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Search for "parallel" in Full Text gives 453 result(s) in Beilstein Journal of Organic Chemistry. Showing first 200.

Nonenzymatic synthesis of anomerically pure, mannosyl-based molecular probes for scramblase identification studies

  • Giovanni Picca,
  • Markus Probst,
  • Simon M. Langenegger,
  • Oleg Khorev,
  • Peter Bütikofer,
  • Anant K. Menon and
  • Robert Häner

Beilstein J. Org. Chem. 2020, 16, 1732–1739, doi:10.3762/bjoc.16.145

Graphical Abstract
  • with radioactively labeled substrates, the use of fluorescently labeled probes offers several advantages, including the continuous monitoring of the transport and a better time resolution. For reasons of comparison, the α-configured ᴅ-mannose probe MPC-3 was synthesized in parallel. The
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Published 20 Jul 2020

Synthesis of the tetrasaccharide repeating unit of the O-specific polysaccharide of Azospirillum doebereinerae type strain GSF71T using linear and one-pot iterative glycosylations

  • Arin Gucchait,
  • Pradip Shit and
  • Anup Kumar Misra

Beilstein J. Org. Chem. 2020, 16, 1700–1705, doi:10.3762/bjoc.16.141

Graphical Abstract
  • obtained following the sequential glycosylation strategy (Scheme 2). It is noteworthy that in parallel to the sequential glycosylation strategy, the desired tetrasaccharide derivative 7 could be achieved in comparably good yield following the one-pot protocol involving the three iterative glycosylations
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Published 15 Jul 2020

Models of necessity

  • Timothy Clark and
  • Martin G. Hicks

Beilstein J. Org. Chem. 2020, 16, 1649–1661, doi:10.3762/bjoc.16.137

Graphical Abstract
  • could exist in parallel to the bonding models used and discussed in teaching and research. This, however, would waste a unique opportunity to rationalize chemical thinking and communication and to establish the concept of models as the language of chemistry. The major requirements of a chemical ontology
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Published 13 Jul 2020

A dynamic combinatorial library for biomimetic recognition of dipeptides in water

  • Florian Klepel and
  • Bart Jan Ravoo

Beilstein J. Org. Chem. 2020, 16, 1588–1595, doi:10.3762/bjoc.16.131

Graphical Abstract
  • the parallel dimer of CHC (p(CHC)2), which binds two molecules of the neurotransmitter N-acetylneuraminic acid (NANA) in a cooperative fashion (K1 = 143, K2 = 5.1 × 103 M−1). Recently we rationalized that since our peptide building blocks consist of the same binding motifs as binding proteins (amines
  • tripeptide dimers can be found after equilibration. We note that this simple mixture of 4 peptides contains 10 different homo- and heterodimer combinations. In addition, since our building blocks are asymmetrical, parallel and antiparallel constitutional isomers are formed (Scheme 1b), which raises the total
  • a) p(CFC)2 to YY b) p(CFC)2 to FF c) a(CFC)2 to YY d) a(CFC)2 to FF. Job plots derived from the continuously varied NMR measurements of a) p(CFC)2 to YY b) p(CFC)2 to FF c) a(CFC)2 to YY d) a(CFC)2 to FF. a) Building blocks included in this study. b) Antiparallel and parallel constitutional isomers
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Published 02 Jul 2020

Highly selective Diels–Alder and Heck arylation reactions in a divergent synthesis of isoindolo- and pyrrolo-fused polycyclic indoles from 2-formylpyrrole

  • Carlos H. Escalante,
  • Eder I. Martínez-Mora,
  • Carlos Espinoza-Hicks,
  • Alejandro A. Camacho-Dávila,
  • Fernando R. Ramos-Morales,
  • Francisco Delgado and
  • Joaquín Tamariz

Beilstein J. Org. Chem. 2020, 16, 1320–1334, doi:10.3762/bjoc.16.113

Graphical Abstract
  • 8b/7c and 8c/7c (Figure 4a,b and Supporting Information File 1, Appendix 6). All the observable π···π interactions were parallel-displaced (offset) π-stacking, and the distance values were within the range of the known values, whether determined from X-ray structures or calculated values (3.2–4.0 Å
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Published 17 Jun 2020

