

• , Clemens-Winkler-Str. 6c, 09116 Chemnitz, Germany FAP Forschungs- und Applikationslabor Plasmatechnik GmbH, Gostritzer Str. 67B, 01217 Dresden, Germany 10.3762/bjnano.14.78 Abstract In this work, we present the development of an atomic layer deposition (ALD) process for metallic cobalt. The process

• . Typically, these systems require ultrathin layers within the nanometre scale [6]. The thickness and conformality criteria of future microelectronics devices require the development of cobalt metal films deposited by ALD. Because of the self-limiting growth process, ALD allows for the sub-nanometre control

• Process equipment The ALD process development was done on a scial Atol 200 single-wafer reactor equipped with cassette loading and a handling robot. This machine was designed and fabricated by scia Systems GmbH in corporation with Fraunhofer Institute for Electronic Nano Systems ENAS, Center for

Prediction of cytotoxicity of heavy metals adsorbed on nano-TiO₂ with periodic table descriptors using machine learning approaches

• Joyita Roy,
• Souvik Pore and
• Kunal Roy

Beilstein J. Nanotechnol. 2023, 14, 939–950, doi:10.3762/bjnano.14.77

• attention due to their widespread applications in different areas, and they are continually designed to yield certain desired properties [1]. With the uninterrupted development of new NPs, engineered nanoparticles in the form of metal oxide nanoparticles are becoming a new area of research. Metal oxides

• nanomaterials based on structure similarities with known substances. Materials with similar structures are likely to produce similar toxicity through comparable mechanisms. The development of machine learning (ML) approaches, such as artificial neural networks (ANNs), decision trees, logistic regression (LR

• /jadavpuruniversity.in/dtc-lab-software/home/machine-learning-model-development-guis?pli=1). GridSearchCV tests all combinations of values in the dictionary and evaluates the model using the cross-validation method for each combination. Therefore, we choose the hyperparameter combination with the best average MAE

Upscaling the urea method synthesis of CoAl layered double hydroxides

• Camilo Jaramillo-Hernández,
• Víctor Oestreicher,
• Martín Mizrahi and
• Gonzalo Abellán

Beilstein J. Nanotechnol. 2023, 14, 927–938, doi:10.3762/bjnano.14.76

• development of efficient and reproducible large-scale synthesis processes. Unfortunately, reliable methods that allow for the production of large quantities of two-dimensional LDHs with well-defined morphologies and high crystallinity are very scarce. In this work, we carry out a scale-up of the urea-based

• storage and conversion [19][20][21], quantum materials [22][23], and others [24]. This wide range of potential applications makes the development of reliable scaling processes crucial. Usually, LDHs are obtained by different synthesis procedures such as co-precipitation [25], hydrothermal synthesis [13

Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics

• Mamta Kumari,
• Amitabha Acharya and
• Praveen Thaggikuppe Krishnamurthy

Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75

• ability to accumulate at tumor sites. More importantly, surface modification and functionalization of NPs to increase their therapeutic efficacy can be achieved very easily. The recent advancement in targeted delivery introduces the development of surface-modified nanosystems that can be used in screening

• -effectiveness. The optimization of these variables depends on NP design parameters such as size, shape, charge, composition, preparation method, and surface decorating moiety. The most crucial aspect in the future development of ACNPs will be the design and fabrication of multiple targeting moieties with the

• trials. To completely exploit the advantages of ACNPs in both preclinical and clinical studies, it is substantial to analyze the gaps between formulation development, selection of appropriate animal models, and clinical safety in humans. Additionally, early detection is one of the most important issues