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Search for "Micrococcus" in Full Text gives 23 result(s) in Beilstein Journal of Organic Chemistry.

Pseudallenes A and B, new sulfur-containing ovalicin sesquiterpenoid derivatives with antimicrobial activity from the deep-sea cold seep sediment-derived fungus Pseudallescheria boydii CS-793

  • Zhen Ying,
  • Xiao-Ming Li,
  • Sui-Qun Yang,
  • Hong-Lei Li,
  • Xin Li,
  • Bin-Gui Wang and
  • Ling-Hong Meng

Beilstein J. Org. Chem. 2024, 20, 470–478, doi:10.3762/bjoc.20.42

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  • –3 were tested against seven human- and marine-derived aquatic pathogenetic bacteria (Edwardsiella tarda, Escherichia coli, Micrococcus luteus, Pseudomonas aeruginosa, Vibrio anguillarum, Vibrio harveyi, and Vibrio vulnificus), and six plant pathogenic fungi (Alternaria brassicae, Colletotrichum
  • pathogenic bacteria (Escherichia coli QDIO-1 and Pseudomonas aeruginosa QDIO-4) and aquatic pathogens (Edwardsiella tarda QDIO-2, Micrococcus luteus QDIO-3, V. anguillarum QDIO-6, Vibrio harveyi QDIO-7, and V. vulnificus QDIO-10), as well as plant pathogenic fungi (Colletotrichum gloeosporioides QDAU-2
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Published 28 Feb 2024

Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities

  • Jorge de Lima Neto and
  • Paulo Henrique Menezes

Beilstein J. Org. Chem. 2023, 19, 399–427, doi:10.3762/bjoc.19.31

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  • taxol® is the most potent antitumor drug, showing GI50 ranging from pmol to nmol against different types of cancer cell lines [77]. When combretastatins D-2, D-4, and some synthetic intermediates were evaluated against Candida albicans (ATCC 90028), Cryptococcus neoformans (ATCC 90112), Micrococcus
  • ) against the bacteria Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus, Escherichia coli, Klebsiella pneumoniae, and the fungi Aspergillus niger, Aspergillus terreus, and Aspergillus flavus. Unfortunately, all compounds were found to be inactive [14]. The use of compounds capable to delay
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Published 29 Mar 2023

Nocarimidazoles C and D, antimicrobial alkanoylimidazoles from a coral-derived actinomycete Kocuria sp.: application of 1JC,H coupling constants for the unequivocal determination of substituted imidazoles and stereochemical diversity of anteisoalkyl chains in microbial metabolites

  • Md. Rokon Ul Karim,
  • Enjuro Harunari,
  • Amit Raj Sharma,
  • Naoya Oku,
  • Kazuaki Akasaka,
  • Daisuke Urabe,
  • Mada Triandala Sibero and
  • Yasuhiro Igarashi

Beilstein J. Org. Chem. 2020, 16, 2719–2727, doi:10.3762/bjoc.16.222

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  • metabolite of marine Verrucosispora, effective against methicillin-resistant Staphylococcus aureus (MRSA) and Mycobacterium tuberculosis [11][12]. The genus Kocuria, formerly categorized in the genus Micrococcus, is a Gram-positive unicellular coccus belonging to the family Micrococcaceae [13]. Members of
  • siderophores and modified peptides, are known from Kocuria and Micrococcus [19][20]. In our continuing investigation on secondary metabolites from marine bacteria, five alkanoylimidazoles were obtained from the culture extract of a Kocuria strain isolated from a stony coral. Alkanoylimidazoles are a new and
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Published 05 Nov 2020

Towards the total synthesis of chondrochloren A: synthesis of the (Z)-enamide fragment

  • Jan Geldsetzer and
  • Markus Kalesse

Beilstein J. Org. Chem. 2020, 16, 670–673, doi:10.3762/bjoc.16.64

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  • (Cmc5) by the groups of Höfle and Reichenbach in 2003 [12]. This PKS/NRPS-derived natural product shows only weak antibiotic effects in agar diffusion tests against Micrococcus luteus, Schizosaccharomyces pombe, Bacillus subtilis and Staphylococcus aureus [12]. The relative and absolute stereochemistry
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Published 14 Apr 2020