The charge-assisted hydrogen-bonded organic framework (CAHOF) self-assembled from the conjugated acid of tetrakis(4-aminophenyl)methane and 2,6-naphthalenedisulfonate as a new class of recyclable Brønsted acid catalysts

  • Svetlana A. Kuznetsova,
  • Alexander S. Gak,
  • Yulia V. Nelyubina,
  • Vladimir A. Larionov,
  • Han Li,
  • Michael North,
  • Vladimir P. Zhereb,
  • Alexander F. Smol'yakov,
  • Artem O. Dmitrienko,
  • Michael G. Medvedev,
  • Igor S. Gerasimov,
  • Ashot S. Saghyan and
  • Yuri N. Belokon

Beilstein J. Org. Chem. 2020, 16, 1124–1134, doi:10.3762/bjoc.16.99

Graphical Abstract
  • crystals were a typical druse setup. Type 2 were well-formed, nonisotropic crystals with two parallel planes in varying sizes (0.3 × 0.4 × 1 mm). The thermogravimetric analysis and differential scanning calorimetry (TGA-DSC) of F-1 was conducted to examine its thermal properties. The TGA curve of the bulk
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Published 26 May 2020

A simple and easy to perform synthetic route to functionalized thienyl bicyclo[3.2.1]octadienes

  • Dragana Vuk,
  • Irena Škorić,
  • Valentina Milašinović,
  • Krešimir Molčanov and
  • Željko Marinić

Beilstein J. Org. Chem. 2020, 16, 1092–1099, doi:10.3762/bjoc.16.96

Graphical Abstract
  • -isomers of compounds 3–7. Molecular structure of compound trans-6. Displacement ellipsoids are drawn for the probability of 30% and hydrogen atoms are shown as spheres of arbitrary radii. Crystal packing of trans-6. (a) Chain parallel to [100] and (b) chain parallel to [010]. 1H NMR spectra (CDCl3) of
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Published 22 May 2020

Synthesis and anticancer activity of bis(2-arylimidazo[1,2-a]pyridin-3-yl) selenides and diselenides: the copper-catalyzed tandem C–H selenation of 2-arylimidazo[1,2-a]pyridine with selenium

  • Mio Matsumura,
  • Tsutomu Takahashi,
  • Hikari Yamauchi,
  • Shunsuke Sakuma,
  • Yukako Hayashi,
  • Tadashi Hyodo,
  • Tohru Obata,
  • Kentaro Yamaguchi,
  • Yasuyuki Fujiwara and
  • Shuji Yasuike

Beilstein J. Org. Chem. 2020, 16, 1075–1083, doi:10.3762/bjoc.16.94

Graphical Abstract
  • phenyl rings that face each other were almost parallel (mean-interplanar angles: Ph(A)–ImdazoPy(B): 4.59° and Ph(B)–ImdazoPy(A): 4.64°, Figure S2, Supporting Information File 1), and 2a exhibited intramolecular π–π interactions over the whole molecule. The monoselenide 3a exhibited a C1A–Se–C2A angle of
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Published 20 May 2020

Accelerating fragment-based library generation by coupling high-performance photoreactors with benchtop analysis

  • Quentin Lefebvre,
  • Christophe Salomé and
  • Thomas C. Fessard

Beilstein J. Org. Chem. 2020, 16, 982–988, doi:10.3762/bjoc.16.87

Graphical Abstract
  • temperatures and a mild base. Inspired by work at Merck on chemical informers, we decided to exploit our library of spirocyclic amines and strained scaffolds to generate a focused list of potential products [13]. We wanted to perform parallel reactions on small scale to gain further knowledge on the reactivity
  • were slightly altered: a smaller excess of amine was used, and dimethyl sulfoxide (DMSO) was chosen as solvent instead of dimethylformamide (DMF) or dimethylacetamide (DMA) to improve work-up and purification. The workflow was devised to ensure maximal productivity, using parallel experimentation
  • enabled rapid and precise assessment of the success of each parallel reaction. As seen in Figure 2, a single TLC plate reporting five different reactions could be analyzed in five minutes, and the identity of the major product confirmed by mass. Finally, after work-up and automated purification, a
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Published 12 May 2020

Synthesis of organic liquid crystals containing selectively fluorinated cyclopropanes

