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Search for "industry" in Full Text gives 360 result(s) in Beilstein Journal of Organic Chemistry. Showing first 200.
Synthesis of trifluoromethyl ketones by nucleophilic trifluoromethylation of esters under a fluoroform/KHMDS/triglyme system
Beilstein J. Org. Chem. 2021, 17, 431–438, doi:10.3762/bjoc.17.39
- , and methyl esters are readily available inexpensive precursors. Besides, glymes are versatile solvents for chemical processes in industry [74] would the protocol be useful for the industrial extension, although there are still many points to be overcome such as requirements of low temperature, two
Coupling biocatalysis with high-energy flow reactions for the synthesis of carbamates and β-amino acid derivatives
Beilstein J. Org. Chem. 2021, 17, 379–384, doi:10.3762/bjoc.17.33
- flow chemistry is by now a mature field with chemists in both academia and industry regularly reporting on the multitude of benefits arising from exploiting reactor miniaturization [1][2][3][4][5]. The steady increase of applications highlighting improved syntheses is thereby paralleled by a growing
- . Batch hydrolysis of the ester group in the presence of the carbamate. Supporting Information Supporting Information File 4: Experimental details and spectroscopic data. Funding We gratefully acknowledge support from Science Foundation Ireland through the SFI Industry Fellowship Program for the project
Supramolecular polymers with reversed viscosity/temperature profile for application in motor oils
Beilstein J. Org. Chem. 2021, 17, 105–114, doi:10.3762/bjoc.17.11
- depicted in the background of the graphical abstract was reproduced from https://thenounproject.com/korawan_m/collection/industry-oil-gas-power-outline/?i=909361 (“motor oil” by BomSymbols, from the Noun Project, distributed under the terms of the Creative Commons Attribution 3.0 United States, https
Synthesis of tetrafluorinated piperidines from nitrones via a visible-light-promoted annelation reaction
Beilstein J. Org. Chem. 2020, 16, 3104–3108, doi:10.3762/bjoc.16.260
- heterocyclic compounds play an important role in pharmaceutical industry and related areas [1][2]. Among the variety of aromatic and saturated structures, the piperidine ring has a special role, as it is the most widely occurring form of nitrogen in FDA-approved drugs [3]. The ability of fluorine atoms to
All-carbon [3 + 2] cycloaddition in natural product synthesis
Beilstein J. Org. Chem. 2020, 16, 3015–3031, doi:10.3762/bjoc.16.251
- that the all-carbon [3 + 2] cycloaddition will gain further attention from the synthetic community, including scientists from academia and pharmaceutical industry, for methodic innovation and the efficient synthesis of biologically important natural products. Highly-substituted five-membered carbocycle
Regioselective synthesis of heterocyclic N-sulfonyl amidines from heteroaromatic thioamides and sulfonyl azides
Beilstein J. Org. Chem. 2020, 16, 2937–2947, doi:10.3762/bjoc.16.243
- , rich chemistry and technically useful properties of heterocyclic compounds have made them a focal point of science and industry over the years. Heterocyclic compounds including azoles and azines have been found in natural products, and they are included in the structures of nucleic acids, vitamins
A novel and robust heterogeneous Cu catalyst using modified lignosulfonate as support for the synthesis of nitrogen-containing heterocycles
Beilstein J. Org. Chem. 2020, 16, 2888–2902, doi:10.3762/bjoc.16.238
- to the fast deactivation of catalysts, which consequently impair the recyclability of the catalysts [8][9][10][11]. Therefore, special efforts should be paid to enhancing the robustness of heterogeneous metal catalysts. Sodium lignosulphonate (LS) is a waste from the paper-making industry, containing
One-pot multicomponent green Hantzsch synthesis of 1,2-dihydropyridine derivatives with antiproliferative activity
Beilstein J. Org. Chem. 2020, 16, 2862–2869, doi:10.3762/bjoc.16.235
- the pharmaceutical industry [3][8]. An analysis of the market shows that there are over 7000 drugs derived from dihydropyridines, some of which are blockbuster drugs, such as Tamiflu®, dioscorine, ibogaine, and isoquinuclidines [9][10]. Classically the Hantzsch synthesis involved the condensation of 2
Dirhamnolipid ester – formation of reverse wormlike micelles in a binary (primerless) system
Beilstein J. Org. Chem. 2020, 16, 2820–2830, doi:10.3762/bjoc.16.232
- described by Leisinger et al. [9]. Rhamnolipids possess some advantages, that make them interesting candidates as cleaning agents or additives for care applications in the consumer goods industry. They can be produced in a fermentation process from renewable nontropic material [10][11]. RL are also
Dawn of a new era in industrial photochemistry: the scale-up of micro- and mesostructured photoreactors
Beilstein J. Org. Chem. 2020, 16, 2484–2504, doi:10.3762/bjoc.16.202