Two antibacterial and PPARα/γ-agonistic unsaturated keto fatty acids from a coral-associated actinomycete of the genus Micrococcus

  • Amit Raj Sharma,
  • Enjuro Harunari,
  • Naoya Oku,
  • Nobuyasu Matsuura,
  • Agus Trianto and
  • Yasuhiro Igarashi

Beilstein J. Org. Chem. 2020, 16, 297–304, doi:10.3762/bjoc.16.29

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  • ), were isolated from the culture broth of an actinomycete of the genus Micrococcus, which was associated with a stony coral, Catalaphyllia sp. Their chemical structures were elucidated by spectroscopic analysis including NMR and MS, with special assistance of spin system simulation studies for the
  • ; Micrococcus; PPAR; Introduction Marine actinobacteria are considered as a potential source for novel natural products with high structural diversity, unique biological activity, and molecular modes of action beneficial to drug development [1][2][3]. Actinobacteria in marine environments are mostly found in
  • strepchloritides [7], nahuoic acids B–E [8], and pteridic acids C–G [9], were obtained from actinobacteria associated with soft corals. There is no report indeed on natural products from actinobacteria residing in stony corals. Actinomycetes of the genus Micrococcus are Gram-positive, aerobic, and nonmotile cocci
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Published 02 Mar 2020

Skeletocutins M–Q: biologically active compounds from the fruiting bodies of the basidiomycete Skeletocutis sp. collected in Africa

  • Tian Cheng,
  • Clara Chepkirui,
  • Cony Decock,
  • Josphat C. Matasyoh and
  • Marc Stadler

Beilstein J. Org. Chem. 2019, 15, 2782–2789, doi:10.3762/bjoc.15.270

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  • (B. subtilis), S. aureus, methicillin-resistant S. aureus (MRSA), and Micrococcus luteus (M. luteus). In the antimicrobial assay, compounds 3 and 5 were observed to interfere with the formation of biofilms commonly associated with S. aureus. When compounds 3 and 5 were evaluated for biofilm
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Published 19 Nov 2019

Current understanding and biotechnological application of the bacterial diterpene synthase CotB2

  • Ronja Driller,
  • Daniel Garbe,
  • Norbert Mehlmer,
  • Monika Fuchs,
  • Keren Raz,
  • Dan Thomas Major,
  • Thomas Brück and
  • Bernhard Loll

Beilstein J. Org. Chem. 2019, 15, 2355–2368, doi:10.3762/bjoc.15.228

Graphical Abstract
  • subtilis of 9 µM and 10 µM for Micrococcus luteus, respectively [25]. For the sustainable, high yield production of bioactive diterpenoids various aspects have to be considered. One key issue in yielding high recombinant terpene production titers, are metabolic bottlenecks in the precursor supply, which
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Published 02 Oct 2019

Isolation and biosynthesis of an unsaturated fatty acid with unusual methylation pattern from a coral-associated bacterium Microbulbifer sp.

  • Amit Raj Sharma,
  • Enjuro Harunari,
  • Tao Zhou,
  • Agus Trianto and
  • Yasuhiro Igarashi

Beilstein J. Org. Chem. 2019, 15, 2327–2332, doi:10.3762/bjoc.15.225

Graphical Abstract
  • and carbons from C3 to C18 are from palmitoyl-CoA. To the best of our knowledge, compound 1 is the first example of a simple fatty acid in which the carbonyl carbon of an acetate unit is methylated with SAM (Figure 3D). Compound 1 was not active against Staphylococcus aureus FDA209P JC-1, Micrococcus
  • microtiter plates against six bacteria, Bacillus subtilis ATCC6633, Micrococcus luteus ATCC9341, Staphylococcus aureus FDA209P JC-1, Ralstonia solanacearum SUPP1541, Rhizobium radiobacter NBRC14554, Escherichia coli NIHJ JC-2, and two yeasts Candida albicans NBRC0197 and Saccharomyces cerevisiae S100 as
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Published 30 Sep 2019

Synthesis and SAR of the antistaphylococcal natural product nematophin from Xenorhabdus nematophila

  • Frank Wesche,
  • Hélène Adihou,
  • Thomas A. Wichelhaus and
  • Helge B. Bode