  • Zeguo Fang,
  • Nawaf Al-Maharik,
  • Peer Kirsch,
  • Matthias Bremer,
  • Alexandra M. Z. Slawin and
  • David O’Hagan

Beilstein J. Org. Chem. 2020, 16, 674–680, doi:10.3762/bjoc.16.65

Graphical Abstract
  • the requirements for different LCD technologies. For the traditional twisted nematic (TN) LCD technology, devices require liquid crystals with display positive dielectric anisotropy by which the molecular dipole moment is oriented parallel to the long axis of the molecule, while for the current
  • dielectric anisotropy by introducing the C–F bond or the dipole of a CF2 group either parallel or perpendicular to the long molecular axis. For example, in the area of negative liquid crystalline materials, Kirsch et al. have reported the synthesis of bicyclohexane and bis(cyclohexyl)ethane liquid crystals
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Published 14 Apr 2020

Rhodium-catalyzed reductive carbonylation of aryl iodides to arylaldehydes with syngas

  • Zhenghui Liu,
  • Peng Wang,
  • Zhenzhong Yan,
  • Suqing Chen,
  • Dongkun Yu,
  • Xinhui Zhao and
  • Tiancheng Mu

Beilstein J. Org. Chem. 2020, 16, 645–656, doi:10.3762/bjoc.16.61

Graphical Abstract
  • yield increased with increasing temperature. At low temperature the reaction did not proceed at all, however, at 90 °C or higher, a nearly quantitative yield of benzaldehyde was obtained (Figure 1d). Next, parallel experiments were conducted at three selected temperatures (80 °C, 90 °C, and 100 °C) to
  • with CO and H2 to afford benzaldehyde. a) Effects of the tested bases; b) effects of base amount; c) effects of tested solvents; d) temperature screen; e) yields at different times for reactions performed at 80, 90 and 100 °C (every point represents an average result of three parallel experiments
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Published 08 Apr 2020

Design and synthesis of diazine-based panobinostat analogues for HDAC8 inhibition

  • Sivaraman Balasubramaniam,
  • Sajith Vijayan,
  • Liam V. Goldman,
  • Xavier A. May,
  • Kyra Dodson,
  • Sweta Adhikari,
  • Fatima Rivas,
  • Davita L. Watkins and
  • Shana V. Stoddard

Beilstein J. Org. Chem. 2020, 16, 628–637, doi:10.3762/bjoc.16.59

Graphical Abstract
  • of this class of inhibitors in HDACs [31][32][33][34]. Again, our work here extends the investigation focusing on HDAC8 due to the need for novel neuroblastoma therapeutics. Each compound was also shown to have two parallel-displaced π–π interactions, one with Phe-152 and the other with Phe-208. The
  • interaction with the Zn2+ ion. TOI3-rev, like that of TOI1, TOI2, and TOI4 produces two parallel-displaced π–π interactions with Phe-152 and Phe-208 (Figure 2). The pyrimidine ring of TOI3-rev also lays planar in the gorge similar to the pyrazine and pyrimidine rings of TOI1 and TOI2. The indole ring of TOI3
  • reaction mixture under heating conditions. In parallel, similar reaction conditions were used for compound 3 and the final coupled product 18 was obtained in 71% yield. The product was confirmed by the expected chemical shift at δ 6.50 and 7.54 ppm with a J value of 15 Hz for compound 16 (Supporting
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Published 07 Apr 2020

Opening up connectivity between documents, structures and bioactivity

  • Christopher Southan

Beilstein J. Org. Chem. 2020, 16, 596–606, doi:10.3762/bjoc.16.54

Graphical Abstract
  • . Although their expert-curated numbers are lower (i.e., ≈2 million compounds against ≈3700 human proteins), these open sources have the great advantage of being merged within PubChem. Parallel efforts have focused on the extraction of document-to-compound (D-C-only) connectivity. In the absence of molecular
  • seems that way). The following is a selection: 1.) PubChem presents users with the complexity of parallel systems of D-C connectivity [28]. For medical subject headings (MeSH) the publication links are biased towards common name matches in many papers (e.g., the MeSH category for chemicals and drugs
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Published 02 Apr 2020

Photophysics and photochemistry of NIR absorbers derived from cyanines: key to new technologies based on chemistry 4.0

