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Search for "carboxamide" in Full Text gives 98 result(s) in Beilstein Journal of Organic Chemistry.

Synthesis and biological profile of 2,3-dihydro[1,3]thiazolo[4,5-b]pyridines, a novel class of acyl-ACP thioesterase inhibitors

  • Jens Frackenpohl,
  • David M. Barber,
  • Guido Bojack,
  • Birgit Bollenbach-Wahl,
  • Ralf Braun,
  • Rahel Getachew,
  • Sabine Hohmann,
  • Kwang-Yoon Ko,
  • Karoline Kurowski,
  • Bernd Laber,
  • Rebecca L. Mattison,
  • Thomas Müller,
  • Anna M. Reingruber,
  • Dirk Schmutzler and
  • Andrea Svejda

Beilstein J. Org. Chem. 2024, 20, 540–551, doi:10.3762/bjoc.20.46

Graphical Abstract
  • -ynylcarbamoyl)-1,3-dioxolane-2-carboxamide [3] and FAM azide, 5-isomer (Broadpharm BP-22544, San Diego, CA) by click chemistry [29] and was purified by flash column chromatography on silica gel. Preemergence efficacy of 2,3-dihydro[1,3]thiazolo[4,5-b]pyridine-based FAT inhibitors 7b, 7c, and 13b as well as
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Published 01 Mar 2024

Synthetic approach to 2-alkyl-4-quinolones and 2-alkyl-4-quinolone-3-carboxamides based on common β-keto amide precursors

  • Yordanka Mollova-Sapundzhieva,
  • Plamen Angelov,
  • Danail Georgiev and
  • Pavel Yanev

Beilstein J. Org. Chem. 2023, 19, 1804–1810, doi:10.3762/bjoc.19.132

Graphical Abstract
  • key o-nitrobenzoyl intermediates 3 in a reaction with o-nitrobenzoyl chloride (Scheme 1, conditions ii). The acylation of 2 to 3 proceeded with variable yields, depending on the substituents R1 and R2. Derivatives 2 with a primary carboxamide group (R2 = H) gave generally lower and poorly reproducible
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Published 23 Nov 2023

N-Sulfenylsuccinimide/phthalimide: an alternative sulfenylating reagent in organic transformations

  • Fatemeh Doraghi,
  • Seyedeh Pegah Aledavoud,
  • Mehdi Ghanbarlou,
  • Bagher Larijani and
  • Mohammad Mahdavi

Beilstein J. Org. Chem. 2023, 19, 1471–1502, doi:10.3762/bjoc.19.106

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  • Lewis base organocatalysts (Scheme 56) [88]. In this procedure, the cyclized products were obtained via the activation of the sulfur electrophile by a Lewis base to generate the thiiranium ion intermediate from the β,γ-unsaturated sulfonyl carboxamide. The attack of the sulfonamide nitrogen atom on this
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Published 27 Sep 2023

Intermediates and shunt products of massiliachelin biosynthesis in Massilia sp. NR 4-1

  • Till Steinmetz,
  • Blaise Kimbadi Lombe and
  • Markus Nett

Beilstein J. Org. Chem. 2023, 19, 909–917, doi:10.3762/bjoc.19.69

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  • formation of the terminal carboxamide in 6 might be due to a spontaneous C–N bond cleavage, which occurs in 1’’ prior to the cyclization, consistent with a mechanism recently proposed in photoxenobactin biosynthesis [34]. Despite the widespread occurrence of siderophores featuring a phenolic moiety with a
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Published 23 Jun 2023

Pyridine C(sp2)–H bond functionalization under transition-metal and rare earth metal catalysis

  • Haritha Sindhe,
  • Malladi Mounika Reddy,
  • Karthikeyan Rajkumar,
  • Akshay Kamble,
  • Amardeep Singh,
  • Anand Kumar and
  • Satyasheel Sharma

Beilstein J. Org. Chem. 2023, 19, 820–863, doi:10.3762/bjoc.19.62

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Published 12 Jun 2023

A new oxidatively stable ligand for the chiral functionalization of amino acids in Ni(II)–Schiff base complexes

  • Alena V. Dmitrieva,
  • Oleg A. Levitskiy,
  • Yuri K. Grishin and
  • Tatiana V. Magdesieva