Beilstein J. Org. Chem. 2019, 15, 535–541, doi:10.3762/bjoc.15.47

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  • , the above mentioned compounds were tested against different pathogenic strains, i.e., methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), Enterococcus faecalis, and Micrococcus luteus. The yields and bioactivities are summarized in Table 1 (and Table S1, Supporting
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Published 25 Feb 2019

N-Acylated amino acid methyl esters from marine Roseobacter group bacteria

  • Hilke Bruns,
  • Lisa Ziesche,
  • Nargis Khakin Taniwal,
  • Laura Wolter,
  • Thorsten Brinkhoff,
  • Jennifer Herrmann,
  • Rolf Müller and
  • Stefan Schulz

Beilstein J. Org. Chem. 2018, 14, 2964–2973, doi:10.3762/bjoc.14.276

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  • program for their antimicrobial activity (Table 3). While the valine derivative 9 was virtually inactive, the other compounds showed some activity. Glycine compound 11 showed good activity against the Gram-positive bacteria Bacillus subtilis, Staphylococcus aureus, and Micrococcus luteus, and against the
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Published 03 Dec 2018

Lanyamycin, a macrolide antibiotic from Sorangium cellulosum, strain Soce 481 (Myxobacteria)

  • Lucky S. Mulwa,
  • Rolf Jansen,
  • Dimas F. Praditya,
  • Kathrin I. Mohr,
  • Patrick W. Okanya,
  • Joachim Wink,
  • Eike Steinmann and
  • Marc Stadler

Beilstein J. Org. Chem. 2018, 14, 1554–1562, doi:10.3762/bjoc.14.132

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  • and the human nasopharyngeal cell line KB3 with IC50 values of 3.1 and 1.5 μM, respectively, and also suppressed the growth of the Gram-positive bacterium Micrococcus luteus. Keywords: antimicrobial; HCV; lanyamycin; macrolide; Sorangium cellulosum; Introduction Viral hepatitis (HCV) has recently
  • -HPLC fractionating and peak-activity correlation we further noted at tR = 18–25 min an inhibition overlap of Micrococcus luteus and Candida albicans, which correlated with some prominent peaks with unique HPLC-DAD-MS characteristics attracting our interest. Consequently, the fermentation process was
  • optimized and scaled up. The main active principle was identified as soraphen A, which is already known from Sorangium cellulosum [9]. However, on close analysis of peak–activity correlation, we detected another biologically active metabolite inhibiting growth of Micrococcus luteus correlating to a
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Published 26 Jun 2018

Synthesis of 1-indanones with a broad range of biological activity

  • Marika Turek,
  • Dorota Szczęsna,
  • Marek Koprowski and
  • Piotr Bałczewski

Beilstein J. Org. Chem. 2017, 13, 451–494, doi:10.3762/bjoc.13.48

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Published 09 Mar 2017

Antibiotics from predatory bacteria

  • Juliane Korp,
  • María S. Vela Gurovic and
  • Markus Nett

Beilstein J. Org. Chem. 2016, 12, 594–607, doi:10.3762/bjoc.12.58

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  • production and predation. However, myxovirescins cannot be considered as universal predatory weapons for M. xanthus DK1622, as the macrolides have no effects on the Gram-positive prey bacterium Micrococcus luteus [82]. It remains unclear whether as yet unidentified antibiotics from the DK1622 metabolome
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Published 30 Mar 2016

Bromotyrosine-derived alkaloids from the Caribbean sponge Aplysina lacunosa

  • Qun Göthel,
  • Thanchanok Sirirak and
  • Matthias Köck

Beilstein J. Org. Chem. 2015, 11, 2334–2342, doi:10.3762/bjoc.11.254

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  • -phase HPLC [70:30 H2O (0.1% TFA)/MeCN (0.1% TFA), v/v] to get a mixture of 3 and 15 (3.5 mg) as well as 4 (3.0 mg). Biological activity test The antimicrobial activities of isolated compounds were evaluated against five microorganisms [Gram-positive: Straptococcus aureus (MRSA and MSSA) and Micrococcus
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Published 26 Nov 2015

The marine sponge Agelas citrina as a source of the new pyrrole–imidazole alkaloids citrinamines A–D and N-methylagelongine