  • Bernd Strehmel,
  • Christian Schmitz,
  • Ceren Kütahya,
  • Yulian Pang,
  • Anke Drewitz and
  • Heinz Mustroph

Beilstein J. Org. Chem. 2020, 16, 415–444, doi:10.3762/bjoc.16.40

Graphical Abstract
  • helped to understand the function and formation H and J-aggregates [46][47][48][49] being aligned parallel or in series, respectively. The capability of cyanines to form J-aggregates exhibiting a huge bathochromic shift, which was reported for the first time by Scheibe [50] and Jelley in 1937 [51
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Published 18 Mar 2020

Oligomeric ricinoleic acid preparation promoted by an efficient and recoverable Brønsted acidic ionic liquid

  • Fei You,
  • Xing He,
  • Song Gao,
  • Hong-Ru Li and
  • Liang-Nian He

Beilstein J. Org. Chem. 2020, 16, 351–361, doi:10.3762/bjoc.16.34

Graphical Abstract
  • used as lubricant for metal cutting oils due to its appropriate viscosity, good adsorptivity and film formation ability on metal surfaces. Furthermore, the biodegradability of these estolides in the environment makes them attractive as green products. In parallel with the increasing demand for high
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Published 10 Mar 2020

Recent developments in photoredox-catalyzed remote ortho and para C–H bond functionalizations

  • Rafia Siddiqui and
  • Rashid Ali

Beilstein J. Org. Chem. 2020, 16, 248–280, doi:10.3762/bjoc.16.26

Graphical Abstract
  • 59 are obtained by the reduction of the Co(II) catalyst 53 by radical 58. In order to form the desired cyclized product, rearomatization of 59 takes place, and protonation of 55 assists the regeneration of 56, with parallel hydrogen release, as shown in Figure 10. C–H cyclization Synthesis of
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Published 26 Feb 2020

Reversible photoswitching of the DNA-binding properties of styrylquinolizinium derivatives through photochromic [2 + 2] cycloaddition and cycloreversion

  • Sarah Kölsch,
  • Heiko Ihmels,
  • Jochen Mattay,
  • Norbert Sewald and
  • Brian O. Patrick

Beilstein J. Org. Chem. 2020, 16, 111–124, doi:10.3762/bjoc.16.13

Graphical Abstract
  • the differential absorption of linearly polarized light, which was polarized parallel and perpendicular to a reference axis, respectively, thus indicating the orientation of the transition moment of the chromophores relative to the electric field vector of the light [75]. The LD spectrum of DNA-bound
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Published 23 Jan 2020

Synthesis of C-glycosyl phosphonate derivatives of 4-amino-4-deoxy-α-ʟ-arabinose

  • Lukáš Kerner and
  • Paul Kosma

Beilstein J. Org. Chem. 2020, 16, 9–14, doi:10.3762/bjoc.16.2

Graphical Abstract
  • in more detail using phosphodiester-linked derivatives in both anomeric configurations and containing short lipid appendages in order to define the minimum structural requirements for Ara4N glycosyltransferase substrates [9]. In parallel, we have started to develop C-phosphonate analogues as these
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Published 02 Jan 2020

Extension of the 5-alkynyluridine side chain via C–C-bond formation in modified organometallic nucleosides using the Nicholas reaction

  • Renata Kaczmarek,
  • Dariusz Korczyński,
  • James R. Green and
  • Roman Dembinski

Beilstein J. Org. Chem. 2020, 16, 1–8, doi:10.3762/bjoc.16.1

Graphical Abstract
  • ]. In parallel, bioorganometallic chemistry provides new tools to influence biological interactions [16][17][18][19][20][21][22][23][24]. Cobalt possesses a diverse array of properties that can be manipulated to yield promising drug candidates [25]. The antiproliferative properties [26], as well as
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Published 02 Jan 2020

Chemical synthesis of tripeptide thioesters for the biotechnological incorporation into the myxobacterial secondary metabolite argyrin via mutasynthesis

  • David C. B. Siebert,
  • Roman Sommer,
  • Domen Pogorevc,
  • Michael Hoffmann,
  • Silke C. Wenzel,
  • Rolf Müller and
  • Alexander Titz