- Leuven, Leuven, Belgium 10.3762/bjoc.16.202 Abstract Photochemical activation routes are gaining the attention of the scientific community since they can offer an alternative to the traditional chemical industry that mainly utilizes thermochemical activation of molecules. Photoreactions are fast and
- : microreactor; microreactor scale-up; monolith reactors; packed bed reactor; photoreactor scale-up; Review Introduction In the traditional chemical industry, thermochemical activation routes are mostly preferred. Light can also activate some molecules, which leads to fast and selective reaction pathways
- sequestration [7]. Still, photochemistry has not been exploited much in industry since the distribution of light inside a photoreactor brings a lot of complexity to the reactor design. Unlike thermochemical reactions, it is not feasible to scale up photoreactions by increasing the dimensions of the reactor due
Conformational preferences of fluorine-containing agrochemicals and their implications for lipophilicity prediction
Beilstein J. Org. Chem. 2020, 16, 2469–2476, doi:10.3762/bjoc.16.200
- lipophilicity with the molecular conformation. Keywords: dipole moment; fluorinated compounds; gauche effect; herbicides; log P; Introduction Whilst in the last years the agrochemical industry has encountered a period of downturn affected by new regulations, low crop prices, biochemical resistance, among
- other variables, recent events have shown signs of recovery [1]. Currently, the agrochemical industry focuses on introducing new efficient and more environmentally friendly products, that attend the new regulation requirements, for replacing those agrochemicals that were banned due to either their
A proposed sustainability index for synthesis plans based on input provenance and output fate: application to academic and industrial synthesis plans for vanillin as a case study
Beilstein J. Org. Chem. 2020, 16, 2346–2362, doi:10.3762/bjoc.16.196
- fossil-fuel derived and renewable sources. Dutch and Belgian chemical engineers proposed an extended thermodynamic analysis considering exergy and lost work to address the sustainability potential of the chemical process industry [2][3][4]. Horvath and co-workers put forth the following sustainability
- assumptions and guesswork since there are no proper centralized data kept for tracking end-of-life waste of any product manufactured in the chemical industry. Hence, for the purposes of calculating SI, estimating is the weakest link. Having described the three mass fractions related to the provenance of
- , unitless), skin dose (SD, mg), and flash point (FP, degrees K). Table 1 shows a revised and expanded formatted listing of normalized OSI values for various solvents used in the chemical industry. In our past work [20] describing a presentation of a “standardized process green synthesis report” for chemical
Photosensitized direct C–H fluorination and trifluoromethylation in organic synthesis
Beilstein J. Org. Chem. 2020, 16, 2151–2192, doi:10.3762/bjoc.16.183
- , light is inexpensive, nontoxic, noncontaminating, ample (or “limitless” in the case of sunlight) and a renewable source of energy for environmentally-friendly and “green” chemical synthesis. As a consequence of comprehending the detrimental impact of human industry on the environment, new methods to
Synthesis of monophosphorylated lipid A precursors using 2-naphthylmethyl ether as a protecting group
Beilstein J. Org. Chem. 2020, 16, 1955–1962, doi:10.3762/bjoc.16.162
- Jundi Xue Ziyi Han Gen Li Khalisha A. Emmanuel Cynthia L. McManus Qiang Sui Dongmian Ge Qi Gao Li Cai Shanghai University of Engineering Science, 333 Long Teng Road, Shanghai 201620, China China State Institute of Pharmaceutical Industry, 285 Gebaini Rd, Shanghai 201203, China Department of
Pauson–Khand reaction of fluorinated compounds
Beilstein J. Org. Chem. 2020, 16, 1662–1682, doi:10.3762/bjoc.16.138
- signal). In addition, the use of fluorinated organic compounds in other key industrial fields is also of paramount importance. The agrochemical and materials industries, together with the aforementioned pharmaceutical industry, are perhaps the fields where organofluorinated compounds have exerted the
Heterogeneous photocatalysis in flow chemical reactors
Beilstein J. Org. Chem. 2020, 16, 1495–1549, doi:10.3762/bjoc.16.125
- has shifted the paradigms of photochemistry, opening new avenues of research with safer and scalable processes that can be readily implemented in academia and industry. Current state-of-the-art photocatalysts are homogeneous transition metal complexes that have favourable photophysical properties
Disposable cartridge concept for the on-demand synthesis of turbo Grignards, Knochel–Hauser amides, and magnesium alkoxides
Beilstein J. Org. Chem. 2020, 16, 1343–1356, doi:10.3762/bjoc.16.115
- chloride–lithium chloride complex (iPrMgCl⋅LiCl), known as turbo Grignard [45]. In addition to being widely cited, turbo Grignard is a popular discovery-scale tool in the pharmaceutical industry [32] and has shown an excellent selectivity on a large scale [46]. Halomagnesium amide LiCl adducts, e.g., the
Anthelmintic drug discovery: target identification, screening methods and the role of open science
