Organo-fluorine chemistry IV

  1. editorImage
  1. Editor: Prof. David O'Hagan
    University of St Andrews

The introduction of fluorine into organic molecules is widely practised particularly when tuning the properties of molecules for specialist functions. Fluorine substitution finds a prominent role in pharmaceutical development, in governing bioactivity in a wide range of agrochemical products, in soft materials chemistry such as liquid crystals, in photoresist polymers, self-assembling monolayers and in positron emission tomography. Allied to this breadth of activity is a steady development in the number and range of fluorination reagents and methods. This Thematic Series aims to provide an insight into these developments.

Preparation of imidazo[1,2-a]-N-heterocyclic derivatives with gem-difluorinated side chains

  1. Layal Hariss,
  2. Kamal Bou Hadir,
  3. Mirvat El-Masri,
  4. Thierry Roisnel,
  5. René Grée and
  6. Ali Hachem
  • Full Research Paper
  • Published 10 Oct 2017

Beilstein J. Org. Chem. 2017, 13, 2115–2121, doi:10.3762/bjoc.13.208

  • Review
  • Published 27 Oct 2017

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Beilstein J. Org. Chem. 2017, 13, 2273–2296, doi:10.3762/bjoc.13.224

  • Full Research Paper
  • Published 30 Oct 2017

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Beilstein J. Org. Chem. 2017, 13, 2297–2303, doi:10.3762/bjoc.13.225

Homologated amino acids with three vicinal fluorines positioned along the backbone: development of a stereoselective synthesis

  1. Raju Cheerlavancha,
  2. Ahmed Ahmed,
  3. Yun Cheuk Leung,
  4. Aggie Lawer,
  5. Qing-Quan Liu,
  6. Marina Cagnes,
  7. Hee-Chan Jang,
  8. Xiang-Guo Hu and
  9. Luke Hunter
  • Full Research Paper
  • Published 01 Nov 2017

Beilstein J. Org. Chem. 2017, 13, 2316–2325, doi:10.3762/bjoc.13.228

Fluorination of some highly functionalized cycloalkanes: chemoselectivity and substrate dependence

  1. Attila Márió Remete,
  2. Melinda Nonn,
  3. Santos Fustero,
  4. Matti Haukka,
  5. Ferenc Fülöp and
  6. Loránd Kiss
  • Full Research Paper
  • Published 06 Nov 2017

Beilstein J. Org. Chem. 2017, 13, 2364–2371, doi:10.3762/bjoc.13.233

  • Full Research Paper
  • Published 16 Nov 2017

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Beilstein J. Org. Chem. 2017, 13, 2442–2457, doi:10.3762/bjoc.13.241

Diastereoselective Mannich reactions of pseudo-C2-symmetric glutarimide with activated imines

  1. Tatsuya Ishikawa,
  2. Tomoko Kawasaki-Takasuka,
  3. Toshio Kubota and
  4. Takashi Yamazaki
  • Full Research Paper
  • Published 21 Nov 2017

Beilstein J. Org. Chem. 2017, 13, 2473–2477, doi:10.3762/bjoc.13.244

Syntheses, structures, and stabilities of aliphatic and aromatic fluorous iodine(I) and iodine(III) compounds: the role of iodine Lewis basicity

  1. Tathagata Mukherjee,
  2. Soumik Biswas,
  3. Andreas Ehnbom,
  4. Subrata K. Ghosh,
  5. Ibrahim El-Zoghbi,
  6. Nattamai Bhuvanesh,
  7. Hassan S. Bazzi and
  8. John A. Gladysz
  • Full Research Paper
  • Published 23 Nov 2017

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  • Supp. Info

Beilstein J. Org. Chem. 2017, 13, 2486–2501, doi:10.3762/bjoc.13.246

  • Letter
  • Published 24 Nov 2017

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  • Supp. Info

Beilstein J. Org. Chem. 2017, 13, 2502–2508, doi:10.3762/bjoc.13.247

  • Full Research Paper
  • Published 06 Dec 2017

Beilstein J. Org. Chem. 2017, 13, 2610–2616, doi:10.3762/bjoc.13.258

Regioselective decarboxylative addition of malonic acid and its mono(thio)esters to 4-trifluoromethylpyrimidin-2(1H)-ones

  1. Sergii V. Melnykov,
  2. Andrii S. Pataman,
  3. Yurii V. Dmytriv,
  4. Svitlana V. Shishkina,
  5. Mykhailo V. Vovk and
  6. Volodymyr A. Sukach
  • Full Research Paper
  • Published 07 Dec 2017

Beilstein J. Org. Chem. 2017, 13, 2617–2625, doi:10.3762/bjoc.13.259

  • Full Research Paper
  • Published 07 Dec 2017

Beilstein J. Org. Chem. 2017, 13, 2626–2630, doi:10.3762/bjoc.13.260

  • Review
  • Published 12 Dec 2017

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Beilstein J. Org. Chem. 2017, 13, 2637–2658, doi:10.3762/bjoc.13.262

Ring-size-selective construction of fluorine-containing carbocycles via intramolecular iodoarylation of 1,1-difluoro-1-alkenes

  1. Takeshi Fujita,
  2. Ryo Kinoshita,
  3. Tsuyoshi Takanohashi,
  4. Naoto Suzuki and
  5. Junji Ichikawa
  • Full Research Paper
  • Published 14 Dec 2017