Beilstein J. Org. Chem. 2019, 15, 2922–2929, doi:10.3762/bjoc.15.286

Graphical Abstract
  • hydroxide deprotection of the ester in compound 40 provided the free acrylate 41. In parallel, Boc-protected sarcosine 42 was transformed into the SNAc thioester 43 and the Boc group was removed to give 44. Then, both building blocks, 44 and 41, were coupled to give the protected tripeptide thioester 35b in
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Published 05 Dec 2019

Influence of the cis/trans configuration on the supramolecular aggregation of aryltriazoles

  • Sara Tejera,
  • Giada Caniglia,
  • Rosa L. Dorta,
  • Andrea Favero,
  • Javier González-Platas and
  • Jesús T. Vázquez

Beilstein J. Org. Chem. 2019, 15, 2881–2888, doi:10.3762/bjoc.15.282

Graphical Abstract
  • from 0° or 180°, since this interaction is governed by an equation with a vectorial product. The lack of exciton pairwise interactions between the two chromophores in positions 1 and 2 of each molecule could be due to the intercalation of a third chromophore between the two former in a parallel
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Published 28 Nov 2019

Preparation of anthracene-based tetraperimidine hexafluorophosphate and selective recognition of chromium(III) ions

  • Qing-Xiang Liu,
  • Feng Yang,
  • Zhi-Xiang Zhao,
  • Shao-Cong Yu and
  • Yue Ding

Beilstein J. Org. Chem. 2019, 15, 2847–2855, doi:10.3762/bjoc.15.278

Graphical Abstract
  • anthracene, and the dihedral angle between two perimidine units of each arm was determined to be 18.1(4)°. Two of the four perimidine groups were parallel to the anthracene plane, with intramolecular π–π interactions [43] being present in this setup (with a face-to-face distance of 3.566(1) Å between
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Published 25 Nov 2019

A review of asymmetric synthetic organic electrochemistry and electrocatalysis: concepts, applications, recent developments and future directions

  • Munmun Ghosh,
  • Valmik S. Shinde and
  • Magnus Rueping

Beilstein J. Org. Chem. 2019, 15, 2710–2746, doi:10.3762/bjoc.15.264

Graphical Abstract
  • to 2-acylimidazole derivatives 94 generates the Lewis acid/enolate complex 100 upon deprotonation (Scheme 35). This is followed by the formation of intermediate 101 by electrolysis-induced SET oxidation. In a parallel electrochemical cycle, benzylic radical species 95 was delivered by the anodic
  • chemistry. Several challenges need to be addressed in order to see widespread application. While recent advancements in electrochemistry have been promising, readily available parallel screening technologies similar to those in homogeneous, heterogeneous, photo- as well as biocatalysis need to be developed
  • . Parallel electrochemical reaction set-ups will, without doubt, accelerate further developments in the field of asymmetric electrochemistry and electrocatalysis. So far, most of the electrochemical reaction set-ups in this area rely on the use of less favorable electrodes, including Pt, Hg or Pb electrodes
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Published 13 Nov 2019

Synthetic terpenoids in the world of fragrances: Iso E Super® is the showcase

  • Alexey Stepanyuk and
  • Andreas Kirschning

Beilstein J. Org. Chem. 2019, 15, 2590–2602, doi:10.3762/bjoc.15.252

Graphical Abstract
  • decades, the demand for fragrances has grown dramatically, so that plantations serve to provide the raw materials. In parallel, synthetic efforts also dramatically expanded to fulfil the huge demand of the consumer markets, new olfactory experiences included. Indeed, synthetic compounds were not
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Published 31 Oct 2019

Probing of local polarity in poly(methyl methacrylate) with the charge transfer transition in Nile red

  • Aydan Yadigarli,
  • Qimeng Song,
  • Sergey I. Druzhinin and
  • Holger Schönherr

Beilstein J. Org. Chem. 2019, 15, 2552–2562, doi:10.3762/bjoc.15.248

Graphical Abstract
  • using νf of NR in PMMA measured at λe = 500 nm, where an overlap of the fluorescence spectra with scattered excitation light is minimal (Figure 4 and Figure S2, Supporting Information File 1). In parallel to νf, the polarity function, having values between 0.159 and 0.191 close to that of the model
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Published 25 Oct 2019
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