  • Christine Cychon,
  • Ellen Lichte and
  • Matthias Köck

Beilstein J. Org. Chem. 2015, 11, 2029–2037, doi:10.3762/bjoc.11.220

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  • cytotoxic activity. Classical agar diffusion assays were performed using the fungus Aspergillus niger, the yeast Saccharomyces cerevisiae as well as the Gram-negative bacterium Escherichia coli, and the Gram-positive bacterium Micrococcus luteus and Mycobacterium phlei as test organisms. In agar diffusion
  • assays with Mycobacterium phlei considerable inhibition zones were observed for citrinamines B, C, and D (2–4), while there was also an activity of citrinamine C (3) against Micrococcus luteus. All compounds (1–4) showed no inhibition of cell proliferation of mouse fibroblasts. Conclusion The analysis of
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Published 29 Oct 2015

Pyridinoacridine alkaloids of marine origin: NMR and MS spectral data, synthesis, biosynthesis and biological activity

  • Louis P. Sandjo,
  • Victor Kuete and
  • Maique W. Biavatti

Beilstein J. Org. Chem. 2015, 11, 1667–1699, doi:10.3762/bjoc.11.183

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  • negative Escherichia coli and the gram positive Micrococcus luteus bacteria [56]. Interestingly, the 9H-quinolino[4,3,2-de][1,10]phenanthrolin-9-one core corresponding to the ascididemin (42) structure once again has proved to be a suitable antibacterial pharmacophore (Figure 17) [56]. The decrease in the
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Published 18 Sep 2015

Sacrolide A, a new antimicrobial and cytotoxic oxylipin macrolide from the edible cyanobacterium Aphanothece sacrum

  • Naoya Oku,
  • Miyako Matsumoto,
  • Kohsuke Yonejima,
  • Keijiroh Tansei and
  • Yasuhiro Igarashi

Beilstein J. Org. Chem. 2014, 10, 1808–1816, doi:10.3762/bjoc.10.190

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  • . Antimicrobial testing against four Gram-positive bacteria (Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus, and Streptomyces lividans), one Gram-negative bacterium (Escherichia coli), two yeasts (Candida albicans and Saccharomyces cerevisiae), and two fungi (Aspergillus oryzae and Penicillum
  • the growth of Gram-positive bacteria (Micrococcus luteus, Streptomyces lividans, Staphylococcus aureus, Bacillus subtilis), a yeast (Saccharomyces cerevisiae) and a fungus (Penicillium chrysogenum) (Table 2). Moreover, 1 was cytotoxic to 3Y1 rat fibroblasts (GI50 4.5 μM). Under microscopic observation
  • strains were grown on agar media (Staphylococcus aureus FDA209P JC-1, Micrococcus luteus ATCC9341, Escherichia coli NIHJ JC-2, Saccharomyces cerevisiae S100, and Candida albicans A9540) or in Sabouraud broth (Penicillum chrysogenum NBRC4626, Streptomyces lividans TK23) overnight and then diluted with
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Published 07 Aug 2014

New sesquiterpene hydroquinones from the Caribbean sponge Aka coralliphagum

  • Qun Göthel and
  • Matthias Köck

Beilstein J. Org. Chem. 2014, 10, 613–621, doi:10.3762/bjoc.10.52

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  • -positive and Gram-negative bacteria, fungi, and for antiproliferative activity. The results given in Table 4 show that siphonodictyal E3 (3) and cyclosiphonodictyol A (5) exhibited mild activity against the Gram-positive bacteria Staphylococcus aureus and Micrococcus luteus, while siphonodictyal E4 (4
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Published 06 Mar 2014

A macrolactonization approach to the total synthesis of the antimicrobial cyclic depsipeptide LI-F04a and diastereoisomeric analogues

  • James R. Cochrane,
  • Dong Hee Yoon,
  • Christopher S. P. McErlean and
  • Katrina A. Jolliffe

Beilstein J. Org. Chem. 2012, 8, 1344–1351, doi:10.3762/bjoc.8.154

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  • strains of Bacillus (Paenebacillus) and exhibit antifungal and antibacterial activity against a range of clinically relevant species, including Candida albicans, Cryptococcus neoformans, Staphylococcus aureus and Micrococcus luteus [1][2][3][4][5][6][7]. These compounds have a cyclic hexadepsipeptide core
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Published 21 Aug 2012