Beilstein J. Org. Chem. 2023, 19, 566–574, doi:10.3762/bjoc.19.41

Graphical Abstract
  • )-1-benzylpyrrolidine-2-carboxamide) and its Ni(II)–Schiff base complexes formed of glycine, serine, and dehydroalanine are reported. A bulky tert-butyl substituent in the phenylene fragment precludes unwanted oxidative dimerization of the Schiff base complex, making it suitable for targeted
  • )-benzylproline lead to (S)-N-(2-benzoyl-5-tert-butylphenyl)-1-benzylpyrrolidine-2-carboxamide (L7) in 73% yield with 96% ee (see Supporting Information File 1). The self-assembly of the three components L7, Ni(NO3)2, and glycine gave the corresponding (GlyNi)L7 complex which was isolated in 66% yield and fully
  • (S)-N-benzylproline-derived ligand (S)-N-(2-benzoyl-5-tert-butylphenyl)-1-benzylpyrrolidine-2-carboxamide and its Ni(II)–Schiff base complexes formed of glycine, serine, and dehydroalanine are reported. The bulky tert-butyl substituent inserted in the phenylene fragment of the ligand allowed to solve
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Published 27 Apr 2023

An efficient metal-free and catalyst-free C–S/C–O bond-formation strategy: synthesis of pyrazole-conjugated thioamides and amides

  • Shubham Sharma,
  • Dharmender Singh,
  • Sunit Kumar,
  • Vaishali,
  • Rahul Jamra,
  • Naveen Banyal,
  • Deepika,
  • Chandi C. Malakar and
  • Virender Singh

Beilstein J. Org. Chem. 2023, 19, 231–244, doi:10.3762/bjoc.19.22

Graphical Abstract
  • product was the desired product, 5-(4-fluorophenyl)-1-phenyl-N-(pyridin-2-yl)-1H-pyrazole-3-carboxamide (1F), as analyzed by spectroscopic data. Next, we screened other organic solvents including DMF, CH3CN, THF, and MeOH to improve the yield of the desired product 1F, but only a slight improvement in the
  • . Using this method, 3-(4-chlorophenyl)-1-phenyl-N-(pyridin-2-yl)-1H-pyrazole-5-carboxamide (10F) was produced in good yield (62%), while 9F was generated in low yield (36%) as depicted in Scheme 8. Based on the current experimental observations and literature reports [62][83] a plausible mechanistic
  • %; Rf 0.68, (hexane/EtOAc 70:30, v/v)). Typical procedure for the synthesis of compounds 1F, 1G, 4F, 9F, and 10F as exemplified for 5-(4-fluorophenyl)-1-phenyl-N-(pyridin-2-yl)-1H-pyrazole-3-carboxamide (1F): To a stirred solution of compound 1 (0.10 g, 0.37 mmol) and 2-aminopyridine (F, 0.04 g, 0.42
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Published 02 Mar 2023

New triazole-substituted triterpene derivatives exhibiting anti-RSV activity: synthesis, biological evaluation, and molecular modeling

  • Elenilson F. da Silva,
  • Krist Helen Antunes Fernandes,
  • Denise Diedrich,
  • Jessica Gotardi,
  • Marcia Silvana Freire Franco,
  • Carlos Henrique Tomich de Paula da Silva,
  • Ana Paula Duarte de Souza and
  • Simone Cristina Baggio Gnoatto

Beilstein J. Org. Chem. 2022, 18, 1524–1531, doi:10.3762/bjoc.18.161

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  • , University of São Paulo, Ribeirão Preto, SP 14040-020, Brazil 10.3762/bjoc.18.161 Abstract Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infections in infants. Currently, ribavirin, a nucleoside analog containing a 1,2,4-triazole-3-carboxamide moiety, is a first-line
  • with COVID-19 precautions; however, they state that less RSV cases now could reduce immunity and they fear there will be a rebound in infections after the pandemic [4][5][6][7]. As a therapeutic resource, ribavirin, a nucleoside analog prodrug containing a 1,2,4-triazole-3-carboxamide moiety (RBV
  • -triazole ring introduced by click chemistry in order to mimic the 1,2,4-triazole-3-carboxamide structure of RBV. This strategy was based on the bioisosteric relationship between both rings established in several papers [32][33][34]. Studies have made modifications at the C-3 and C-28 positions of
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Published 09 Nov 2022