Beilstein J. Org. Chem. 2017, 13, 2682–2689, doi:10.3762/bjoc.13.266

Development of a fluorogenic small substrate for dipeptidyl peptidase-4

  1. Futa Ogawa,
  2. Masanori Takeda,
  3. Kanae Miyanaga,
  4. Keita Tani,
  5. Ryuji Yamazawa,
  6. Kiyoshi Ito,
  7. Atsushi Tarui,
  8. Kazuyuki Sato and
  9. Masaaki Omote
  • Full Research Paper
  • Published 14 Dec 2017

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Beilstein J. Org. Chem. 2017, 13, 2690–2697, doi:10.3762/bjoc.13.267

  • Full Research Paper
  • Published 19 Dec 2017

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Beilstein J. Org. Chem. 2017, 13, 2764–2799, doi:10.3762/bjoc.13.272

  • Full Research Paper
  • Published 19 Dec 2017

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Beilstein J. Org. Chem. 2017, 13, 2800–2818, doi:10.3762/bjoc.13.273

The use of 4,4,4-trifluorothreonine to stabilize extended peptide structures and mimic β-strands

  1. Yaochun Xu,
  2. Isabelle Correia,
  3. Tap Ha-Duong,
  4. Nadjib Kihal,
  5. Jean-Louis Soulier,
  6. Julia Kaffy,
  7. Benoît Crousse,
  8. Olivier Lequin and
  9. Sandrine Ongeri
  • Full Research Paper
  • Published 21 Dec 2017

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Beilstein J. Org. Chem. 2017, 13, 2842–2853, doi:10.3762/bjoc.13.276

Position-dependent impact of hexafluoroleucine and trifluoroisoleucine on protease digestion

  1. Susanne Huhmann,
  2. Anne-Katrin Stegemann,
  3. Kristin Folmert,
  4. Damian Klemczak,
  5. Johann Moschner,
  6. Michelle Kube and
  7. Beate Koksch
  • Full Research Paper
  • Published 22 Dec 2017

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Beilstein J. Org. Chem. 2017, 13, 2869–2882, doi:10.3762/bjoc.13.279

The synthesis of the 2,3-difluorobutan-1,4-diol diastereomers

  1. Robert Szpera,
  2. Nadia Kovalenko,
  3. Kalaiselvi Natarajan,
  4. Nina Paillard and
  5. Bruno Linclau
  • Full Research Paper
  • Published 27 Dec 2017

Beilstein J. Org. Chem. 2017, 13, 2883–2887, doi:10.3762/bjoc.13.280

  • Full Research Paper
  • Published 29 Dec 2017

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Beilstein J. Org. Chem. 2017, 13, 2915–2921, doi:10.3762/bjoc.13.284

Microfluidic radiosynthesis of [18F]FEMPT, a high affinity PET radiotracer for imaging serotonin receptors

  1. Thomas Lee Collier,
  2. Steven H. Liang,
  3. J. John Mann,
  4. Neil Vasdev and
  5. J. S. Dileep Kumar
  • Full Research Paper
  • Published 29 Dec 2017

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Beilstein J. Org. Chem. 2017, 13, 2922–2927, doi:10.3762/bjoc.13.285

Stereochemical outcomes of C–F activation reactions of benzyl fluoride

  1. Neil S. Keddie,
  2. Pier Alexandre Champagne,
  3. Justine Desroches,
  4. Jean-François Paquin and
  5. David O'Hagan
  • Full Research Paper
  • Published 09 Jan 2018

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Beilstein J. Org. Chem. 2018, 14, 106–113, doi:10.3762/bjoc.14.6

Gram-scale preparation of negative-type liquid crystals with a CF2CF2-carbocycle unit via an improved short-step synthetic protocol

  1. Tatsuya Kumon,
  2. Shohei Hashishita,
  3. Takumi Kida,
  4. Shigeyuki Yamada,
  5. Takashi Ishihara and
  6. Tsutomu Konno
  • Full Research Paper
  • Published 15 Jan 2018

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Beilstein J. Org. Chem. 2018, 14, 148–154, doi:10.3762/bjoc.14.10

Progress in copper-catalyzed trifluoromethylation

  1. Guan-bao Li,
  2. Chao Zhang,
  3. Chun Song and
  4. Yu-dao Ma
  • Review
  • Published 17 Jan 2018

  • PDF

Beilstein J. Org. Chem. 2018, 14, 155–181, doi:10.3762/bjoc.14.11

Nucleophilic fluoroalkylation/cyclization route to fluorinated phthalides

  1. Masanori Inaba,
  2. Tatsuya Sakai,
  3. Shun Shinada,
  4. Tsuyuka Sugiishi,
  5. Yuta Nishina,
  6. Norio Shibata and
  7. Hideki Amii
  • Full Research Paper
  • Published 19 Jan 2018

Beilstein J. Org. Chem. 2018, 14, 182–186, doi:10.3762/bjoc.14.12

  • Full Research Paper
  • Published 08 Feb 2018

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Beilstein J. Org. Chem. 2018, 14, 373–380, doi:10.3762/bjoc.14.25

Synthesis and stability of strongly acidic benzamide derivatives

  1. Frederik Diness,
  2. Niels J. Bjerrum and
  3. Mikael Begtrup
  • Full Research Paper
  • Published 27 Feb 2018

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Beilstein J. Org. Chem. 2018, 14, 523–530, doi:10.3762/bjoc.14.38

Copper-catalyzed asymmetric methylation of fluoroalkylated pyruvates with dimethylzinc

  1. Kohsuke Aikawa,
  2. Kohei Yabuuchi,
  3. Kota Torii and
  4. Koichi Mikami
  • Full Research Paper
  • Published 07 Mar 2018

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2018, 14, 576–582, doi:10.3762/bjoc.14.44

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