Similarity analysis, synthesis, and bioassay of antibacterial cyclic peptidomimetics

  • Workalemahu M. Berhanu,
  • Mohamed A. Ibrahim,
  • Girinath G. Pillai,
  • Alexander A. Oliferenko,
  • Levan Khelashvili,
  • Farukh Jabeen,
  • Bushra Mirza,
  • Farzana Latif Ansari,
  • Ihsan ul-Haq,
  • Said A. El-Feky and
  • Alan R. Katritzky

Beilstein J. Org. Chem. 2012, 8, 1146–1160, doi:10.3762/bjoc.8.128

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  • . Some of the synthesized compounds were tested against an array of microorganisms and showed antibacterial activity against Bordetella bronchistepica, Micrococcus luteus, and Salmonella typhimurium. Keywords: antibacterial; cluster analysis; N-acylbenzotriazoles; peptidomimetics; similarity
  • antibiotics roxithromycin and cefixime were used as positive controls. It is seen that peptidomimetic 37b exhibits moderate activity against Bordetella bronchiseptica, Micrococcus luteus, and Salmonella typhimurium. For a “bare” scaffold with no tailor-made substitution, this should be considered as an
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Published 24 Jul 2012

Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum

  • Friederike I. Nollmann,
  • Andrea Dowling,
  • Marcel Kaiser,
  • Klaus Deckmann,
  • Sabine Grösch,
  • Richard ffrench-Constant and
  • Helge B. Bode

Beilstein J. Org. Chem. 2012, 8, 528–533, doi:10.3762/bjoc.8.60

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  • different Gram-positive (Micrococcus luteus, Bacillus subtilis, Staphylococcus aureus) and Gram-negative (Escherichia coli, Pseudomonas aeroginosa) bacteria, as well as yeast (Candida albicans, Saccharomyces cerivisiae). However, consistent with the published data [12], no antibacterial or antifungal
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Published 11 Apr 2012

Carbamate derivatives and sesquiterpenoids from the South China Sea gorgonian Melitodes squamata

  • Li-Si Huang,
  • Fei He,
  • Hui Huang,
  • Xiao-Yong Zhang and
  • Shu-Hua Qi

Beilstein J. Org. Chem. 2012, 8, 170–176, doi:10.3762/bjoc.8.18

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  • 1, 2, 6, and 7 have not been previously reported. The cytotoxicity of 1–9 against human malignant melanoma A735 and cervical carcinoma HeLa cell lines, and the antibacterial activity of 1–5 and 7 towards bacteria Escherichia coli, Bacillus subtilis and Micrococcus luteus were evaluated. The possible
  • by MTT assay. The results show that 1–9 does not exhibit cytotoxicity against A735 and HeLa cell lines with IC50 > 200 μg/mL. Antibacterial activity of compounds 1–5 at a concentration of 25 μg/disc (diameter 6 mm) was measured against bacteria Escherichia coli, Bacillus subtilis, and Micrococcus
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Published 31 Jan 2012

Pyridinium based amphiphilic hydrogelators as potential antibacterial agents

  • Sayanti Brahmachari,
  • Sisir Debnath,
  • Sounak Dutta and
  • Prasanta Kumar Das

Beilstein J. Org. Chem. 2010, 6, 859–868, doi:10.3762/bjoc.6.101

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  • -negative bacteria with minimum inhibitory concentration (MIC) values as low as 0.4 µg/mL for Micrococcus luteus. In addition, amphiphile 2 was investigated for cytotoxicity with mammalian cells (NIH3T3) and showed sufficient viability throughout a range of concentrations. Results and Discussion Gelation is
  • (Bacillus subtilis and Micrococcus luteus) and Gram-negative (Escherichia coli and Klebsiella aerogenes) bacteria. Minimum inhibitory concentrations (MIC), the lowest amphiphile concentration at which no viable bacterial cell is present, are presented in Table 1. Both 1 and 2 were found to be effective in
  • killing bacteria with MIC values of 0.4–2.0 μg/mL for Gram-positive bacteria and 5.0–20.0 μg/mL for Gram-negative bacteria. However, 2 was found to have slightly better antibacterial activity than 1 with MIC values of only 0.4 μg/mL for Gram-positive Micrococcus luteus and 10 μg/mL for Gram-negative
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Published 21 Sep 2010
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