A versatile way for the synthesis of monomethylamines by reduction of N-substituted carbonylimidazoles with the NaBH4/I2 system

  • Lin Chen,
  • Xuan Zhou,
  • Zhiyong Chen,
  • Changxu Wang,
  • Shunjie Wang and
  • Hanbing Teng

Beilstein J. Org. Chem. 2022, 18, 1032–1039, doi:10.3762/bjoc.18.104

Graphical Abstract
  • materials including amines, carboxylic acids and isocyanates under mild and safe reaction conditions. Results and Discussion Initially, N-phenethyl-1H-imidazole-1-carboxamide (1b) was chosen as a model substrate to react with 3.0 equiv of NaBH4 and 1.0 equiv of I2 in THF at reflux temperature, as expected
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Published 17 Aug 2022

Molecular diversity of the base-promoted reaction of phenacylmalononitriles with dialkyl but-2-ynedioates

  • Hui Zheng,
  • Ying Han,
  • Jing Sun and
  • Chao-Guo Yan

Beilstein J. Org. Chem. 2022, 18, 991–998, doi:10.3762/bjoc.18.99

Graphical Abstract
  • multifunctionalized carboxamide-bridged dicyclopentenes in moderate to good yields and with high diastereoselectivity. Keywords: carboxamide; cycloaddition; cyclopentene; electron-deficient alkyne; phenacylmalononitrile; Introduction Phenacylmalononitrile is one of the privileged functionalized compounds [1][2][3
  • base-promoted reactions between phenacylmalononitriles and dialkyl but-2-ynedioates. Here we wish to report the selective synthesis of cyclopent-1-ene-1,2-dicarboxylates and complex carboxamide-bridged dicyclopentene derivatives in good yields and with high diastereoselectivity (reaction 5 in Scheme 1
  • ). From the two figures, it can be seen that a cyclopentadiene moiety is connected to a cyclopent-1-ene moiety by a carboxamide unit (CONH). Although one hydroxy group is eliminated to give the cyclopentadiene ring, another hydroxy group is still present in the cyclopent-1-ene ring. Additionally, in the
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Published 08 Aug 2022

Synthetic strategies for the preparation of γ-phostams: 1,2-azaphospholidine 2-oxides and 1,2-azaphospholine 2-oxides

  • Jiaxi Xu

Beilstein J. Org. Chem. 2022, 18, 889–915, doi:10.3762/bjoc.18.90

Graphical Abstract
  • reaction of 2-imino-2H-chromene-3-carboxamide (228) and diethyl phosphite at 80–90 °C under the catalysis of boron trifluoride, afforded 4-amino-1-ethoxy-9b-hydrochromeno[4,3-c][1,2]azaphosphol-3(2H)-one 1-oxide (229) in 40% yield through the Michael addition and subsequent tautomerization and
  • intramolecular aminolysis. Under similar conditions, the reaction of 2-imino-2H-chromene-3-carboxamide (228) and tris(2-chloroethyl) phosphite (232) generated 4-amino-1-(2-chloroethoxy)-9b-hydrochromeno[4,3-c][1,2]azaphosphol-3(2H)-one 1-oxide (233) in 30% yield through the Michael addition and subsequent
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Published 22 Jul 2022

An isoxazole strategy for the synthesis of 4-oxo-1,4-dihydropyridine-3-carboxylates

  • Timur O. Zanakhov,
  • Ekaterina E. Galenko,
  • Mikhail S. Novikov and
  • Alexander F. Khlebnikov

Beilstein J. Org. Chem. 2022, 18, 738–745, doi:10.3762/bjoc.18.74

Graphical Abstract
  • , contain the fragment of 4-oxo-1,4-dihydropyridine-3-carboxamide [5][6][7]. Finding new synthetic methods for the preparation of derivatives of 4-oxo-1,4-dihydropyridine-3-carboxylic acid are therefore relevant. Some alkyl 6-aryl-2-methyl-4-oxo-1,4-dihydropyridine-3-carboxylates were prepared by refluxing
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Published 23 Jun 2022

Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures

  • Sangram Gore,
  • Sundarababu Baskaran and
  • Burkhard König

Beilstein J. Org. Chem. 2022, 18, 331–336, doi:10.3762/bjoc.18.37

Graphical Abstract
  • raltegravir, the first HIV-integrase inhibitor approved by the FDA for the treatment of HIV infection, derived from 5,6-dihydroxypyrimidine-4-carboxamide and N-methyl-4-hydroxypyrimidinone-carboxamide [18] and hydroxypyrimidinone carboxamide derivative P01, a potent inhibitor of Mycobacterium tuberculosis
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Published 22 Mar 2022