Beilstein J. Org. Chem. 2020, 16, 1203–1224, doi:10.3762/bjoc.16.105
- livestock with parasitic worms has important animal welfare implications and can result in considerable economic losses to the livestock industry. In industrialised countries most livestock are routinely given anthelmintics to control or prevent infections and it is estimated the number of sheep, goats and
- cattle treated annually is hundreds of millions [1]. Treatment of horses, other equids, and companion animals is also a major use of anthelmintics. Anthelmintic drug discovery has been a continued emphasis in the animal health industry, driven by the spread of resistance to the macrocyclic lactones [2
- and other control solutions for human helminth infection, these indications have been largely ignored by the pharmaceutical industry, presumably for commercial reasons. Indeed, no new chemical entities were approved between 2000 and 2011 [71][72]. Since then only moxidectin (8, 2018) and
Activated carbon as catalyst support: precursors, preparation, modification and characterization
Beilstein J. Org. Chem. 2020, 16, 1188–1202, doi:10.3762/bjoc.16.104
- coals. However, the size of these pores is very small [5]. Activated carbons prepared from bituminous coals are more durable compared to other coal-based carbons [6]. Petroleum coke as byproduct of the refinery industry, show a high carbon content, low amount of ash and is widely available [7
The charge-assisted hydrogen-bonded organic framework (CAHOF) self-assembled from the conjugated acid of tetrakis(4-aminophenyl)methane and 2,6-naphthalenedisulfonate as a new class of recyclable Brønsted acid catalysts
Beilstein J. Org. Chem. 2020, 16, 1124–1134, doi:10.3762/bjoc.16.99
- catalysis are well-known and documented [1][2][3]. However, problems associated with catalyst recovery limit the application of homogeneous catalysts in industry and sometimes make their heterogenization necessary. Unfortunately, the immobilization of a homogeneous catalyst onto supports, such as
- synthetic protocols for the matrix synthesis hamper the routine use of MOFs and COFs in industry, even for the production of high-added-value products. Recently, new supramolecular porous materials named hydrogen-bonded organic frameworks (HOFs) or supramolecular organic frameworks (SOFs) have been
A method to determine the correct photocatalyst concentration for photooxidation reactions conducted in continuous flow reactors
Beilstein J. Org. Chem. 2020, 16, 871–879, doi:10.3762/bjoc.16.78
- sources over mercury arcs and other light sources commonly used in industry and classical synthetic organic photochemistry. LEDs typically have much narrower emission spectra when compared to these light sources, all of which have broad emission spectra except for low-pressure sodium vapor lamps [15][16
Aldehydes as powerful initiators for photochemical transformations
Beilstein J. Org. Chem. 2020, 16, 833–857, doi:10.3762/bjoc.16.76
Recent advances in Cu-catalyzed C(sp3)–Si and C(sp3)–B bond formation
Beilstein J. Org. Chem. 2020, 16, 691–737, doi:10.3762/bjoc.16.67
- organosilicon [17][18][19][20] and organoboron [21][22][23][24] compounds (i.e., C(sp3)–Si and C(sp3)–B). Nonetheless, considering the extent of their use and their increasing popularity in the pharmaceutical industry, as well as the significant growth in the development of Cu-catalyzed processes applied to
Rhodium-catalyzed reductive carbonylation of aryl iodides to arylaldehydes with syngas
Beilstein J. Org. Chem. 2020, 16, 645–656, doi:10.3762/bjoc.16.61
- crucial for new practical applications. Syngas is a mixture of CO and H2, which is cheap, abundant and widely used in chemical industry productions [14][15][16]. In spite of its comprehensive utilization in industry, reactions involving CO are relatively seldom employed in fine chemicals syntheses. This
- chemical industry by offering a practical synthetic tool for the conversion of aryl iodides to arylaldehydes. Results and Discussion Effects of Rh species Rhodium salts coordinated with proper ligands have been reported to be able to realize the activation of CO and H2 and thus might achieve the reductive
A systematic review on silica-, carbon-, and magnetic materials-supported copper species as efficient heterogeneous nanocatalysts in “click” reactions
Beilstein J. Org. Chem. 2020, 16, 551–586, doi:10.3762/bjoc.16.52
- nanocomposite, carbon nanocomposite, and magnetic nanocomposites and their catalytic uses in CuAACs will be helpful to the community of scientists working in industry and scholarly laboratories, respectively. This review aims to cover recently published reports from 2014 to 2019 presenting synthetic routes and
- applications that focused on the title catalysts in CuAAC reactions. Review Copper anchored on functionalized silica materials: efficient and recyclable catalysts for CuAAC reactions In recent years, silica or silicon dioxide nanomaterials have received much attention from researchers and industry and have
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