The ethoxycarbonyl group as both activating and protective group in N-acyl-Pictet–Spengler reactions using methoxystyrenes. A short approach to racemic 1-benzyltetrahydroisoquinoline alkaloids

  • Marco Keller,
  • Karl Sauvageot-Witzku,
  • Franz Geisslinger,
  • Nicole Urban,
  • Michael Schaefer,
  • Karin Bartel and
  • Franz Bracher

Beilstein J. Org. Chem. 2021, 17, 2716–2725, doi:10.3762/bjoc.17.183

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  • highly electrophilic N-acyliminium intermediates [17]. As a special aspect, we used a carbamate unit (instead of the commonly used carboxamide), ending up with 1-benzyl-1,2,3,4-tetrahydroisoquinolines bearing an N-ethoxycarbonyl residue, which in turn was easily converted directly into an N-methyl group
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Published 05 Nov 2021

Isolation and characterization of new phenolic siderophores with antimicrobial properties from Pseudomonas sp. UIAU-6B

  • Emmanuel T. Oluwabusola,
  • Olusoji O. Adebisi,
  • Fernando Reyes,
  • Kojo S. Acquah,
  • Mercedes De La Cruz,
  • Larry L. Mweetwa,
  • Joy E. Rajakulendran,
  • Digby F. Warner,
  • Deng Hai,
  • Rainer Ebel and
  • Marcel Jaspars

Beilstein J. Org. Chem. 2021, 17, 2390–2398, doi:10.3762/bjoc.17.156

Graphical Abstract
  • presence of an oxazoline ring similar to that found in vulnibactin [27]. The key HMBC cross-peaks (Figure 2 and Supporting Information File 1) from H-9 (δH 4.46, J = 7.3 Hz, d) and H-11(δH 4.90, qd, J = 6.3, 7.3 Hz) to carboxamide C-10 (δC 175.6) and C-7 (δC 167.8), confirmed the proposed structure which
  • carboxamide C-10 (δC 172.9) and the quaternary carbon C-16 (δC 140.2), between H2-15 and H-18/20 to the quaternary carbon C-16, and a strong correlation from H-15 and H-19 to C-17/20 (δC 129.9). The new oxazoline derivative 5 was named pseudomonbactin B. The absolute configuration of the threonine residue in
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Published 13 Sep 2021

Regioselective N-alkylation of the 1H-indazole scaffold; ring substituent and N-alkylating reagent effects on regioisomeric distribution

  • Ryan M. Alam and
  • John J. Keating

Beilstein J. Org. Chem. 2021, 17, 1939–1951, doi:10.3762/bjoc.17.127

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  • observed > 99% N-1 regioselectivity for 3-carboxymethyl, 3-tert-butyl, 3-COMe, and 3-carboxamide indazoles. Further extension of this optimized (NaH in THF) protocol to various C-3, -4, -5, -6, and -7 substituted indazoles has highlighted the impact of steric and electronic effects on N-1/N-2 regioisomeric
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Published 02 Aug 2021

Development of N-F fluorinating agents and their fluorinations: Historical perspective

  • Teruo Umemoto,
  • Yuhao Yang and
  • Gerald B. Hammond

Beilstein J. Org. Chem. 2021, 17, 1752–1813, doi:10.3762/bjoc.17.123

Graphical Abstract
  • ] In 1996, the Banks group reported perfluoro[N-fluoro-N-(4-pyridyl)acetamide] (21-3) as a carboxamide analogue of perfluoro[N-fluoro-N-(4-pyridyl)methanesulfonamide] (11-2, see section 1-11) [82]. Its precursor, 21-2, was prepared from pentafluoropyridine by either one of two methods (Scheme 46
  • ). Precursor 21-2 was treated with neat F2 at 10–20 mmHg pressure in acetonitrile at −35 °C to produce the N-F carboxamide 21-3 in 75% yield but the resulting product was a 79:18 mixture of the desired N-F product 21-3 and the protonated compound 21-1. As a reagent N-F carboxamide 21-2 fluorinated electron
  • -rich substrates such as sodium diethyl (phenyl)malonate, 1-morpholinocyclohexene, phenol, and anisole (Scheme 47). The fluorination power of the carboxamide 21-2 was less than that of its N-F sulfonamide analog 11-2. 1-22. N,N’-Difluoro-1,4-diazoniabicyclo[2.2.2]octane salts In 1996, Umemoto and co
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Published 27 Jul 2021

19F NMR as a tool in chemical biology

  • Diana Gimenez,
  • Aoife Phelan,
  • Cormac D. Murphy and
  • Steven L. Cobb

Beilstein J. Org. Chem. 2021, 17, 293–318, doi:10.3762/bjoc.17.28

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Published 28 Jan 2021

Novel library synthesis of 3,4-disubstituted pyridin-2(1H)-ones via cleavage of pyridine-2-oxy-7-azabenzotriazole ethers under ionic hydrogenation conditions at room temperature

  • Romain Pierre,
  • Anne Brethon,
  • Sylvain A. Jacques,
  • Aurélie Blond,
  • Sandrine Chambon,
  • Sandrine Talano,
  • Catherine Raffin,
  • Branislav Musicki,
  • Claire Bouix-Peter,
  • Loic Tomas,
  • Gilles Ouvry,
  • Rémy Morgentin,
  • Laurent F. Hennequin and
  • Craig S. Harris

Beilstein J. Org. Chem. 2021, 17, 156–165, doi:10.3762/bjoc.17.16

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  • , 60, Avenue Rockefeller, Bioparc, Bioserra 1 Building, 69008 Lyon, France 10.3762/bjoc.17.16 Abstract In our hands, efficient access to the 4-amino-3-carboxamide disubstituted pyridine-2(1H)-one kinase hinge-binder motif proved to be more challenging than anticipated requiring a significant
  • -azabenzotriazole; hinge-binder; ionic hydrogenation; library; pyridine-2(1H)-one; Introduction During a recent medicinal chemistry program targeting a kinase to treat skin disorders, we identified the 4-amino-3-carboxamide disubstituted pyridine-2(1H)-one motif (1) as an interesting starting point. Recently, both
  • affording only acceptable yields of pyridine intermediate (9a–c) with the major byproduct arising from the dechlorination of 8. Application of the same conditions with aromatic amides at C-3 (8d,e) failed with only trace quantities of final product observed. We speculated that the aromatic carboxamide NH
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Published 18 Jan 2021

Three-component reactions of aromatic amines, 1,3-dicarbonyl compounds, and α-bromoacetaldehyde acetal to access N-(hetero)aryl-4,5-unsubstituted pyrroles

  • Wenbo Huang,
  • Kaimei Wang,
  • Ping Liu,
  • Minghao Li,
  • Shaoyong Ke and
  • Yanlong Gu

Beilstein J. Org. Chem. 2020, 16, 2920–2928, doi:10.3762/bjoc.16.241

Graphical Abstract
  • with aniline (1a) or amantadine in the presence of HATU or EDCI to form the multisubstituted pyrrole-3-carboxamide derivatives 4x and 4y (Scheme 4). These skeletons have been proven to be promising inhibitors for the production of cytokines [47]. A plausible mechanism for the model reaction was
  • . Direct synthesis of pyrrole-3-carboxamide derivatives. Plausible mechanism of the three-component reaction. Synthesis of polysubstituted pyrazolo[3,4-b]pyridine derivatives. Optimization of the conditions for the reaction between 1a, 2a, and 3a.a Supporting Information Supporting Information File 500
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Published 30 Nov 2020

Three new O-isocrotonyl-3-hydroxybutyric acid congeners produced by a sea anemone-derived marine bacterium of the genus Vibrio

  • Dandan Li,
  • Enjuro Harunari,
  • Tao Zhou,
  • Naoya Oku and
  • Yasuhiro Igarashi

Beilstein J. Org. Chem. 2020, 16, 1869–1874, doi:10.3762/bjoc.16.154

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  • three deshielded resonances (H3, H2', and H3') and a pair of mutually coupled doublet-of-doublets resonances (H22), indicating a shared core structure (Table 1, Table 2, and Supporting Information File 1). In fact, the 13C NMR spectra all had signals in common: two carboxy (carboxamide) and two olefinic
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Published 29 Jul 2020

Anthelmintic drug discovery: target identification, screening methods and the role of open science

  • Frederick A. Partridge,
  • Ruth Forman,
  • Carole J. R. Bataille,
  • Graham M. Wynne,
  • Marina Nick,
  • Angela J. Russell,
  • Kathryn J. Else and
  • David B. Sattelle

Beilstein J. Org. Chem. 2020, 16, 1203–1224, doi:10.3762/bjoc.16.105

Graphical Abstract
  • . mansoni [161]) and the cestode E. multilocularis [162]. Perhaps the most promising lead from the Pathogen Box so far is tolfenpyrad, a pyrazole-5-carboxamide insecticide, which was first identified as an anthelmintic with activity against exsheathed L3 and L4 parasitic life stages of Haemonchus contortus
  • follow-up study identified two additional pyrazole-5-carboxamide compounds with activity against H. contortus, although not improving on the potency of tolfenpyrad [166]. Tolfenpyrad acts in arthropods as an inhibitor of mitochondrial complex I [167]. It will be interesting if a tolfenpyrad derivative
  • through systematic alteration of the pyrazole-5-carboxamide and phenoxybenzyloxy moieties within tolfenpyrad 19 (Table 4). The systematic variation of the p-methylphenyl ring within 19 gave rise to a number of aromatic and heteroaromatic analogues with similar levels of potency to tolfenpyrad (Table 4
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Published 02 Jun 2020

Fluorinated phenylalanines: synthesis and pharmaceutical applications

  • Laila F. Awad and
  • Mohammed Salah Ayoup

Beilstein J. Org. Chem. 2020, 16, 1022–1050, doi:10.3762/bjoc.16.91

Graphical Abstract
  • which was immediately hydrolyzed to provide the racemic carboxamide 172. The subsequent removal of the chiral auxiliary by catalytic hydrogenation then afforded the carboxamide 173. Finally, an acid-mediated hydrolysis of the carboxamide 173 to generate the free amino acids ʟ- or ᴅ-168a, was carried out
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Published 15 May 2020

Copper-catalyzed remote C–H arylation of polycyclic aromatic hydrocarbons (PAHs)

  • Anping Luo,
  • Min Zhang,
  • Zhangyi Fu,
  • Jingbo Lan,
  • Di Wu and
  • Jingsong You

Beilstein J. Org. Chem. 2020, 16, 530–536, doi:10.3762/bjoc.16.49

Graphical Abstract
  • groups. Under standard conditions, the remote C–H arylation of other PAHs including phenanthrene-9-carboxamide, pyrene-1-carboxamide and fluoranthene-3-carboxamide has also accomplished, which provides an opportunity for the development of diverse organic optoelectronic materials. Keywords: C–H
  • -9-carboxamide, pyrene-1-carboxamide and fluoranthene-3-carboxamide, which provides an opportunity for the development of diverse organic photoelectrical materials. Results and Discussion Our investigation commenced with the reaction between N-(tert-butyl)-1-naphthamide (1a) and mesityl(phenyl
  • arylation of PAHs is challenging, and so far, there are no examples on the selective remote C–H arylation of phenanthrene-9-carboxamide, pyrene-1-carboxamide and fluoranthene-3-carboxamide. Gratifyingly, the remote C–H arylation of these PAH substrates occurred smoothly, giving the corresponding arylation
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Published 30 Mar 2020

Controlling alkyne reactivity by means of a copper-catalyzed radical reaction system for the synthesis of functionalized quaternary carbons

  • Goki Hirata,
  • Yu Yamane,
  • Naoya Tsubaki,
  • Reina Hara and
  • Takashi Nishikata

Beilstein J. Org. Chem. 2020, 16, 502–508, doi:10.3762/bjoc.16.45

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  • . Moreover, the reaction of α-bromocarbonyl compound 2 and an alkyne 4 possessing a carboxamide moiety undergoes tandem alkyl radical addition/C–H coupling to produce indolinone derivative 5. Keywords: copper catalyst; 1,3-enyne; functionalized quaternary carbon; indolinone; tandem alkyl radical addition
  • addition at a C–C triple bond followed by Sonogashira coupling to produce 1,3-enyne compounds. On the other hand, the reaction with alkyne possessing a carboxamide moiety underwent tandem alkyl radical addition at the C–C triple bond followed by C–H coupling to produce indolinone derivatives. These results
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Published 26 Mar 2020
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